5-Hydroxy-1-(3-hydroxy-4-methoxyphenyl)decan-3-one (BioDeep_00000179414)

   

human metabolite blood metabolite natural product


代谢物信息卡片


5-Hydroxy-1-(3-hydroxy-4-methoxyphenyl)decan-3-one

化学式: C17H26O4 (294.1831)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 99.59%

分子结构信息

SMILES: CCCCCC(CC(=O)CCC1=CC(=C(C=C1)OC)O)O
InChI: InChI=1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-17(21-2)16(20)11-13/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3

描述信息

同义名列表

2 个代谢物同义名

5-Hydroxy-1-(3-hydroxy-4-methoxyphenyl)decan-3-one; 6-Gingerol



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Sang Keun Ha, Eunjung Moon, Mi Sun Ju, Dong Hyun Kim, Jong Hoon Ryu, Myung Sook Oh, Sun Yeou Kim. 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. Neuropharmacology. 2012 Aug; 63(2):211-23. doi: 10.1016/j.neuropharm.2012.03.016. [PMID: 22465818]
  • Min-Ji Bak, Seon Ok, Mira Jun, Woo-Sik Jeong. 6-shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice. Molecules (Basel, Switzerland). 2012 Jul; 17(7):8037-55. doi: 10.3390/molecules17078037. [PMID: 22763741]
  • Raghavendra Haniadka, Antappa Govindaraju Rajeev, Princy L Palatty, Rajesh Arora, Manjeshwar S Baliga. Zingiber officinale (ginger) as an anti-emetic in cancer chemotherapy: a review. Journal of alternative and complementary medicine (New York, N.Y.). 2012 May; 18(5):440-4. doi: 10.1089/acm.2010.0737. [PMID: 22540971]
  • Xiao Liu, Linqian Fan, Hao Cai, Baochang Cai. [Simultaneous determination of four components in sini tang by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Mar; 37(6):803-5. doi: . [PMID: 22715726]
  • Naritsara Saenghong, Jintanaporn Wattanathorn, Supaporn Muchimapura, Terdthai Tongun, Nawanant Piyavhatkul, Chuleratana Banchonglikitkul, Tanwarat Kajsongkram. Zingiber officinale Improves Cognitive Function of the Middle-Aged Healthy Women. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):383062. doi: 10.1155/2012/383062. [PMID: 22235230]
  • Chia Ju Chang, Thing-Fong Tzeng, Shorong-Shii Liou, Yuan-Shiun Chang, I-Min Liu. Absence of Genotoxic and Mutagenic Effects of Zingiber zerumbet (L.) Smith (Zingiberaceae) Extract. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):406296. doi: 10.1155/2012/406296. [PMID: 22844331]
  • Manal A Hamed, Sanaa A Ali, Nagy Saba El-Rigal. Therapeutic potential of ginger against renal injury induced by carbon tetrachloride in rats. TheScientificWorldJournal. 2012; 2012(?):840421. doi: 10.1100/2012/840421. [PMID: 22566780]
  • Evan Prince Sabina, Samuel Joshua Pragasam, Suresh Kumar, Mahaboobkhan Rasool. 6-gingerol, an active ingredient of ginger, protects acetaminophen-induced hepatotoxicity in mice. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2011 Nov; 9(11):1264-9. doi: 10.3736/jcim20111116. [PMID: 22088594]
  • Guang Yang, Laifu Zhong, Liping Jiang, Chengyan Geng, Jun Cao, Xiance Sun, Xiaofang Liu, Min Chen, Yufang Ma. 6-gingerol prevents patulin-induced genotoxicity in HepG2 cells. Phytotherapy research : PTR. 2011 Oct; 25(10):1480-5. doi: 10.1002/ptr.3446. [PMID: 21953711]
  • Qingliang Qiao, Qizhen Du. Preparation of the monomers of gingerols and 6-shogaol by flash high speed counter-current chromatography. Journal of chromatography. A. 2011 Sep; 1218(36):6187-90. doi: 10.1016/j.chroma.2010.12.062. [PMID: 21195411]
  • Hye Jin Yang, Jin Yeul Ma, Jin Bae Weon, Choong Je Ma. Simultaneous determination of eight marker compounds in the traditional herbal medicine, Sipjundaebo-tang by HPLC-DAD. Archives of pharmacal research. 2011 Sep; 34(9):1503-8. doi: 10.1007/s12272-011-0912-7. [PMID: 21975812]
  • Yanke Yu, Suzanna Zick, Xiaoqin Li, Peng Zou, Benjamin Wright, Duxin Sun. Examination of the pharmacokinetics of active ingredients of ginger in humans. The AAPS journal. 2011 Sep; 13(3):417-26. doi: 10.1208/s12248-011-9286-5. [PMID: 21638149]
  • John H Beattie, Fergus Nicol, Margaret-Jane Gordon, Martin D Reid, Louise Cantlay, Graham W Horgan, In-Sook Kwun, Ji-Yun Ahn, Tae-Youl Ha. Ginger phytochemicals mitigate the obesogenic effects of a high-fat diet in mice: a proteomic and biomarker network analysis. Molecular nutrition & food research. 2011 Sep; 55 Suppl 2(?):S203-13. doi: 10.1002/mnfr.201100193. [PMID: 21954187]
  • Jin Bae Weon, Hwayong Park, Hye Jin Yang, Jin Yeul Ma, Choong Je Ma. Simultaneous quantification of marker components in Ojeok-san by HPLC-DAD. Journal of natural medicines. 2011 Apr; 65(2):375-80. doi: 10.1007/s11418-010-0494-6. [PMID: 21188642]
  • Hai Zhong Huo, Bing Wang, Yong Kang Liang, Yong Yang Bao, Yan Gu. Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats. International journal of molecular sciences. 2011; 12(10):6529-43. doi: 10.3390/ijms12106529. [PMID: 22072903]
  • N J Yob, S Mohd Jofrry, M M R Meor Mohd Affandi, L K Teh, M Z Salleh, Z A Zakaria. Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):543216. doi: 10.1155/2011/543216. [PMID: 21584247]
  • Ali Ghasemzadeh, Hawa Z E Jaafar, Asmah Rahmat. Synthesis of phenolics and flavonoids in ginger (Zingiber officinale Roscoe) and their effects on photosynthesis rate. International journal of molecular sciences. 2010 Nov; 11(11):4539-55. doi: 10.3390/ijms11114539. [PMID: 21151455]
  • Muxin Gong, Yaxun Wang, Yafang Song, Zhimin Wang, Qiwei Zhang, Weihao Wang, Jingjing Zhu. [Everted intestinal sac method for quick finding absorption ingredients of Wuzhuyu decoction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Jun; 35(11):1399-404. doi: . [PMID: 20822007]
  • Shizuka Hirai, Nobuyuki Takahashi, Tsuyoshi Goto, Shan Lin, Taku Uemura, Rina Yu, Teruo Kawada. Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies. Mediators of inflammation. 2010; 2010(?):367838. doi: 10.1155/2010/367838. [PMID: 20508825]
  • Eun-Jin Yang, Eun-Young Yim, Gwanpil Song, Gi-Ok Kim, Chang-Gu Hyun. Inhibition of nitric oxide production in lipopolysaccharide-activated RAW 264.7 macrophages by Jeju plant extracts. Interdisciplinary toxicology. 2009 Dec; 2(4):245-9. doi: 10.2478/v10102-009-0022-2. [PMID: 21217861]
  • Amy C Brown, Chirag Shah, Jessie Liu, Jimmy T H Pham, Jian Gang Zhang, Martin R Jadus. Ginger's (Zingiber officinale Roscoe) inhibition of rat colonic adenocarcinoma cells proliferation and angiogenesis in vitro. Phytotherapy research : PTR. 2009 May; 23(5):640-5. doi: 10.1002/ptr.2677. [PMID: 19117330]
  • Wei Wang, Chang-Yin Li, Xiao-Dong Wen, Ping Li, Lian-Wen Qi. Plasma pharmacokinetics, tissue distribution and excretion study of 6-gingerol in rat by liquid chromatography-electrospray ionization time-of-flight mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2009 May; 49(4):1070-4. doi: 10.1016/j.jpba.2009.01.020. [PMID: 19217234]
  • Tzung-Yan Lee, Ko-Chen Lee, Shih-Yuan Chen, Hen-Hong Chang. 6-Gingerol inhibits ROS and iNOS through the suppression of PKC-alpha and NF-kappaB pathways in lipopolysaccharide-stimulated mouse macrophages. Biochemical and biophysical research communications. 2009 Apr; 382(1):134-9. doi: 10.1016/j.bbrc.2009.02.160. [PMID: 19268427]
  • Wei Wang, Chang-Yin Li, Xiao-Dong Wen, Ping Li, Lian-Wen Qi. Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: Application to pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Mar; 877(8-9):671-9. doi: 10.1016/j.jchromb.2009.01.021. [PMID: 19201263]
  • Kunyou Zhan, Chao Wang, Kun Xu, Hongzong Yin. [Analysis of volatile and non-volatile compositions in ginger oleoresin by gas chromatography-mass spectrometry]. Se pu = Chinese journal of chromatography. 2008 Nov; 26(6):692-6. doi: . [PMID: 19253546]
  • Muhammad N Ghayur, Anwarul H Gilani, Touqeer Ahmed, Asaad Khalid, Sarfraz A Nawaz, Joseph M Agbedahunsi, Muhammad I Choudhary, Peter J Houghton. Muscarinic, Ca(++) antagonist and specific butyrylcholinesterase inhibitory activity of dried ginger extract might explain its use in dementia. The Journal of pharmacy and pharmacology. 2008 Oct; 60(10):1375-83. doi: 10.1211/jpp/60.10.0014. [PMID: 18812031]
  • Tomoko Hibino, Mitsutoshi Yuzurihara, Kiyoshi Terawaki, Hitomi Kanno, Yoshio Kase, Atsushi Takeda. Goshuyuto, a traditional Japanese medicine for migraine, inhibits platelet aggregation in guinea-pig whole blood. Journal of pharmacological sciences. 2008 Sep; 108(1):89-94. doi: 10.1254/jphs.08058fp. [PMID: 18776713]
  • Hong Nie, Lan-zhen Meng, Hui Zhang, Jian-yu Zhang, Zhen Yin, Xue-song Huang. Analysis of anti-platelet aggregation components of Rhizoma Zingiberis using chicken thrombocyte extract and high performance liquid chromatography. Chinese medical journal. 2008 Jul; 121(13):1226-9. doi: . [PMID: 18710644]
  • Wenxia Zhang, Lee-Yong Lim. Effects of spice constituents on P-glycoprotein-mediated transport and CYP3A4-mediated metabolism in vitro. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1283-90. doi: 10.1124/dmd.107.019737. [PMID: 18385293]
  • Min-Hsiung Pan, Min-Chi Hsieh, Jen-Min Kuo, Ching-Shu Lai, Hou Wu, Shengmin Sang, Chi-Tang Ho. 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. Molecular nutrition & food research. 2008 May; 52(5):527-37. doi: 10.1002/mnfr.200700157. [PMID: 18384088]
  • Paola Minghetti, Silvio Sosa, Francesco Cilurzo, Antonella Casiraghi, Elisabetta Alberti, Aurelia Tubaro, Roberto Della Loggia, Luisa Montanari. Evaluation of the topical anti-inflammatory activity of ginger dry extracts from solutions and plasters. Planta medica. 2007 Dec; 73(15):1525-30. doi: 10.1055/s-2007-993741. [PMID: 18058610]
  • Kazuhiro Ishiguro, Takafumi Ando, Osamu Maeda, Naoki Ohmiya, Yasumasa Niwa, Kenji Kadomatsu, Hidemi Goto. Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. Biochemical and biophysical research communications. 2007 Oct; 362(1):218-223. doi: 10.1016/j.bbrc.2007.08.012. [PMID: 17706603]
  • Rosanna Y Y Lam, Anthony Y H Woo, Po-Sing Leung, Christopher H K Cheng. Antioxidant actions of phenolic compounds found in dietary plants on low-density lipoprotein and erythrocytes in vitro. Journal of the American College of Nutrition. 2007 Jun; 26(3):233-42. doi: 10.1080/07315724.2007.10719606. [PMID: 17634168]
  • Alexandra Bukovská, Stefan Cikos, Stefan Juhás, Gabriela Il'ková, Pavol Rehák, Juraj Koppel. Effects of a combination of thyme and oregano essential oils on TNBS-induced colitis in mice. Mediators of inflammation. 2007; 2007(?):23296. doi: 10.1155/2007/23296. [PMID: 18288268]
  • S M Sagar, D Yance, R K Wong. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 2. Current oncology (Toronto, Ont.). 2006 Jun; 13(3):99-107. doi: ". [PMID: 17576449]
  • Harvey A Schwertner, Deborah C Rios, Joshua E Pascoe. Variation in concentration and labeling of ginger root dietary supplements. Obstetrics and gynecology. 2006 Jun; 107(6):1337-43. doi: 10.1097/01.aog.0000217697.33787.8c. [PMID: 16738161]
  • Muhammad Nabeel Ghayur, Anwarul Hassan Gilani. Species differences in the prokinetic effects of ginger. International journal of food sciences and nutrition. 2006 Feb; 57(1-2):65-73. doi: 10.1080/09637480600656074. [PMID: 16849115]
  • Anurag Kuhad, Naveen Tirkey, Sangeeta Pilkhwal, Kanwaljit Chopra. 6-Gingerol prevents cisplatin-induced acute renal failure in rats. BioFactors (Oxford, England). 2006; 26(3):189-200. doi: 10.1002/biof.5520260304. [PMID: 16971750]
  • Shishir Shishodia, Gautam Sethi, Bharat B Aggarwal. Curcumin: getting back to the roots. Annals of the New York Academy of Sciences. 2005 Nov; 1056(?):206-17. doi: 10.1196/annals.1352.010. [PMID: 16387689]
  • Ching-Chiung Wang, Lih-Geeng Chen, Lain-Tze Lee, Ling-Ling Yang. Effects of 6-gingerol, an antioxidant from ginger, on inducing apoptosis in human leukemic HL-60 cells. In vivo (Athens, Greece). 2003 Nov; 17(6):641-5. doi: ". [PMID: 14758732]
  • Wei-hao Wang, Zhi-min Wang, Li-zhen Xu, Shi-lin Yang. [HPLC determination of 6-gingerol in Rhizoma Zingiberis Recens]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2002 May; 27(5):348-9. doi: ". [PMID: 12774323]