5-Methoxysalicylic acid (BioDeep_00000017692)

 

Secondary id: BioDeep_00000400493, BioDeep_00000598514

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


InChI=1/C8H8O4/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4,9H,1H3,(H,10,11

化学式: C8H8O4 (168.0422568)
中文名称: 5-甲氧基水杨酸
谱图信息: 最多检出来源 Viridiplantae(plant) 0.19%

分子结构信息

SMILES: COC1=CC(=C(C=C1)O)C(=O)O
InChI: InChI=1S/C8H8O4/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4,9H,1H3,(H,10,11)

描述信息

5-methoxysalicylic acid is a methoxysalicylic acid that is salicylic acid which is carrying a methoxy group at position 5. It has a role as a bacterial metabolite and a human urinary metabolite. 5-Methoxysalicylic acid is also known as 2-hydroxy-5-methoxybenzoate or 5-methoxy-2-hydroxybenzoate and belongs to the class of organic compounds known as m-methoxybenzoic acids and derivatives. These are benzoic acids in which the hydrogen atom at position 3 of the benzene ring is replaced by a methoxy group. Outside of the human body, 5-Methoxysalicylic acid has been detected, but not quantified in herbs and spices and tea.
5-methoxysalicylic acid is a methoxysalicylic acid that is salicylic acid which is carrying a methoxy group at position 5. It has a role as a bacterial metabolite and a human urinary metabolite.
5-Methoxysalicylic acid is a natural product found in Thalictrum fargesii, Amycolatopsis, and Conyza bonariensis with data available.
D000893 - Anti-Inflammatory Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D012459 - Salicylates
A methoxysalicylic acid that is salicylic acid which is carrying a methoxy group at position 5.
Isolated from Primula veris (cowslip)
5-Methoxysalicylic acid (5-MeOSA) is a natural compound, used as a useful matrix in the MALDI MS analysis of oligonucleotides when combined with spermine[1].

同义名列表

29 个代谢物同义名

InChI=1/C8H8O4/c1-12-5-2-3-7(9)6(4-5)8(10)11/h2-4,9H,1H3,(H,10,11; 5-Methoxysalicylic acid 2-Hydroxy-5-methoxybenzoic acid; 2-Hydroxy-5-methoxybenzoic acid, 98\\%; 5-methoxysalicylic acid, sodium salt; 2-hydroxy-5-(methyloxy)benzoic acid; Benzoic acid, 2-hydroxy-5-methoxy-; 2-Hydroxyl-5-methoxybenzoic acid; 2-hydroxy-5-methoxy-benzoic acid; 2-Hydroxy-5-methoxybenzoic acid; 5-Methoxy-2-hydroxybenzoic acid; 5-methoxy-2-hydroxobenzoic acid; 2-hydroxy 5-methoxybenzoic acid; 2-Hydroxy-5-methoxybenzoicAcid; 2-hydroxy-5-methoxybenzoate; 5-Methoxy-2-hydroxybenzoate; m-Anisic acid, 6-hydroxy-; 5-methoxy-salicylic acid; 5-methoxysalicyclic acid; 5-o-METHYL GENTISIC ACID; 5-Methoxysalicylic acid; 6-hydroxy-m-anisic acid; 6-methoxy-m-anisic acid; Acid5-methoxysalicylic; 5-O-Methyl gentisate; 6-Methoxy-m-anisate; 6-hydroxy-m-Anisate; 5-Methoxysalicylate; AI3-24048; 5-MeOSA



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Luisa M Ostertag, Niamh O'Kennedy, Graham W Horgan, Paul A Kroon, Garry G Duthie, Baukje de Roos. In vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations. Molecular nutrition & food research. 2011 Nov; 55(11):1624-36. doi: 10.1002/mnfr.201100135. [PMID: 21898791]
  • H S Yun-Choi, J H Kim, J R Lee. Potential inhibitors of platelet aggregation from plant sources, III. Journal of natural products. 1987 Nov; 50(6):1059-64. doi: 10.1021/np50054a008. [PMID: 3127544]
  • T Nishihata, J H Rytting, A Kamada, T Higuchi. Enhanced intestinal absorption of insulin in rats in the presence of sodium 5-methoxysalicylate. Diabetes. 1981 Dec; 30(12):1065-7. doi: 10.2337/diab.30.12.1065. [PMID: 7030832]
  • R A Scherrer, S M Howard. Use of distribution coefficients in quantitative structure-activity relationships. Journal of medicinal chemistry. 1977 Jan; 20(1):53-8. doi: 10.1021/jm00211a010. [PMID: 13215]