Pipermethystine (BioDeep_00000020904)

   

human metabolite natural product


代谢物信息卡片


6-oxo-1-(3-Phenylpropanoyl)-1,2,3,6-tetrahydropyridin-3-yl acetic acid

化学式: C16H17NO4 (287.11575220000003)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OC1C=CC(=O)N(C(=O)CCc2ccccc2)C1
InChI: InChI=1S/C16H17NO4/c1-12(18)21-14-8-10-16(20)17(11-14)15(19)9-7-13-5-3-2-4-6-13/h2-6,8,10,14H,7,9,11H2,1H3

描述信息

Pipermethystine is found in beverages. Pipermethystine is an alkaloid from the leaves of kava (Piper methysticum). FDA advises against use of kava in food due to potential risk of severe liver damage (2002) Pipermethystine is an alkaloid present in the aerial (aboveground) portions of the kava plant.
Alkaloid from the leaves of kava (Piper methysticum). FDA advises against use of kava in food due to potential risk of severe liver damage (2002)

同义名列表

5 个代谢物同义名

6-oxo-1-(3-Phenylpropanoyl)-1,2,3,6-tetrahydropyridin-3-yl acetic acid; 6-oxo-1-(3-phenylpropanoyl)-1,2,3,6-tetrahydropyridin-3-yl acetate; 6-oxo-1-(3-phenylpropanoyl)-2,3-dihydropyridin-3-yl acetate; 5-Acetoxy-5,6-dihydro-1-(3-phenylpropanoyl)-2(1H)-pyridone; Pipermethystine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rolf Teschke, Samuel X Qiu, Vincent Lebot. Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2011 Sep; 43(9):676-81. doi: 10.1016/j.dld.2011.01.018. [PMID: 21377431]
  • M Lechtenberg, B Quandt, M Schmidt, A Nahrstedt. Is the alkaloid pipermethystine connected with the claimed liver toxicity of Kava products?. Die Pharmazie. 2008 Jan; 63(1):71-4. doi: . [PMID: 18271308]
  • Steven T S Lim, Klaus Dragull, Chung-Shih Tang, Harry C Bittenbender, Jimmy T Efird, Pratibha V Nerurkar. Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats. Toxicological sciences : an official journal of the Society of Toxicology. 2007 May; 97(1):214-21. doi: 10.1093/toxsci/kfm035. [PMID: 17329236]
  • Pratibha V Nerurkar, Klaus Dragull, Chung-Shih Tang. In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones. Toxicological sciences : an official journal of the Society of Toxicology. 2004 May; 79(1):106-11. doi: 10.1093/toxsci/kfh067. [PMID: 14737001]