3-Pyridylacetic acid (BioDeep_00000017777)

 

Secondary id: BioDeep_00000405452

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


alpha-(3-Pyridyl)acetic acid

化学式: C7H7NO2 (137.0476762)
中文名称: 3-吡啶乙酸
谱图信息: 最多检出来源 Homo sapiens(blood) 10.06%

分子结构信息

SMILES: C1=CC(=CN=C1)CC(=O)O
InChI: InChI=1S/C7H7NO2/c9-7(10)4-6-2-1-3-8-5-6/h1-3,5H,4H2,(H,9,10)

描述信息

3-Pyridylacetic acid is a breakdown product of nicotine (and other tobacco alkaloids) and is part of the nicotine degradation pathway. It is formed from 4-(3-pyridyl)-butanoate. One alkaloid in particular, myosmine, appears to be a major source for 3-pyridylacetic acid. The alkaloid myosmine is present not only in tobacco products but also in various foods. Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N-nitrosonornicotine. The two major metabolites of myosmine metabolism have been identified as 3-pyridylacetic acid (20-26\\\%) and 4-oxo-4-(3-pyridyl)butyric acid (50-60\\\%) (PMID: 16079272). 3-pyridylacetatic acid is an analog of nicotinic acid. (PMID 13898750) [HMDB]
3-Pyridylacetic acid is a breakdown product of nicotine (and other tobacco alkaloids) and is part of the nicotine degradation pathway. It is formed from 4-(3-pyridyl)-butanoate. One alkaloid in particular, myosmine, appears to be a major source for 3-pyridylacetic acid. The alkaloid myosmine is present not only in tobacco products but also in various foods. Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N-nitrosonornicotine. The two major metabolites of myosmine metabolism have been identified as 3-pyridylacetic acid (20-26\\\%) and 4-oxo-4-(3-pyridyl)butyric acid (50-60\\\%) (PMID:16079272). 3-pyridylacetatic acid is an analog of nicotinic acid. (PMID 13898750).
3-Pyridineacetic acid is a higher homologue of nicotinic acid, a breakdown product of nicotine (and other tobacco alkaloids)[1][2].

同义名列表

22 个代谢物同义名

alpha-(3-Pyridyl)acetic acid; 2-(Pyridin-3-yl)acetic acid; 2-(3-Pyridine)acetic acid; a-(3-Pyridyl)acetic acid; 2-(3-Pyridyl)acetic acid; alpha-(3-Pyridyl)acetate; 3-Carboxymethylpyridine; Pyridin-3-ylacetic acid; 2-(Pyridin-3-yl)acetate; 3-pyridineacetic acid; 2-(3-Pyridyl)acetate; a-(3-Pyridyl)acetate; 3-Pyridylacetic acid; Pyridin-3-ylacetate; 3-Pyridylacetate; Piristerol; Lessterol; Piridil; Minedil; Coletin; Lioxone; Toneon



数据库引用编号

10 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiangjun Liao, Jiping Zhu, Mamoona Rubab, Yong-Lai Feng, Raymond Poon. An analytical method for the measurement of acid metabolites of tryptophan-NAD pathway and related acids in urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Apr; 878(13-14):1003-6. doi: 10.1016/j.jchromb.2010.02.017. [PMID: 20299289]
  • Wolfgang Zwickenpflug, Stefan Tyroller, Elmar Richter. Metabolism of myosmine in Wistar rats. Drug metabolism and disposition: the biological fate of chemicals. 2005 Nov; 33(11):1648-56. doi: 10.1124/dmd.104.003087. [PMID: 16079272]
  • A Delaney, T J Gal. Hazards of anesthesia and operation in maple-syrup-urine disease. Anesthesiology. 1976 Jan; 44(1):83-6. doi: 10.1097/00000542-197601000-00023. [PMID: 931]