4-(2,6-Dimethylhepta-1,5-dienyl)-7,11-dimethyldodeca-6,10-dien-2-one (BioDeep_00000185294)
human metabolite blood metabolite
代谢物信息卡片
4-(2,6-dimethylhepta-1,5-dien-1-yl)-7,11-dimethyldodeca-6,10-dien-2-one
化学式: C23H38O (330.2922498)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)=CCCC(C)=CCC(CC(C)=O)C=C(C)CCC=C(C)C
InChI: InChI=1S/C23H38O/c1-18(2)10-8-12-20(5)14-15-23(17-22(7)24)16-21(6)13-9-11-19(3)4/h10-11,14,16,23H,8-9,12-13,15,17H2,1-7H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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Plant Reactome(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jian-Wen Ning, Guan-Bin Lin, Feng Ji, Jia Xu, Najeeb Sharify. Preventive effects of geranylgeranylacetone on rat ethanol-induced gastritis.
World journal of gastroenterology.
2012 May; 18(18):2262-9. doi:
10.3748/wjg.v18.i18.2262. [PMID: 22611321] - Aditya Ambade, Pranoti Mandrekar. Oxidative stress and inflammation: essential partners in alcoholic liver disease.
International journal of hepatology.
2012; 2012(?):853175. doi:
10.1155/2012/853175. [PMID: 22500241] - Joan Smith Sonneborn. Alternative strategy for Alzheimer's disease: stress response triggers.
International journal of Alzheimer's disease.
2012; 2012(?):684283. doi:
10.1155/2012/684283. [PMID: 22655213] - Hailong Cao, Lei Xue, Xiaohan Xu, Yanhu Wu, Jinfu Zhu, Liang Chen, Duan Chen, Yijiang Chen. Heat shock proteins in stabilization of spontaneously restored sinus rhythm in permanent atrial fibrillation patients after mitral valve surgery.
Cell stress & chaperones.
2011 Sep; 16(5):517-28. doi:
10.1007/s12192-011-0263-9. [PMID: 21455828] - Kylie Kavanagh, David M Flynn, Kurt A Jenkins, Li Zhang, Janice D Wagner. Restoring HSP70 deficiencies improves glucose tolerance in diabetic monkeys.
American journal of physiology. Endocrinology and metabolism.
2011 May; 300(5):E894-901. doi:
10.1152/ajpendo.00699.2010. [PMID: 21325107] - Zhiyong Wang, Jonathan M Gall, Ramon G B Bonegio, Andrea Havasi, Clayton R Hunt, Michael Y Sherman, John H Schwartz, Steven C Borkan. Induction of heat shock protein 70 inhibits ischemic renal injury.
Kidney international.
2011 Apr; 79(8):861-70. doi:
10.1038/ki.2010.527. [PMID: 21270764] - Marcela P Vizcaychipi, Dafydd G Lloyd, Yanjie Wan, Mark G Palazzo, Mervyn Maze, Daqing Ma. Xenon pretreatment may prevent early memory decline after isoflurane anesthesia and surgery in mice.
PloS one.
2011; 6(11):e26394. doi:
10.1371/journal.pone.0026394. [PMID: 22073162] - Shuzo Ohata, Chihiro Moriyama, Atsushi Yamashita, Tadashi Nishida, Chiaki Kusumoto, Shinsuke Mochida, Yukari Minami, Junya Nakada, Kohei Shomori, Yoshimi Inagaki, Yoshiji Ohta, Tatsuya Matsura. Polaprezinc Protects Mice against Endotoxin Shock.
Journal of clinical biochemistry and nutrition.
2010 May; 46(3):234-43. doi:
10.3164/jcbn.09-125. [PMID: 20490319] - Yi Zhou, Haiping Mao, Shu Li, Shirong Cao, Zhijian Li, Shougang Zhuang, Jinjin Fan, Xiuqing Dong, Steven C Borkan, Yihan Wang, Xueqing Yu. HSP72 inhibits Smad3 activation and nuclear translocation in renal epithelial-to-mesenchymal transition.
Journal of the American Society of Nephrology : JASN.
2010 Apr; 21(4):598-609. doi:
10.1681/asn.2009050552. [PMID: 20133478] - Yong-Qi Zhao, Jun-Tao Gao, Shou-Hong Liu, Yan Wu, Mao-Tsun Lin, Ming Fan. Geranylgeranylacetone preconditioning may attenuate heat-induced inflammation and multiorgan dysfunction in rats.
The Journal of pharmacy and pharmacology.
2010 Jan; 62(1):99-105. doi:
10.1211/jpp.62.01.0011. [PMID: 20723005] - Tadashi Nishida, Shuzo Ohata, Chiaki Kusumoto, Shinsuke Mochida, Junya Nakada, Yoshimi Inagaki, Yoshiji Ohta, Tatsuya Matsura. Zinc Supplementation with Polaprezinc Protects Mouse Hepatocytes against Acetaminophen-Induced Toxicity via Induction of Heat Shock Protein 70.
Journal of clinical biochemistry and nutrition.
2010 Jan; 46(1):43-51. doi:
10.3164/jcbn.09-60. [PMID: 20104264] - Haiping Mao, Zhilian Li, Yi Zhou, Zhijian Li, Shougang Zhuang, Xin An, Baiyu Zhang, Wei Chen, Jing Nie, Zhiyong Wang, Steven C Borkan, Yihan Wang, Xueqing Yu. HSP72 attenuates renal tubular cell apoptosis and interstitial fibrosis in obstructive nephropathy.
American journal of physiology. Renal physiology.
2008 Jul; 295(1):F202-14. doi:
10.1152/ajprenal.00468.2007. [PMID: 18417540] - Tsutomu Nishida, Yuki Yabe, Hai Ying Fu, Yujiro Hayashi, Kayoko Asahi, Hiroshi Eguchi, Shingo Tsuji, Masahiko Tsujii, Norio Hayashi, Sunao Kawano. Geranylgeranylacetone induces cyclooxygenase-2 expression in cultured rat gastric epithelial cells through NF-kappaB.
Digestive diseases and sciences.
2007 Aug; 52(8):1890-6. doi:
10.1007/s10620-006-9661-8. [PMID: 17404846] - Li Ding, Tian Zhu, Qinxin Song, Yindi Zhang, Jianping Shen. HPLC-APCI-MS for the determination of teprenone in human plasma: method and clinical application.
Journal of pharmaceutical and biomedical analysis.
2007 Jul; 44(3):779-85. doi:
10.1016/j.jpba.2007.03.021. [PMID: 17482416] - Wei-li Liu, Shu-jie Chen, Yan Chen, Lei-min Sun, Wei Zhang, Ya-min Zeng, Tian-hua Zhou, Jian-min Si. Protective effects of heat shock protein70 induced by geranylgeranylacetone in atrophic gastritis in rats.
Acta pharmacologica Sinica.
2007 Jul; 28(7):1001-6. doi:
10.1111/j.1745-7254.2007.00589.x. [PMID: 17588336] - Zhipeng Wang, Li Liu, Qibing Mei, Linna Liu, Yuhua Ran, Rong Zhang. Increased expression of heat shock protein 72 protects renal proximal tubular cells from gentamicin-induced injury.
Journal of Korean medical science.
2006 Oct; 21(5):904-10. doi:
10.3346/jkms.2006.21.5.904. [PMID: 17043427] - Tadashi Nishida, Tatsuya Matsura, Junya Nakada, Aki Togawa, Masachika Kai, Isao Sumioka, Yukari Minami, Yoshimi Inagaki, Yuichi Ishibe, Hisao Ito, Yoshiji Ohta, Kazuo Yamada. Geranylgeranylacetone protects against acetaminophen-induced hepatotoxicity by inducing heat shock protein 70.
Toxicology.
2006 Feb; 219(1-3):187-96. doi:
10.1016/j.tox.2005.11.018. [PMID: 16377054] - Junya Nakada, Tatsuya Matsura, Naoto Okazaki, Tadashi Nishida, Aki Togawa, Yukari Minami, Yoshimi Inagaki, Hisao Ito, Kazuo Yamada, Yuichi Ishibe. Oral administration of geranylgeranylacetone improves survival rate in a rat endotoxin shock model: administration timing and heat shock protein 70 induction.
Shock (Augusta, Ga.).
2005 Nov; 24(5):482-7. doi:
10.1097/01.shk.0000180980.63247.a9. [PMID: 16247336] - Bin Lü, Lu Zhang, Yi-hong Fan, Li-na Meng, Shuo Zhang. [Protection of gastric mucosa against steroids-induced damage by teprenone].
Zhonghua yi xue za zhi.
2005 Oct; 85(39):2749-53. doi:
. [PMID: 16324314] - Yoshiji Ohta, Takashi Kobayashi, Yoichiro Imai, Kazuo Inui, Junji Yoshino, Saburo Nakazawa. Effect of gefarnate on acute gastric mucosal lesion progression in rats treated with compound 48/80, a mast cell degranulator, in comparison with that of teprenone.
Biological & pharmaceutical bulletin.
2005 Aug; 28(8):1424-30. doi:
10.1248/bpb.28.1424. [PMID: 16079487] - Satoshi Suzuki, Shoichi Maruyama, Waichi Sato, Yoshiki Morita, Fumihiko Sato, Yusuke Miki, Sawako Kato, Masahisa Katsuno, Gen Sobue, Yukio Yuzawa, Seiichi Matsuo. Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70.
Kidney international.
2005 Jun; 67(6):2210-20. doi:
10.1111/j.1523-1755.2005.00326.x. [PMID: 15882264] - Yuji Ishii, Takumi Ishida, Junpei Mutoh, Hideyuki Yamada, Kazuta Oguri. [Possible candidates for the compound which is expected to attenuate dioxin toxicity].
Fukuoka igaku zasshi = Hukuoka acta medica.
2005 May; 96(5):204-13. doi:
. [PMID: 15997774] - Takumi Ishida, Tomomi Oshimo, Akihisa Nishimura, Junpei Mutoh, Yuji Ishii, Nobuyuki Koga, Hideyuki Yamada, Isao Hashiguchi, Akifumi Akamine, Kazuta Oguri. Reduction of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice using an antiulcer drug, geranylgeranylacetone.
Biological & pharmaceutical bulletin.
2004 Sep; 27(9):1397-402. doi:
10.1248/bpb.27.1397. [PMID: 15340226] - Yoshiji Ohta, Takashi Kobayashi, Kazuo Inui, Junji Yoshino, Akira Kitagawa, Saburo Nakazawa. Preventive effect of teprenone on acute gastric mucosal lesion progression in compound 48/80-treated rats.
European journal of pharmacology.
2004 Mar; 487(1-3):223-32. doi:
10.1016/j.ejphar.2004.01.032. [PMID: 15033395] - Yoshiji Ohta, Takashi Kobayashi, Kazuo Inui, Junji Yoshino, Saburo Nakazawa. Protective effect of teprenone against acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats.
Journal of pharmacological sciences.
2003 Nov; 93(3):337-46. doi:
10.1254/jphs.93.337. [PMID: 14646252] - Shohko Kunimoto, Wataru Murofushi, Isao Yamatsu, Yukie Hasegawa, Narie Sasaki, Susumu Kobayashi, Tetsuyuki Kobayashi, Hiromu Murofushi, Kimiko Murakami-Murofushi. Cholesteryl glucoside-induced protection against gastric ulcer.
Cell structure and function.
2003 Jun; 28(3):179-86. doi:
10.1247/csf.28.179. [PMID: 12951438] - Hironobu Oda, Hidenori Miyake, Takashi Iwata, Kenji Kusumoto, Kazuhito Rokutan, Seiki Tashiro. Geranylgeranylacetone suppresses inflammatory responses and improves survival after massive hepatectomy in rats.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract.
2002 May; 6(3):464-72; discussion 473. doi:
10.1016/s1091-255x(01)00043-9. [PMID: 12023001] - Kiichi Hirota, Hajime Nakamura, Hiroshi Masutani, Junji Yodoi. Thioredoxin superfamily and thioredoxin-inducing agents.
Annals of the New York Academy of Sciences.
2002 May; 957(?):189-99. doi:
10.1111/j.1749-6632.2002.tb02916.x. [PMID: 12074972] - Y Fudaba, H Ohdan, H Tashiro, H Ito, Y Fukuda, K Dohi, T Asahara. Geranylgeranylacetone, a heat shock protein inducer, prevents primary graft nonfunction in rat liver transplantation.
Transplantation.
2001 Jul; 72(2):184-9. doi:
10.1097/00007890-200107270-00003. [PMID: 11477336] - T Kobayashi, Y Ohta, J Yoshino, S Nakazawa. Teprenone promotes the healing of acetic acid-induced chronic gastric ulcers in rats by inhibiting neutrophil infiltration and lipid peroxidation in ulcerated gastric tissues.
Pharmacological research.
2001 Jan; 43(1):23-30. doi:
10.1006/phrs.2000.0748. [PMID: 11207062]