Tropicamide (BioDeep_00000017977)

Main id: BioDeep_00000014990

 

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide

  化学式: C17H20N2O2 (284.1525)
中文名称: 托吡卡胺
  谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC1=CC=NC=C1)C(=O)C(CO)C1=CC=CC=C1
InChI: InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3


描述信息

Tropicamide is only found in individuals that have used or taken this drug. It is one of the muscarinic antagonists with pharmacologic action similar to atropine and used mainly as an ophthalmic parasympatholytic or mydriatic. [PubChem]Tropicamide binds to and blocks the receptors in the muscles of the eye (muscarinic receptor M4). Tropicamide acts by blocking the responses of the iris sphincter muscle to the iris and ciliary muscles to cholinergic stimulation, producing dilation of the pupil and paralysis of the ciliary muscle.
S - Sensory organs > S01 - Ophthalmologicals > S01F - Mydriatics and cycloplegics > S01FA - Anticholinergics
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D009184 - Mydriatics

同义名列表

129 个代谢物同义名

N-Ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide; N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide; Tropicamide monohydrochloride, (R)-isomer; Tropicamide monohydrochloride, (S)-isomer; Medical ophthalmics brand OF tropicamide; Cahill may roberts brand OF tropicamide; N-Ethyl-N-(4-pyridylmethyl)tropamide; Bournonville brand OF tropicamide; Pharmafair brand OF tropicamide; Novartis brand OF tropicamide; Stulln brand 2 OF tropicamide; Stulln brand 1 OF tropicamide; Ocusoft brand OF tropicamide; Tropicamide pharmafair brand; Chauvin brand OF tropicamide; Ocumed brand OF tropicamide; Alcon brand OF tropicamide; Akorn brand OF tropicamide; Rivex brand OF tropicamide; Tropicamide novartis brand; Tropicamide chauvin brand; Tropicamide, (+-)-isomer; Tropicamide ocumed brand; Tropicamide, (S)-isomer; Tropicamide rivex brand; Tropicamide alcon brand; Tropicamide, (R)-isomer; Colircusi tropicamida; Tropicamide monofree; Minims tropicamide; Tropicamide minims; Tropicamide faure; Triaminic DM; Mydriaticum; tropicamide; Mydriafair; Ocu-tropic; Ocu tropic; Tropicacyl; OcuTropic; Mydriacyl; Mydral; Mydrum; Tropicamide; (+-)-N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide; (+/-)-N-ETHYL-2-PHENYL-N-(4-PYRIDYLMETHYL)HYDRACRYLAMIDE; 5-22-09-00359 (Beilstein Handbook Reference); Benzeneacetamide, N-ethyl-.alpha.-(hydroxymethyl)-N-(4-pyridinylmethyl)-; BENZENEACETAMIDE, N-ETHYL-.ALPHA.-(HYDROXYMETHYL)-N-(4-PYRIDINYLMETHYL)-, (+/-)-; Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-; Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-, (+-)-; Bistropamide; BPBio1_000303; component of Paremyd; DivK1c_000448; Epitromina; Hydracrylamide, N-ethyl-2-phenyl-N-(4-pyridylmethyl)-; IDI1_000448; KBio1_000448; KBio2_001064; KBio2_003632; KBio2_006200; KBio3_001509; l-Picamide; Lopac0_001223; MYDCOMBI COMPONENT TROPICAMIDE; Mydriacyl (TN); N-Ethyl-2-phenyl-N-(4-pyridylmethyl hydracrylamide; N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide; N-Ethyl-3-hydroxy-2-phenyl-N-(4-pyridinylmethyl)propanamide #; N-Ethyl-3-hydroxy-2-phenyl-N-[(pyridin-4-yl)methyl]propanamide; N-Ethyl-a-(hydroxymethyl)-N-(4-pyridinylmethyl)benzeneacetamide; N-Ethyl-N-(4-pyridylmethyl)tropamid; N0A3Z5XTC6; Opticyl; PAREMYD COMPONENT TROPICAMIDE; Prestwick0_000228; Prestwick1_000228; Prestwick2_000228; Prestwick3_000228; Ro 1-7683; RO-1-7683; S01FA06; SMP1_000304; Spectrum2_000936; Spectrum3_000655; Spectrum4_000377; Spectrum5_001585; Tox21_110297; Tox21_110297_1; Tox21_501223; Tropicamid; Tropicamida; Tropicamida (INN-Spanish); Tropicamida [INN-Spanish]; TROPICAMIDE (EP MONOGRAPH); Tropicamide (JP18/USP/INN); TROPICAMIDE (MART.); Tropicamide (Standard); Tropicamide (USAN:USP:INN:BAN:JAN); TROPICAMIDE (USP MONOGRAPH); TROPICAMIDE (USP-RS); TROPICAMIDE [EP MONOGRAPH]; TROPICAMIDE [INN]; TROPICAMIDE [JAN]; TROPICAMIDE [MART.]; TROPICAMIDE [MI]; TROPICAMIDE [ORANGE BOOK]; Tropicamide [USAN:USP:INN:BAN:JAN]; TROPICAMIDE [USAN]; TROPICAMIDE [USP MONOGRAPH]; TROPICAMIDE [USP-RS]; TROPICAMIDE [VANDF]; TROPICAMIDE [WHO-DD]; TROPICAMIDE [WHO-IP]; TROPICAMIDE COMPONENT OF PAREMYD; Tropicamide for peak identification; Tropicamide for peak identification, European Pharmacopoeia (EP) Reference Standard; Tropicamide, European Pharmacopoeia (EP) Reference Standard; Tropicamide, solid; Tropicamide, United States Pharmacopeia (USP) Reference Standard; Tropicamidum; Tropicamidum (INN-Latin); Tropicamidum [INN-Latin]; TROPICAMIDUM [WHO-IP LATIN]; Tropikamid; Tropimil; UNII-N0A3Z5XTC6; Visumidriatic



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Michel Y Fares, Nada S Abdelwahab, Maha A Hegazy, Maha M Abdelrahman, Amr M Mahmoud, Ghada M El-Sayed. Nanoparticle-enhanced in-line potentiometric ion sensor for point-of-care diagnostics for tropicamide abuse in biological fluid. Analytica chimica acta. 2022 Feb; 1192(?):339350. doi: 10.1016/j.aca.2021.339350. [PMID: 35057968]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Xin Zhao, Xiaotong Wang, Wei Zu, Shichao Chen, Yang Tong, Jidong Liu. An UPLC-MS/MS Method for Simultaneous Determination of Tropicamide and Phenylephrine in Rabbit Ocular Tissues and Plasma. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2020 06; 36(5):282-289. doi: 10.1089/jop.2019.0152. [PMID: 32320311]
  • Liang Chen, Yuanbo Liang, Meiping Xu, Jingwei Zheng, Huanyun Yu, Lewei Tang. Effect of plum-blossom needling versus tropicamide eye drops on adolescent myopia: protocol for a randomized crossover trial. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2020 04; 40(2):333-339. doi: ". [PMID: 32242400]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Maritza Omaña-Molina, Virginia Vanzzini-Zago, Dolores Hernández-Martínez, María Reyes-Batlle, Ismael Castelan-Ramírez, Perla Hernández-Olmos, Lizbeth Salazar-Villatoro, Arturo González-Robles, Elizabeth Ramírez-Flores, Christopher Servín-Flores, Víctor Flores-Alvarado, Marino Alcántara-Castro, Jacob Lorenzo-Morales. Acanthamoeba keratitis in Mexico: Report of a clinical case and importance of sensitivity assays for a better outcome. Experimental parasitology. 2019 Jan; 196(?):22-27. doi: 10.1016/j.exppara.2018.11.005. [PMID: 30472333]
  • Xianyong Yu, Zhixi Liao, Qing Yao, Heting Liu, Xiaofang Li, Pinggui Yi. The investigation of the interaction between Tropicamide and bovine serum albumin by spectroscopic methods. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2014 Jan; 118(?):331-6. doi: 10.1016/j.saa.2013.08.103. [PMID: 24056312]
  • Francesco Saverio Bersani, Ornella Corazza, Pierluigi Simonato, Anna Mylokosta, Ermelinda Levari, Raffaele Lovaste, Fabrizio Schifano. Drops of madness? Recreational misuse of tropicamide collyrium; early warning alerts from Russia and Italy. General hospital psychiatry. 2013 Sep; 35(5):571-3. doi: 10.1016/j.genhosppsych.2013.04.013. [PMID: 23706777]
  • Neeraj Dilbaghi, Harmanmeet Kaur, Munish Ahuja, Sandeep Kumar. Evaluation of tropicamide-loaded tamarind seed xyloglucan nanoaggregates for ophthalmic delivery. Carbohydrate polymers. 2013 Apr; 94(1):286-91. doi: 10.1016/j.carbpol.2013.01.054. [PMID: 23544540]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Jan Declercq, Hendrik De Bosschere, Ilona Schwarzkopf, Lies Declercq. Papular cutaneous lesions in a cat associated with feline infectious peritonitis. Veterinary dermatology. 2008 Oct; 19(5):255-8. doi: 10.1111/j.1365-3164.2008.00684.x. [PMID: 18927951]
  • Stéphane Mouly, Isabelle Mahé, Belkacem Haouchine, Marie-José Sanson-le-Pors, Patrick Blain, Yves Tillet, Jean Dewailly, Jean-Jacques Mongold, Jean-François Bergmann. Pharmacodynamics of a new ophthalmic mydriatic insert in healthy volunteers: potential alternative as drug delivery system prior to cataract surgery. Basic & clinical pharmacology & toxicology. 2006 Jun; 98(6):547-54. doi: 10.1111/j.1742-7843.2006.pto_362.x. [PMID: 16700815]
  • Fenglei Huang, Clinton E Browne, Whei-Mei Wu, Attila Juhász, Fubao Ji, Nicholas Bodor. Design, pharmacokinetic, and pharmacodynamic evaluation of a new class of soft anticholinergics. Pharmaceutical research. 2003 Oct; 20(10):1681-9. doi: 10.1023/a:1026160023030. [PMID: 14620526]
  • S M Saw, G Gazzard, K-G Au Eong, D T H Tan. Myopia: attempts to arrest progression. The British journal of ophthalmology. 2002 Nov; 86(11):1306-11. doi: 10.1136/bjo.86.11.1306. [PMID: 12386095]
  • M Mori, K Inamochi, M Araie. Evaluation of albumin concentration in rabbit anterior chamber with laser flare-cell meter. Current eye research. 1995 Jul; 14(7):593-9. doi: 10.3109/02713689508998407. [PMID: 7587306]
  • M L Vuori, T Kaila, E Iisalo, K M Saari. Systemic absorption and anticholinergic activity of topically applied tropicamide. Journal of ocular pharmacology. 1994; 10(2):431-7. doi: 10.1089/jop.1994.10.431. [PMID: 8083562]
  • M Mori, M Araie, M Sakurai, T Oshika. Effects of pilocarpine and tropicamide on blood-aqueous barrier permeability in man. Investigative ophthalmology & visual science. 1992 Feb; 33(2):416-23. doi: NULL. [PMID: 1740374]