5-(1,3-Benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one (BioDeep_00000181815)

human metabolite blood metabolite natural product

代谢物信息卡片

5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

化学式: C17H19NO3 (285.13648639999997)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 98.04%

分子结构信息

SMILES: O=C(C=CC=CC1=CC=C2OCOC2=C1)N1CCCCC1
InChI: InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2

描述信息

同义名列表

2 个代谢物同义名

5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one; 5-(1,3-Benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one

数据库引用编号

4 个数据库交叉引用编号

PubChem: 4840
HMDB: HMDB0255778
chemspider: 4674
LOTUS: LTS0271968

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

145 个相关的物种来源信息

201006 - Aglaia: LTS0271968
306512 - Aglaia perviridis: 10.1080/10286020903565226
306512 - Aglaia perviridis: LTS0271968
4890 - Ascomycota: LTS0271968
147541 - Dothideomycetes: LTS0271968
2759 - Eukaryota: LTS0271968
4751 - Fungi: LTS0271968
9606 - Homo sapiens: -
3398 - Magnoliopsida: LTS0271968
43707 - Meliaceae: LTS0271968
97971 - Periconia: 10.1038/JA.2011.27
97971 - Periconia: LTS0271968
1898439 - Periconiaceae: LTS0271968
13215 - Piper: 10.1002/JBT.20251
13215 - Piper: 10.1007/S13277-013-1433-4
13215 - Piper: 10.1016/J.EJPHAR.2015.01.038
13215 - Piper: 10.1016/J.FCT.2008.06.014
13215 - Piper: 10.1016/J.INTIMP.2004.08.005
13215 - Piper: 10.1016/S0031-9422(00)00226-0
13215 - Piper: 10.1038/JA.2011.27
13215 - Piper: 10.1055/S-1999-14031
13215 - Piper: LTS0271968
13217 - Piper betle: 10.1002/JBT.20251
13217 - Piper betle: 10.1007/S13277-013-1433-4
13217 - Piper betle: 10.1016/J.EJPHAR.2015.01.038
13217 - Piper betle: 10.1016/J.FCT.2008.06.014
13217 - Piper betle: 10.1016/J.INTIMP.2004.08.005
13217 - Piper betle: 10.1016/S0031-9422(00)00226-0
13217 - Piper betle: 10.1016/S0031-9422(98)00208-8
13217 - Piper betle: 10.1038/JA.2011.27
13217 - Piper betle: 10.1055/S-1999-14031
13217 - Piper betle: LTS0271968
247681 - Piper capense: 10.3390/MOLECULES14093833
247681 - Piper capense: LTS0271968
405322 - Piper cubeba: 10.1002/BIO.1209
405322 - Piper cubeba: LTS0271968
511543 - Piper guineense:
511543 - Piper guineense: 10.1002/JBT.20251
511543 - Piper guineense: 10.1007/S13277-013-1433-4
511543 - Piper guineense: 10.1016/J.EJPHAR.2015.01.038
511543 - Piper guineense: 10.1016/J.FCT.2008.06.014
511543 - Piper guineense: 10.1016/J.INTIMP.2004.08.005
511543 - Piper guineense: 10.1016/S0031-9422(00)00226-0
511543 - Piper guineense: 10.1021/NP030475E
511543 - Piper guineense: 10.1038/JA.2011.27
511543 - Piper guineense: 10.1039/P19740002195
511543 - Piper guineense: 10.1055/S-1999-14031
511543 - Piper guineense: LTS0271968
49511 - Piper longum:
49511 - Piper longum: 10.1002/JBT.20251
49511 - Piper longum: 10.1007/S11010-005-3702-Z
49511 - Piper longum: 10.1007/S13277-013-1433-4
49511 - Piper longum: 10.1016/J.EJPHAR.2015.01.038
49511 - Piper longum: 10.1016/J.FCT.2008.06.014
49511 - Piper longum: 10.1016/J.INTIMP.2004.08.005
49511 - Piper longum: 10.1016/S0031-9422(00)00226-0
49511 - Piper longum: 10.1021/NP030475E
49511 - Piper longum: 10.1038/JA.2011.27
49511 - Piper longum: 10.1055/S-1999-14031
49511 - Piper longum: 10.1055/S-2006-957982
49511 - Piper longum: 10.1080/10286020.2010.546789
49511 - Piper longum: 10.1248/CPB.31.3562
49511 - Piper longum: 10.1248/CPB.53.832
49511 - Piper longum: LTS0271968
13216 - Piper nigrum:
13216 - Piper nigrum: 10.1002/JBT.20251
13216 - Piper nigrum: 10.1007/S13277-013-1433-4
13216 - Piper nigrum: 10.1016/J.EJMECH.2010.04.033
13216 - Piper nigrum: 10.1016/J.EJPHAR.2015.01.038
13216 - Piper nigrum: 10.1016/J.FCT.2008.06.014
13216 - Piper nigrum: 10.1016/J.INTIMP.2004.08.005
13216 - Piper nigrum: 10.1016/S0031-9422(00)00226-0
13216 - Piper nigrum: 10.1016/S0031-9422(97)00202-1
13216 - Piper nigrum: 10.1016/S0968-0896(02)00130-X
13216 - Piper nigrum: 10.1021/JF60178A026
13216 - Piper nigrum: 10.1021/NP030475E
13216 - Piper nigrum: 10.1021/NP900656G
13216 - Piper nigrum: 10.1038/JA.2011.27
13216 - Piper nigrum: 10.1055/S-1999-14031
13216 - Piper nigrum: 10.1055/S-2001-11505
13216 - Piper nigrum: 10.1080/00021369.1981.10864708
13216 - Piper nigrum: 10.1080/14786410902757998
13216 - Piper nigrum: 10.1177/1934578X0600100101
13216 - Piper nigrum: 10.1248/CPB.45.685
13216 - Piper nigrum: 10.1271/BBB1961.45.1257
13216 - Piper nigrum: 10.1590/S0103-50532010001000003
13216 - Piper nigrum: 10.3390/MOLECULES15042398
13216 - Piper nigrum: LTS0271968
1595994 - Piper peepuloides: LTS0271968
130414 - Piper retrofractum:
130414 - Piper retrofractum: 10.1002/JBT.20251
130414 - Piper retrofractum: 10.1007/S13277-013-1433-4
130414 - Piper retrofractum: 10.1016/0031-9422(92)83736-I
130414 - Piper retrofractum: 10.1016/J.EJPHAR.2015.01.038
130414 - Piper retrofractum: 10.1016/J.FCT.2008.06.014
130414 - Piper retrofractum: 10.1016/J.INTIMP.2004.08.005
130414 - Piper retrofractum: 10.1016/S0031-9422(00)00226-0
130414 - Piper retrofractum: 10.1038/JA.2011.27
130414 - Piper retrofractum: 10.1055/S-1999-14031
130414 - Piper retrofractum: 10.1271/BBB.57.1329
130414 - Piper retrofractum: LTS0271968
405344 - Piper swartzianum:
405344 - Piper swartzianum: 10.1002/JBT.20251
405344 - Piper swartzianum: 10.1007/S13277-013-1433-4
405344 - Piper swartzianum: 10.1016/J.BMC.2010.03.013
405344 - Piper swartzianum: 10.1016/J.EJPHAR.2015.01.038
405344 - Piper swartzianum: 10.1016/J.FCT.2008.06.014
405344 - Piper swartzianum: 10.1016/J.INTIMP.2004.08.005
405344 - Piper swartzianum: 10.1016/S0031-9422(00)00226-0
405344 - Piper swartzianum: 10.1038/JA.2011.27
405344 - Piper swartzianum: 10.1055/S-1999-14031
405344 - Piper swartzianum: LTS0271968
405346 - Piper thomsonii: 10.1002/JBT.20251
405346 - Piper thomsonii: 10.1007/S13277-013-1433-4
405346 - Piper thomsonii: 10.1016/J.EJPHAR.2015.01.038
405346 - Piper thomsonii: 10.1016/J.FCT.2008.06.014
405346 - Piper thomsonii: 10.1016/J.INTIMP.2004.08.005
405346 - Piper thomsonii: 10.1016/S0031-9422(00)00226-0
405346 - Piper thomsonii: 10.1038/JA.2011.27
405346 - Piper thomsonii: 10.1055/S-1999-14031
405346 - Piper thomsonii: LTS0271968
1595995 - Piper trichostachyon: 10.1002/JBT.20251
1595995 - Piper trichostachyon: 10.1007/S13277-013-1433-4
1595995 - Piper trichostachyon: 10.1016/J.EJPHAR.2015.01.038
1595995 - Piper trichostachyon: 10.1016/J.FCT.2008.06.014
1595995 - Piper trichostachyon: 10.1016/J.INTIMP.2004.08.005
1595995 - Piper trichostachyon: 10.1016/S0031-9422(00)00226-0
1595995 - Piper trichostachyon: 10.1038/JA.2011.27
1595995 - Piper trichostachyon: 10.1055/S-1999-14031
1595995 - Piper trichostachyon: LTS0271968
247704 - Piper tuberculatum:
247704 - Piper tuberculatum: 10.1002/JBT.20251
247704 - Piper tuberculatum: 10.1007/S13277-013-1433-4
247704 - Piper tuberculatum: 10.1016/J.BMC.2010.03.013
247704 - Piper tuberculatum: 10.1016/J.EJPHAR.2015.01.038
247704 - Piper tuberculatum: 10.1016/J.FCT.2008.06.014
247704 - Piper tuberculatum: 10.1016/J.INTIMP.2004.08.005
247704 - Piper tuberculatum: 10.1016/S0031-9422(00)00226-0
247704 - Piper tuberculatum: 10.1038/JA.2011.27
247704 - Piper tuberculatum: 10.1055/S-1999-14031
247704 - Piper tuberculatum: LTS0271968
16739 - Piperaceae: LTS0271968
35493 - Streptophyta: LTS0271968
58023 - Tracheophyta: LTS0271968
33090 - Viridiplantae: LTS0271968

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Markus Brückner, Sabine Westphal, Wolfram Domschke, Torsten Kucharzik, Andreas Lügering. Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis. Journal of Crohn's & colitis. 2012 Mar; 6(2):226-35. doi: 10.1016/j.crohns.2011.08.012. [PMID: 22325177]
Banibrata Das, Juthika Kundu, Sitesh Chandra Bachar, Mohammad Aftab Uddin, Joydeb Kumar Kundu. Antitumor and antibacterial activity of ethylacetate extract of Ludwigia hyssopifolia linn and its active principle piperine. Pakistan journal of pharmaceutical sciences. 2007 Apr; 20(2):128-31. doi: . [PMID: 17416568]
Ravisekhar Kasibhatta, M U R Naidu. Influence of piperine on the pharmacokinetics of nevirapine under fasting conditions: a randomised, crossover, placebo-controlled study. Drugs in R&D. 2007; 8(6):383-91. doi: 10.2165/00126839-200708060-00006. [PMID: 17963429]
Ramasamy Subramanian Vijayakumar, Namasivayamin Nalini. Piperine, an active principle from Piper nigrum, modulates hormonal and apo lipoprotein profiles in hyperlipidemic rats. Journal of basic and clinical physiology and pharmacology. 2006; 17(2):71-86. doi: 10.1515/jbcpp.2006.17.2.71. [PMID: 16910313]
M Ahmed, M W Rahman, M T Rahman, C F Hossain. Analgesic principle from the bark of Careya arborea. Die Pharmazie. 2002 Oct; 57(10):698-701. doi: . [PMID: 12426952]
C Lans, T Harper, K Georges, E Bridgewater. Medicinal and ethnoveterinary remedies of hunters in Trinidad. BMC complementary and alternative medicine. 2001; 1(?):10. doi: 10.1186/1472-6882-1-10. [PMID: 11737880]