Narasin (BioDeep_00000017926)

   

human metabolite Endogenous natural product


代谢物信息卡片


2H-Pyran-2-acetic acid, alpha-ethyl-6-(5-(2-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro(4.1.5.3)pentadec-13-en-9-yl)-2-hydroxy-1,3-dimethyl-4-oxoheptyl)tetrahydro-3,5-dimethyl-

化学式: C43H72O11 (764.5074)
中文名称: 甲基盐霉素
谱图信息: 最多检出来源 not specific(not specific) 0%

分子结构信息

SMILES: CCC(C(=O)O)C1OC(C(C)C(O)C(C)C(=O)C(CC)C2OC3(C=CC(O)C4(CCC(C)(C5CCC(O)(CC)C(C)O5)O4)O3)C(C)CC2C)C(C)CC1C
InChI: InChI=1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)

描述信息

D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
Ionophore effective against viruses and particularly against coccidial infections in chickens
Ionophore effective against viruses and particularly against coccidial infections in chicken
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents

同义名列表

21 个代谢物同义名

2H-Pyran-2-acetic acid, alpha-ethyl-6-(5-(2-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro(4.1.5.3)pentadec-13-en-9-yl)-2-hydroxy-1,3-dimethyl-4-oxoheptyl)tetrahydro-3,5-dimethyl-; 2-(6-{6-[2-(5-ethyl-5-hydroxy-6-methyloxan-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5⁷.3⁵]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl}-3,5-dimethyloxan-2-yl)butanoic acid; 2-(6-{6-[2-(5-ethyl-5-hydroxy-6-methyloxan-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5⁷.3⁵]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl}-3,5-dimethyloxan-2-yl)butanoate; Salinomycin, 4-methyl-, (4S); 4-Methylsalinomycin, 9ci; Narasin monosodium salt; Narasin, ban, inn, usan; 4-Methylsalinomycin; Antibiotic a 28086a; Antibiotic C 7819b; Lilly 79891; Narasinum; Narasin a; C 18-205; Monteban; Narasino; a 28086a; Narasine; C 7819b; Narasul; narasin



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Brian J Kerr, Steven L Trabue, Mark B van Weelden, Daniel S Andersen, Laura M Pepple. Impact of narasin on manure composition, microbial ecology, and gas emissions from finishing pigs fed either a corn-soybean meal or a corn-soybean meal-dried distillers grains with solubles diets. Journal of animal science. 2018 Apr; 96(4):1317-1329. doi: 10.1093/jas/sky053. [PMID: 29669070]
  • B J Kerr, S L Trabue, D S Andersen. Narasin effects on energy, nutrient, and fiber digestibility in corn-soybean meal or corn-soybean meal-dried distillers grains with solubles diets fed to 16-, 92-, and 141-kg pigs. Journal of animal science. 2017 Sep; 95(9):4030-4036. doi: 10.2527/jas2017.1732. [PMID: 28991990]
  • X Wang, Y Z Farnell, E D Peebles, A S Kiess, K G S Wamsley, W Zhai. Effects of prebiotics, probiotics, and their combination on growth performance, small intestine morphology, and resident Lactobacillus of male broilers. Poultry science. 2016 Jun; 95(6):1332-40. doi: 10.3382/ps/pew030. [PMID: 26944975]
  • Trine Eggen, Tone Normann Asp, Kari Grave, Victor Hormazabal. Uptake and translocation of metformin, ciprofloxacin and narasin in forage- and crop plants. Chemosphere. 2011 Sep; 85(1):26-33. doi: 10.1016/j.chemosphere.2011.06.041. [PMID: 21757221]
  • Tracey L Cash Ward, John W Moran, James M Turner, Mark R Coleman. Validation of a method for the determination of narasin in the edible tissues of chickens by liquid chromatography. Journal of AOAC International. 2005 Jan; 88(1):95-101. doi: 10.1093/jaoac/88.1.95. [PMID: 15759731]
  • Marit Sørum, Gudmund Holstad, Atle Lillehaug, Hilde Kruse. Prevalence of vancomycin resistant enterococci on poultry farms established after the ban of avoparcin. Avian diseases. 2004 Dec; 48(4):823-8. doi: 10.1637/7197-042004r. [PMID: 15666863]
  • L Waldenstedt, A Lundén, K Elwinger, P Thebo, A Uggla. Comparison between a live, attenuated anticoccidial vaccine and an anticoccidial ionophore, on performance of broilers raised with or without a growth promoter, in an initially Eimeria-free environment. Acta veterinaria Scandinavica. 1999; 40(1):11-21. doi: 10.1186/bf03547037. [PMID: 10418192]
  • A Daugschies, U Gässlein, M Rommel. Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials. Veterinary parasitology. 1998 Apr; 76(3):163-71. doi: 10.1016/s0304-4017(97)00203-3. [PMID: 9615950]
  • A J Wuethrich, L F Richardson, D H Mowrey, R E Paxton, D B Anderson. The effect of narasin on apparent nitrogen digestibility and large intestine volatile fatty acid concentrations in finishing swine. Journal of animal science. 1998 Apr; 76(4):1056-63. doi: 10.2527/1998.7641056x. [PMID: 9581929]
  • G Gerhardt, C D Salisbury, H M Campbell. Determination of ionophores in the tissues of food animals by liquid chromatography. Food additives and contaminants. 1995 Nov; 12(6):731-7. doi: 10.1080/02652039509374365. [PMID: 8608847]
  • K Elwinger, C Schneitz, E Berndtson, O Fossum, B Teglöf, B Engstöm. Factors affecting the incidence of necrotic enteritis, caecal carriage of Clostridium perfringens and bird performance in broiler chicks. Acta veterinaria Scandinavica. 1992; 33(4):369-78. doi: 10.1186/bf03547304. [PMID: 1488953]
  • D R Catherman, J Szabo, D B Batson, A H Cantor, R E Tucker, G E Mitchell. Metabolism of narasin in chickens and Japanese quail. Poultry science. 1991 Jan; 70(1):120-5. doi: 10.3382/ps.0700120. [PMID: 2017406]
  • F G Riddell, S J Tompsett. The transport of Na+ and K+ ions through phospholipid bilayers mediated by the antibiotics salinomycin and narasin studied by 23Na- and 39K-NMR spectroscopy. Biochimica et biophysica acta. 1990 May; 1024(1):193-7. doi: 10.1016/0005-2736(90)90225-d. [PMID: 2337616]
  • P R Fitzgerald, M E Mansfield. Effects of inoculations with Eimeria zuernii on young calves treated with decoquinate or narasin with or without dexamethasone. American journal of veterinary research. 1989 Jul; 50(7):1056-9. doi: NULL. [PMID: 2774323]
  • K W Bafundo. Effect of nicarbazin and narasin-nicarbazin combinations on broiler pigmentation. Poultry science. 1989 Mar; 68(3):374-9. doi: 10.3382/ps.0680374. [PMID: 2704695]
  • D M Schmatz, M S Crane, P K Murray. Eimeria tenella: parasite-specific incorporation of 3H-uracil as a quantitative measure of intracellular development. The Journal of protozoology. 1986 Feb; 33(1):109-14. doi: 10.1111/j.1550-7408.1986.tb05568.x. [PMID: 3959004]
  • J E Peeters, R Geeroms, O Antoine, M Mammerickx, P Halen. Efficacy of narasin against hepatic and intestinal coccidiosis in rabbits. Parasitology. 1981 Oct; 83(Pt 2):293-301. doi: 10.1017/s0031182000085309. [PMID: 7329720]
  • C K Smith, R B Galloway, S L White. Effect of ionophores on survival, penetration, and development of Eimeria tenella sporozoites in vitro. The Journal of parasitology. 1981 Aug; 67(4):511-6. doi: 10.2307/3280482. [PMID: 7264837]
  • R M Weppelman, G Olson, D A Smith, T Tamas, A Van Iderstine. Comparison of anticoccidial efficacy, resistance and tolerance of narasin, monensin and lasalocid in chicken battery trials. Poultry science. 1977 Sep; 56(5):1550-9. doi: 10.3382/ps.0561550. [PMID: 605098]