3-hydroxydecanoate (BioDeep_00000017767)

 

Secondary id: BioDeep_00001872082

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


L-beta-Hydroxydecanoic acid

化学式: C10H20O3 (188.141237)
中文名称: (±)-3-羟基癸酸, 3-羟基癸酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.45%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

3-hydroxydecanoate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/3-hydroxydecanoate (retrieved 2024-09-18) (BioDeep RN: BioDeep_00000017767). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCCCCCCC(CC(=O)O)O
InChI: InChI=1S/C10H20O3/c1-2-3-4-5-6-7-9(11)8-10(12)13/h9,11H,2-8H2,1H3,(H,12,13)

描述信息

3-Hydroxycapric acid (CAS: 14292-26-3) is a normally occurring carboxylic acid in human blood plasma. Medium- and long-chain 3-hydroxymonocarboxylic acids represent intermediates in the beta-oxidation of fatty acids. They accumulate in the plasma of patients with an inherited deficiency of long-chain 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) (PMID: 1912723). 3-Hydroxyacyl-CoA dehydrogenase (HADH) deficiency has been described in diverse clinical cases: juvenile-onset recurrent myoglobinuria, hypoketotic hypoglycemic encephalopathy, hypertrophic/dilatative cardiomyopathy, sudden infant death, and fulminant hepatic failure (OMIM: 231530). 3-Hydroxycapric acid has some shape-transforming action on the membrane of intact human erythrocytes (PMID: 7318031).
3-hydroxycapric acid is a normally occurring carboxylic acid in human blood plasma. Medium- and long-chain 3-hydroxymonocarboxylic acids represent intermediates in the beta-oxidation of fatty acids. They accumulate in the plasma of patients with an inherited deficiency of long-chain 3-hydroxyacylCoA dehydrogenase [EC 1.1.1.35]. (PMID: 1912723)
3-Hydroxycapric acid is an inhibitor for mitotic progression.

同义名列表

31 个代谢物同义名

L-beta-Hydroxydecanoic acid; (3S)-3-Hydroxydecanoic acid; (+)-3-Hydroxydecanoic acid; (±)-3-hydroxydecanoic acid; beta-Hydroxydecanoic acid; 3(S)-Hydroxydecanoic acid; L-Β-hydroxydecanoic acid; S-3-Hydroxydecanoic acid; (3S)-3-Hydroxydecanoate; beta-Hydroxycapric acid; L-beta-Hydroxydecanoate; 3-Hydroxydecanoic acid; 3-Hydroxidecanoic acid; (±)-3-hydroxydecanoate; (+)-3-Hydroxydecanoate; (S)-3-Hydroxydecanoate; Β-hydroxydecanoic acid; 3(S)-Hydroxydecanoate; beta-Hydroxydecanoate; S-3-Hydroxydecanoate; L-Β-hydroxydecanoate; 3-Hydroxycapric acid; Β-hydroxycapric acid; beta-Hydroxycaprate; Β-hydroxydecanoate; 3-Hydroxidecanoate; 3-Hydroxydecanoate; Β-hydroxycaprate; 3-Hydroxycaprate; FA(10:0(3S-OH)); FA(10:0(3-OH))



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Araceli Flores-Sánchez, Arthi Rathinasabapathy, Ma Del Rocío López-Cuellar, Berenice Vergara-Porras, Fermín Pérez-Guevara. Biosynthesis of polyhydroxyalkanoates from vegetable oil under the co-expression of fadE and phaJ genes in Cupriavidus necator. International journal of biological macromolecules. 2020 Dec; 164(?):1600-1607. doi: 10.1016/j.ijbiomac.2020.07.275. [PMID: 32768477]
  • Meryem Köse, Thanigaimalai Pillaiyar, Vigneshwaran Namasivayam, Elisabetta De Filippo, Katharina Sylvester, Trond Ulven, Ivar von Kügelgen, Christa E Müller. An Agonist Radioligand for the Proinflammatory Lipid-Activated G Protein-Coupled Receptor GPR84 Providing Structural Insights. Journal of medicinal chemistry. 2020 03; 63(5):2391-2410. doi: 10.1021/acs.jmedchem.9b01339. [PMID: 31721581]
  • Alexander Kutschera, Corinna Dawid, Nicolas Gisch, Christian Schmid, Lars Raasch, Tim Gerster, Milena Schäffer, Elwira Smakowska-Luzan, Youssef Belkhadir, A Corina Vlot, Courtney E Chandler, Romain Schellenberger, Dominik Schwudke, Robert K Ernst, Stéphan Dorey, Ralph Hückelhoven, Thomas Hofmann, Stefanie Ranf. Bacterial medium-chain 3-hydroxy fatty acid metabolites trigger immunity in Arabidopsis plants. Science (New York, N.Y.). 2019 04; 364(6436):178-181. doi: 10.1126/science.aau1279. [PMID: 30975887]
  • Justyna Mozejko, Andreas Wilke, Grzegorz Przybyłek, Slawomir Ciesielski. Mcl-PHAs produced by Pseudomonas sp. Gl01 using fed-batch cultivation with waste rapeseed oil as carbon source. Journal of microbiology and biotechnology. 2012 Mar; 22(3):371-7. doi: 10.4014/jmb.1106.06039. [PMID: 22450793]
  • Andreas Wittgens, Till Tiso, Torsten T Arndt, Pamela Wenk, Johannes Hemmerich, Carsten Müller, Rolf Wichmann, Benjamin Küpper, Michaela Zwick, Susanne Wilhelm, Rudolf Hausmann, Christoph Syldatk, Frank Rosenau, Lars M Blank. Growth independent rhamnolipid production from glucose using the non-pathogenic Pseudomonas putida KT2440. Microbial cell factories. 2011 Oct; 10(?):80. doi: 10.1186/1475-2859-10-80. [PMID: 21999513]
  • Anelise M Tonin, Mateus Grings, Estela N B Busanello, Alana P Moura, Gustavo C Ferreira, Carolina M Viegas, Carolina G Fernandes, Patrícia F Schuck, Moacir Wajner. Long-chain 3-hydroxy fatty acids accumulating in LCHAD and MTP deficiencies induce oxidative stress in rat brain. Neurochemistry international. 2010 Jul; 56(8):930-6. doi: 10.1016/j.neuint.2010.03.025. [PMID: 20381565]
  • Cristina Cigana, Laura Curcurù, Maria Rosaria Leone, Teresa Ieranò, Nicola Ivan Lorè, Irene Bianconi, Alba Silipo, Flora Cozzolino, Rosa Lanzetta, Antonio Molinaro, Maria Lina Bernardini, Alessandra Bragonzi. Pseudomonas aeruginosa exploits lipid A and muropeptides modification as a strategy to lower innate immunity during cystic fibrosis lung infection. PloS one. 2009 Dec; 4(12):e8439. doi: 10.1371/journal.pone.0008439. [PMID: 20037649]
  • Shane T Kenny, Jasmina Nikodinovic Runic, Walter Kaminsky, Trevor Woods, Ramesh P Babu, Chris M Keely, Werner Blau, Kevin E O'Connor. Up-cycling of PET (polyethylene terephthalate) to the biodegradable plastic PHA (polyhydroxyalkanoate). Environmental science & technology. 2008 Oct; 42(20):7696-701. doi: 10.1021/es801010e. [PMID: 18983095]
  • Christelle Simon-Colin, Gérard Raguénès, Philippe Crassous, Xavier Moppert, Jean Guezennec. A novel mcl-PHA produced on coprah oil by Pseudomonas guezennei biovar. tikehau, isolated from a 'kopara' mat of French Polynesia. International journal of biological macromolecules. 2008 Aug; 43(2):176-81. doi: 10.1016/j.ijbiomac.2008.04.011. [PMID: 18538385]
  • Robert K Ernst, Samuel M Moskowitz, Julia C Emerson, Gretchen M Kraig, Kristin N Adams, Megan D Harvey, Bonnie Ramsey, David P Speert, Jane L Burns, Samuel I Miller. Unique lipid a modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis. The Journal of infectious diseases. 2007 Oct; 196(7):1088-92. doi: 10.1086/521367. [PMID: 17763333]
  • Nehal Thakor, Ujjval Trivedi, K C Patel. Biosynthesis of medium chain length poly(3-hydroxyalkanoates) (mcl-PHAs) by Comamonas testosteroni during cultivation on vegetable oils. Bioresource technology. 2005 Nov; 96(17):1843-50. doi: 10.1016/j.biortech.2005.01.030. [PMID: 16084364]
  • E V Vorob'eva, A S Dmitrenok, P S Dmitrenok, V V Isakov, I N Krasikova, T F Solov'eva. [The structure of uncommon lipid A from the marine bacterium Marinomonas communis ATCC 27118T]. Bioorganicheskaia khimiia. 2005 Jul; 31(4):404-13. doi: ". [PMID: 16119460]
  • Ivan Mikhail, Håkan H Yildirim, Emma C H Lindahl, Elke K H Schweda. Structural characterization of lipid A from nontypeable and type f Haemophilus influenzae: variability of fatty acid substitution. Analytical biochemistry. 2005 May; 340(2):303-16. doi: 10.1016/j.ab.2005.02.020. [PMID: 15840504]
  • N V Kapustina, I N Krasikova, V V Isakov, N M Gorshkova, T F Solov'eva. Structure of lipid A from the marine gamma-proteobacterium Marinomonas vaga ATCC 27119T lipopolysaccharide. Biochemistry. Biokhimiia. 2004 Apr; 69(4):407-12. doi: 10.1023/b:biry.0000026196.90337.01. [PMID: 15170376]
  • Ken-Ichi Tanamoto, Takatoshi Iida, Yuji Haishima, Satoko Azumi. Endotoxic properties of lipid A from Comamonas testosteroni. Microbiology (Reading, England). 2001 May; 147(Pt 5):1087-1094. doi: 10.1099/00221287-147-5-1087. [PMID: 11320112]
  • K Takahashi, T Murakami, A Kamata, R Yumoto, Y Higashi, N Yata. Pharmacokinetic analysis of the absorption enhancing action of decanoic acid and its derivatives in rats. Pharmaceutical research. 1994 Mar; 11(3):388-92. doi: 10.1023/a:1018908903475. [PMID: 8008704]