2-Butenedioic acid (2E)-, 1,4-diethyl ester (BioDeep_00000178252)
human metabolite blood metabolite
代谢物信息卡片
2-Butenedioic acid (2E)-, 1,4-diethyl ester
化学式: C8H12O4 (172.0735552)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 81.25%
分子结构信息
SMILES: CCOC(=O)C=CC(=O)OCC
InChI: InChI=1S/C8H12O4/c1-3-11-7(9)5-6-8(10)12-4-2/h5-6H,3-4H2,1-2H3
描述信息
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ehsan Ali, Kaikai Mao, Xun Liao, Ruoheng Jin, Jianhong Li. Cross-resistance and biochemical characterization of buprofezin resistance in the white-backed planthopper, Sogatella furcifera (Horvath).
Pesticide biochemistry and physiology.
2019 Jul; 158(?):47-53. doi:
10.1016/j.pestbp.2019.04.008. [PMID: 31378360] - Chunyan Yin, Ran Wang, Chen Luo, Kang Zhao, Qiongyou Wu, Zhenyu Wang, Guangfu Yang. Monitoring, Cross-Resistance, Inheritance, and Synergism of Plutella xylostella (Lepidoptera: Plutellidae) Resistance to Pyridalyl in China.
Journal of economic entomology.
2019 02; 112(1):329-334. doi:
10.1093/jee/toy334. [PMID: 30371797] - Muhammad Shahid Arain, Muhammad Shakeel, Mohammed Esmail Abdalla Elzaki, Muhammad Farooq, Muhammad Hafeez, Muhammad Rafiq Shahid, Syed Ali Haider Shah, Fawad Zafar Ahmad Khan, Qaiser Shakeel, Abdalla Markaz Abdalla Salim, Guo-Qing Li. Association of detoxification enzymes with butene-fipronil in larvae and adults of Drosophila melanogaster.
Environmental science and pollution research international.
2018 Apr; 25(10):10006-10013. doi:
10.1007/s11356-018-1202-4. [PMID: 29380196] - Takeshi Kumagai, Yosuke Kozakai, Tomohiro Ishino, Yuichi Yajima, Yasuhito Nakagawa, Hirotaka Imai. Nrf2 up-regulates the induction of acidic sphingomyelinase by electrophiles.
Journal of biochemistry.
2015 Aug; 158(2):127-37. doi:
10.1093/jb/mvv030. [PMID: 25762726] - Yoshio Nakagawa, Toshinari Suzuki, Kazuo Nakajima, Akiko Inomata, Akio Ogata, Dai Nakae. Effects of N-acetyl-L-cysteine on target sites of hydroxylated fullerene-induced cytotoxicity in isolated rat hepatocytes.
Archives of toxicology.
2014 Jan; 88(1):115-26. doi:
10.1007/s00204-013-1096-3. [PMID: 23877122] - Fahad A Al-Abbasi. Acrylonitrile-induced gastric toxicity in rats: the role of xanthine oxidase.
Medical science monitor : international medical journal of experimental and clinical research.
2012 Jun; 18(6):BR208-14. doi:
10.12659/msm.882896. [PMID: 22648241] - Naoko Shibuya, Shigeki Kobayashi, Yasunaga Yoshikawa, Kiyotaka Watanabe, Koichi Orino. Effects of oxidative stress caused by tert-butylhydroquinone on cytotoxicity in MDCK cells.
The Journal of veterinary medical science.
2012 May; 74(5):583-9. doi:
10.1292/jvms.11-0412. [PMID: 22185773] - Wei-Hua Jiang, Wei-Ping Lu, Wen-Chao Guo, Zhen-Han Xia, Wen-Jun Fu, Guo-Qing Li. Chlorantraniliprole susceptibility in Leptinotarsa decemlineata in the north Xinjiang Uygur autonomous region in China.
Journal of economic entomology.
2012 Apr; 105(2):549-54. doi:
10.1603/ec11194. [PMID: 22606826] - Fei Hu, Wei Dou, Jing-Jing Wang, Fu-Xian Jia, Jin-Jun Wang. Purification and biochemical characterization of glutathione S-transferases from four field populations of Bactrocera dorsalis (Hendel) (Diptera: Tephritidae).
Archives of insect biochemistry and physiology.
2011 Dec; 78(4):201-15. doi:
10.1002/arch.20453. [PMID: 22105666] - Rajesh K Saharan, Sukesh C Sharma. Effects of glutathione modulation on oxidative stress and enzymatic antioxidant defence in yeast Pachysolen tannophilus.
Current microbiology.
2011 Mar; 62(3):944-9. doi:
10.1007/s00284-010-9808-x. [PMID: 21061124] - Whitney P Bowe, Alan C Logan. Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles.
Lipids in health and disease.
2010 Dec; 9(?):141. doi:
10.1186/1476-511x-9-141. [PMID: 21143923] - Khaled M M Koriem, Mahmoud S Arbid, Nadia F I El-Gendy. The protective role of Tropaeolum majus on blood and liver toxicity induced by diethyl maleate in rats.
Toxicology mechanisms and methods.
2010 Nov; 20(9):579-86. doi:
10.3109/15376516.2010.518171. [PMID: 20883155] - Ching-Hsuan Lin, Siwy Ling Yang, Nan-Yi Wang, Kuang-Ren Chung. The FUS3 MAPK signaling pathway of the citrus pathogen Alternaria alternata functions independently or cooperatively with the fungal redox-responsive AP1 regulator for diverse developmental, physiological and pathogenic processes.
Fungal genetics and biology : FG & B.
2010 Apr; 47(4):381-91. doi:
10.1016/j.fgb.2009.12.009. [PMID: 20036749] - Yuntao Feng, Qingjun Wu, Shaoli Wang, Xiaoli Chang, Wen Xie, Baoyun Xu, Youjun Zhang. Cross-resistance study and biochemical mechanisms of thiamethoxam resistance in B-biotype Bemisia tabaci (Hemiptera: Aleyrodidae).
Pest management science.
2010 Mar; 66(3):313-8. doi:
10.1002/ps.1877. [PMID: 19937914] - Yi-Quan Lan, Shi-Xi Zhao. [Resistance mechanisms of Spodoptera exigua (Hübner) to fenvalerate and alpha-cypermethrin].
Ying yong sheng tai xue bao = The journal of applied ecology.
2010 Jan; 21(1):203-8. doi:
". [PMID: 20387444] - Rajat Singh, Yongjun Wang, Jörn M Schattenberg, Youqing Xiang, Mark J Czaja. Chronic oxidative stress sensitizes hepatocytes to death from 4-hydroxynonenal by JNK/c-Jun overactivation.
American journal of physiology. Gastrointestinal and liver physiology.
2009 Nov; 297(5):G907-17. doi:
10.1152/ajpgi.00151.2009. [PMID: 20501438] - Dong Wang, Xinghui Qiu, Xuexiang Ren, Wencheng Zhang, Kaiyun Wang. Effects of spinosad on Helicoverpa armigera (Lepidoptera: Noctuidae) from China: tolerance status, synergism and enzymatic responses.
Pest management science.
2009 Sep; 65(9):1040-6. doi:
10.1002/ps.1794. [PMID: 19533589] - Hadi Mosallanejad, Guy Smagghe. Biochemical mechanisms of methoxyfenozide resistance in the cotton leafworm Spodoptera littoralis.
Pest management science.
2009 Jul; 65(7):732-6. doi:
10.1002/ps.1753. [PMID: 19367570] - Yoshio Nakagawa, Toshinari Suzuki, Kazuo Nakajima, Hidemi Ishii, Akio Ogata. Biotransformation and cytotoxic effects of hydroxychavicol, an intermediate of safrole metabolism, in isolated rat hepatocytes.
Chemico-biological interactions.
2009 Jun; 180(1):89-97. doi:
10.1016/j.cbi.2009.02.003. [PMID: 19428348] - Jing Wu, Hui Ji, Ying Yu Wang, Ying Wang, Yong Qi Li, Wei Guang Li, Yan Long, Yuan Zheng Xia, Hao Hong. Glutathione depletion upregulates P-glycoprotein expression at the blood-brain barrier in rats.
The Journal of pharmacy and pharmacology.
2009 Jun; 61(6):819-24. doi:
10.1211/jpp/61.06.0016. [PMID: 19505374] - Alison L Wadey, Hakan Muyderman, Perrin T Kwek, Neil R Sims. Mitochondrial glutathione uptake: characterization in isolated brain mitochondria and astrocytes in culture.
Journal of neurochemistry.
2009 May; 109 Suppl 1(?):101-8. doi:
10.1111/j.1471-4159.2009.05936.x. [PMID: 19393015] - Fagen Zhang, Michael J Bartels, David R Geter, Yo-Chan Jeong, Melissa R Schisler, Amanda J Wood, Lynn Kan, B Bhaskar Gollapudi. Quantitation of glutathione by liquid chromatography/positive electrospray ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2008 Nov; 22(22):3608-14. doi:
10.1002/rcm.3776. [PMID: 18937228] - Yanhua Wang, Congfen Gao, Zhiping Xu, Yu Cheng Zhu, Jiushuang Zhang, Wenhong Li, Dejiang Dai, Youwei Lin, Weijun Zhou, Jinliang Shen. Buprofezin susceptibility survey, resistance selection and preliminary determination of the resistance mechanism in Nilaparvata lugens (Homoptera: Delphacidae).
Pest management science.
2008 Oct; 64(10):1050-6. doi:
10.1002/ps.1606. [PMID: 18506673] - Jun Zhu, Sheng Li, Zermeena M Marshall, A R Whorton. A cystine-cysteine shuttle mediated by xCT facilitates cellular responses to S-nitrosoalbumin.
American journal of physiology. Cell physiology.
2008 Apr; 294(4):C1012-20. doi:
10.1152/ajpcell.00411.2007. [PMID: 18287333] - Toshiharu Oba, Yoshitaka Maeno, Masataka Nagao, Nagahiko Sakuma, Takashi Murayama. Cellular redox state protects acetaldehyde-induced alteration in cardiomyocyte function by modifying Ca2+ release from sarcoplasmic reticulum.
American journal of physiology. Heart and circulatory physiology.
2008 Jan; 294(1):H121-33. doi:
10.1152/ajpheart.00520.2007. [PMID: 17982019] - Daniel A Rossignol, Lanier W Rossignol, S Jill James, Stepan Melnyk, Elizabeth Mumper. The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study.
BMC pediatrics.
2007 Nov; 7(?):36. doi:
10.1186/1471-2431-7-36. [PMID: 18005455] - Bettina Ebert, Albrecht Seidel, Alfonso Lampen. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
Toxicological sciences : an official journal of the Society of Toxicology.
2007 Apr; 96(2):227-36. doi:
10.1093/toxsci/kfl147. [PMID: 17077187] - Ian Stewart, Philip J Schluter, Glen R Shaw. Cyanobacterial lipopolysaccharides and human health - a review.
Environmental health : a global access science source.
2006 Mar; 5(?):7. doi:
10.1186/1476-069x-5-7. [PMID: 16563160] - Oscar A Bizzozero, Jennifer L Ziegler, Gisela De Jesus, Federico Bolognani. Acute depletion of reduced glutathione causes extensive carbonylation of rat brain proteins.
Journal of neuroscience research.
2006 Mar; 83(4):656-67. doi:
10.1002/jnr.20771. [PMID: 16447283] - Qiang Xu, Huqi Liu, Lee Zhang, Nannan Liu. Resistance in the mosquito, Culex quinquefasciatus, and possible mechanisms for resistance.
Pest management science.
2005 Nov; 61(11):1096-102. doi:
10.1002/ps.1090. [PMID: 16032654] - Huqi Liu, Qiang Xu, Lee Zhang, Nannan Liu. Chlorpyrifos resistance in mosquito Culex quinquefasciatus.
Journal of medical entomology.
2005 Sep; 42(5):815-20. doi:
10.1093/jmedent/42.5.815. [PMID: 16363165] - Jun Chen, Andrea Small-Howard, Amy Yin, Marla J Berry. The responses of Ht22 cells to oxidative stress induced by buthionine sulfoximine (BSO).
BMC neuroscience.
2005 Feb; 6(?):10. doi:
10.1186/1471-2202-6-10. [PMID: 15707499] - Gang Wu, Shuren Jiang, Tadashi Miyata. Effects of synergists on toxicity of six insecticides in parasitoid Diaeretiella rapae (Hymenoptera: Aphidiidae).
Journal of economic entomology.
2004 Dec; 97(6):2057-66. doi:
10.1093/jee/97.6.2057. [PMID: 15666765] - Mushtaq Ahmad, Robert M Hollingworth. Synergism of insecticides provides evidence of metabolic mechanisms of resistance in the obliquebanded leafroller Choristoneura rosaceana (Lepidoptera: Tortricidae).
Pest management science.
2004 May; 60(5):465-73. doi:
10.1002/ps.829. [PMID: 15154513] - Tetsuro Ishii, Ken Itoh, Emilio Ruiz, David S Leake, Hiroyuki Unoki, Masayuki Yamamoto, Giovanni E Mann. Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages: activation by oxidatively modified LDL and 4-hydroxynonenal.
Circulation research.
2004 Mar; 94(5):609-16. doi:
10.1161/01.res.0000119171.44657.45. [PMID: 14752028] - Franca Esposito, Giuseppa Chirico, Nicola Montesano Gesualdi, Inmaculada Posadas, Rosario Ammendola, Tommaso Russo, Giuseppe Cirino, Filiberto Cimino. Protein kinase B activation by reactive oxygen species is independent of tyrosine kinase receptor phosphorylation and requires SRC activity.
The Journal of biological chemistry.
2003 Jun; 278(23):20828-34. doi:
10.1074/jbc.m211841200. [PMID: 12682076] - Christopher J Mingone, Sachin A Gupte, Shuo Quan, Nader G Abraham, Michael S Wolin. Influence of heme and heme oxygenase-1 transfection of pulmonary microvascular endothelium on oxidant generation and cGMP.
Experimental biology and medicine (Maywood, N.J.).
2003 May; 228(5):535-9. doi:
10.1177/15353702-0322805-22. [PMID: 12709582] - S Okuno, H Sato, K Kuriyama-Matsumura, M Tamba, H Wang, S Sohda, H Hamada, H Yoshikawa, T Kondo, S Bannai. Role of cystine transport in intracellular glutathione level and cisplatin resistance in human ovarian cancer cell lines.
British journal of cancer.
2003 Mar; 88(6):951-6. doi:
10.1038/sj.bjc.6600786. [PMID: 12644836] - Yoshimasa Nakamura, Masaaki Miyamoto, Akira Murakami, Hajime Ohigashi, Toshihiko Osawa, Koji Uchida. A phase II detoxification enzyme inducer from lemongrass: identification of citral and involvement of electrophilic reaction in the enzyme induction.
Biochemical and biophysical research communications.
2003 Mar; 302(3):593-600. doi:
10.1016/s0006-291x(03)00219-5. [PMID: 12615076] - Wen-Chang Chang. Identification of an endogenous inhibitor of arachidonate metabolism in human epidermoid carcinoma A431 cells.
Journal of biomedical science.
2003; 10(6 Pt 1):599-606. doi:
10.1159/000073525. [PMID: 14576462] - Nhu Tiên Nguyên-nhu, Bernard Knoops. Alkyl hydroperoxide reductase 1 protects Saccharomyces cerevisiae against metal ion toxicity and glutathione depletion.
Toxicology letters.
2002 Oct; 135(3):219-28. doi:
10.1016/s0378-4274(02)00280-1. [PMID: 12270680] - Laura J C Bolchoz, Jason D Morrow, David J Jollow, David C McMillan. Primaquine-induced hemolytic anemia: effect of 6-methoxy-8-hydroxylaminoquinoline on rat erythrocyte sulfhydryl status, membrane lipids, cytoskeletal proteins, and morphology.
The Journal of pharmacology and experimental therapeutics.
2002 Oct; 303(1):141-8. doi:
10.1124/jpet.102.036921. [PMID: 12235244] - Nicholas J Hegarty, R William G Watson, Leonie S Young, Amanda J O'Neill, Hugh R Brady, John M Fitzpatrick. Cytoprotective effects of nitrates in a cellular model of hydronephrosis.
Kidney international.
2002 Jul; 62(1):70-7. doi:
10.1046/j.1523-1755.2002.00404.x. [PMID: 12081565] - D B Fragoso, R N C Guedes, R N C Guedes, M C Picanço, L Zambolim. Insecticide use and organophosphate resistance in the coffee leaf miner Leucoptera coffeella (Lepidoptera: Lyonetiidae).
Bulletin of entomological research.
2002 Jun; 92(3):203-12. doi:
10.1079/ber2002156. [PMID: 12088537] - Mark A Lal, Hjalmar Brismar, Ann-Christine Eklöf, Anita Aperia. Role of oxidative stress in advanced glycation end product-induced mesangial cell activation.
Kidney international.
2002 Jun; 61(6):2006-14. doi:
10.1046/j.1523-1755.2002.00367.x. [PMID: 12028441] - Toshio Norikura, David O Kennedy, Alexander K Nyarko, Akiko Kojima, Isao Matsui-Yuasa. Protective effect of aloe extract against the cytotoxicity of 1,4-naphthoquinone in isolated rat hepatocytes involves modulations in cellular thiol levels.
Pharmacology & toxicology.
2002 May; 90(5):278-84. doi:
10.1034/j.1600-0773.2002.900508.x. [PMID: 12076309] - Sjofn Gunnarsdottir, Marian Rucki, Adnan A Elfarra. Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice.
The Journal of pharmacology and experimental therapeutics.
2002 Apr; 301(1):77-86. doi:
10.1124/jpet.301.1.77. [PMID: 11907160] - Yoshimasa Nakamura, Makiko Kawakami, Akira Yoshihiro, Noriyuki Miyoshi, Hajime Ohigashi, Kiyoshi Kawai, Toshihiko Osawa, Koji Uchida. Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis.
The Journal of biological chemistry.
2002 Mar; 277(10):8492-9. doi:
10.1074/jbc.m109760200. [PMID: 11751909] - Lawrence M Milchak, J Douglas Bricker. The effects of glutathione and vitamin E on iron toxicity in isolated rat hepatocytes.
Toxicology letters.
2002 Feb; 126(3):169-77. doi:
10.1016/s0378-4274(01)00436-2. [PMID: 11814705] - M Vairetti, P Griffini, G Pietrocola, P Richelmi, I Freitas. Cold-induced apoptosis in isolated rat hepatocytes: protective role of glutathione.
Free radical biology & medicine.
2001 Oct; 31(8):954-61. doi:
10.1016/s0891-5849(01)00670-0. [PMID: 11595380] - J G Zhang, M A Tirmenstein, F A Nicholls-Grzemski, M W Fariss. Mitochondrial electron transport inhibitors cause lipid peroxidation-dependent and -independent cell death: protective role of antioxidants.
Archives of biochemistry and biophysics.
2001 Sep; 393(1):87-96. doi:
10.1006/abbi.2001.2486. [PMID: 11516165] - S Maity, J R Vedasiromoni, L Chaudhuri, D K Ganguly. Role of reduced glutathione and nitric oxide in the black tea extract-mediated protection against ulcerogen-induced changes in motility and gastric emptying in rats.
Japanese journal of pharmacology.
2001 Apr; 85(4):358-64. doi:
10.1254/jjp.85.358. [PMID: 11388638] - L Nicod, S Rodriguez, A Jacqueson, C Viollon-Abadie, A Berthelot, L Richert. Clofibric acid or diethylmaleate supplemented diet decrease blood pressure in DOCA-salt treated male Sprague Dawley rats--relation with liver antioxidant status.
Molecular and cellular biochemistry.
2000 Oct; 213(1-2):65-73. doi:
10.1023/a:1007112130769. [PMID: 11129960] - M A Tirmenstein, F A Nicholls-Grzemski, J G Zhang, M W Fariss. Glutathione depletion and the production of reactive oxygen species in isolated hepatocyte suspensions.
Chemico-biological interactions.
2000 Jul; 127(3):201-17. doi:
10.1016/s0009-2797(00)00180-0. [PMID: 10967318] - A Gupta, A Gupta, M Datta, G S Shukla. Cerebral antioxidant status and free radical generation following glutathione depletion and subsequent recovery.
Molecular and cellular biochemistry.
2000 Jun; 209(1-2):55-61. doi:
10.1023/a:1007000430394. [PMID: 10942201] - Y Ohta, A Ito, H Torii. Opacification of isolated rat lenses intoxicated with diethylmaleate: relation to lens membrane dysfunction.
In vitro & molecular toxicology.
2000; 13(4):223-36. doi:
". [PMID: 11319274] - R Agarwal, G S Shukla. Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat.
Neurochemical research.
1999 Dec; 24(12):1507-14. doi:
10.1023/a:1021191729865. [PMID: 10591399] - H Sakamoto, J Kitahara, Y Nakagawa. Effect of intracellular glutathione on the production of prostaglandin D2 in RBL-2H3 cells oxidized by tert-butyl hydroperoxide.
Journal of biochemistry.
1999 Jan; 125(1):90-5. doi:
10.1093/oxfordjournals.jbchem.a022274. [PMID: 9880802] - M Madesh, O Benard, K A Balasubramanian. Glutathione modulates lipid composition of human colon derived HT-29 cells.
The international journal of biochemistry & cell biology.
1998 Dec; 30(12):1345-52. doi:
10.1016/s1357-2725(98)00097-1. [PMID: 9924804] - S Maity, J R Vedasiromoni, D K Ganguly. Role of glutathione in the antiulcer effect of hot water extract of black tea (Camellia sinensis).
Japanese journal of pharmacology.
1998 Nov; 78(3):285-92. doi:
10.1254/jjp.78.285. [PMID: 9869262] - R Nøding, S A Schønberg, H E Krokan, K S Bjerve. Effects of polyunsaturated fatty acids and their n-6 hydroperoxides on growth of five malignant cell lines and the significance of culture media.
Lipids.
1998 Mar; 33(3):285-93. doi:
10.1007/s11745-998-0207-9. [PMID: 9560803] - T A Sarafian, N Rajper, B Grigorian, A Kim, H Shau. Cellular antioxidant properties of human natural killer enhancing factor B.
Free radical research.
1997 Mar; 26(3):281-9. doi:
10.3109/10715769709097806. [PMID: 9161849] - E Altomare, I Grattagliano, G Vendemiale, V Palmieri, G Palasciano. Acute ethanol administration induces oxidative changes in rat pancreatic tissue.
Gut.
1996 May; 38(5):742-6. doi:
10.1136/gut.38.5.742. [PMID: 8707122] - R F Burk, K E Hill, J A Awad, J D Morrow, P R Lyons. Liver and kidney necrosis in selenium-deficient rats depleted of glutathione.
Laboratory investigation; a journal of technical methods and pathology.
1995 Jun; 72(6):723-30. doi:
NULL. [PMID: 7783430] - A Hagiwara, H Tanaka, S Tamano, K Imaida, S Takahashi, S Fukushima. Inhibiting effects of diethylmaleate or NH4Cl on NaHCO3, but not butylated hydroxyanisole, promotion of urinary bladder carcinogenesis in male F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
The Journal of toxicological sciences.
1994 Nov; 19(4):189-95. doi:
10.2131/jts.19.4_189. [PMID: 7884829] - A R Goeptar, E J Groot, H Scheerens, J N Commandeur, N P Vermeulen. Cytotoxicity of mitomycin C and adriamycin in freshly isolated rat hepatocytes: the role of cytochrome P450.
Cancer research.
1994 May; 54(9):2411-8. doi:
". [PMID: 8162589] - E Maellaro, B Del Bello, L Sugherini, A Pompella, A F Casini, M Comporti. Protection by ascorbic acid against oxidative injury of isolated hepatocytes.
Xenobiotica; the fate of foreign compounds in biological systems.
1994 Mar; 24(3):281-9. doi:
10.3109/00498259409043239. [PMID: 8009890] - C F Morales, A Anzueto, F Andrade, S M Levine, L C Maxwell, R A Lawrence, S G Jenkinson. Diethylmaleate produces diaphragmatic impairment after resistive breathing.
Journal of applied physiology (Bethesda, Md. : 1985).
1993 Dec; 75(6):2406-11. doi:
10.1152/jappl.1993.75.6.2406. [PMID: 8125857] - K Imai, T Aimoto, M Sato, R Kimura. Antioxidative effect of protoporphyrin and increase of glutathione in protoporphyrin-administered rat liver.
Biological & pharmaceutical bulletin.
1993 Aug; 16(8):759-61. doi:
10.1248/bpb.16.759. [PMID: 8106076] - C P Sparrow, J Olszewski. Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metal ions.
Journal of lipid research.
1993 Jul; 34(7):1219-28. doi:
10.1016/s0022-2275(20)37709-9. [PMID: 8103788] - G Cighetti, S Debiasi, R Paroni. Effect of glutathione depletion on the conversion of xanthine dehydrogenase to oxidase in rat liver.
Biochemical pharmacology.
1993 Jun; 45(11):2359-61. doi:
10.1016/0006-2952(93)90213-g. [PMID: 8517879] - H J Stein, M M Oosthuizen, R A Hinder, H Lamprechts. Effect of verapamil on hepatic ischemia/reperfusion injury.
American journal of surgery.
1993 Jan; 165(1):96-100. doi:
10.1016/s0002-9610(05)80410-6. [PMID: 8418706] - J A Szymańska, E A Swietlicka, J K Piotrowski, M Skrzypińska-Gawrysiak, S Sporny. Effects of 3-methylcholanthrene or diethyl maleate on the hepatotoxicity of acetaminophen.
Journal of applied toxicology : JAT.
1992 Dec; 12(6):415-9. doi:
10.1002/jat.2550120609. [PMID: 1452975] - M H Nasr-Esfahani, M H Johnson. Quantitative analysis of cellular glutathione in early preimplantation mouse embryos developing in vivo and in vitro.
Human reproduction (Oxford, England).
1992 Oct; 7(9):1281-90. doi:
10.1093/oxfordjournals.humrep.a137843. [PMID: 1479014] - H Ochi, I Morita, S Murota. Roles of glutathione and glutathione peroxidase in the protection against endothelial cell injury induced by 15-hydroperoxyeicosatetraenoic acid.
Archives of biochemistry and biophysics.
1992 May; 294(2):407-11. doi:
10.1016/0003-9861(92)90704-z. [PMID: 1314541] - B Peter, M Wartena, H H Kampinga, A W Konings. Role of lipid peroxidation and DNA damage in paraquat toxicity and the interaction of paraquat with ionizing radiation.
Biochemical pharmacology.
1992 Feb; 43(4):705-15. doi:
10.1016/0006-2952(92)90234-a. [PMID: 1540224] - K Sai, T Umemura, A Takagi, R Hasegawa, Y Kurokawa. The protective role of glutathione, cysteine and vitamin C against oxidative DNA damage induced in rat kidney by potassium bromate.
Japanese journal of cancer research : Gann.
1992 Jan; 83(1):45-51. doi:
10.1111/j.1349-7006.1992.tb02350.x. [PMID: 1544873] - H Hiraishi, A Terano, S Ota, H Mutoh, T Sugimoto, M Razandi, K J Ivey. Antioxidant defenses of cultured gastric cells against oxygen metabolites: role of GSH redox cycle and endogenous catalase.
The American journal of physiology.
1991 Dec; 261(6 Pt 1):G921-8. doi:
10.1152/ajpgi.1991.261.6.g921. [PMID: 1767853] - J R Park, A L Tappel. Protein damage and lipid peroxidation: effects of diethyl maleate, bromotrichloromethane and vitamin E on ammonia, urea and enzymes involved in ammonia metabolism.
Toxicology letters.
1991 Sep; 58(1):29-36. doi:
10.1016/0378-4274(91)90187-b. [PMID: 1680252] - G Girardi, M M Elias. Effectiveness of N-acetylcysteine in protecting against mercuric chloride-induced nephrotoxicity.
Toxicology.
1991 Apr; 67(2):155-64. doi:
10.1016/0300-483x(91)90139-r. [PMID: 1674384] - A M Torres, J E Ochoa, M M Elias. Role of lipid peroxidation on renal dysfunction associated with glutathione depletion. Effects of vitamin E.
Toxicology.
1991; 70(2):163-72. doi:
10.1016/0300-483x(91)90043-z. [PMID: 1763413] - C R Göldlin, U A Boelsterli. Reactive oxygen species and non-peroxidative mechanisms of cocaine-induced cytotoxicity in rat hepatocyte cultures.
Toxicology.
1991; 69(1):79-91. doi:
10.1016/0300-483x(91)90155-t. [PMID: 1926157] - C J Dillard, M L Hu, A L Tappel. Vitamin E, diethylmaleate and bromotrichloromethane interactions in oxidative damage in vivo.
Free radical biology & medicine.
1991; 10(1):51-60. doi:
10.1016/0891-5849(91)90021-t. [PMID: 2050297] - E Maellaro, A F Casini, B Del Bello, M Comporti. Lipid peroxidation and antioxidant systems in the liver injury produced by glutathione depleting agents.
Biochemical pharmacology.
1990 May; 39(10):1513-21. doi:
10.1016/0006-2952(90)90515-m. [PMID: 2337408] - A F Casini, E Maellaro, B Del Bello, M Comporti. The role of vitamin E in the hepatotoxicity by glutathione depleting agents.
Advances in experimental medicine and biology.
1990; 264(?):105-10. doi:
10.1007/978-1-4684-5730-8_14. [PMID: 2244480] - S Nakano, M Gemba. Potentiation of cisplatin-induced lipid peroxidation in kidney cortical slices by glutathione depletion.
Japanese journal of pharmacology.
1989 Jun; 50(2):87-92. doi:
10.1254/jjp.50.87. [PMID: 2770062] - R J Zimmerman, B J Marafino, A Chan, P Landre, J L Winkelhake. The role of oxidant injury in tumor cell sensitivity to recombinant human tumor necrosis factor in vivo. Implications for mechanisms of action.
Journal of immunology (Baltimore, Md. : 1950).
1989 Feb; 142(4):1405-9. doi:
". [PMID: 2915120] - P Dogterom, G J Mulder, J F Nagelkerke. Lipid peroxidation-dependent and -independent protein thiol modifications in isolated rat hepatocytes: differential effects of vitamin E and disulfiram.
Chemico-biological interactions.
1989; 71(2-3):291-306. doi:
10.1016/0009-2797(89)90042-2. [PMID: 2598304] - M E Kyle, A Serroni, J L Farber. The inhibition of lipid peroxidation by disulfiram prevents the killing of cultured hepatocytes by allyl alcohol, tert-butyl hydroperoxide, hydrogen peroxide and diethyl maleate.
Chemico-biological interactions.
1989; 72(3):269-75. doi:
10.1016/0009-2797(89)90003-3. [PMID: 2605670] - S Miccadei, M E Kyle, D Gilfor, J L Farber. Toxic consequence of the abrupt depletion of glutathione in cultured rat hepatocytes.
Archives of biochemistry and biophysics.
1988 Sep; 265(2):311-20. doi:
10.1016/0003-9861(88)90133-6. [PMID: 3421709] - S Kubow, T M Bray. The effect of lung concentrations of glutathione and vitamin E on the pulmonary toxicity of 3-methylindole.
Canadian journal of physiology and pharmacology.
1988 Jul; 66(7):863-7. doi:
10.1139/y88-140. [PMID: 3214796] - P Dogterom, J F Nagelkerke, J van Steveninck, G J Mulder. Inhibition of lipid peroxidation by disulfiram and diethyldithiocarbamate does not prevent hepatotoxin-induced cell death in isolated rat hepatocytes. A study with allyl alcohol, tert-butyl hydroperoxide, diethyl maleate, bromoisovalerylurea and carbon tetrachloride.
Chemico-biological interactions.
1988; 66(3-4):251-65. doi:
10.1016/0009-2797(88)90075-0. [PMID: 2840217] - R van de Straat, J de Vries, A J Debets, N P Vermeulen. The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress.
Biochemical pharmacology.
1987 Jul; 36(13):2065-70. doi:
10.1016/0006-2952(87)90132-8. [PMID: 3606627] - D J Porubek, M Rundgren, P J Harvison, S D Nelson, P Moldéus. Investigation of mechanisms of acetaminophen toxicity in isolated rat hepatocytes with the acetaminophen analogues 3,5-dimethylacetaminophen and 2,6-dimethylacetaminophen.
Molecular pharmacology.
1987 Jun; 31(6):647-53. doi:
. [PMID: 3600610] - S A Jewell, D Di Monte, P Richelmi, G Bellomo, S Orrenius. tert-Butylhydroperoxide-induced toxicity in isolated hepatocytes: contribution of thiol oxidation and lipid peroxidation.
Journal of biochemical toxicology.
1986 Sep; 1(3):13-22. doi:
10.1002/jbt.2570010303. [PMID: 3271878] - T Ekström, A Ståhl, K Sigvardsson, J Högberg. Lipid peroxidation in vivo monitored as ethane exhalation and malondialdehyde excretion in urine after oral administration of chloroform.
Acta pharmacologica et toxicologica.
1986 Apr; 58(4):289-96. doi:
10.1111/j.1600-0773.1986.tb00111.x. [PMID: 3716824] - H Fukino, M Hirai, Y M Hsueh, S Moriyasu, Y Yamane. Mechanism of protection by zinc against mercuric chloride toxicity in rats: effects of zinc and mercury on glutathionine metabolism.
Journal of toxicology and environmental health.
1986; 19(1):75-89. doi:
10.1080/15287398609530908. [PMID: 2875192] - D B Mitchell, D Acosta, J V Bruckner. Role of glutathione depletion in the cytotoxicity of acetaminophen in a primary culture system of rat hepatocytes.
Toxicology.
1985 Oct; 37(1-2):127-46. doi:
10.1016/0300-483x(85)90119-2. [PMID: 4060164] - S Kubow, T M Bray, E G Janzen. Spin-trapping studies on the effects of vitamin E and glutathione on free radical production induced by 3-methylindole.
Biochemical pharmacology.
1985 Apr; 34(7):1117-9. doi:
10.1016/0006-2952(85)90619-7. [PMID: 2985085]