Sirolimus (BioDeep_00000002122)

Main id: BioDeep_00000230911

 

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone

化学式: C51H79NO13 (913.5551124)
中文名称: 雷帕霉素(DMSO溶液)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC
InChI: InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1

描述信息

Sirolimus is a macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. [PubChem]
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01E - Protein kinase inhibitors > L01EG - Mammalian target of rapamycin (mtor) kinase inhibitors
L - Antineoplastic and immunomodulating agents > L04 - Immunosuppressants > L04A - Immunosuppressants > L04AA - Selective immunosuppressants
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
COVID info from Guide to PHARMACOLOGY, clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000970 - Antineoplastic Agents > D000903 - Antibiotics, Antineoplastic > D020123 - Sirolimus
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2201 - mTOR Inhibitor
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C784 - Protein Synthesis Inhibitor > C261 - Macrolide Antibiotic
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant
C254 - Anti-Infective Agent > C258 - Antibiotic
S - Sensory organs > S01 - Ophthalmologicals
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].
Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].
Rapamycin (Sirolimus; AY 22989) is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1[1]. Rapamycin is an autophagy activator, an immunosuppressant[2].

同义名列表

17 个代谢物同义名

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-ep; Antibiotic ay 22989; (RS)-rapamycin; Rapamycin (TN); (-)-Rapamycin; sirolimusum; Rapamycin; Rapammune; Sirolimus; Rapamysin; Rapamune; Perceiva; RAPA; RPM; AY-22989



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaodan Chen, Faranak Bahramimehr, Nasim Shahhamzehei, Huangjie Fu, Siyi Lin, Hanxiao Wang, Changyu Li, Thomas Efferth, Chunlan Hong. Anti-aging effects of medicinal plants and their rapid screening using the nematode Caenorhabditis elegans. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155665. doi: 10.1016/j.phymed.2024.155665. [PMID: 38768535]
  • Cheng-Wen He, Chunlian Qin, Yi Zhang, Yan Zhang, Kaiqiang Li, Yuqun Cai, Wei Zhang, Ning Hu, Zhen Wang. A cardiomyocyte-based biosensing platform for dynamic and quantitative investigation of excessive autophagy. Biosensors & bioelectronics. 2024 May; 251(?):116113. doi: 10.1016/j.bios.2024.116113. [PMID: 38364328]
  • Yung-Shun Su, Ming-Jen Cheng, Aij-Lie Kwan, Shu-Ping Huang, Yu-Chang Tyan, Chee-Yin Chai, Bin Huang. The crude extract obtained from Cinnamomum macrostemon Hayata regulates oxidative stress and mitophagy in keratinocytes. Bioscience, biotechnology, and biochemistry. 2024 Apr; 88(5):529-537. doi: 10.1093/bbb/zbae022. [PMID: 38509025]
  • Yuanhao Zhao, Xiaoyan Chen, Penghui He, Xuanyu Wang, Yanhua Xu, Rui Hu, Yangsen Ou, Zhihua Zhang, Zhibing Zhang, Guangsheng Du, Xun Sun. Transdermal Microneedles Alleviated Rheumatoid Arthritis by Inducing Immune Tolerance via Skin-Resident Antigen Presenting Cells. Small (Weinheim an der Bergstrasse, Germany). 2024 Apr; 20(16):e2307366. doi: 10.1002/smll.202307366. [PMID: 38039446]
  • Jie Dong, Qian Xu, Chenxi Qian, Lu Wang, Alison DiSciullo, Jun Lei, Hui Lei, Song Yan, Jingjing Wang, Ni Jin, Yujing Xiong, Jianhua Zhang, Irina Burd, Xiaohong Wang. Fetal growth restriction exhibits various mTOR signaling in different regions of mouse placentas with altered lipid metabolism. Cell biology and toxicology. 2024 03; 40(1):15. doi: 10.1007/s10565-024-09855-8. [PMID: 38451382]
  • Liping Feng, Meixia Dong, Zhirui Huang, Qian Wang, Bang An, Chaozu He, Qiannan Wang, Hongli Luo. CgCFEM1 Is Required for the Full Virulence of Colletotrichum gloeosporioides. International journal of molecular sciences. 2024 Mar; 25(5):. doi: 10.3390/ijms25052937. [PMID: 38474183]
  • Yulin Yang, Shushu Wang, Chunxiang Sheng, Jialin Tan, Junmin Chen, Tianjiao Li, Xiaoqin Ma, Haipeng Sun, Xiao Wang, Libin Zhou. Branched-chain amino acid catabolic defect promotes α-cell proliferation via activating mTOR signaling. Molecular and cellular endocrinology. 2024 Mar; 582(?):112143. doi: 10.1016/j.mce.2023.112143. [PMID: 38158148]
  • Maria Juliana Calderan-Rodrigues, Camila Caldana. Impact of the TOR pathway on plant growth via cell wall remodeling. Journal of plant physiology. 2024 Mar; 294(?):154202. doi: 10.1016/j.jplph.2024.154202. [PMID: 38422631]
  • Yi Liu, Qian Huang, Mengyun He, Tingting Chen, Xia Chu. A nano-bioconjugate modified with anti-SIRPα antibodies and antisense oligonucleotides of mTOR for anti-atherosclerosis therapy. Acta biomaterialia. 2024 Mar; 176(?):356-366. doi: 10.1016/j.actbio.2023.12.031. [PMID: 38160854]
  • María Victoria Canal, Natanael Mansilla, Diana E Gras, Agustín Ibarra, Carlos M Figueroa, Daniel H Gonzalez, Elina Welchen. Cytochrome c levels affect the TOR pathway to regulate growth and metabolism under energy-deficient conditions. The New phytologist. 2024 Mar; 241(5):2039-2058. doi: 10.1111/nph.19506. [PMID: 38191763]
  • Md Torikul Islam, Shelby A Hall, Tavia Dutson, Samuel I Bloom, R Colton Bramwell, John Kim, Jordan R Tucker, Daniel R Machin, Anthony J Donato, Lisa A Lesniewski. Endothelial cell-specific reduction in mTOR ameliorates age-related arterial and metabolic dysfunction. Aging cell. 2024 Feb; 23(2):e14040. doi: 10.1111/acel.14040. [PMID: 38017701]
  • Iftah Marash, Rupali Gupta, Gautam Anand, Meirav Leibman-Markus, Naomi Lindner, Alon Israeli, Dov Nir, Adi Avni, Maya Bar. TOR coordinates cytokinin and gibberellin signals mediating development and defense. Plant, cell & environment. 2024 Feb; 47(2):629-650. doi: 10.1111/pce.14748. [PMID: 37904283]
  • Jialong Yang, Jiapeng Deng, Kaitao Wang, An Wang, Guodong Chen, Qingyu Chen, Minle Ye, Xinyu Wu, Xinye Wang, Dingsheng Lin. Tetrahydropalmatine promotes random skin flap survival in rats via the PI3K/AKT signaling pathway. Journal of ethnopharmacology. 2024 Jan; 324(?):117808. doi: 10.1016/j.jep.2024.117808. [PMID: 38280663]
  • Yang Kong, Xiangrong Li, Huanle Zhang, Bin Fu, Hua-Ye Jiang, Hui-Lin Yang, Jin Dai. Targeting POLRMT by a first-in-class inhibitor IMT1 inhibits osteosarcoma cell growth in vitro and in vivo. Cell death & disease. 2024 01; 15(1):57. doi: 10.1038/s41419-024-06444-9. [PMID: 38228583]
  • Emanuela Fabiola Craparo, Marta Cabibbo, Cinzia Scialabba, Luca Casula, Francesco Lai, Gennara Cavallaro. Rapamycin-based inhaled therapy for potential treatment of COPD-related inflammation: production and characterization of aerosolizable nano into micro (NiM) particles. Biomaterials science. 2024 Jan; 12(2):387-401. doi: 10.1039/d3bm01210g. [PMID: 37997957]
  • Jianyang Bai, Zhangqi Zuo, Haonan DuanMu, Meizhen Li, Haojie Tong, Yang Mei, Yiqi Xiao, Kang He, Mingxing Jiang, Shuping Wang, Fei Li. Endosymbiont Tremblaya phenacola influences the reproduction of cotton mealybugs by regulating the mechanistic target of rapamycin pathway. The ISME journal. 2024 Jan; 18(1):. doi: 10.1093/ismejo/wrae052. [PMID: 38519099]
  • Leonel E Lopez, Javier Martinez Pacheco, José M Estevez. The exception to the rule? TORC1 triggers growth under low nutrient environments. Trends in plant science. 2024 01; 29(1):13-15. doi: 10.1016/j.tplants.2023.10.001. [PMID: 37848359]
  • Jie Cai, Danni Xie, Fanjing Kong, Zhenwei Zhai, Zhishan Zhu, Yanru Zhao, Ying Xu, Tao Sun. Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies. Journal of Alzheimer's disease : JAD. 2024; 99(1):53-84. doi: 10.3233/jad-231249. [PMID: 38640155]
  • B Li, Y Wang, F Hou, J DU, X Tong. [Rapamycin enhances inhibitory effect of RSL3 on proliferation, invasion and migration of testicular cancer I-10 cells in vitro]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2023 Dec; 43(12):2145-2151. doi: 10.12122/j.issn.1673-4254.2023.12.21. [PMID: 38189403]
  • Yuting Yin, Chun Wu, Yufeng Zhou, Meiyin Zhang, Shijuan Mai, Minshan Chen, Hui-Yun Wang. Ezetimibe Induces Paraptosis through Niemann-Pick C1-like 1 Inhibition of Mammalian-Target-of-Rapamycin Signaling in Hepatocellular Carcinoma Cells. Genes. 2023 Dec; 15(1):. doi: 10.3390/genes15010004. [PMID: 38275586]
  • Don Luu, Tariq Shah, Prashant Sakharkar, David I Min. Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development of new-onset diabetes after kidney transplantation. Transplant immunology. 2023 12; 81(?):101947. doi: 10.1016/j.trim.2023.101947. [PMID: 37918578]
  • Romain Perdoux, Adam Barrada, Manal Boulaiz, Camille Garau, Clément Belbachir, Cécile Lecampion, Marie-Hélène Montané, Benoît Menand. A drug-resistant mutation in plant target of rapamycin validates the specificity of ATP-competitive TOR inhibitors in vivo. The Plant journal : for cell and molecular biology. 2023 Nov; ?(?):. doi: 10.1111/tpj.16564. [PMID: 38011587]
  • Chenglong Ji, Jingya Zhou, Daoyong Yang, Bowen Yuan, Rongxia Tang, Yong Liu, Dehui Xi. ATG8f Interacts with Chilli Veinal Mottle Virus 6K2 Protein to Limit Virus Infection. Viruses. 2023 Nov; 15(12):. doi: 10.3390/v15122324. [PMID: 38140565]
  • Sang-Min Kim, Dong Yeol Kim, Jiwon Park, Young-Ah Moon, Inn-Oc Han. Glucosamine increases macrophage lipid accumulation by regulating the mammalian target of rapamycin signaling pathway. BMB reports. 2023 Nov; ?(?):. doi: . [PMID: 37964636]
  • Wu Xiong, Xue Bai, Xi Zhang, Huajuan Lei, Hui Xiao, Luyao Zhang, Yuting Xiao, Qianpei Yang, Xiaoling Zou. Endothelial Progenitor-Cell-Derived Exosomes Induced by Astragaloside IV Accelerate Type I Diabetic-wound Healing via the PI3K/AKT/mTOR Pathway in Rats. Frontiers in bioscience (Landmark edition). 2023 Nov; 28(11):282. doi: 10.31083/j.fbl2811282. [PMID: 38062822]
  • Iara Bastos de Andrade, Vinicius Alves, Luiza Pereira, Bruna Miranda, Dario Corrêa-Junior, Maria Helena Galdino Figueiredo-Carvalho, Marcos Vinicius Santos, Rodrigo Almeida-Paes, Susana Frases. Effect of rapamycin on Cryptococcus neoformans: cellular organization, biophysics and virulence factors. Future microbiology. 2023 11; 18(?):1061-1075. doi: 10.2217/fmb-2023-0097. [PMID: 37721517]
  • Ya-Fei Deng, Shu-Ting Wu, Hong-Yan Peng, Lei Tian, Ya-Na Li, Yao Yang, Meng Meng, Lan-Lan Huang, Pei-Wen Xiong, Song-Yang Li, Qing-Lan Yang, Li-Li Wang, Xiao-Yao Li, Li-Ping Li, Xiu-Lan Lu, Xiao-Hui Li, Yan-Ling Wei, Zheng-Hui Xiao, Jian-Hua Yu, You-Cai Deng. mTORC2 acts as a gatekeeper for mTORC1 deficiency-mediated impairments in ILC3 development. Acta pharmacologica Sinica. 2023 Nov; 44(11):2243-2252. doi: 10.1038/s41401-023-01120-8. [PMID: 37407703]
  • Yanjie Li, Wang Liu, Ruoyu Zhao, Yuanyuan An, Mingzhu Zhang, Xiaobin Ren, Hongbing He. Yunnan Baiyao Inhibits Periodontitis by Suppressing the Autophagic Flux. International dental journal. 2023 Oct; ?(?):. doi: 10.1016/j.identj.2023.09.005. [PMID: 37852809]
  • Xiaodan Ren, Ying Dai, Mengya Shan, Jing Zheng, Zhongyi Zhang, Tao Shen. Astragalus polysaccharide restores insulin secretion impaired by lipopolysaccharides through the protein kinase B /mammalian target of rapamycin/glucose transporter 2 pathway. BMC complementary medicine and therapies. 2023 Oct; 23(1):358. doi: 10.1186/s12906-023-04188-1. [PMID: 37817130]
  • Vivek Panwar, Aishwarya Singh, Manini Bhatt, Rajiv K Tonk, Shavkatjon Azizov, Agha Saquib Raza, Shinjinee Sengupta, Deepak Kumar, Manoj Garg. Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. Signal transduction and targeted therapy. 2023 10; 8(1):375. doi: 10.1038/s41392-023-01608-z. [PMID: 37779156]
  • Shuangdi Duan, Nong Qin, Jiayi Pi, Pei Sun, Yating Gao, Lamei Liu, Zenghui Li, Ya Li, Liyang Shi, Qiang Gao, Ye Qiu, Songqing Tang, Chun-Hsiang Wang, Tzu-Ying Chen, Sin-Tian Wang, Kung-Chia Young, Hung-Yu Sun. Antagonizing apolipoprotein J chaperone promotes proteasomal degradation of mTOR and relieves hepatic lipid deposition. Hepatology (Baltimore, Md.). 2023 10; 78(4):1182-1199. doi: 10.1097/hep.0000000000000185. [PMID: 37013405]
  • Qin Zhao, Hong Su, Wei Jiang, Haodong Luo, Lu Pan, Yuan Liu, Ce Yang, Ying Yin, Lehua Yu, Botao Tan. IGF-1 Combined with OPN Promotes Neuronal Axon Growth in Vitro Through the IGF-1R/Akt/mTOR Signaling Pathway in Lipid Rafts. Neurochemical research. 2023 Oct; 48(10):3190-3201. doi: 10.1007/s11064-023-03971-3. [PMID: 37395917]
  • Jennifer Saile, Theresa Wießner-Kroh, Katarina Erbstein, Dominik M Obermüller, Anne Pfeiffer, Denis Janocha, Jan Lohmann, Andreas Wachter. SNF1-RELATED KINASE 1 and TARGET OF RAPAMYCIN control light-responsive splicing events and developmental characteristics in etiolated Arabidopsis seedlings. The Plant cell. 2023 09; 35(9):3413-3428. doi: 10.1093/plcell/koad168. [PMID: 37338062]
  • Thomas J Wert, Stephanie Heeney, Maddy Morrison. Conversion between sirolimus and everolimus in heart transplant recipients. Clinical transplantation. 2023 Aug; ?(?):e15102. doi: 10.1111/ctr.15102. [PMID: 37589884]
  • Yihan Dong, Ola Srour, Nina Lukhovitskaya, Joelle Makarian, Nicolas Baumberger, Oxana Galzitskaya, David Elser, Mikhail Schepetilnikov, Lyubov A Ryabova. Functional analogs of mammalian 4E-BPs reveal a role for TOR in global plant translation. Cell reports. 2023 Jul; 42(8):112892. doi: 10.1016/j.celrep.2023.112892. [PMID: 37516965]
  • A R Tornero-Écija, M A Navas, S Muñoz-Braceras, O Vincent, R Escalante. Effect of rapamycin on lysosomal accumulation in a CRISPR/Cas9-based cellular model of VPS13A deficiency. Journal of cellular and molecular medicine. 2023 May; ?(?):. doi: 10.1111/jcmm.17768. [PMID: 37163371]
  • Huikyong Cho, Michael Banf, Zaigham Shahzad, Jelle Van Leene, Flavia Bossi, Sandrine Ruffel, Nadia Bouain, Pengfei Cao, Gabiel Krouk, Geert De Jaeger, Benoit Lacombe, Federica Brandizzi, Seung Y Rhee, Hatem Rouached. ARSK1 activates TORC1 signaling to adjust growth to phosphate availability in Arabidopsis. Current biology : CB. 2023 05; 33(9):1778-1786.e5. doi: 10.1016/j.cub.2023.03.005. [PMID: 36963384]
  • Shraddha Parate, Vikas Kumar, Jong Chan Hong, Keun Woo Lee. Investigation of Macrocyclic mTOR Modulators of Rapamycin Binding Site via Pharmacoinformatics Approaches. Computational biology and chemistry. 2023 Apr; 104(?):107875. doi: 10.1016/j.compbiolchem.2023.107875. [PMID: 37148678]
  • Camille Ingargiola, Isabelle Jéhanno, Céline Forzani, Anne Marmagne, Justine Broutin, Gilles Clément, Anne-Sophie Leprince, Christian Meyer. The Arabidopsis Target of Rapamycin (TOR) kinase regulates ammonium assimilation and glutamine metabolism. Plant physiology. 2023 Apr; ?(?):. doi: 10.1093/plphys/kiad216. [PMID: 37042394]
  • Qiumin Chen, Mengqi Qu, Qinglei Chen, Xiangnan Meng, Haiyan Fan. Phosphoproteomics analysis of the effect of target of rapamycin kinase inhibition on Cucumis sativus in response to Podosphaera xanthii. Plant physiology and biochemistry : PPB. 2023 Apr; 197(?):107641. doi: 10.1016/j.plaphy.2023.107641. [PMID: 36940522]
  • Xiang Zheng, Weijie Zhang, Hua Zhou, Ronghua Cao, Zhangfei Shou, Shuwei Zhang, Ying Cheng, Xuchun Chen, Chenguang Ding, Ning Li, Shaohua Shi, Qiang Zhou, Qiuyuan Chen, Gang Chen, Zheng Chen, Peijun Zhou, Xiaopeng Hu, Wujun Xue, Xiaodong Zhang, Ning Na, Wei Wang. A multi-center randomized controlled trial to evaluate efficacy and safety of early conversion to a low-dose calcineurin inhibitor combined with sirolimus in renal transplant patients. Chinese medical journal. 2023 03; 136(5):607-609. doi: 10.1097/cm9.0000000000002604. [PMID: 36921118]
  • Ying-Ya Cao, Yang Qiao, Zhong-Han Wang, Qun Chen, Yu-Peng Qi, Zi-Meng Lu, Zhen Wang, Wei-Hua Lu. The Polo-Like Kinase 1-Mammalian Target of Rapamycin Axis Regulates Autophagy to Prevent Intestinal Barrier Dysfunction During Sepsis. The American journal of pathology. 2023 03; 193(3):296-312. doi: 10.1016/j.ajpath.2022.11.008. [PMID: 36509119]
  • Peiyu Liu, Yang Xu, Jiaxue Ye, Jingrui Tan, Jie Hou, Yazhuo Wang, Jianwei Li, Weizhen Cui, Shiyuan Wang, Qingyang Zhao. Qingre Huazhuo Jiangsuan Decoction promotes autophagy by inhibiting PI3K/AKT/mTOR signaling pathway to relieve acute gouty arthritis. Journal of ethnopharmacology. 2023 Feb; 302(Pt A):115875. doi: 10.1016/j.jep.2022.115875. [PMID: 36328206]
  • Lishan Ouyang, Jiaqi Li, Xiaonan Chen, Huiming Huang, Yingying Tian, Xingxing Li, Daoran Pang, Xuejiao Wei, Jinxin Xie, Longyan Wang, Dongxiao Liu, Pengfei Tu, Jun Li, Zhongdong Hu. Chinese dragon's blood ethyl acetate extract suppresses gastric cancer progression through induction of apoptosis and autophagy mediated by activation of MAPK and downregulation of the mTOR-Beclin1 signalling cascade. Phytotherapy research : PTR. 2023 Feb; 37(2):689-701. doi: 10.1002/ptr.7652. [PMID: 36245270]
  • Yongpeng Huang, Hui Tang, Xiangyan Meng, Hui Zhong, Yunyang Song, Bo Chen, Zhiyun Zou. [Rapid and simultaneous determination of two immunosuppressants in whole blood by high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2023 Feb; 41(2):152-159. doi: 10.3724/sp.j.1123.2022.03033. [PMID: 36725711]
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