Cryptochrome (BioDeep_00000020530)
human metabolite Endogenous
代谢物信息卡片
2-[(2Z,4Z,6E,8Z,10E,12E,14Z)-15-(4,4,7a-trimethyl-2,4,5,6,7,7a-hexahydro-1-benzofuran-2-yl)-6,11-dimethylhexadeca-2,4,6,8,10,12,14-heptaen-2-yl]-4,4,7a-trimethyl-2,4,5,6,7,7a-hexahydro-1-benzofuran-6-ol
化学式: C40H56O3 (584.4229226)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CC=CC=C(C)C=CC=C(C)C1C=C2C(CC(CC2(O1)C)O)(C)C)C=CC=C(C)C3C=C4C(CCCC4(O3)C)(C)C
InChI: InChI=1S/C40H56O3/c1-28(18-13-20-30(3)33-24-35-37(5,6)22-15-23-39(35,9)42-33)16-11-12-17-29(2)19-14-21-31(4)34-25-36-38(7,8)26-32(41)27-40(36,10)43-34/h11-14,16-21,24-25,32-34,41H,15,22-23,26-27H2,1-10H3/b12-11-,18-13+,19-14-,28-16+,29-17+,30-20-,31-21-
描述信息
Isolated from Prunus persica (peach) and fruits of Averrhoa carambola. Cryptochrome is found in star fruit, fruits, and peach.
Cryptochrome is found in fruits. Cryptochrome is isolated from Prunus persica (peach) and fruits of Averrhoa carambol
同义名列表
7 个代谢物同义名
2-[(2Z,4Z,6E,8Z,10E,12E,14Z)-15-(4,4,7a-trimethyl-2,4,5,6,7,7a-hexahydro-1-benzofuran-2-yl)-6,11-dimethylhexadeca-2,4,6,8,10,12,14-heptaen-2-yl]-4,4,7a-trimethyl-2,4,5,6,7,7a-hexahydro-1-benzofuran-6-ol; 2-[(2Z,4Z,6E,8Z,10E,12E,14Z)-15-(4,4,7a-trimethyl-2,5,6,7-tetrahydro-1-benzofuran-2-yl)-6,11-dimethylhexadeca-2,4,6,8,10,12,14-heptaen-2-yl]-4,4,7a-trimethyl-2,5,6,7-tetrahydro-1-benzofuran-6-ol; 5,8:5,8-Diepoxy-5,5,8,8-tetrahydro-beta,beta-caroten-3-ol; 5,8:5,8-Diepoxy-5,5,8,8-tetrahydro-b,b-caroten-3-ol; Cryptochrome proteins; Cryptochromes; Cryptochrome
数据库引用编号
10 个数据库交叉引用编号
- PubChem: 131750919
- PubChem: 609563
- HMDB: HMDB0029857
- Wikipedia: Cryptochrome
- MeSH: Cryptochromes
- KNApSAcK: C00022957
- foodb: FDB001079
- chemspider: 35013093
- CAS: 73745-06-9
- PMhub: MS000045440
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yin Yeng Lee, Sibel Cal-Kayitmazbatir, Lauren J Francey, Michael Seifu Bahiru, Katharina E Hayer, Gang Wu, Molly J Zeller, Robyn Roberts, James Speers, Justin Koshalek, Mark E Berres, Eric L Bittman, John B Hogenesch. duper is a null mutation of Cryptochrome 1 in Syrian hamsters.
Proceedings of the National Academy of Sciences of the United States of America.
2022 05; 119(18):e2123560119. doi:
10.1073/pnas.2123560119. [PMID: 35471909] - Lina K Sciesielski, Matthias Felten, Laura Michalick, Karin M Kirschner, Georgia Lattanzi, Charlotte L J Jacobi, Thomas Wallach, Veronika Lang, Dominic Landgraf, Achim Kramer, Christof Dame. The circadian clock regulates rhythmic erythropoietin expression in the murine kidney.
Kidney international.
2021 11; 100(5):1071-1080. doi:
10.1016/j.kint.2021.07.012. [PMID: 34332958] - Seong J An, Felix Rivera-Molina, Alexander Anneken, Zhiqun Xi, Brian McNellis, Vladimir I Polejaev, Derek Toomre. An active tethering mechanism controls the fate of vesicles.
Nature communications.
2021 09; 12(1):5434. doi:
10.1038/s41467-021-25465-y. [PMID: 34521845] - Kazuhito Tsuzuki, Yuuki Shimizu, Junya Suzuki, Zhongyue Pu, Shukuro Yamaguchi, Yusuke Fujikawa, Katsuhiro Kato, Koji Ohashi, Mikito Takefuji, Yasuko K Bando, Noriyuki Ouchi, John W Calvert, Rei Shibata, Toyoaki Murohara. Adverse Effect of Circadian Rhythm Disorder on Reparative Angiogenesis in Hind Limb Ischemia.
Journal of the American Heart Association.
2021 08; 10(16):e020896. doi:
10.1161/jaha.121.020896. [PMID: 34348468] - Aniceta Ada Mikulska, Teresa Grzelak, Marta Pelczyńska, Paweł Bogdański, Krystyna Czyżewska. Assessment of Selected Clock Proteins (CLOCK and CRY1) and Their Relationship with Biochemical, Anthropometric, and Lifestyle Parameters in Hypertensive Patients.
Biomolecules.
2021 03; 11(4):. doi:
10.3390/biom11040517. [PMID: 33808431] - Yi Chang, Chunsong Zhao, Hui Ding, Ting Wang, Caixia Yang, Xiuhong Nie, Yanning Cai. Serum factor(s) from lung adenocarcinoma patients regulates the molecular clock expression.
Journal of cancer research and clinical oncology.
2021 Feb; 147(2):493-498. doi:
10.1007/s00432-020-03467-5. [PMID: 33221997] - Anjara Rabearivony, Huan Li, Shiyao Zhang, Siyu Chen, Xiaofei An, Chang Liu. Housing temperature affects the circadian rhythm of hepatic metabolism and clock genes.
The Journal of endocrinology.
2020 11; 247(2):183-195. doi:
10.1530/joe-20-0100. [PMID: 33032261] - Melissa L Erickson, Hui Zhang, Jacob T Mey, John P Kirwan. Exercise Training Impacts Skeletal Muscle Clock Machinery in Prediabetes.
Medicine and science in sports and exercise.
2020 10; 52(10):2078-2085. doi:
10.1249/mss.0000000000002368. [PMID: 32496736] - Iker Lamas, Nathalie Weber, Sophie G Martin. Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast.
Cells.
2020 09; 9(9):. doi:
10.3390/cells9092089. [PMID: 32932721] - Peiyuan Huang, Aofei Liu, Yutong Song, Jen M Hope, Bianxiao Cui, Liting Duan. Optical Activation of TrkB Signaling.
Journal of molecular biology.
2020 06; 432(13):3761-3770. doi:
10.1016/j.jmb.2020.05.002. [PMID: 32422149] - Ziliang Huang, Yiqian Wu, Molly E Allen, Yijia Pan, Phillip Kyriakakis, Shaoying Lu, Ya-Ju Chang, Xin Wang, Shu Chien, Yingxiao Wang. Engineering light-controllable CAR T cells for cancer immunotherapy.
Science advances.
2020 02; 6(8):eaay9209. doi:
10.1126/sciadv.aay9209. [PMID: 32128416] - Takahiro Sato, Kanae Oishi, Takanori Ida, Masayasu Kojima. Suppressive effect of ghrelin on nicotine-induced clock gene expression in the mouse pancreas.
Endocrine journal.
2020 Jan; 67(1):73-80. doi:
10.1507/endocrj.ej19-0169. [PMID: 31611477] - Maaike Schilperoort, Nathalie Bravenboer, Joann Lim, Kathrin Mletzko, Björn Busse, Leo van Ruijven, Jan Kroon, Patrick C N Rensen, Sander Kooijman, Elizabeth M Winter. Circadian disruption by shifting the light-dark cycle negatively affects bone health in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 01; 34(1):1052-1064. doi:
10.1096/fj.201901929r. [PMID: 31914701] - Laura Sardon Puig, Nicolas J Pillon, Erik Näslund, Anna Krook, Juleen R Zierath. Influence of obesity, weight loss, and free fatty acids on skeletal muscle clock gene expression.
American journal of physiology. Endocrinology and metabolism.
2020 01; 318(1):E1-E10. doi:
10.1152/ajpendo.00289.2019. [PMID: 31613643] - Yawei Guo, Xiaohui Zhu, Sha Zeng, Mingyi He, Xiurong Xing, Changyuan Wang. miRNA-10a-5p Alleviates Insulin Resistance and Maintains Diurnal Patterns of Triglycerides and Gut Microbiota in High-Fat Diet-Fed Mice.
Mediators of inflammation.
2020; 2020(?):8192187. doi:
10.1155/2020/8192187. [PMID: 32879620] - Meng-Jun Qiu, Li-Ping Liu, Si Jin, Xie-Fan Fang, Xiao-Xiao He, Zhi-Fan Xiong, Sheng-Li Yang. Research on circadian clock genes in common abdominal malignant tumors.
Chronobiology international.
2019 07; 36(7):906-918. doi:
10.1080/07420528.2018.1477792. [PMID: 31014126] - Stuart Sullivan, Eros Kharshiing, Janet Laird, Tatsuya Sakai, John M Christie. Deetiolation Enhances Phototropism by Modulating NON-PHOTOTROPIC HYPOCOTYL3 Phosphorylation Status.
Plant physiology.
2019 06; 180(2):1119-1131. doi:
10.1104/pp.19.00206. [PMID: 30918082] - Lei Liu, Xin-Lu Pang, Wen-Jun Shang, Hong-Chang Xie, Jun-Xiang Wang, Gui-Wen Feng. Over-expressed microRNA-181a reduces glomerular sclerosis and renal tubular epithelial injury in rats with chronic kidney disease via down-regulation of the TLR/NF-κB pathway by binding to CRY1.
Molecular medicine (Cambridge, Mass.).
2018 09; 24(1):49. doi:
10.1186/s10020-018-0045-2. [PMID: 30241461] - Ning Wei, Michelle L Gumz, Anita T Layton. Predicted effect of circadian clock modulation of NHE3 of a proximal tubule cell on sodium transport.
American journal of physiology. Renal physiology.
2018 09; 315(3):F665-F676. doi:
10.1152/ajprenal.00008.2018. [PMID: 29537313] - Wen-Ya Huang, Xin Zou, Fu-Er Lu, Hao Su, Chu Zhang, Yan-Lin Ren, Ke Fang, Li-Jun Xu, Kai-Fu Wang, Qing-Jie Chen, Hui Dong. Jiao-tai-wan Up-regulates Hypothalamic and Peripheral Circadian Clock Gene Cryptochrome and Activates PI3K/AKT Signaling in Partially Sleep-deprived Rats.
Current medical science.
2018 Aug; 38(4):704-713. doi:
10.1007/s11596-018-1934-x. [PMID: 30128882] - Ibrahim Abdul Kareem Al-Sarraf, Violet Kasabri, Amal Akour, Randa Naffa. Melatonin and cryptochrome 2 in metabolic syndrome patients with or without diabetes: a cross-sectional study.
Hormone molecular biology and clinical investigation.
2018 May; 35(2):. doi:
10.1515/hmbci-2018-0016. [PMID: 29813030] - Jérôme Mermet, Jake Yeung, Clémence Hurni, Daniel Mauvoisin, Kyle Gustafson, Céline Jouffe, Damien Nicolas, Yann Emmenegger, Cédric Gobet, Paul Franken, Frédéric Gachon, Félix Naef. Clock-dependent chromatin topology modulates circadian transcription and behavior.
Genes & development.
2018 03; 32(5-6):347-358. doi:
10.1101/gad.312397.118. [PMID: 29572261] - Rimawati Tedjasukmana, Jan Sudir Purba, Septelia Inawati Wanandi, Franciscus D Suyatna. Neuroglobin correlates with cryptochrome-1 in obstructive sleep apnea with primary aldosteronism.
PloS one.
2018; 13(9):e0204390. doi:
10.1371/journal.pone.0204390. [PMID: 30235329] - Leticia Aragao-Santiago, Celso E Gomez-Sanchez, Paolo Mulatero, Ariadni Spyroglou, Martin Reincke, Tracy Ann Williams. Mouse Models of Primary Aldosteronism: From Physiology to Pathophysiology.
Endocrinology.
2017 12; 158(12):4129-4138. doi:
10.1210/en.2017-00637. [PMID: 29069360] - Qi Cao, Xuan Zhao, Jingwen Bai, Sigal Gery, Haibo Sun, De-Chen Lin, Qi Chen, Zhengshan Chen, Lauren Mack, Henry Yang, Ruishu Deng, Xianping Shi, Ling-Wa Chong, Han Cho, Jianjun Xie, Quan-Zhen Li, Markus Müschen, Annette R Atkins, Christopher Liddle, Ruth T Yu, Serhan Alkan, Jonathan W Said, Ye Zheng, Michael Downes, Ronald M Evans, H Phillip Koeffler. Circadian clock cryptochrome proteins regulate autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America.
2017 11; 114(47):12548-12553. doi:
10.1073/pnas.1619119114. [PMID: 29109286] - Z Y Sun, D Y Geng, C F Chen, P P Wang, T Song. [Influence of extremely low-frequency magnetic field on circadian rhythm of cryptochrome in mouse embryonic fibroblasts].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2017 Jun; 35(6):459-462. doi:
10.3760/cma.j.issn.1001-9391.2017.06.015. [PMID: 28780826] - Ali Mteyrek, Elisabeth Filipski, Catherine Guettier, Malgorzata Oklejewicz, Gijsbertus T J van der Horst, Alper Okyar, Francis Lévi. Critical cholangiocarcinogenesis control by cryptochrome clock genes.
International journal of cancer.
2017 06; 140(11):2473-2483. doi:
10.1002/ijc.30663. [PMID: 28224616] - Léo Valon, Ariadna Marín-Llauradó, Thomas Wyatt, Guillaume Charras, Xavier Trepat. Optogenetic control of cellular forces and mechanotransduction.
Nature communications.
2017 02; 8(?):14396. doi:
10.1038/ncomms14396. [PMID: 28186127] - Leena Kovanen, Kati Donner, Mari Kaunisto, Timo Partonen. PRKCDBP (CAVIN3) and CRY2 associate with major depressive disorder.
Journal of affective disorders.
2017 Jan; 207(?):136-140. doi:
10.1016/j.jad.2016.09.034. [PMID: 27721187] - Wignand W D Mühlhäuser, Maximilian Hörner, Wilfried Weber, Gerald Radziwill. Light-Regulated Protein Kinases Based on the CRY2-CIB1 System.
Methods in molecular biology (Clifton, N.J.).
2017; 1596(?):257-270. doi:
10.1007/978-1-4939-6940-1_16. [PMID: 28293892] - Zsolt Nagy, Alexa Marta, Henriett Butz, Istvan Liko, Karoly Racz, Attila Patocs. Modulation of the circadian clock by glucocorticoid receptor isoforms in the H295R cell line.
Steroids.
2016 12; 116(?):20-27. doi:
10.1016/j.steroids.2016.10.002. [PMID: 27725099] - Christine Nießner, Julia Christina Gross, Susanne Denzau, Leo Peichl, Gerta Fleissner, Wolfgang Wiltschko, Roswitha Wiltschko. Seasonally Changing Cryptochrome 1b Expression in the Retinal Ganglion Cells of a Migrating Passerine Bird.
PloS one.
2016; 11(3):e0150377. doi:
10.1371/journal.pone.0150377. [PMID: 26953690] - Daniel Pouly, Sébastien Chenaux, Virginie Martin, Maja Babis, Rafael Koch, Emi Nagoshi, Vladimir L Katanaev, Frédéric Gachon, Olivier Staub. USP2-45 Is a Circadian Clock Output Effector Regulating Calcium Absorption at the Post-Translational Level.
PloS one.
2016; 11(1):e0145155. doi:
10.1371/journal.pone.0145155. [PMID: 26756164] - Leo Valon, Fred Etoc, Amanda Remorino, Florencia di Pietro, Xavier Morin, Maxime Dahan, Mathieu Coppey. Predictive Spatiotemporal Manipulation of Signaling Perturbations Using Optogenetics.
Biophysical journal.
2015 Nov; 109(9):1785-97. doi:
10.1016/j.bpj.2015.08.042. [PMID: 26536256] - Jonathan Cedernaes, Megan E Osler, Sarah Voisin, Jan-Erik Broman, Heike Vogel, Suzanne L Dickson, Juleen R Zierath, Helgi B Schiöth, Christian Benedict. Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men.
The Journal of clinical endocrinology and metabolism.
2015 Sep; 100(9):E1255-61. doi:
10.1210/jc.2015-2284. [PMID: 26168277] - Ximing Qin, Tetsuya Mori, Yunfei Zhang, Carl Hirschie Johnson. PER2 Differentially Regulates Clock Phosphorylation versus Transcription by Reciprocal Switching of CK1ε Activity.
Journal of biological rhythms.
2015 Jun; 30(3):206-16. doi:
10.1177/0748730415582127. [PMID: 25994100] - Akiko Sugiyama, Toshiaki Yujiri, Mayumi Tanaka, Yoshinori Tanaka, Yukinori Nakamura, Yukio Tanizawa. Altered expression of circadian clock genes during peripheral blood stem cell mobilization induced by granulocyte colony-stimulating factor.
Chronobiology international.
2015; 32(7):934-41. doi:
10.3109/07420528.2015.1053910. [PMID: 26158633] - Yuyan Han, Paolo Onori, Fanyin Meng, Sharon DeMorrow, Julie Venter, Heather Francis, Antonio Franchitto, Debolina Ray, Lindsey Kennedy, John Greene, Anastasia Renzi, Romina Mancinelli, Eugenio Gaudio, Shannon Glaser, Gianfranco Alpini. Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis.
American journal of physiology. Gastrointestinal and liver physiology.
2014 Nov; 307(9):G894-904. doi:
10.1152/ajpgi.00288.2014. [PMID: 25214401] - Jacob Richards, Alexander N Diaz, Michelle L Gumz. Clock genes in hypertension: novel insights from rodent models.
Blood pressure monitoring.
2014 Oct; 19(5):249-54. doi:
10.1097/mbp.0000000000000060. [PMID: 25025868] - Vivian Meyer, Alexander Lerchl. Evidence for species-specific clock gene expression patterns in hamster peripheral tissues.
Gene.
2014 Sep; 548(1):101-11. doi:
10.1016/j.gene.2014.07.019. [PMID: 25016070] - Patrick R O'Neill, N Gautam. Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration.
Molecular biology of the cell.
2014 Aug; 25(15):2305-14. doi:
10.1091/mbc.e14-04-0870. [PMID: 24920824] - Theresa M Casey, Jennifer Crodian, Emily Erickson, Karen K Kuropatwinski, Anatoli S Gleiberman, Marina P Antoch. Tissue-specific changes in molecular clocks during the transition from pregnancy to lactation in mice.
Biology of reproduction.
2014 Jun; 90(6):127. doi:
10.1095/biolreprod.113.116137. [PMID: 24759789] - Sabrina Wend, Hanna J Wagner, Konrad Müller, Matias D Zurbriggen, Wilfried Weber, Gerald Radziwill. Optogenetic control of protein kinase activity in mammalian cells.
ACS synthetic biology.
2014 May; 3(5):280-5. doi:
10.1021/sb400090s. [PMID: 24090449] - Sébastien Anthérieu, Dounia Le Guillou, Cédric Coulouarn, Karima Begriche, Viviane Trak-Smayra, Sophie Martinais, Mathieu Porceddu, Marie-Anne Robin, Bernard Fromenty. Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice.
Toxicology and applied pharmacology.
2014 Apr; 276(1):63-72. doi:
10.1016/j.taap.2014.01.019. [PMID: 24525044] - Dwi Aris Agung Nugrahaningsih, Noriaki Emoto, Nicolas Vignon-Zellweger, Eko Purnomo, Keiko Yagi, Kazuhiko Nakayama, Masao Doi, Hitoshi Okamura, Ken-ichi Hirata. Chronic hyperaldosteronism in cryptochrome-null mice induces high-salt- and blood pressure-independent kidney damage in mice.
Hypertension research : official journal of the Japanese Society of Hypertension.
2014 Mar; 37(3):202-9. doi:
10.1038/hr.2013.143. [PMID: 24108235] - Ritsuko Matsumura, Akihiko Okamoto, Koichi Node, Makoto Akashi. Compensation for intracellular environment in expression levels of mammalian circadian clock genes.
Scientific reports.
2014 Feb; 4(?):4032. doi:
10.1038/srep04032. [PMID: 24504324] - Masanobu Kawai, Saori Kinoshita, Shigeki Shimba, Keiichi Ozono, Toshimi Michigami. Sympathetic activation induces skeletal Fgf23 expression in a circadian rhythm-dependent manner.
The Journal of biological chemistry.
2014 Jan; 289(3):1457-66. doi:
10.1074/jbc.m113.500850. [PMID: 24302726] - Daniel Mauvoisin, Jingkui Wang, Céline Jouffe, Eva Martin, Florian Atger, Patrice Waridel, Manfredo Quadroni, Frédéric Gachon, Felix Naef. Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver.
Proceedings of the National Academy of Sciences of the United States of America.
2014 Jan; 111(1):167-72. doi:
10.1073/pnas.1314066111. [PMID: 24344304] - Olof Idevall-Hagren, Pietro Decamilli. Manipulation of plasma membrane phosphoinositides using photoinduced protein-protein interactions.
Methods in molecular biology (Clifton, N.J.).
2014; 1148(?):109-28. doi:
10.1007/978-1-4939-0470-9_8. [PMID: 24718798] - Qi Qu, Bingguang Dai, Bo Yang, Xuelian Li, Yimin Liu, Fuling Zhang. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.
BioMed research international.
2014; 2014(?):603415. doi:
10.1155/2014/603415. [PMID: 25003119] - Jacob Richards, Kit-Yan Cheng, Sean All, George Skopis, Lauren Jeffers, I Jeanette Lynch, Charles S Wingo, Michelle L Gumz. A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention.
American journal of physiology. Renal physiology.
2013 Dec; 305(12):F1697-704. doi:
10.1152/ajprenal.00472.2013. [PMID: 24154698] - Jacob Richards, Sean All, George Skopis, Kit-Yan Cheng, Brandy Compton, Nitya Srialluri, Lisa Stow, Lauren A Jeffers, Michelle L Gumz. Opposing actions of Per1 and Cry2 in the regulation of Per1 target gene expression in the liver and kidney.
American journal of physiology. Regulatory, integrative and comparative physiology.
2013 Oct; 305(7):R735-47. doi:
10.1152/ajpregu.00195.2013. [PMID: 23824961] - Sameer Gupta, Chandana Haldar, Sarika Singh. Daily variations in plasma melatonin and melatonin receptor (MT1), PER1 and CRY1 expression in suprachiasmatic nuclei of tropical squirrel, Funambulus pennanti.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology.
2013 Sep; 199(9):763-73. doi:
10.1007/s00359-013-0836-4. [PMID: 23852344] - Cai-Xia Li, Dong-Dong Liang, Guo-Hao Xie, Bao-Li Cheng, Qi-Xing Chen, Shui-Jing Wu, Jun-Lu Wang, William Cho, Xiang-Ming Fang. Altered melatonin secretion and circadian gene expression with increased proinflammatory cytokine expression in early-stage sepsis patients.
Molecular medicine reports.
2013 Apr; 7(4):1117-22. doi:
10.3892/mmr.2013.1331. [PMID: 23426900] - Eugin Destici, Edwin H Jacobs, Filippo Tamanini, Maarten Loos, Gijsbertus T J van der Horst, Małgorzata Oklejewicz. Altered phase-relationship between peripheral oscillators and environmental time in Cry1 or Cry2 deficient mouse models for early and late chronotypes.
PloS one.
2013; 8(12):e83602. doi:
10.1371/journal.pone.0083602. [PMID: 24386234] - Nicola Manzella, Massimo Bracci, Sara Staffolani, Elisabetta Strafella, Venerando Rapisarda, Matteo Valentino, Monica Amati, Alfredo Copertaro, Lory Santarelli. Styrene altered clock gene expression in serum-shocked cultured human fibroblasts.
Bioscience, biotechnology, and biochemistry.
2013; 77(6):1296-8. doi:
10.1271/bbb.120944. [PMID: 23748757] - Tao Wu, Ou Fu, Ling Yao, Lu Sun, Fen Zhuge, Zhengwei Fu. Differential responses of peripheral circadian clocks to a short-term feeding stimulus.
Molecular biology reports.
2012 Oct; 39(10):9783-9. doi:
10.1007/s11033-012-1844-0. [PMID: 22714924] - Olof Idevall-Hagren, Eamonn J Dickson, Bertil Hille, Derek K Toomre, Pietro De Camilli. Optogenetic control of phosphoinositide metabolism.
Proceedings of the National Academy of Sciences of the United States of America.
2012 Aug; 109(35):E2316-23. doi:
10.1073/pnas.1211305109. [PMID: 22847441] - Xin Tong, Katie Buelow, Anirvan Guha, Rebecca Rausch, Lei Yin. USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals.
The Journal of biological chemistry.
2012 Jul; 287(30):25280-91. doi:
10.1074/jbc.m112.340786. [PMID: 22669941] - Wen Su, Zhongwen Xie, Zhenheng Guo, Marilyn J Duncan, Jenny Lutshumba, Ming C Gong. Altered clock gene expression and vascular smooth muscle diurnal contractile variations in type 2 diabetic db/db mice.
American journal of physiology. Heart and circulatory physiology.
2012 Feb; 302(3):H621-33. doi:
10.1152/ajpheart.00825.2011. [PMID: 22140039] - Jihye Bang, Hyuk Won Chang, Hae-Ra Jung, Chul-Hyun Cho, Ji-An Hur, Sang-Il Lee, Tae Hyun Choi, Sang-Hyon Kim, Eunyoung Ha. Melatonin attenuates clock gene cryptochrome1, which may aggravate mouse anti-type II collagen antibody-induced arthritis.
Rheumatology international.
2012 Feb; 32(2):379-85. doi:
10.1007/s00296-010-1641-9. [PMID: 21113809] - P Gómez-Abellán, J A Madrid, J A Luján, M D Frutos, R González, O Martínez-Augustín, F Sánchez de Medina, J M Ordovás, M Garaulet. Sexual dimorphism in clock genes expression in human adipose tissue.
Obesity surgery.
2012 Jan; 22(1):105-12. doi:
10.1007/s11695-011-0539-2. [PMID: 22081238] - Anastasia Renzi, Shannon Glaser, Sharon Demorrow, Romina Mancinelli, Fanyin Meng, Antonio Franchitto, Julie Venter, Mellanie White, Heather Francis, Yuyan Han, Domenico Alvaro, Eugenio Gaudio, Guido Carpino, Yoshiyuki Ueno, Paolo Onori, Gianfranco Alpini. Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors.
American journal of physiology. Gastrointestinal and liver physiology.
2011 Oct; 301(4):G634-43. doi:
10.1152/ajpgi.00206.2011. [PMID: 21757639] - Yanfang Yuan, Wentao Xu, Yunbo Luo, Haiyan Liu, Jiao Lu, Chunyuan Su, Kunlun Huang. Effects of genetically modified T2A-1 rice on faecal microflora of rats during 90 day supplementation.
Journal of the science of food and agriculture.
2011 Aug; 91(11):2066-72. doi:
10.1002/jsfa.4421. [PMID: 21520451] - Tien-sheng Huang, Peter Ruoff, Per G Fjelldal. Diurnal expression of clock genes in pineal gland and brain and plasma levels of melatonin and cortisol in Atlantic salmon parr and smolts.
Chronobiology international.
2010 Oct; 27(9-10):1697-714. doi:
10.3109/07420528.2010.514630. [PMID: 20969518] - Tien-Sheng Huang, Peter Ruoff, Per G Fjelldal. Effect of continuous light on daily levels of plasma melatonin and cortisol and expression of clock genes in pineal gland, brain, and liver in atlantic salmon postsmolts.
Chronobiology international.
2010 Oct; 27(9-10):1715-34. doi:
10.3109/07420528.2010.521272. [PMID: 20969519] - Satoru Hayashida, Yukako Kuramoto, Satoru Koyanagi, Katsutaka Oishi, Junya Fujiki, Naoya Matsunaga, Eriko Ikeda, Shigehiro Ohdo, Hiroshi Shimeno, Shinji Soeda. Proxisome proliferator-activated receptor-α mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice.
Chronobiology international.
2010 Oct; 27(9-10):1735-53. doi:
10.3109/07420528.2010.515324. [PMID: 20969520] - Jonathon Bostwick, Diane Nguyen, Germaine Cornélissen, Franz Halberg, Willemijntje A Hoogerwerf. Effects of acute and chronic STZ-induced diabetes on clock gene expression and feeding in the gastrointestinal tract.
Molecular and cellular biochemistry.
2010 May; 338(1-2):203-13. doi:
10.1007/s11010-009-0354-4. [PMID: 20091094] - Sudeep Bose, Fredric R Boockfor. Episodes of prolactin gene expression in GH3 cells are dependent on selective promoter binding of multiple circadian elements.
Endocrinology.
2010 May; 151(5):2287-96. doi:
10.1210/en.2009-1252. [PMID: 20215567] - Guosheng Wu, John N Cameron, Karin Ljung, Edgar P Spalding. A role for ABCB19-mediated polar auxin transport in seedling photomorphogenesis mediated by cryptochrome 1 and phytochrome B.
The Plant journal : for cell and molecular biology.
2010 Apr; 62(2):179-91. doi:
10.1111/j.1365-313x.2010.04137.x. [PMID: 20088903] - Tao Wu, Yinhua Ni, Yue Dong, Jiafeng Xu, Xiaohong Song, Hisanori Kato, Zhengwei Fu. Regulation of circadian gene expression in the kidney by light and food cues in rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Mar; 298(3):R635-41. doi:
10.1152/ajpregu.00578.2009. [PMID: 20053963] - Yoko Kubo, Takahiro Takeuchi, Keiko Okano, Toshiyuki Okano. Cryptochrome genes are highly expressed in the ovary of the African clawed frog, Xenopus tropicalis.
PloS one.
2010 Feb; 5(2):e9273. doi:
10.1371/journal.pone.0009273. [PMID: 20174658] - Akeo Kadota, Noboru Yamada, Noriyuki Suetsugu, Mana Hirose, Chieko Saito, Keiko Shoda, Satoshi Ichikawa, Takatoshi Kagawa, Akihiko Nakano, Masamitsu Wada. Short actin-based mechanism for light-directed chloroplast movement in Arabidopsis.
Proceedings of the National Academy of Sciences of the United States of America.
2009 Aug; 106(31):13106-11. doi:
10.1073/pnas.0906250106. [PMID: 19620714] - Akiko Harada, Ken-ichiro Shimazaki. Measurement of changes in cytosolic Ca2+ in Arabidopsis guard cells and mesophyll cells in response to blue light.
Plant & cell physiology.
2009 Feb; 50(2):360-73. doi:
10.1093/pcp/pcn203. [PMID: 19106118] - Lisa W Chu, Yong Zhu, Kai Yu, Tongzhang Zheng, Anand P Chokkalingam, Frank Z Stanczyk, Yu-Tang Gao, Ann W Hsing. Correlation between circadian gene variants and serum levels of sex steroids and insulin-like growth factor-I.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2008 Nov; 17(11):3268-73. doi:
10.1158/1055-9965.epi-08-0073. [PMID: 18990770] - Hadas Sherman, Oren Froy. Expression of human beta-defensin 1 is regulated via c-Myc and the biological clock.
Molecular immunology.
2008 Jun; 45(11):3163-7. doi:
10.1016/j.molimm.2008.03.004. [PMID: 18433872] - Cristiano Bertolucci, Nicola Cavallari, Ilaria Colognesi, Jacopo Aguzzi, Zheng Chen, Pierpaolo Caruso, Augusto Foá, Gianluca Tosini, Francesco Bernardi, Mirko Pinotti. Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators.
Molecular and cellular biology.
2008 May; 28(9):3070-5. doi:
10.1128/mcb.01931-07. [PMID: 18316400] - A Zienkiewicz, K Zienkiewicz, J Kopcewicz. Intracellular distribution of phototropin 1 protein in the short-day plant Ipomoea nil.
Protoplasma.
2008; 233(1-2):141-7. doi:
10.1007/s00709-008-0292-0. [PMID: 18523724] - P Gómez-Abellán, J J Hernández-Morante, J A Luján, J A Madrid, M Garaulet. Clock genes are implicated in the human metabolic syndrome.
International journal of obesity (2005).
2008 Jan; 32(1):121-8. doi:
10.1038/sj.ijo.0803689. [PMID: 17653067] - Dario R Lemos, Leela Goodspeed, Luciana Tonelli, Marina P Antoch, Sergio R Ojeda, Henryk F Urbanski. Evidence for circadian regulation of activating transcription factor 5 but not tyrosine hydroxylase by the chromaffin cell clock.
Endocrinology.
2007 Dec; 148(12):5811-21. doi:
10.1210/en.2007-0610. [PMID: 17823250] - Xiying Wu, Sanjin Zvonic, Z Elizabeth Floyd, Gail Kilroy, Brian C Goh, Teri L Hernandez, Robert H Eckel, Randall L Mynatt, Jeffrey M Gimble. Induction of circadian gene expression in human subcutaneous adipose-derived stem cells.
Obesity (Silver Spring, Md.).
2007 Nov; 15(11):2560-70. doi:
10.1038/oby.2007.308. [PMID: 18070747] - Sam-Geun Kong, Toshinori Kinoshita, Ken-Ichiro Shimazaki, Nobuyoshi Mochizuki, Tomomi Suzuki, Akira Nagatani. The C-terminal kinase fragment of Arabidopsis phototropin 2 triggers constitutive phototropin responses.
The Plant journal : for cell and molecular biology.
2007 Sep; 51(5):862-73. doi:
10.1111/j.1365-313x.2007.03187.x. [PMID: 17662032] - Holger Marten, Rainer Hedrich, M Rob G Roelfsema. Blue light inhibits guard cell plasma membrane anion channels in a phototropin-dependent manner.
The Plant journal : for cell and molecular biology.
2007 Apr; 50(1):29-39. doi:
10.1111/j.1365-313x.2006.03026.x. [PMID: 17319842] - Oleg Tsinkalovsky, Rune Smaaland, Benedikte Rosenlund, Robert B Sothern, Asle Hirt, Solrun Steine, Azadeh Badiee, Jenny Foss Abrahamsen, Hans Geir Eiken, Ole Didrik Laerum. Circadian variations in clock gene expression of human bone marrow CD34+ cells.
Journal of biological rhythms.
2007 Apr; 22(2):140-50. doi:
10.1177/0748730406299078. [PMID: 17440215] - Wen-Ning Zhao, Nikolay Malinin, Fu-Chia Yang, David Staknis, Nicholas Gekakis, Bert Maier, Silke Reischl, Achim Kramer, Charles J Weitz. CIPC is a mammalian circadian clock protein without invertebrate homologues.
Nature cell biology.
2007 Mar; 9(3):268-75. doi:
10.1038/ncb1539. [PMID: 17310242] - Mamoru Tanida, Atsushi Yamatodani, Akira Niijima, Jiao Shen, Takeshi Todo, Katsuya Nagai. Autonomic and cardiovascular responses to scent stimulation are altered in cry KO mice.
Neuroscience letters.
2007 Feb; 413(2):177-82. doi:
10.1016/j.neulet.2006.11.050. [PMID: 17175102] - Shu Liu, Yanning Cai, Robert B Sothern, Yunqian Guan, Piu Chan. Chronobiological analysis of circadian patterns in transcription of seven key clock genes in six peripheral tissues in mice.
Chronobiology international.
2007; 24(5):793-820. doi:
10.1080/07420520701672556. [PMID: 17994338] - N Ohkura, K Oishi, N Fukushima, M Kasamatsu, G-I Atsumi, N Ishida, S Horie, J Matsuda. Circadian clock molecules CLOCK and CRYs modulate fibrinolytic activity by regulating the PAI-1 gene expression.
Journal of thrombosis and haemostasis : JTH.
2006 Nov; 4(11):2478-85. doi:
10.1111/j.1538-7836.2006.02210.x. [PMID: 16970803] - Michio Doi, Masamitsu Wada, Ken-Ichiro Shimazaki. The fern Adiantum capillus-veneris lacks stomatal responses to blue light.
Plant & cell physiology.
2006 Jun; 47(6):748-55. doi:
10.1093/pcp/pcj048. [PMID: 16621842] - Toshinori Kinoshita, Ken-ichiro Shimazaki. [Plasma membrane H+-ATPase in stomatal guard cells].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.
2006 Jun; 51(7):871-6. doi:
NULL. [PMID: 16758933] - An Chen, Lizhong Du, Yaping Xu, Liqing Chen, Yidong Wu. The effect of blue light exposure on the expression of circadian genes: bmal1 and cryptochrome 1 in peripheral blood mononuclear cells of jaundiced neonates.
Pediatric research.
2005 Dec; 58(6):1180-4. doi:
10.1203/01.pdr.0000183663.98446.05. [PMID: 16306190] - Hidetoshi Uenaka, Masamitsu Wada, Akeo Kadota. Four distinct photoreceptors contribute to light-induced side branch formation in the moss Physcomitrella patens.
Planta.
2005 Nov; 222(4):623-31. doi:
10.1007/s00425-005-0009-y. [PMID: 16034589] - Shin-ichiro Inoue, Toshinori Kinoshita, Ken-ichiro Shimazaki. Possible involvement of phototropins in leaf movement of kidney bean in response to blue light.
Plant physiology.
2005 Aug; 138(4):1994-2004. doi:
10.1104/pp.105.062026. [PMID: 16040656] - Håkan Andersson, Jonathan D Johnston, Sophie Messager, David Hazlerigg, Gerald Lincoln. Photoperiod regulates clock gene rhythms in the ovine liver.
General and comparative endocrinology.
2005 Jul; 142(3):357-63. doi:
10.1016/j.ygcen.2005.02.012. [PMID: 15935162] - Kumi Ueno, Toshinori Kinoshita, Shin-Ichiro Inoue, Takashi Emi, Ken-Ichiro Shimazaki. Biochemical characterization of plasma membrane H+-ATPase activation in guard cell protoplasts of Arabidopsis thaliana in response to blue light.
Plant & cell physiology.
2005 Jun; 46(6):955-63. doi:
10.1093/pcp/pci104. [PMID: 15821287] - Mohammad Saifur Rohman, Noriaki Emoto, Hidemi Nonaka, Ryusuke Okura, Masataka Nishimura, Kazuhiro Yagita, Gijsbertus T J van der Horst, Masafumi Matsuo, Hitoshi Okamura, Mitsuhiro Yokoyama. Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney.
Kidney international.
2005 Apr; 67(4):1410-9. doi:
10.1111/j.1523-1755.2005.00218.x. [PMID: 15780093] - Hidenori Hamaguchi, Katsumi Fujimoto, Takeshi Kawamoto, Mitsuhide Noshiro, Koji Maemura, Norihiko Takeda, Ryozo Nagai, Masae Furukawa, Sato Honma, Ken-ichi Honma, Hidemi Kurihara, Yukio Kato. Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system.
The Biochemical journal.
2004 Aug; 382(Pt 1):43-50. doi:
10.1042/bj20031760. [PMID: 15147242] - Kaiyao Huang, Tim Kunkel, Christoph F Beck. Localization of the blue-light receptor phototropin to the flagella of the green alga Chlamydomonas reinhardtii.
Molecular biology of the cell.
2004 Aug; 15(8):3605-14. doi:
10.1091/mbc.e04-01-0010. [PMID: 15155806] - Dmitri Chilov, Martin Fussenegger. Toward construction of a self-sustained clock-like expression system based on the mammalian circadian clock.
Biotechnology and bioengineering.
2004 Jul; 87(2):234-42. doi:
10.1002/bit.20143. [PMID: 15236253]