3',4'-Diacetylafzelin (BioDeep_00000020291)

human metabolite PANOMIX_OTCML-2023

代谢物信息卡片

3-(Acetyloxy)-6-{[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl]oxy}-5-hydroxy-2-methyloxan-4-yl acetic acid

化学式: C25H24O12 (516.1267703999999)
中文名称: 3,4-二-O-乙酰基阿福豆苷, 3'',4''-二-O-乙酰基阿福豆苷
谱图信息: 最多检出来源 Anoectochilus roxburghii(viridiplantae) 14.55%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(c(c2=O)O[C@@H]1O[C@H]([C@@H]([C@H]([C@@H]1O)OC(=O)C)OC(=O)C)C)c1ccc(cc1)O)O)O
InChI: InChI=1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-30,32H,1-3H3

描述信息

3,4-Diacetylafzelin is found in herbs and spices. 3,4-Diacetylafzelin is a constituent of Zingiber zerumbet (wild ginger).
Constituent of Zingiber zerumbet (wild ginger). 3,4-Diacetylafzelin is found in herbs and spices.
SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM[1]. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a Ki of 1 μM[2].
SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM[1]. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a Ki of 1 μM[2].

同义名列表

8 个代谢物同义名

3-(Acetyloxy)-6-{[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl]oxy}-5-hydroxy-2-methyloxan-4-yl acetic acid; 3-(acetyloxy)-6-{[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl]oxy}-5-hydroxy-2-methyloxan-4-yl acetate; 3-(acetyloxy)-6-{[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxochromen-3-yl]oxy}-5-hydroxy-2-methyloxan-4-yl acetate; kaempferol-alpha-L-diacetylrhamnoside; Kaempferol 3-(3,4-diacetylrhamnoside); 3,4-Diacetylafzelin; SL 0101-1; SL0101

数据库引用编号

11 个数据库交叉引用编号

ChEBI: CHEBI:176210
PubChem: 14825856
HMDB: HMDB0040139
ChEMBL: CHEMBL3187298
KNApSAcK: C00005866
foodb: FDB019836
chemspider: 21613100
CAS: 735315-15-8
CAS: 77307-50-7
PMhub: MS000041059
medchemexpress: HY-15237

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

387687 Forsteronia refracta: 10.1016/J.BMC.2006.01.066
94328 Zingiber officinale:
188518 Zingiber spectabile:
311405 Zingiber zerumbet:
387687 Forsteronia refracta: 10.1016/J.BMC.2006.01.066
94328 Zingiber officinale:
188518 Zingiber spectabile:
311405 Zingiber zerumbet:
9606 Homo sapiens: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Shuai Chen, Carol Mackintosh. Differential regulation of NHE1 phosphorylation and glucose uptake by inhibitors of the ERK pathway and p90RSK in 3T3-L1 adipocytes. Cellular signalling. 2009 Dec; 21(12):1984-93. doi: 10.1016/j.cellsig.2009.09.009. [PMID: 19765648]