Senecionine N-oxide (BioDeep_00000183775)

human metabolite blood metabolite natural product

代谢物信息卡片

4-ethylidene-7-hydroxy-6,7-dimethyl-3,8-dioxo-2,9-dioxa-14-azatricyclo[9.5.1.0¹⁴,¹⁷]heptadec-11-en-14-ium-14-olate

化学式: C18H25NO6 (351.168179)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C=C1/C[C@@H](C)[C@@](C)(O)C(=O)OCC2=CC[N+]3([O-])CC[C@@H](OC1=O)[C@@H]23
InChI: InChI=1S/C18H25NO6/c1-4-12-9-11(2)18(3,22)17(21)24-10-13-5-7-19(23)8-6-14(15(13)19)25-16(12)20/h4-5,11,14-15,22H,6-10H2,1-3H3

描述信息

同义名列表

2 个代谢物同义名

4-ethylidene-7-hydroxy-6,7-dimethyl-3,8-dioxo-2,9-dioxa-14-azatricyclo[9.5.1.0¹⁴,¹⁷]heptadec-11-en-14-ium-14-olate; Senecionine N-oxide

数据库引用编号

3 个数据库交叉引用编号

PubChem: 4416755
HMDB: HMDB0258230
LOTUS: LTS0177061

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

39 个相关的物种来源信息

4210 - Asteraceae: LTS0177061
46036 - Castilleja: LTS0177061
109560 - Dorobaea: LTS0177061
109561 - Dorobaea pimpinellifolia: 10.1016/S0031-9422(00)81571-X
109561 - Dorobaea pimpinellifolia: LTS0177061
2759 - Eukaryota: LTS0177061
9606 - Homo sapiens: -
405757 - Jacobaea: LTS0177061
189238 - Jacobaea erucifolia: 10.1007/S004250050420
189238 - Jacobaea erucifolia: LTS0177061
252537 - Jacobaea maritima: LTS0177061
98722 - Jacobaea vulgaris: 10.1007/S004250050420
98722 - Jacobaea vulgaris: LTS0177061
3398 - Magnoliopsida: LTS0177061
91896 - Orobanchaceae: LTS0177061
34220 - Packera glabella: 10.1139/CJR39B-002
18794 - Senecio: LTS0177061
462520 - Senecio deferens: 10.1016/S0031-9422(00)95221-X
462520 - Senecio deferens: LTS0177061
121545 - Senecio gallicus: 10.1016/0031-9422(88)80225-5
121545 - Senecio gallicus: LTS0177061
58524 - Senecio inaequidens: 10.1007/S004250050420
58524 - Senecio inaequidens: LTS0177061
121550 - Senecio nebrodensis: 10.1016/S0031-9422(00)95221-X
121550 - Senecio nebrodensis: LTS0177061
1886452 - Senecio rosmarinifolius: 10.1016/S0031-9422(00)84745-7
121554 - Senecio squalidus: 10.1016/S0031-9422(00)95221-X
121554 - Senecio squalidus: LTS0177061
462567 - Senecio triangularis: 10.1016/B978-0-444-59433-4.00002-X
462567 - Senecio triangularis: LTS0177061
93496 - Senecio vernalis: 10.1007/S004250050420
93496 - Senecio vernalis: LTS0177061
76276 - Senecio vulgaris: 10.1002/JPS.2600770522
76276 - Senecio vulgaris: 10.1007/S004250050420
76276 - Senecio vulgaris: 10.1016/S0031-9422(97)00193-3
76276 - Senecio vulgaris: LTS0177061
35493 - Streptophyta: LTS0177061
58023 - Tracheophyta: LTS0177061
33090 - Viridiplantae: LTS0177061

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Yan Chen, Yingying Tang, Pei Liu, Jinyuan Wang, Weiqian Wang, Changhong Wang, Lili Ding, Li Yang, Aizhen Xiong, Zhengtao Wang. Species difference in toxicokinetics and safety assessment of senecionine N-oxide in a UDP-glucuronosyltransferase 1A4 humanized mouse model. Chemico-biological interactions. 2023 Apr; ?(?):110505. doi: 10.1016/j.cbi.2023.110505. [PMID: 37080376]
Mengbi Yang, Jianqing Ruan, Hong Gao, Na Li, Jiang Ma, Junyi Xue, Yang Ye, Peter Pi-Cheng Fu, Jiyao Wang, Ge Lin. First evidence of pyrrolizidine alkaloid N-oxide-induced hepatic sinusoidal obstruction syndrome in humans. Archives of toxicology. 2017 Dec; 91(12):3913-3925. doi: 10.1007/s00204-017-2013-y. [PMID: 28620673]
Xiaojie Liu, Peter G L Klinkhamer, Klaas Vrieling. The effect of structurally related metabolites on insect herbivores: A case study on pyrrolizidine alkaloids and western flower thrips. Phytochemistry. 2017 Jun; 138(?):93-103. doi: 10.1016/j.phytochem.2017.02.027. [PMID: 28267991]
Elizabeth M Mudge, A Maxwell P Jones, Paula N Brown. Quantification of pyrrolizidine alkaloids in North American plants and honey by LC-MS: single laboratory validation. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2015; 32(12):2068-74. doi: 10.1080/19440049.2015.1099743. [PMID: 26482059]
M Peterka, S Sarin, E Roeder, H Wiedenfeld, M Halasková. Differing embryotoxic effects of senecionine and senecionine-N-oxide on the chick embryo. Functional and developmental morphology. 1994; 4(2):89-92. doi: . [PMID: 7873804]