Typhaneoside (BioDeep_00000019665)

Main id: BioDeep_00000230612

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3-({4,5-dihydroxy-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]-6-{[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]methyl}oxan-2-yl}oxy)-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one

化学式: C34H42O20 (770.2269)
中文名称: 香蒲新苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)OC)OC6C(C(C(C(O6)C)O)O)O)O)O)O)O)O
InChI: InChI=1S/C34H42O20/c1-10-20(38)24(42)27(45)32(49-10)48-9-18-22(40)26(44)31(54-33-28(46)25(43)21(39)11(2)50-33)34(52-18)53-30-23(41)19-15(37)7-13(35)8-17(19)51-29(30)12-4-5-14(36)16(6-12)47-3/h4-8,10-11,18,20-22,24-28,31-40,42-46H,9H2,1-3H3

描述信息

Isolated from Calendula officinalis (pot marigold). Typhaneoside is found in narrowleaf cattail and ginkgo nuts.
Typhaneoside is found in ginkgo nuts. Typhaneoside is isolated from Calendula officinalis (pot marigold).
Typhaneoside, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function[1].
Typhaneoside, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function[1].

同义名列表

5 个代谢物同义名

3-({4,5-dihydroxy-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]-6-{[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]methyl}oxan-2-yl}oxy)-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one; 3-({4,5-dihydroxy-3-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]-6-{[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]methyl}oxan-2-yl}oxy)-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one; 3-[4,5-Dihydroxy-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxy-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one; CID 14353383; Typhaneoside



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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26 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yi Zheng, Jian Zhao, Deyu Miao, Tingting Xu, Liziniu Wang, Changhui Liu, Yong Gao, Lili Yu, Chuangpeng Shen. Hepatoprotective effect of Typhaneoside on non-alcoholic fatty liver disease via farnesoid X receptor in vivo and in vitro. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jun; 164(?):114957. doi: 10.1016/j.biopha.2023.114957. [PMID: 37295248]
  • Kuan-Ming Chiu, Tzu-Yu Lin, Ming-Yi Lee, Cheng-Wei Lu, Ming-Jiuh Wang, Su-Jane Wang. Typhaneoside Suppresses Glutamate Release Through Inhibition of Voltage-Dependent Calcium Entry in Rat Cerebrocortical Nerve Terminals. Chemical research in toxicology. 2021 05; 34(5):1286-1295. doi: 10.1021/acs.chemrestox.0c00446. [PMID: 33621091]
  • X Zhang, K Yang, H Zhang, W Dong, W Peng, Y Zhao. Effect of typhaneoside on ventricular remodeling and regulation of PI3K/Akt/mTOR pathway. Herz. 2020 Dec; 45(Suppl 1):113-122. doi: 10.1007/s00059-019-4819-2. [PMID: 31201434]
  • Xiaoyan Wang, Xuanhao Chen, Jin Li, Owusu Boadi Evans, Hui Wang, Xuejing Yang, Jun He, Xiu-Mei Gao, Yan-Xu Chang. Thrombin-based discovery strategy of bioactive-chemical quality marker combination for pollen of Typha orientalis by metabolomics coupled with chemometrics. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Aug; 75(?):153246. doi: 10.1016/j.phymed.2020.153246. [PMID: 32510336]
  • Lvkeng Luo, Shuling Wu, Xiaoxiao Zhu, Weiwei Su. The profiling and identification of the absorbed constituents and metabolites of Naoshuantong capsule in mice biofluids and brain by ultra- fast liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Oct; 1129(?):121791. doi: 10.1016/j.jchromb.2019.121791. [PMID: 31610480]
  • Huiting Zeng, Ping Xue, Shulan Su, Xiaochen Huang, Erxin Shang, Jianming Guo, Dawei Qian, Yuping Tang, Jin-ao Duan. Comparative Pharmacokinetics of three major bioactive components in rats after oral administration of Typhae Pollen-Trogopterus Feces drug pair before and after compatibility. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2016 Jan; 24(?):2. doi: 10.1186/s40199-016-0140-2. [PMID: 26792373]
  • Sali Cao, Boran Ni, Lijun Feng, Xingbin Yin, Haoran Dou, Jing Fu, Longfei Lin, Jian Ni. Simultaneous Determination of Typhaneoside and Isorhamnetin-3-O-Neohesperidoside in Rats After Oral Administration of Pollen Typhae Extract by UPLC-MS/MS. Journal of chromatographic science. 2015 Jul; 53(6):866-71. doi: 10.1093/chromsci/bmu132. [PMID: 25349196]
  • Xiaochen Huang, Shulan Su, Wenxia Cui, Pei Liu, Jin-Ao Duan, Jianming Guo, Zhenhao Li, Erxin Shang, Dawei Qian, Zhijun Huang. Simultaneous determination of paeoniflorin, albiflorin, ferulic acid, tetrahydropalmatine, protopine, typhaneoside, senkyunolide I in Beagle dogs plasma by UPLC-MS/MS and its application to a pharmacokinetic study after Oral Administration of Shaofu Zhuyu Decoction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Jul; 962(?):75-81. doi: 10.1016/j.jchromb.2014.05.032. [PMID: 24907546]
  • Peidong Chen, Shijia Liu, Guoliang Dai, Liyan Xie, Jie Xu, Ling Zhou, Wenzheng Ju, Anwei Ding. Determination of typhaneoside in rat plasma by liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2012 Nov; 70(?):636-9. doi: 10.1016/j.jpba.2012.06.032. [PMID: 22818028]
  • Shulan Su, Yongqing Hua, Jin-Ao Duan, Wei Zhou, Erxin Shang, Yuping Tang. Inhibitory effects of active fraction and its main components of Shaofu Zhuyu decoction on uterus contraction. The American journal of Chinese medicine. 2010; 38(4):777-87. doi: 10.1142/s0192415x10008238. [PMID: 20626062]
  • Shu-Lan Su, Li Yu, Yong-Qing Hua, Jin-Ao Duan, Hai-Shan Deng, Yu-Ping Tang, Yin Lu, An-Wei Ding. Screening and analyzing the potential bioactive components from Shaofu Zhuyu decoction, using human umbilical vein endothelial cell extraction and high-performance liquid chromatography coupled with mass spectrometry. Biomedical chromatography : BMC. 2008 Dec; 22(12):1385-92. doi: 10.1002/bmc.1070. [PMID: 18655214]
  • S H Zhang, S Q Wang, C H Liu, Y H Yang. [Studies on quality standards for Pollen Typhae(puhuang)]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2000 Mar; 25(3):136-9. doi: . [PMID: 12212094]
  • Y Yang, S Wang, S Zhang. [Determination of flavonoids in pollen typhae(Puhuang) by HPCE and HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1999 Nov; 24(11):682-4, 703. doi: ". [PMID: 12212088]
  • B Liu, Y Lu. [HPLC determination of two flavonoids in pollen Typhae (puhuang) and its different processed products]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1998 Jul; 23(7):402-4, 447. doi: ". [PMID: 11601348]
  • S S Jia, Y L Liu, C M Ma, S L Yang, H M Zhou, D C Zhao, D Liu, S Y Li. [Studies on the constituents of the flavonoids from the pollen of Typha angustfolia L. (puhuang)]. Yao xue xue bao = Acta pharmaceutica Sinica. 1986 Jun; 21(6):441-6. doi: ". [PMID: 3811929]