Secalonic acid A (BioDeep_00000183753)

   

human metabolite blood metabolite natural product


代谢物信息卡片


methyl 4,8,9-trihydroxy-3-methyl-1-oxo-7-[4,8,9-trihydroxy-4a-(methoxycarbonyl)-3-methyl-1-oxo-2,3,4,4a-tetrahydro-1H-xanthen-7-yl]-2,3,4,4a-tetrahydro-1H-xanthene-4a-carboxylate

化学式: C32H30O14 (638.163548)
中文名称:
谱图信息: 最多检出来源 Escherichia coli(natural_products) 50%

分子结构信息

SMILES: c12c(C(=O)C3=C(C[C@@H]([C@H]([C@@]3(O1)C(=O)OC)O)C)O)c(c(cc2)c1ccc2c(C(=O)C3=C(C[C@@H]([C@H]([C@@]3(O2)C(=O)OC)O)C)O)c1O)O
InChI: InChI=1S/C32H30O14/c1-11-9-15(33)21-25(37)19-17(45-31(21,27(11)39)29(41)43-3)7-5-13(23(19)35)14-6-8-18-20(24(14)36)26(38)22-16(34)10-12(2)28(40)32(22,46-18)30(42)44-4/h5-8,11-12,27-28,33-36,39-40H,9-10H2,1-4H3/t11-,12-,27+,28+,31+,32+/m0/s1

描述信息

同义名列表

5 个代谢物同义名

methyl 4,8,9-trihydroxy-3-methyl-1-oxo-7-[4,8,9-trihydroxy-4a-(methoxycarbonyl)-3-methyl-1-oxo-2,3,4,4a-tetrahydro-1H-xanthen-7-yl]-2,3,4,4a-tetrahydro-1H-xanthene-4a-carboxylate; Secalonic acid A; Secalonic acid D; Secalonic acid; Secalonate D



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sagou Dominique, Pakora Gilles Alex, Essoh You Christiane, Yeo Dodehe, Kacou N'douba Adèle. Diversity of Endophytic Fungi Isolated from the Bark of Ceiba pentandra (L.) Gaertn., (Bombacaceae) and Antibacterial Potential of Secalonic Acid A Produced by Diaporthe searlei EC 321. Chemistry & biodiversity. 2023 Nov; 20(11):e202301010. doi: 10.1002/cbdv.202301010. [PMID: 37814192]
  • Friederike Lünne, Jens Köhler, Christina Stroh, Lena Müller, Constantin G Daniliuc, Christian Mück-Lichtenfeld, Ernst-Ulrich Würthwein, Melanie Esselen, Hans-Ulrich Humpf, Svetlana A Kalinina. Insights into Ergochromes of the Plant Pathogen Claviceps purpurea. Journal of natural products. 2021 10; 84(10):2630-2643. doi: 10.1021/acs.jnatprod.1c00264. [PMID: 34553942]
  • Santosh Kumar Guru, Anup Singh Pathania, Suresh Kumar, Deshidi Ramesh, Manjeet Kumar, Satiander Rana, Ajay Kumar, Fayaz Malik, P R Sharma, B K Chandan, Sundeep Jaglan, J P Sharma, Bhahwal Ali Shah, Sheikh Abdullah Tasduq, Surrinder K Lattoo, Abdul Faruk, A K Saxena, R A Vishwakarma, Shashi Bhushan. Secalonic Acid-D Represses HIF1α/VEGF-Mediated Angiogenesis by Regulating the Akt/mTOR/p70S6K Signaling Cascade. Cancer research. 2015 Jul; 75(14):2886-96. doi: 10.1158/0008-5472.can-14-2312. [PMID: 25977334]
  • Ren Hong. Secalonic acid D as a novel DNA topoisomerase I inhibitor from marine lichen-derived fungus Gliocladium sp. T31. Pharmaceutical biology. 2011 Aug; 49(8):796-9. doi: 10.3109/13880209.2010.548817. [PMID: 21495809]
  • Yanhong Wang, Xiaomin Wu, Xindong Yang, Xiaokun Li. [Studies on identification and secondary metabolites of endophytic fungi strain E8 from Curcuma wenyujin]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Mar; 36(6):770-4. doi: 10.4268/cjcmm20110626. [PMID: 21710748]
  • Pore Vandana Sudhir, Deshpande Sunita Ranjan, Aher Nilkanth Ganpat. Antifungal agents, WO2009025733. Expert opinion on therapeutic patents. 2010 Jan; 20(1):137-43. doi: 10.1517/13543770903338768. [PMID: 19874257]
  • Rensen Zeng, Shiming Luo, Yuehong Shi. [Allelopathic effects of secalonic acid F produced by Aspergillus japonicus on Zea mays]. Ying yong sheng tai xue bao = The journal of applied ecology. 2004 Jan; 15(1):145-8. doi: ". [PMID: 15139208]
  • B H Wang, G M Polya. The fungal teratogen secalonic acid D is an inhibitor of protein kinase C and of cyclic AMP-dependent protein kinase. Planta medica. 1996 Apr; 62(2):111-4. doi: 10.1055/s-2006-957829. [PMID: 8657739]
  • R V Reddy, M M Eldeib, C S Reddy. Inhibition of adenylate cyclase in perfusion mouse palate by secalonic acid D. Journal of toxicology and environmental health. 1994 Feb; 41(2):175-85. doi: 10.1080/15287399409531835. [PMID: 8301697]
  • B Bolon, V E St Omer. Biochemical correlates for behavioral deficits induced by secalonic acid D in developing mice. Neuroscience and biobehavioral reviews. 1992; 16(2):171-5. doi: 10.1016/s0149-7634(05)80178-2. [PMID: 1630728]
  • M M Eldeib, C S Reddy. Role of maternal plasma corticosterone elevation in the teratogenicity of secalonic acid D in mice. Teratology. 1990 Feb; 41(2):137-46. doi: 10.1002/tera.1420410203. [PMID: 2321159]
  • J N Neucere. Enzyme-linked immunosorbent assay for secalonic acid D. Mycopathologia. 1986 Jan; 93(1):39-43. doi: 10.1007/bf00437013. [PMID: 3960100]
  • C S Reddy, R V Reddy, A W Hayes, W O Berndt. Disposition of [14C]secalonic acid D in male mice. Toxicology and applied pharmacology. 1981 Dec; 61(3):399-406. doi: 10.1016/0041-008x(81)90362-8. [PMID: 7330880]
  • C S Reddy, R V Reddy, A W Hayes. High-performance liquid chromatographic analysis of the mycotoxin secalonic acid D and its application to biological fluids. Journal of chromatography. 1981 Apr; 208(1):17-26. doi: 10.1016/s0021-9673(00)87954-6. [PMID: 7276113]