Pheniramine (BioDeep_00000018037)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine

化学式: C16H20N2 (240.16264)
中文名称: 非尼拉敏
谱图信息: 最多检出来源 Homo sapiens(COVID-19)(blood) 50%

分子结构信息

SMILES: CN(C)CCC(C1=CC=CC=C1)C1=CC=CC=N1
InChI: InChI=1S/C16H20N2/c1-18(2)13-11-15(14-8-4-3-5-9-14)16-10-6-7-12-17-16/h3-10,12,15H,11,13H2,1-2H3

描述信息

Pheniramine is only found in individuals that have used or taken this drug. It is one of the histamine H1 antagonists with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. [PubChem]Antihistamines such as pheniramine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. Antihistamines suppress the histamine-induced wheal (swelling) and flare (vasodilation) response by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells. They effectively exert competitive antagonism of histamine for H1-receptors.
D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AA - Antihistamines for topical use
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AB - Substituted alkylamines
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D003879 - Dermatologic Agents > D000982 - Antipruritics
D018926 - Anti-Allergic Agents

同义名列表

13 个代谢物同义名

dimethyl[3-phenyl-3-(pyridin-2-yl)propyl]amine; Aventis brand OF pheniramine maleate; Bimaleate, pheniramine; Pheniramine bimaleate; Maleate, pheniramine; Pheniramine maleate; Prophenpyridamine; Histapyridamine; Propheniramine; pheniramine; Feniramine; Daneral; Avil



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Raka Jain, Siddharth Sarkar, Nizamuddin Saifi, Shayani Ghosh. Urinalysis based assessment of compliance and drug use patterns in patients prescribed tramadol: A cross-sectional study from a tertiary care centre. Asian journal of psychiatry. 2022 May; 71(?):103080. doi: 10.1016/j.ajp.2022.103080. [PMID: 35305452]
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  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Yaqi Yao, Bo Zhang, Shuang Li, Jia Yu, Xingjie Guo. Enantioselective analysis of pheniramine in rat using large volume sample stacking or cation-selective exhaustive injection and sweeping coupled with cyclodextrin modified electrokinetic chromatography. Talanta. 2019 Jan; 192(?):226-232. doi: 10.1016/j.talanta.2018.09.052. [PMID: 30348382]
  • Ercan Yuvanc, Devrim Tuglu, Tunc Ozan, Ucler Kisa, Mahi Balci, Ertan Batislam, Erdal Yilmaz. Investigation of the antioxidant effects of pheniramine maleate and nebivolol on testicular damage in rats with experimentally induced testis torsion. Acta cirurgica brasileira. 2018 Feb; 33(2):125-133. doi: 10.1590/s0102-865020180020000004. [PMID: 29513811]
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  • Juraj Piešťanský, Katarína Maráková, Marián Kovaľ, Peter Mikuš. Comparison of hydrodynamically closed isotachophoresis-capillary zone electrophoresis with hydrodynamically open capillary zone electrophoresis hyphenated with tandem mass spectrometry in drug analysis: pheniramine, its metabolite and phenylephrine in human urine. Journal of chromatography. A. 2014 Sep; 1358(?):285-92. doi: 10.1016/j.chroma.2014.06.083. [PMID: 25035234]
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  • Imran Ali, Zeid A Al-Othman, Abdulrahman Al-Warthan, Syed Dilshad Alam, Javed A Farooqi. Enantiomeric separation and simulation studies of pheniramine, oxybutynin, cetirizine, and brinzolamide chiral drugs on amylose-based columns. Chirality. 2014 Mar; 26(3):136-43. doi: 10.1002/chir.22276. [PMID: 24464520]
  • Katarína Maráková, Juraj Piešt'anský, Lucia Veizerová, Jaroslav Galba, Svetlana Dokupilová, Emil Havránek, Peter Mikuš. Multidrug analysis of pharmaceutical and urine matrices by on-line coupled capillary electrophoresis and triple quadrupole mass spectrometry. Journal of separation science. 2013 Jun; 36(11):1805-16. doi: 10.1002/jssc.201200980. [PMID: 23494966]
  • Orhan Gokalp, Ismail Yurekli, Muge Kiray, Alper Bagriyanik, Ufuk Yetkin, Banu Sarer Yurekli, Serkan Gur, Murat Aksun, Ismail Safa Satoglu, Gamze Gokalp, Ali Gurbuz. Assessment of protective effects of pheniramine maleate on reperfusion injury in lung after distant organ ischemia: a rat model. Vascular and endovascular surgery. 2013 Apr; 47(3):219-24. doi: 10.1177/1538574413475885. [PMID: 23377174]
  • Rajeev B Ahuja, Gaurav K Gupta. A four arm, double blind, randomized and placebo controlled study of pregabalin in the management of post-burn pruritus. Burns : journal of the International Society for Burn Injuries. 2013 Feb; 39(1):24-9. doi: 10.1016/j.burns.2012.09.016. [PMID: 23089176]
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