3-Indoxyl sulfate (BioDeep_00000017888)
Main id: BioDeep_00000398347
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Toxin BioNovoGene_Lab2019
代谢物信息卡片
1H-indol-3-Ol hydrogen sulfate ester
化学式: C8H7NO4S (213.0095782)
中文名称: 3-吲哚硫酸酯, 硫酸吲哚, 吲苷 钾盐
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
Reviewed
Last reviewed on 2024-09-13.
Cite this Page
3-Indoxyl sulfate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/3-indoxyl_sulfate (retrieved
2024-11-08) (BioDeep RN: BioDeep_00000017888). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C1=CC=C2C(=C1)C(=CN2)OS(=O)(=O)O
InChI: InChI=1S/C8H7NO4S/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8/h1-5,9H,(H,10,11,12)
描述信息
Indoxyl sulfate is a dietary protein metabolite and also a metabolite of the common amino acid tryptophan. It has been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821). It is a circulating uremic toxin stimulating glomerular sclerosis and interstitial fibrosis. Indoxyl sulfate is one of the well-known substances of a group of protein-bound uremic retention solutes. Indoxyl sulfate increases the rate of progression of renal failure. In plasma, indoxyl sulfate is a protein-bound uremic solute that induces endothelial dysfunction by inhibiting endothelial proliferation and migration in vitro. Some studies suggest that indoxyl sulfate is also involved in oxidative stress. In hemodialyzed patients, serum levels of indoxyl sulfate are associated with levels of pentosidine, a marker of carbonyl and oxidative stress. In vitro, indoxyl sulfate increases reactive oxygen species (ROS) production in tubular cells and increases NAD(P)H oxidase activity in endothelial cells. Indoxyl sulfate impairs osteoblast function and induces abnormalities of bone turnover. Indoxyl sulfate strongly decreases the levels of glutathione, one of the most active antioxidant systems of the cell (PMID: 10681668 , 14681860 , 17471003 , 17403109). Indoxyl sulfate is a microbial metabolite found in Escherichia (PMID: 19946322).
Indoxyl sulfate is a dietary protein metabolite, and also the metabolite of the common amino acid tryptophan. Indoxyl sulfate is a circulating uremic toxin stimulating glomerular sclerosis and interstitial fibrosis. Indoxyl sulfate is one of the well known substances of a group of protein-bound uremic retention solutes. Indoxyl sulfate increases the rate of progression of renal failure. In plasma, indoxyl sulfate is a protein-bound uremic solute that induces endothelial dysfunction by inhibiting endothelial proliferation and migration in vitro. Some studies suggest that indoxyl sulfate is also involved in oxidative stress. In hemodialyzed patients, serum levels of indoxyl sulfate are associated with levels of pentosidine, a marker of carbonyl and oxidative stress; in vitro, indoxyl sulfate increases reactive oxygen species (ROS) production in tubular cells, and increases NAD(P)H oxidase activity in endothelial cells. Indoxyl sulfate impairs osteoblst function and induces abnormalities of bone turnover. Indoxyl sulfate strongly decreases the levels of glutathione, one of the most active antioxidant systems of the cell. (PMID: 10681668, 14681860, 17471003, 17403109) [HMDB]
同义名列表
51 个代谢物同义名
1H-indol-3-Ol hydrogen sulfate ester; (1H-indol-3-yl)oxidanesulfonic acid; indol-3-yl Hydrogen sulphuric acid; 3-Indolyl hydrogen sulphuric acid; indol-3-yl Hydrogen sulfuric acid; 3-Indolyl hydrogen sulfuric acid; 1H-indol-3-yl Hydrogen sulphate; 1H-indol-3-yl Hydrogen sulfate; indol-3-yl Hydrogen sulphate; 3-Indolyl hydrogen sulphate; indol-3-yl Hydrogen sulfate; Monopotassium salt, indican; 3-Indolyl hydrogen sulfate; Indican monopotassium salt; indol-3-yl Sulphuric acid; 3-Indoxyl sulphuric acid; indol-3-yl Sulfuric acid; Indoxyl-3-sulphuric acid; Monosodium salt, indican; 3-Indolyl sulphuric acid; 3-Indolyl sulfuric acid; 3-Indoxyl sulfuric acid; Indican monosodium salt; 3-Indoxylsulphuric acid; Indoxyl-3-sulfuric acid; 3-Indoxylsulfuric acid; Indoxyl sulphuric acid; Indoxylsulphuric acid; 3-Sulphooxy-1H-indole; Indoxyl sulfuric acid; 3-sulfooxy-1H-indole; Indoxylsulfuric acid; indol-3-yl Sulphate; Indoxyl sulfic acid; 3-Indolyl sulphate; Indoxyl-3-sulphate; 3-Indoxyl sulphate; indol-3-yl Sulfate; Indoxyl-3-sulfate; 3-Indolyl sulfate; 3-Indoxylsulphate; 3-Indoxyl sulfate; Indoxyl sulphate; 3-Indoxylsulfate; Sulfate, indoxyl; Indoxyl sulfate; Indoxylsulphate; Indoxylsulfate; indol-3-Ol; Indican; Indoxyl sulfate
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:43355
- PubChem: 10258
- HMDB: HMDB0000682
- DrugBank: DB07992
- ChEMBL: CHEMBL1233636
- Wikipedia: Indoxyl sulfate
- MeSH: Indican
- KNApSAcK: C00052323
- foodb: FDB022179
- chemspider: 9840
- CAS: 487-94-5
- PMhub: MS000000929
- RefMet: Indoxyl sulfate
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-263
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
7 个相关的物种来源信息
- 673185 - Calanthe discolor: 10.1248/CPB.46.886
- 46112 - Celosia argentea: 10.5650/JOS1996.47.25
- 165299 - Cissus discolor: 10.1248/CPB.57.1089
- 289665 - Cissus verticillata: 10.1248/CPB.57.1089
- 9606 - Homo sapiens: -
- 161756 - Isatis tinctoria:
- 222567 - Strobilanthes cusia: 10.1016/0031-9422(92)83613-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- HongXia Chen, Hao Zhou, Changwei Zhang, Wenjun Li, Xingying Xue, ChengZhang Wang. Convenient preparation of indigo from the Ieaves of Baphicacanthus cusia(Nees) Bremek by enzymatic method and its MALDI-TOF-MS and UPLC-Q-TOF/MS analysis.
Enzyme and microbial technology.
2024 Aug; 178(?):110440. doi:
10.1016/j.enzmictec.2024.110440. [PMID: 38574422] - Christo J Botha, Magdaleen Vosser, Mohammed I A Ibrahim, Elizabeth du Plessis, Antoinette V Lensink, Wiehan J Rudolph, Luke Invernizzi. Indigofera cryptantha-induced pigmenturia in cattle in South Africa.
Toxicon : official journal of the International Society on Toxinology.
2024 May; 242(?):107690. doi:
10.1016/j.toxicon.2024.107690. [PMID: 38508242] - Hongyan Xie, Ninghao Yang, Chen Yu, Limin Lu. Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor.
Cellular & molecular biology letters.
2024 Mar; 29(1):38. doi:
10.1186/s11658-024-00550-4. [PMID: 38491448] - Gonzalo Nahuel Bidart, David Teze, Charlotte Uldahl Jansen, Eleonora Pasutto, Natalia Putkaradze, Anna-Mamusu Sesay, Folmer Fredslund, Leila Lo Leggio, Olafur Ögmundarson, Sumesh Sukumara, Katrine Qvortrup, Ditte Hededam Welner. Chemoenzymatic indican for light-driven denim dyeing.
Nature communications.
2024 Feb; 15(1):1489. doi:
10.1038/s41467-024-45749-3. [PMID: 38413572] - Krzysztof Łukawski, Grzegorz Raszewski, Stanisław J Czuczwar. Effects of the uremic toxin indoxyl sulfate on seizure activity, learning and brain oxidative stress parameters in mice.
Neuroscience letters.
2024 Jan; 820(?):137594. doi:
10.1016/j.neulet.2023.137594. [PMID: 38096971] - Natalia Stepanova, Ganna Tolstanova, Iryna Aleksandrova, Lesya Korol, Taisa Dovbynchuk, Victoria Driianska, Svitlana Savchenko. Gut Microbiota's Oxalate-Degrading Activity and Its Implications on Cardiovascular Health in Patients with Kidney Failure: A Pilot Prospective Study.
Medicina (Kaunas, Lithuania).
2023 Dec; 59(12):. doi:
10.3390/medicina59122189. [PMID: 38138292] - Jing Wang, Birui Shi, Yueqing Pan, Zhuan Yang, Wei Zou, Menghua Liu. Asperulosidic Acid Ameliorates Renal Interstitial Fibrosis via Removing Indoxyl Sulfate by Up-Regulating Organic Anion Transporters in a Unilateral Ureteral Obstruction Mice Model.
Molecules (Basel, Switzerland).
2023 Nov; 28(23):. doi:
10.3390/molecules28237690. [PMID: 38067420] - Cong Lu, Li Wu, Mu-Yao Tang, Yi-Fan Liu, Lei Liu, Xi-Ya Liu, Chun Zhang, Liang Huang. Indoxyl sulfate in atherosclerosis.
Toxicology letters.
2023 Jul; 383(?):204-212. doi:
10.1016/j.toxlet.2023.07.001. [PMID: 37414304] - Yenan Mo, Dongmei Hu, Wanlin Yu, Chunlan Ji, Yin Li, Xusheng Liu, Zhaoyu Lu. Astragaloside IV attenuates indoxyl sulfate-induced injury of renal tubular epithelial cells by inhibiting the aryl hydrocarbon receptor pathway.
Journal of ethnopharmacology.
2023 May; 308(?):116244. doi:
10.1016/j.jep.2023.116244. [PMID: 36764562] - Jinxia Wei, Rui Li, Penghui Zhang, Haiqun Jin, Zhenjie Zhang, Yubo Li, Yao Chen. Efficient selective removal of uremic toxin precursor by olefin-linked covalent organic frameworks for nephropathy treatment.
Nature communications.
2023 May; 14(1):2805. doi:
10.1038/s41467-023-38427-3. [PMID: 37193688] - Wan-Chuan Tsai, Shih-Ping Hsu, Yen-Ling Chiu, Hon-Yen Wu, Chia-Chin Luan, Ju-Yeh Yang, Mei-Fen Pai, Cheng-Jui Lin, Wan-Yu Lin, Wen-Huei Sun, Yu-Sen Peng. Short-Term Effects of a Therapeutic Diet on Biochemical Parameters in Hemodialysis Patients: A Randomized Crossover Trial.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2023 Apr; ?(?):. doi:
10.1053/j.jrn.2023.04.003. [PMID: 37120127] - Robin Schürfeld, Benjamin Sandner, Annett Hoffmann, Nora Klöting, Ekaterine Baratashvili, Marcin Nowicki, Sabine Paeschke, Joanna Kosacka, Susan Kralisch, Anette Bachmann, Armin Frille, Anja Dietel, Jens-Uwe Stolzenburg, Matthias Blüher, Ming-Zhi Zhang, Raymond C Harris, Berend Isermann, Michael Stumvoll, Anke Tönjes, Thomas Ebert. Renal function is a major predictor of circulating acyl-CoA-binding protein/diazepam-binding inhibitor.
Frontiers in endocrinology.
2023; 14(?):1152444. doi:
10.3389/fendo.2023.1152444. [PMID: 37288304] - Ran Zhang, Yan-Yan Li, Zhong-Biao Nie, Xue-Qin Zhang, Yan-Miao Ma, Yong-Hui Wang. Scientometric analysis of kidney disease and gut microbiota from 2001 to 2020 based on Web of Science.
Medicine.
2022 Dec; 101(48):e32081. doi:
10.1097/md.0000000000032081. [PMID: 36482594] - Kyoko Fujita, Taisei Nonaka, Rina Kutsuno, Kimiyoshi Ichida. Electrochemical sensing of the secretion of indoxyl sulfate in a rat intestinal loop using a self-assembled monolayer-modified gold bead electrode.
Talanta.
2022 Sep; 247(?):123551. doi:
10.1016/j.talanta.2022.123551. [PMID: 35649325] - Li Chen, Junhe Shi, Xiaojuan Ma, Dazhuo Shi, Hua Qu. Effects of Microbiota-Driven Therapy on Circulating Indoxyl Sulfate and P-Cresyl Sulfate in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Advances in nutrition (Bethesda, Md.).
2022 08; 13(4):1267-1278. doi:
10.1093/advances/nmab149. [PMID: 34905018] - Haibo Yu, Chunyu Zhou, Dayong Hu, Changbin Li, Qiang Wang, Wen Xue, Ai Peng. Uremic toxin indoxyl sulfate induces dysfunction of vascular smooth muscle cells via integrin-β1/ERK signaling pathway.
Clinical and experimental nephrology.
2022 Jul; 26(7):640-648. doi:
10.1007/s10157-022-02195-z. [PMID: 35333997] - Ichiro Wakabayashi, Mikio Marumo. Evidence for Indoxyl Sulfate as an Inducer of Oxidative Stress in Patients With Diabetes.
In vivo (Athens, Greece).
2022 Jul; 36(4):1790-1794. doi:
10.21873/invivo.12893. [PMID: 35738626] - Qian Li, Shuang Zhang, Qi-Jun Wu, Jia Xiao, Zhi-Hong Wang, Xiang-Wei Mu, Yu Zhang, Xue-Na Wang, Lian-Lian You, Sheng-Nan Wang, Jia-Ni Song, Xiu-Nan Zhao, Zhen-Zhen Wang, Xin-Yi Yan, Yu-Xin Jin, Bo-Wen Jiang, Shu-Xin Liu. Serum total indoxyl sulfate levels and all-cause and cardiovascular mortality in maintenance hemodialysis patients: a prospective cohort study.
BMC nephrology.
2022 06; 23(1):231. doi:
10.1186/s12882-022-02862-z. [PMID: 35764943] - Stanislas Bataille, Laetitia Dou, Marc Bartoli, Marion Sallée, Julien Aniort, Borhane Ferkak, Rania Chermiti, Nathalie McKay, Nathalie Da Silva, Stéphane Burtey, Stéphane Poitevin. Mechanisms of myostatin and activin A accumulation in chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2022 06; 37(7):1249-1260. doi:
10.1093/ndt/gfac136. [PMID: 35333341] - Anna Pieniazek, Michal Kopera, Lukasz Gwozdzinski, Krzysztof Gwozdzinski. Indoxyl Sulfate Induces Oxidative Changes in Plasma and Hemolysate.
Molecules (Basel, Switzerland).
2022 Jun; 27(12):. doi:
10.3390/molecules27123848. [PMID: 35744968] - Jordana D Lima, Murilo Guedes, Silvia D Rodrigues, Ana Clara S Flórido, Andrea N Moreno-Amaral, Ana Beatriz Barra, Maria Eugênia Canziani, Américo Cuvello-Neto, Carlos Eduardo Poli-de-Figueiredo, Roberto Pecoits-Filho, Lia S Nakao. High-volume hemodiafiltration decreases the pre-dialysis concentrations of indoxyl sulfate and p-cresyl sulfate compared to hemodialysis: a post-hoc analysis from the HDFit randomized controlled trial.
Journal of nephrology.
2022 Jun; 35(5):1449-1456. doi:
10.1007/s40620-022-01283-3. [PMID: 35239175] - Teresa Arcidiacono, Lorenza Macrina, Simone Premaschi, Arianna Bologna, Giulia Magni, Nadia Foligno, Monica Avino, Cristina Belloni, Nicola Palmieri, Ferruccio Conte, Sergio Bisegna, Marco Simonini, Giorgio Slaviero, Massimo Locatelli, Giuseppe Vezzoli. Serum concentrations of free indoxyl and p-cresyl sulfate are associated with mineral metabolism variables and cardiovascular risk in hemodialysis patients.
Journal of nephrology.
2022 06; 35(5):1457-1465. doi:
10.1007/s40620-022-01271-7. [PMID: 35175580] - Jean Christ Cédras Capo-Chichi, Natália Alvarenga Borges, Drielly Cristhiny Mendes de Vargas Reis, Lia S Nakao, Denise Mafra. Is there an association between the plasma levels of uremic toxins from gut microbiota and anemia in patients on hemodialysis?.
International urology and nephrology.
2022 Jun; 54(6):1271-1277. doi:
10.1007/s11255-021-03001-7. [PMID: 34561817] - Duk-Soo Kim, Seong-Wook Kim, Hyo-Wook Gil. Emotional and cognitive changes in chronic kidney disease.
The Korean journal of internal medicine.
2022 05; 37(3):489-501. doi:
10.3904/kjim.2021.492. [PMID: 35249316] - Ayako Oda, Yosuke Suzuki, Banri Sato, Haruki Sato, Ryota Tanaka, Hiroyuki Ono, Tadasuke Ando, Toshitaka Shin, Hiromitsu Mimata, Hiroki Itoh, Keiko Ohno. Highly sensitive simultaneous quantification of indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid in human plasma using ultra-high-performance liquid chromatography coupled with tandem mass spectrometry.
Journal of separation science.
2022 May; 45(10):1672-1682. doi:
10.1002/jssc.202100950. [PMID: 35247297] - Sabbir Ahmed, Rolf W Sparidans, Jingyi Lu, Silvia M Mihaila, Karin G F Gerritsen, Rosalinde Masereeuw. A robust, accurate, sensitive LC-MS/MS method to measure indoxyl sulfate, validated for plasma and kidney cells.
Biomedical chromatography : BMC.
2022 May; 36(5):e5307. doi:
10.1002/bmc.5307. [PMID: 34978088] - Andreana De Mauri, Deborah Carrera, Matteo Vidali, Marco Bagnati, Roberta Rolla, Sergio Riso, Doriana Chiarinotti, Massimo Torreggiani. Does Mediterranean Adequacy Index Correlate with Cardiovascular Events in Patients with Advanced Chronic Kidney Disease? An Exploratory Study.
Nutrients.
2022 Apr; 14(9):. doi:
10.3390/nu14091687. [PMID: 35565655] - Achilles Ntranos, Hye-Jin Park, Maureen Wentling, Vladimir Tolstikov, Mario Amatruda, Benjamin Inbar, Seunghee Kim-Schulze, Carol Frazier, Judy Button, Michael A Kiebish, Fred Lublin, Keith Edwards, Patrizia Casaccia. Bacterial neurotoxic metabolites in multiple sclerosis cerebrospinal fluid and plasma.
Brain : a journal of neurology.
2022 04; 145(2):569-583. doi:
10.1093/brain/awab320. [PMID: 34894211] - Bjorn Meijers, Jerome Lowenstein. The Evolving View of Uremic Toxicity.
Toxins.
2022 04; 14(4):. doi:
10.3390/toxins14040274. [PMID: 35448883] - Sota Todoriki, Yui Hosoda, Tae Yamamoto, Mayu Watanabe, Akiyo Sekimoto, Hiroshi Sato, Takefumi Mori, Mariko Miyazaki, Nobuyuki Takahashi, Emiko Sato. Methylglyoxal Induces Inflammation, Metabolic Modulation and Oxidative Stress in Myoblast Cells.
Toxins.
2022 04; 14(4):. doi:
10.3390/toxins14040263. [PMID: 35448872] - Regiane Stafim da Cunha, Paulo Cézar Gregório, Rayana Ariane Pereira Maciel, Giane Favretto, Célia Regina Cavichiolo Franco, Jenifer Pendiuk Gonçalves, Marina Luise Viola de Azevedo, Roberto Pecoits-Filho, Andréa Emilia Marques Stinghen. Uremic toxins activate CREB/ATF1 in endothelial cells related to chronic kidney disease.
Biochemical pharmacology.
2022 04; 198(?):114984. doi:
10.1016/j.bcp.2022.114984. [PMID: 35245485] - Kazutoshi Yamaguchi, Maimaiti Yisireyili, Sumie Goto, Xian Wu Cheng, Takayuki Nakayama, Tadashi Matsushita, Toshimitsu Niwa, Toyoaki Murohara, Kyosuke Takeshita. Indoxyl Sulfate Activates NLRP3 Inflammasome to Induce Cardiac Contractile Dysfunction Accompanied by Myocardial Fibrosis and Hypertrophy.
Cardiovascular toxicology.
2022 04; 22(4):365-377. doi:
10.1007/s12012-021-09718-2. [PMID: 35088197] - Shuxin Liu, Lingyun Jia, Jia Xiao, Jingyu Li, Fangfang Mei, Jianan Zhou, Lulu Han, Lin Li, Jing Shan. Increased clearance of indoxyl sulphate in renal failure rats with the addition of water-soluble poly-β-cyclodextrin to the dialysate.
Nephrology (Carlton, Vic.).
2022 Apr; 27(4):376-382. doi:
10.1111/nep.14008. [PMID: 34841612] - Raymond Vanholder, Sanjay K Nigam, Stéphane Burtey, Griet Glorieux. What If Not All Metabolites from the Uremic Toxin Generating Pathways Are Toxic? A Hypothesis.
Toxins.
2022 03; 14(3):. doi:
10.3390/toxins14030221. [PMID: 35324718] - Sofía Campillo, Lourdes Bohorquez, Elena Gutiérrez-Calabrés, Diego García-Ayuso, Verónica Miguel, Mercedes Griera, Yolanda Calle, Sergio de Frutos, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol, Laura Calleros. Indoxyl sulfate- and P-cresol-induced monocyte adhesion and migration is mediated by integrin-linked kinase-dependent podosome formation.
Experimental & molecular medicine.
2022 03; 54(3):226-238. doi:
10.1038/s12276-022-00738-8. [PMID: 35246616] - Romain Vial, Stéphane Poitevin, Nathalie McKay, Stéphane Burtey, Claire Cerini. Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells.
International journal of molecular sciences.
2022 Feb; 23(4):. doi:
10.3390/ijms23042369. [PMID: 35216489] - Jing Yang, Hongxia Li, Chi Zhang, Yafeng Zhou. Indoxyl sulfate reduces Ito,f by activating ROS/MAPK and NF-κB signaling pathways.
JCI insight.
2022 02; 7(3):. doi:
10.1172/jci.insight.145475. [PMID: 35132967] - Erika Yoshihara, Makoto Sasaki, Ahmed Nabil, Michihiro Iijima, Mitsuhiro Ebara. Temperature Responsive Polymer Conjugate Prepared by 'Grafting from' Proteins toward the Adsorption and Removal of Uremic Toxin.
Molecules (Basel, Switzerland).
2022 Feb; 27(3):. doi:
10.3390/molecules27031051. [PMID: 35164316] - Cindy Nguyen, Amanda J Edgley, Darren J Kelly, Andrew R Kompa. Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endothelial Dysfunction in Rat Aortic Rings.
Toxins.
2022 01; 14(2):. doi:
10.3390/toxins14020100. [PMID: 35202128] - Andreas Zietzer, Eva Steffen, Sven Niepmann, Philip Düsing, Mohammed Rabiul Hosen, Weiyi Liu, Paul Jamme, Baravan Al-Kassou, Philipp Roger Goody, Sebastian Zimmer, Katrin S Reiners, Alexander Pfeifer, Michael Böhm, Nikos Werner, Georg Nickenig, Felix Jansen. MicroRNA-mediated vascular intercellular communication is altered in chronic kidney disease.
Cardiovascular research.
2022 01; 118(1):316-333. doi:
10.1093/cvr/cvaa322. [PMID: 33135066] - Nkiruka V Arinze, Wenqing Yin, Saran Lotfollahzadeh, Marc Arthur Napoleon, Sean Richards, Joshua A Walker, Mostafa Belghasem, Jonathan D Ravid, Mohamed Hassan Kamel, Stephen A Whelan, Norman Lee, Jeffrey J Siracuse, Stephan Anderson, Alik Farber, David Sherr, Jean Francis, Naomi M Hamburg, Nader Rahimi, Vipul C Chitalia. Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease.
The Journal of clinical investigation.
2022 01; 132(1):. doi:
10.1172/jci142260. [PMID: 34752422] - Anders H Berg, Sanjeev Kumar, S Ananth Karumanchi. Indoxyl sulfate in uremia: an old idea with updated concepts.
The Journal of clinical investigation.
2022 01; 132(1):. doi:
10.1172/jci155860. [PMID: 34981787] - Zhuo Li, Guibao Ke, Li Song, Junlin Huang, Yamei Zhang, Jie Xiao, Shuangxin Liu, Xinling Liang. Association between Cardiac Outcomes and Indoxyl Sulfate Levels in Hemodialysis Patients: A Cross-Sectional Study.
Kidney & blood pressure research.
2022; 47(4):239-246. doi:
10.1159/000521422. [PMID: 34942617] - Keisuke Nakagawa, Ryosuke Tanaka, Masahide Donouchi, Masaya Kanda, Saaya Kamada, Shuhei Kobuchi, Masashi Tawa, Yasuo Matsumura, Mamoru Ohkita. Vascular Endothelial Dysfunction in the Thoracic Aorta of Rats with Ischemic Acute Kidney Injury: Contribution of Indoxyl Sulfate.
Oxidative medicine and cellular longevity.
2022; 2022(?):7547269. doi:
10.1155/2022/7547269. [PMID: 35251481] - Yuanyuan Shi, Huajun Tian, Yifeng Wang, Yue Shen, Qiuyu Zhu, Feng Ding. Improved Dialysis Removal of Protein-Bound Uraemic Toxins with a Combined Displacement and Adsorption Technique.
Blood purification.
2022; 51(6):548-558. doi:
10.1159/000518065. [PMID: 34515053] - Sophie Liabeuf, Marion Pepin, Casper F M Franssen, Davide Viggiano, Sol Carriazo, Ron T Gansevoort, Loreto Gesualdo, Gaye Hafez, Jolanta Malyszko, Christopher Mayer, Dorothea Nitsch, Alberto Ortiz, Vesna Pešić, Andrzej Wiecek, Ziad A Massy. Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2021 12; 37(Suppl 2):ii33-ii44. doi:
10.1093/ndt/gfab223. [PMID: 34718753] - Takehiro Nakano, Hiroshi Watanabe, Tadashi Imafuku, Kai Tokumaru, Issei Fujita, Nanaka Arimura, Hitoshi Maeda, Motoko Tanaka, Kazutaka Matsushita, Masafumi Fukagawa, Toru Maruyama. Indoxyl Sulfate Contributes to mTORC1-Induced Renal Fibrosis via The OAT/NADPH Oxidase/ROS Pathway.
Toxins.
2021 12; 13(12):. doi:
10.3390/toxins13120909. [PMID: 34941746] - Jia-Huang Chen, Chia-Ter Chao, Jenq-Wen Huang, Kuan-Yu Hung, Shing-Hwa Liu, Der-Cherng Tarng, Chih-Kang Chiang. Early elimination of uremic toxin ameliorates AKI-to-CKD transition.
Clinical science (London, England : 1979).
2021 12; 135(23):2643-2658. doi:
10.1042/cs20210858. [PMID: 34796904] - Yu-Chin Huang, Tzu-Chun Tsai, Chia-Hsin Chang, Kuo-Ting Chang, Pin-Hao Ko, Liang-Chuan Lai. Indoxyl Sulfate Elevated Lnc-SLC15A1-1 Upregulating CXCL10/CXCL8 Expression in High-Glucose Endothelial Cells by Sponging MicroRNAs.
Toxins.
2021 12; 13(12):. doi:
10.3390/toxins13120873. [PMID: 34941711] - Sheng-Chao Wang, Yu-Hsien Lai, Chin-Hung Liu, Chih-Hsien Wang, Bang-Gee Hsu, Jen-Pi Tsai. Association between serum indoxyl sulfate levels with carotid-femoral pulse wave velocity in patients with chronic kidney disease.
Renal failure.
2021 Dec; 43(1):796-802. doi:
10.1080/0886022x.2021.1921797. [PMID: 33941031] - Kullaya Takkavatakarn, Thunyatorn Wuttiputinun, Jeerath Phannajit, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong. Protein-bound uremic toxin lowering strategies in chronic kidney disease: a systematic review and meta-analysis.
Journal of nephrology.
2021 Dec; 34(6):1805-1817. doi:
10.1007/s40620-020-00955-2. [PMID: 33484425] - Christof Ulrich, Leonie Kneser, Roman Fiedler, Julia Beckert, Susann Wildgrube, Eric Seibert, Sylvia Fick, Christoph Schäfer, Silke Markau, Bogusz Trojanowicz, Matthias Girndt. Pyroptosis: A Common Feature of Immune Cells of Haemodialysis Patients.
Toxins.
2021 11; 13(12):. doi:
10.3390/toxins13120839. [PMID: 34941677] - Kenshiro Hirata, Tokunori Ikeda, Hiroshi Watanabe, Toru Maruyama, Motoko Tanaka, Victor Tuan Giam Chuang, Yuji Uchida, Keiki Sakurama, Koji Nishi, Keishi Yamasaki, Masaki Otagiri. The Binding of Aripiprazole to Plasma Proteins in Chronic Renal Failure Patients.
Toxins.
2021 11; 13(11):. doi:
10.3390/toxins13110811. [PMID: 34822595] - Catherine McFarlane, Rathika Krishnasamy, Tony Stanton, Emma Savill, Matthew Snelson, Gabor Mihala, Mark Morrison, David W Johnson, Katrina L Campbell. Diet Quality and Protein-Bound Uraemic Toxins: Investigation of Novel Risk Factors and the Role of Microbiome in Chronic Kidney Disease.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2021 Nov; ?(?):. doi:
10.1053/j.jrn.2021.10.003. [PMID: 34776340] - Robert D Mair, Seolhyun Lee, Natalie S Plummer, Tammy L Sirich, Timothy W Meyer. Impaired Tubular Secretion of Organic Solutes in Advanced Chronic Kidney Disease.
Journal of the American Society of Nephrology : JASN.
2021 11; 32(11):2877-2884. doi:
10.1681/asn.2021030336. [PMID: 34408065] - Jasia King, Sangita Swapnasrita, Roman Truckenmüller, Stefan Giselbrecht, Rosalinde Masereeuw, Aurélie Carlier. Modeling indoxyl sulfate transport in a bioartificial kidney: Two-step binding kinetics or lumped parameters model for uremic toxin clearance?.
Computers in biology and medicine.
2021 11; 138(?):104912. doi:
10.1016/j.compbiomed.2021.104912. [PMID: 34628208] - Joshua A Walker, Sean Richards, Stephen A Whelan, Sung Bok Yoo, Teresa L Russell, Nkiruka Arinze, Saran Lotfollahzadeh, Marc A Napoleon, Mostafa Belghasem, Norman Lee, Laura M Dember, Katya Ravid, Vipul C Chitalia. Indoleamine 2,3-dioxygenase-1, a Novel Therapeutic Target for Post-Vascular Injury Thrombosis in CKD.
Journal of the American Society of Nephrology : JASN.
2021 11; 32(11):2834-2850. doi:
10.1681/asn.2020091310. [PMID: 34716244] - Fatima Guerrero, Andres Carmona, Maria Jose Jimenez, Teresa Obrero, Victoria Pulido, Juan Antonio Moreno, Sagrario Soriano, Alejandro Martín-Malo, Pedro Aljama. Passage Number-Induced Replicative Senescence Modulates the Endothelial Cell Response to Protein-Bound Uremic Toxins.
Toxins.
2021 10; 13(10):. doi:
10.3390/toxins13100738. [PMID: 34679030] - Yunjia Lai, Chih-Wei Liu, Yifei Yang, Yun-Chung Hsiao, Hongyu Ru, Kun Lu. High-coverage metabolomics uncovers microbiota-driven biochemical landscape of interorgan transport and gut-brain communication in mice.
Nature communications.
2021 10; 12(1):6000. doi:
10.1038/s41467-021-26209-8. [PMID: 34667167] - Jia-Fwu Shyu, Wen-Chih Liu, Cai-Mei Zheng, Te-Chao Fang, Yi-Chou Hou, Chiz-Tzung Chang, Ting-Ying Liao, Yin-Cheng Chen, Kuo-Cheng Lu. Toxic Effects of Indoxyl Sulfate on Osteoclastogenesis and Osteoblastogenesis.
International journal of molecular sciences.
2021 Oct; 22(20):. doi:
10.3390/ijms222011265. [PMID: 34681927] - Yuichi Ichimura, Natsumi Kudoh, Takashi Murabe, Takumi Akao, Sho Watanuki, Takanao Suzuki, Toshihide Saito, Masako Oda, Hiroshi Saitoh. Inhibitory effects of indoxyl sulfate and creatinine on the renal transport of meropenem and biapenem in rats.
Drug metabolism and pharmacokinetics.
2021 Oct; 40(?):100406. doi:
10.1016/j.dmpk.2021.100406. [PMID: 34352708] - Ophélie Fourdinier, Griet Glorieux, Benjamin Brigant, Momar Diouf, Anneleen Pletinck, Raymond Vanholder, Gabriel Choukroun, Francis Verbeke, Ziad A Massy, Valérie Metzinger-Le Meuth, Laurent Metzinger, On Behalf Of The European Uremic Toxin Work Group-EUTox. Syndecan-1 and Free Indoxyl Sulfate Levels Are Associated with miR-126 in Chronic Kidney Disease.
International journal of molecular sciences.
2021 Sep; 22(19):. doi:
10.3390/ijms221910549. [PMID: 34638892] - Kullaya Takkavatakarn, Pongpratch Puapatanakul, Jeerath Phannajit, Warumphon Sukkumme, Pajaree Chariyavilaskul, Patita Sitticharoenchai, Asada Leelahavanichkul, Pisut Katavetin, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong. Protein-Bound Uremic Toxins Lowering Effect of Sevelamer in Pre-Dialysis Chronic Kidney Disease Patients with Hyperphosphatemia: A Randomized Controlled Trial.
Toxins.
2021 09; 13(10):. doi:
10.3390/toxins13100688. [PMID: 34678981] - Wei Ling Lau, Yongen Chang, Nosratola D Vaziri. The consequences of altered microbiota in immune-related chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2021 09; 36(10):1791-1798. doi:
10.1093/ndt/gfaa087. [PMID: 32437554] - Jasia King, Silvia M Mihaila, Sabbir Ahmed, Roman Truckenmüller, Stefan Giselbrecht, Rosalinde Masereeuw, Aurélie Carlier. The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule: An Integrated Computational and In Vitro Study.
Toxins.
2021 09; 13(10):. doi:
10.3390/toxins13100674. [PMID: 34678967] - Cheng Chen, Lin Wu, Caidie Xie, Xiufen Zhao, Huijuan Mao, Changying Xing. The role of AMP-activated protein kinase α1-mediated endoplasmic reticulum stress in alleviating the toxic effect of uremic toxin indoxyl sulfate on vascular endothelial cells by Klotho.
Journal of applied toxicology : JAT.
2021 09; 41(9):1446-1455. doi:
10.1002/jat.4135. [PMID: 33458837] - Giane Favretto, Regiane Stafim da Cunha, Andressa Flores Santos, Amanda Leitolis, Elberth Manfron Schiefer, Paulo Cézar Gregório, Célia Regina Cavichiolo Franco, Ziad Massy, Maria Aparecida Dalboni, Andréa Emilia Marques Stinghen. Uremic endothelial-derived extracellular vesicles: Mechanisms of formation and their role in cell adhesion, cell migration, inflammation, and oxidative stress.
Toxicology letters.
2021 Sep; 347(?):12-22. doi:
10.1016/j.toxlet.2021.04.019. [PMID: 33945863] - Natalia Korytowska, Aleksandra Wyczałkowska-Tomasik, Leszek Pączek, Joanna Giebułtowicz. Evaluation of Salivary Indoxyl Sulfate with Proteinuria for Predicting Graft Deterioration in Kidney Transplant Recipients.
Toxins.
2021 08; 13(8):. doi:
10.3390/toxins13080571. [PMID: 34437442] - Yan Chen, Leila R Zelnick, Matthew P Huber, Ke Wang, Nisha Bansal, Andrew N Hoofnagle, Rajan K Paranji, Susan R Heckbert, Noel S Weiss, Alan S Go, Chi-Yuan Hsu, Harold I Feldman, Sushrut S Waikar, Rupal C Mehta, Anand Srivastava, Stephen L Seliger, James P Lash, Anna C Porter, Dominic S Raj, Bryan R Kestenbaum. Association Between Kidney Clearance of Secretory Solutes and Cardiovascular Events: The Chronic Renal Insufficiency Cohort (CRIC) Study.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2021 08; 78(2):226-235.e1. doi:
10.1053/j.ajkd.2020.12.005. [PMID: 33421453] - Jia-Feng Chang, Chih-Yu Hsieh, Jian-Chiun Liou, Kuo-Cheng Lu, Cai-Mei Zheng, Mai-Szu Wu, Shu-Wei Chang, Ting-Ming Wang, Chang-Chin Wu. Circulating p-Cresyl Sulfate, Non-Hepatic Alkaline Phosphatase and Risk of Bone Fracture Events in Chronic Kidney Disease-Mineral Bone Disease.
Toxins.
2021 07; 13(7):. doi:
10.3390/toxins13070479. [PMID: 34357951] - Elisabetta Margiotta, Lara Caldiroli, Maria Luisa Callegari, Francesco Miragoli, Francesca Zanoni, Silvia Armelloni, Vittoria Rizzo, Piergiorgio Messa, Simone Vettoretti. Association of Sarcopenia and Gut Microbiota Composition in Older Patients with Advanced Chronic Kidney Disease, Investigation of the Interactions with Uremic Toxins, Inflammation and Oxidative Stress.
Toxins.
2021 07; 13(7):. doi:
10.3390/toxins13070472. [PMID: 34357944] - Roberta T Salarolli, Livia Alvarenga, Ludmila F M F Cardozo, Karla T R Teixeira, Laís de S G Moreira, Jordana D Lima, Silvia D Rodrigues, Lia S Nakao, Denis Fouque, Denise Mafra. Can curcumin supplementation reduce plasma levels of gut-derived uremic toxins in hemodialysis patients? A pilot randomized, double-blind, controlled study.
International urology and nephrology.
2021 Jun; 53(6):1231-1238. doi:
10.1007/s11255-020-02760-z. [PMID: 33438085] - Selena Z Kuo, Katja Dettmer, Medini K Annavajhala, David H Chong, Anne-Catrin Uhlemann, Julian A Abrams, Peter J Oefner, Daniel E Freedberg. Associations between urinary 3-indoxyl sulfate, a gut microbiome-derived biomarker, and patient outcomes after intensive care unit admission.
Journal of critical care.
2021 06; 63(?):15-21. doi:
10.1016/j.jcrc.2021.01.005. [PMID: 33549909] - Griet Glorieux, Raymond Vanholder, Wim Van Biesen, Anneleen Pletinck, Eva Schepers, Nathalie Neirynck, Marijn Speeckaert, Dirk De Bacquer, Francis Verbeke. Free p-cresyl sulfate shows the highest association with cardiovascular outcome in chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2021 05; 36(6):998-1005. doi:
10.1093/ndt/gfab004. [PMID: 33508125] - Carmela Cosola, Maria Teresa Rocchetti, Ighli di Bari, Paola Maria Acquaviva, Valentina Maranzano, Simone Corciulo, Agostino Di Ciaula, Domenica Maria Di Palo, Flavia Maria La Forgia, Sergio Fontana, Maria De Angelis, Piero Portincasa, Loreto Gesualdo. An Innovative Synbiotic Formulation Decreases Free Serum Indoxyl Sulfate, Small Intestine Permeability and Ameliorates Gastrointestinal Symptoms in a Randomized Pilot Trial in Stage IIIb-IV CKD Patients.
Toxins.
2021 05; 13(5):. doi:
10.3390/toxins13050334. [PMID: 34063068] - Yung-Chuan Lu, Cheng-Ching Wu, I-Ting Tsai, Wei-Chin Hung, Thung-Lip Lee, Chin-Feng Hsuan, Teng-Hung Yu, Ching-Ting Wei, Fu-Mei Chung, Yau-Jiunn Lee, Chao-Ping Wang. Associations among total p-cresylsulfate, indoxyl sulfate and hippuric acid levels with hemodialysis quality indicators in maintenance hemodialysis patients.
Clinica chimica acta; international journal of clinical chemistry.
2021 May; 516(?):83-91. doi:
10.1016/j.cca.2021.01.015. [PMID: 33508250] - Lara Caldiroli, Silvia Armelloni, Alessandra Eskander, Piergiorgio Messa, Vittoria Rizzo, Elisabetta Margiotta, Matteo Cesari, Simone Vettoretti. Association between the uremic toxins indoxyl-sulfate and p-cresyl-sulfate with sarcopenia and malnutrition in elderly patients with advanced chronic kidney disease.
Experimental gerontology.
2021 05; 147(?):111266. doi:
10.1016/j.exger.2021.111266. [PMID: 33529747] - Feby Savira, Andrew R Kompa, Ruth Magaye, Xin Xiong, Li Huang, Beat M Jucker, Robert N Willette, Darren J Kelly, Bing H Wang. Apoptosis signal-regulating kinase 1 inhibition reverses deleterious indoxyl sulfate-mediated endothelial effects.
Life sciences.
2021 May; 272(?):119267. doi:
10.1016/j.lfs.2021.119267. [PMID: 33631173] - Takaaki Higashihara, Hiroshi Nishi, Koji Takemura, Hiroshi Watanabe, Toru Maruyama, Reiko Inagi, Tetsuhiro Tanaka, Masaomi Nangaku. β2-adrenergic receptor agonist counteracts skeletal muscle atrophy and oxidative stress in uremic mice.
Scientific reports.
2021 04; 11(1):9130. doi:
10.1038/s41598-021-88438-7. [PMID: 33911115] - Ziad A Massy, Tilman B Drueke. Diet-microbiota interaction and kidney disease progression.
Kidney international.
2021 04; 99(4):797-800. doi:
10.1016/j.kint.2020.11.006. [PMID: 33245991] - Ying Li, Jing Yan, Minjia Wang, Jing Lv, Fei Yan, Jin Chen. Uremic toxin indoxyl sulfate promotes proinflammatory macrophage activation by regulation of β-catenin and YAP pathways.
Journal of molecular histology.
2021 Apr; 52(2):197-205. doi:
10.1007/s10735-020-09936-y. [PMID: 33387144] - Tetsuya Taniguchi, Koichi Omura, Keisuke Motoki, Miku Sakai, Noriko Chikamatsu, Naoki Ashizawa, Tappei Takada, Takashi Iwanaga. Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2.
Scientific reports.
2021 03; 11(1):7232. doi:
10.1038/s41598-021-86662-9. [PMID: 33790363] - James Ludwig, Josh Smith, Jim Pfaendtner. Analyzing the Long Time-Scale Dynamics of Uremic Toxins Bound to Sudlow Site II in Human Serum Albumin.
The journal of physical chemistry. B.
2021 03; 125(11):2910-2920. doi:
10.1021/acs.jpcb.1c00221. [PMID: 33715376] - Alonso Jerez-Morales, José S Merino, Sindy T Díaz-Castillo, Carlos T Smith, Jorge Fuentealba, Humberto Bernasconi, Gerson Echeverría, Apolinaria García-Cancino. The Administration of the Synbiotic Lactobacillus bulgaricus 6c3 Strain, Inulin and Fructooligosaccharide Decreases the Concentrations of Indoxyl Sulfate and Kidney Damage in a Rat Model.
Toxins.
2021 03; 13(3):. doi:
10.3390/toxins13030192. [PMID: 33800029] - Stacie Summers, Jessica Quimby, Linxing Yao, Ann Hess, Corey Broeckling, Michael Lappin. Biological variation of major gut-derived uremic toxins in the serum of healthy adult cats.
Journal of veterinary internal medicine.
2021 Mar; 35(2):902-911. doi:
10.1111/jvim.16043. [PMID: 33537991] - Fabien Szabo de Edelenyi, Catherine Philippe, Nathalie Druesne-Pecollo, Laurent Naudon, Sylvie Rabot, Serge Hercberg, Paule Latino-Martel, Emmanuelle Kesse-Guyot, Pilar Galan. Depressive symptoms, fruit and vegetables consumption and urinary 3-indoxylsulfate concentration: a nested case-control study in the French Nutrinet-Sante cohort.
European journal of nutrition.
2021 Mar; 60(2):1059-1069. doi:
10.1007/s00394-020-02306-0. [PMID: 32588216] - Chiao-Yin Sun, Jian-Ri Li, Ya-Yu Wang, Shih-Yi Lin, Yen-Chuan Ou, Cheng-Jui Lin, Jiaan-Der Wang, Su-Lan Liao, Chun-Jung Chen. Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy.
Aging.
2021 02; 13(5):6681-6701. doi:
10.18632/aging.202523. [PMID: 33621199] - Ping-Hsun Wu, Yi-Ting Lin, Yi-Wen Chiu, Gabriel Baldanzi, Jiun-Chi Huang, Shih-Shin Liang, Su-Chu Lee, Szu-Chia Chen, Ya-Ling Hsu, Mei-Chuan Kuo, Shang-Jyh Hwang. The relationship of indoxyl sulfate and p-cresyl sulfate with target cardiovascular proteins in hemodialysis patients.
Scientific reports.
2021 02; 11(1):3786. doi:
10.1038/s41598-021-83383-x. [PMID: 33589722] - Nozomi Yabuuchi, Huixian Hou, Nao Gunda, Yuki Narita, Hirofumi Jono, Hideyuki Saito. Suppressed Hepatic Production of Indoxyl Sulfate Attenuates Cisplatin-Induced Acute Kidney Injury in Sulfotransferase 1a1-Deficient Mice.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22041764. [PMID: 33578912] - Suguru Yamamoto, Kenichi Sasahara, Mio Domon, Keiichi Yamaguchi, Toru Ito, Shin Goto, Yuji Goto, Ichiei Narita. pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro.
Toxins.
2021 02; 13(2):. doi:
10.3390/toxins13020116. [PMID: 33557434] - Zachary R Salyers, Madeline Coleman, Nicholas P Balestrieri, Terence E Ryan. Indoxyl sulfate impairs angiogenesis via chronic aryl hydrocarbon receptor activation.
American journal of physiology. Cell physiology.
2021 02; 320(2):C240-C249. doi:
10.1152/ajpcell.00262.2020. [PMID: 33406025] - Takaya Abe, Mitsutaka Onoda, Tomohiko Matsuura, Jun Sugimura, Wataru Obara, Nariyuki Sasaki, Tetsuo Kato, Kenta Tatsumi, Toru Maruyama. Evaluation of a new measurement method of indoxyl sulfate in hemodialysis patients.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2021 Feb; 25(1):44-49. doi:
10.1111/1744-9987.13500. [PMID: 32281288] - Mohammed Al Za'abi, Suhail Al Salam, Yousuf Al Suleimani, Mohammed Ashique, Priyadarsini Manoj, Abderrahim Nemmar, Badreldin H Ali. Effects of repeated increasing doses of cisplatin as models of acute kidney injury and chronic kidney disease in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2021 02; 394(2):249-259. doi:
10.1007/s00210-020-01976-1. [PMID: 32936352] - Anna Pieniazek, Artur Szczepocki. Structural component changes of erythrocytes caused by oxidative stress generated by indoxyl sulfate.
Toxicology in vitro : an international journal published in association with BIBRA.
2021 Feb; 70(?):105013. doi:
10.1016/j.tiv.2020.105013. [PMID: 33038466] - Shara Francesca Rapa, Francesco Prisco, Ada Popolo, Valentina Iovane, Giuseppina Autore, Biagio Raffaele Di Iorio, Fabrizio Dal Piaz, Orlando Paciello, Fuyu Nishijima, Stefania Marzocco. Pro-Inflammatory Effects of Indoxyl Sulfate in Mice: Impairment of Intestinal Homeostasis and Immune Response.
International journal of molecular sciences.
2021 Jan; 22(3):. doi:
10.3390/ijms22031135. [PMID: 33498967] - Keisuke Nakagawa, Mayuko Itoya, Nao Takemoto, Yuika Matsuura, Masashi Tawa, Yasuo Matsumura, Mamoru Ohkita. Indoxyl sulfate induces ROS production via the aryl hydrocarbon receptor-NADPH oxidase pathway and inactivates NO in vascular tissues.
Life sciences.
2021 Jan; 265(?):118807. doi:
10.1016/j.lfs.2020.118807. [PMID: 33232689] - Chih-Yu Yang, Ting-Wen Chen, Wan-Lun Lu, Shih-Shin Liang, Hsien-Da Huang, Ching-Ping Tseng, Der-Cherng Tarng. Synbiotics Alleviate the Gut Indole Load and Dysbiosis in Chronic Kidney Disease.
Cells.
2021 01; 10(1):. doi:
10.3390/cells10010114. [PMID: 33435396] - Li-Chun Ho, Ting-Yun Wu, Tsun-Mei Lin, Hung-Hsiang Liou, Shih-Yuan Hung. Indoxyl Sulfate Mediates the Low Inducibility of the NLRP3 Inflammasome in Hemodialysis Patients.
Toxins.
2021 Jan; 13(1):. doi:
10.3390/toxins13010038. [PMID: 33430226] - Youn Kyung Kee, Sang Youb Han, Duk Hee Kang, Jung Woo Noh, Kyung Hwan Jeong, Gheun Ho Kim, Yang Wook Kim, Beom Seok Kim. Comparison of Different Types of Oral Adsorbent Therapy in Patients with Chronic Kidney Disease: A Multicenter, Randomized, Phase IV Clinical Trial.
Yonsei medical journal.
2021 Jan; 62(1):41-49. doi:
10.3349/ymj.2021.62.1.41. [PMID: 33381933]