Cephaeline (BioDeep_00000177151)

   

human metabolite blood metabolite natural product


代谢物信息卡片


1-({3-ethyl-9,10-dimethoxy-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-yl}methyl)-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol

化学式: C28H38N2O4 (466.2831)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 89.22%

分子结构信息

SMILES: CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)O)OC)OC)OC
InChI: InChI=1S/C28H38N2O4/c1-5-17-16-30-9-7-19-13-27(33-3)28(34-4)15-22(19)24(30)11-20(17)10-23-21-14-26(32-2)25(31)12-18(21)6-8-29-23/h12-15,17,20,23-24,29,31H,5-11,16H2,1-4H3

描述信息

同义名列表

6 个代谢物同义名

1-({3-ethyl-9,10-dimethoxy-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-yl}methyl)-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol; desmethyl-emetine; desmethylemetine; Cephaeline; cephaline; cephaelin



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

73 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Luiz Orlando de Oliveira, Ana Aparecida Bandini Rossi, Ernane Ronie Martins, Flávia Reis de Carvalho Batista, Roberta Santos Silva. Molecular phylogeography of Carapichea ipecacuanha, an amphitropical shrub that occurs in the understory of both semideciduous and evergreen forests. Molecular ecology. 2010 Apr; 19(7):1410-22. doi: 10.1111/j.1365-294x.2010.04591.x. [PMID: 20298468]
  • Takayuki Asano, Kazuhisa Ishihara, Yoko Wakui, Toshihiko Yanagisawa, Masayuki Kimura, Hideo Kamei, Takemi Yoshida, Yukio Kuroiwa, Yuichi Fujii, Mamoru Yamashita, Takanori Kuramochi, Hiroki Tomisawa, Mitsuru Tateishi. Absorption, distribution and excretion of 3H-labeled cephaeline- and emetine-spiked ipecac syrup in rats. European journal of drug metabolism and pharmacokinetics. 2002 Jan; 27(1):17-27. doi: 10.1007/bf03190401. [PMID: 11996323]
  • Takayuki Asano, Junko Watanabe, Chiharu Sadakane, Kazuhisa Ishihara, Kazuhiro Hirakura, Yoko Wakui, Toshihiko Yanagisawa, Masayuki Kimura, Hideo Kamei, Takemi Yoshida, Yuichi Fujii, Mamoru Yamashita. Biotransformation of the ipecac alkaloids cephaeline and emetine from ipecac syrup in rats. European journal of drug metabolism and pharmacokinetics. 2002 Jan; 27(1):29-35. doi: 10.1007/bf03190402. [PMID: 11996324]
  • T Asano, C Sadakane, K Ishihara, T Yanagisawa, M Kimura, H Kamei. High-performance liquid chromatographic assay with fluorescence detection for the determination of cephaeline and emetine in human plasma and urine. Journal of chromatography. B, Biomedical sciences and applications. 2001 Jun; 757(2):197-206. doi: 10.1016/s0378-4347(01)00170-0. [PMID: 11417863]
  • T Asano, H Kushida, C Sadakane, K Ishihara, Y Wakui, T Yanagisawa, M Kimura, H Kamei, T Yoshida. Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities. Biological & pharmaceutical bulletin. 2001 Jun; 24(6):678-82. doi: 10.1248/bpb.24.678. [PMID: 11411558]
  • E J Scharman, J M Hutzler, J G Rosencrance, T S Tracy. Single dose pharmacokinetics of syrup of ipecac. Therapeutic drug monitoring. 2000 Oct; 22(5):566-73. doi: 10.1097/00007691-200010000-00011. [PMID: 11034262]
  • M F Lachman, R Romeo, R B McComb. Emetine identified in urine by HPLC, with fluorescence and ultraviolet/diode array detection, in a patient with cardiomyopathy. Clinical chemistry. 1989 Mar; 35(3):499-502. doi: . [PMID: 2920426]
  • H Szmigielska. The effect of prolonged vasopressin administration on the level and metabolism of catecholamines in the rat brain and kidneys. Acta physiologica Polonica. 1976 May; 27(3):259-64. doi: NULL. [PMID: 7918]
  • H Loeb. [Systematic diagnosis of chronic diarrhea in infants and small children]. Kinderarztliche Praxis. 1976 Jan; 44(1):36-41. doi: NULL. [PMID: 3677]
  • W WISNIEWSKI, A PIETURA. [Colorimetric method for the determination of emetine and cephaeline in Cephaelis roots and in galenicals obtained from them]. Acta poloniae pharmaceutica. 1963; 20(?):43-51. doi: ". [PMID: 14001348]
  • F D'ABRAMO, E TOMASOS. [Biosynthesis of cephaline in the kidney]. Bollettino della Societa italiana di biologia sperimentale. 1955 Sep; 31(9-10):1395-7. doi: NULL. [PMID: 13329139]
  • . . . . doi: . [PMID: 20061395]