phenacemide (BioDeep_00001867855)
Main id: BioDeep_00000006496
代谢物信息卡片
化学式: C9H10N2O2 (178.0742)
中文名称: 苯乙酰脲
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)CC(=O)NC(=O)N
InChI: InChI=1S/C9H10N2O2/c10-9(13)11-8(12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,10,11,12,13)
描述信息
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics
同义名列表
3 个代谢物同义名
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 | |
---|---|---|
Cytoplasm | 1 | POMC |
cytosol | 1 | AVP |
dendrite | 1 | AVP |
extracellular space | 2 | AVP, POMC |
Secreted | 2 | AVP, POMC |
extracellular region | 2 | AVP, POMC |
secretory granule | 2 | AVP, POMC |
secretory granule lumen | 1 | POMC |
neuronal dense core vesicle | 1 | AVP |
clathrin-coated endocytic vesicle membrane | 1 | AVP |
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964
. [PMID: 31515284] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068
. [PMID: 22961681] - Patrina Gunness, Katarina Aleksa, Gideon Koren. The effect of acyclovir on the tubular secretion of creatinine in vitro.
Journal of translational medicine.
2010 Dec; 8(?):139. doi:
10.1186/1479-5876-8-139
. [PMID: 21192814] - E Andreev, M Koopman, L Arisz. A rise in plasma creatinine that is not a sign of renal failure: which drugs can be responsible?.
Journal of internal medicine.
1999 Sep; 246(3):247-52. doi:
10.1046/j.1365-2796.1999.00515.x
. [PMID: 10475992] - R Cahen, A Martin, B Francois, P Baltassat, P Louisot. Creatinine metabolism impairment by an anticonvulsant drug, phenacemide.
The Annals of pharmacotherapy.
1994 Jan; 28(1):49-51. doi:
10.1177/106002809402800110
. [PMID: 8123960] - S B Coker, E W Holmes, R T Egel. Phenacemide therapy of complex partial epilepsy in children: determination of plasma drug concentrations.
Neurology.
1987 Dec; 37(12):1861-6. doi:
10.1212/wnl.37.12.1861
. [PMID: 3683877] - E Duggan, L Hoffman, R E Baska, K Lea, S Hellerstein. Elevated serum creatinine levels in three patients treated with phenacemide.
Drug intelligence & clinical pharmacy.
1986 Mar; 20(3):225-8. doi:
10.1177/106002808602000311
. [PMID: 3956382] - R K Richards. Structure-activity relationships in the effects of phenacemide analogs on serum creatinine and anticonvulsant activity.
Archives internationales de pharmacodynamie et de therapie.
1980 Mar; 244(1):107-12. doi:
NULL
. [PMID: 7416882] - R K Richards, T D Bjornsson, L D Waterbury. Rise in serum and urine creatinine after phenacemide.
Clinical pharmacology and therapeutics.
1978 Apr; 23(4):430-7. doi:
10.1002/cpt1978234430
. [PMID: 630790] - M CACHIN, C LEVY, F PERGOLA, R LEVILLAIN. [Icterus gravis in an epileptic patient treated with phenylacetylurea].
Archives des maladies de l'appareil digestif et des maladies de la nutrition.
1957 Oct; 46(10):990-5. doi:
. [PMID: 13488506]
- L C WEAVER, E A SWINYARD, L S GOODMAN. Effects of liver injury and nephrectomy on the anticonvulsant activity of phenacemide.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1952 Aug; 80(4):744-6. doi:
10.3181/00379727-80-19749
. [PMID: 12983400] - R W LEVY, D J SIMONS, S ARONSON. Fatal hepatorenal syndrome associated with phenurone therapy.
The New England journal of medicine.
1950 Jun; 242(24):933-6. doi:
10.1056/nejm195006152422404
. [PMID: 15423683]