b-Boswellic acid (BioDeep_00000176405)
Main id: BioDeep_00000017375
human metabolite PANOMIX_OTCML-2023 blood metabolite natural product
代谢物信息卡片
化学式: C30H48O3 (456.36032579999994)
中文名称: β-Boswellic acid
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1[C@H]([C@@]([C@H]2[C@](C1)([C@@H]1[C@@](CC2)([C@]2(C(=CC1)[C@H]1[C@@](CC2)(CC[C@H]([C@@H]1C)C)C)C)C)C)(C(=O)O)C)O
InChI: InChI=1S/C30H48O3/c1-18-10-13-26(3)16-17-28(5)20(24(26)19(18)2)8-9-21-27(4)14-12-23(31)30(7,25(32)33)22(27)11-15-29(21,28)6/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)
描述信息
Constituent of frankincense (Boswellia subspecies) and olibanum oil
β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation[1]. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells[2].
β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation[1]. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells[2].
β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation[1]. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells[2].
同义名列表
9 个代谢物同义名
3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid; 3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picene-4-carboxylic acid; beta-Boswellic Acid; b-Boswellic acid; β-Boswellic acid; beta-Boswellate; boswellic acid; Β-boswellate; b-Boswellate
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
19 个相关的物种来源信息
- 80276 - Boswellia: 10.1021/NP040142X
- 80276 - Boswellia: LTS0186004
- 1461607 - Boswellia papyrifera: 10.1016/S0031-9422(02)00538-1
- 173701 - Boswellia sacra: 10.1080/10286020.2010.548808
- 173701 - Boswellia sacra: LTS0186004
- 613112 - Boswellia serrata: 10.1016/0031-9422(95)99386-3
- 613112 - Boswellia serrata: LTS0186004
- 4014 - Burseraceae: LTS0186004
- 117166 - Cyclocarya: LTS0186004
- 117167 - Cyclocarya paliurus: 10.1055/S-2008-1034309
- 117167 - Cyclocarya paliurus: LTS0186004
- 2759 - Eukaryota: LTS0186004
- 9606 - Homo sapiens: -
- 16714 - Juglandaceae: LTS0186004
- 3398 - Magnoliopsida: LTS0186004
- 33090 - Plants: -
- 35493 - Streptophyta: LTS0186004
- 58023 - Tracheophyta: LTS0186004
- 33090 - Viridiplantae: LTS0186004
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Jakob Lauß, Christoph Kappacher, Olivia Isser, Christian W Huck, Matthias Rainer. Species-Specific quantification of bioactive boswellic acids in Boswellia resin using NIR spectroscopy, HPLC and Multivariate data analysis.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2024 Aug; 316(?):124384. doi:
10.1016/j.saa.2024.124384
. [PMID: 38701576] - Ehab A Ragab, Mohammed F Abd El-Wahab, Ahmed S Doghish, Rania M Salama, Nermin Eissa, Samar F Darwish. The journey of boswellic acids from synthesis to pharmacological activities.
Naunyn-Schmiedeberg's archives of pharmacology.
2024 03; 397(3):1477-1504. doi:
10.1007/s00210-023-02725-w
. [PMID: 37740772] - Smruti Mukadam, Chetana Ghule, Aboli Girme, Vaibhav M Shinde, Lal Hingorani, Kakasaheb R Mahadik. A Simple HPTLC Approach of Quantification of Serratol and Tirucallic Acid with Boswellic Acids in Boswellia serrata by Validated Densitometric Method with MS/MS Characterization.
Journal of chromatographic science.
2023 Mar; ?(?):. doi:
10.1093/chromsci/bmad012
. [PMID: 36892162] - Friedemann Börner, Simona Pace, Paul M Jordan, Jana Gerstmeier, Mario Gomez, Antonietta Rossi, Nathaniel C Gilbert, Marcia E Newcomer, Oliver Werz. Allosteric Activation of 15-Lipoxygenase-1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2023 02; 10(6):e2205604. doi:
10.1002/advs.202205604
. [PMID: 36567268] - Akhalesh Kumar, Saurabh Sharma, Sudhanshu Mishra, Smriti Ojha, Pawan Upadhyay. ADME Prediction, Structure-activity Relationship of Boswellic Acid Scaffold for the Aspect of Anticancer & Anti-inflammatory Potency.
Anti-cancer agents in medicinal chemistry.
2023; 23(13):1499-1505. doi:
10.2174/1871520623666230417080437
. [PMID: 37070442] - Arezoo Rajabian, Mohammadreza Farzanehfar, Hossein Hosseini, Fahimeh Lavi Arab, Ali Nikkhah. Boswellic acids as promising agents for the management of brain diseases.
Life sciences.
2023 Jan; 312(?):121196. doi:
10.1016/j.lfs.2022.121196
. [PMID: 36400202] - Faezeh Khaafi, Behjat Javadi. Molecular Targets Underlying the Neuroprotective Effects of Boswellic Acid: A Systematic Review.
Mini reviews in medicinal chemistry.
2023; 23(19):1912-1925. doi:
10.2174/1389557523666230330113611
. [PMID: 36998129] - Eman A Mohamed, Hebatalla I Ahmed, Heba S Zaky, Amira M Badr. Boswellic acids ameliorate neurodegeneration induced by AlCl3: the implication of Wnt/β-catenin pathway.
Environmental science and pollution research international.
2022 Oct; 29(50):76135-76143. doi:
10.1007/s11356-022-20611-5
. [PMID: 35668264] - Ya-Chu Tsai, Hsun-Hao Chang, Sheng-Chieh Chou, Thomas W Chu, Yu-Jou Hsu, Chien-Yu Hsiao, Yuan-Hsin Lo, Nan-Lin Wu, Der-Chen Chang, Chi-Feng Hung. Evaluation of the Anti-Atopic Dermatitis Effects of α-Boswellic Acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice.
International journal of molecular sciences.
2022 Aug; 23(17):. doi:
10.3390/ijms23179863
. [PMID: 36077254] - David Banji, Otilia J F Banji, Shaik Rashida, Saeed Alshahrani, Saad S Alqahtani. Bioavailability, anti-inflammatory and anti-arthritic effect of Acetyl Keto Boswellic acid and its combination with methotrexate in an arthritic animal model.
Journal of ethnopharmacology.
2022 Jun; 292(?):115200. doi:
10.1016/j.jep.2022.115200
. [PMID: 35306043] - Petr Jaroš, Elizaveta Timkina, Jana Michailidu, Dominik Maršík, Markéta Kulišová, Irena Kolouchová, Kateřina Demnerová. Boswellic Acids as Effective Antibacterial Antibiofilm Agents.
Molecules (Basel, Switzerland).
2022 Jun; 27(12):. doi:
10.3390/molecules27123795
. [PMID: 35744925] - Marzieh Dehghan Shasaltaneh, Nasser Naghdi, Sadrollah Ramezani, Leila Alizadeh, Gholam Hossein Riazi. Protection of Beta Boswellic Acid against Streptozotocin-induced Alzheimer's Model by Reduction of Tau Phosphorylation Level and Enhancement of Reelin Expression.
Planta medica.
2022 Apr; 88(5):367-379. doi:
10.1055/a-1502-7083
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Mar; 147(?):112669. doi:
10.1016/j.biopha.2022.112669
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Naunyn-Schmiedeberg's archives of pharmacology.
2021 11; 394(11):2167-2185. doi:
10.1007/s00210-021-02154-7
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The Plant journal : for cell and molecular biology.
2021 09; 107(5):1403-1419. doi:
10.1111/tpj.15388
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Inflammopharmacology.
2021 Aug; 29(4):1033-1048. doi:
10.1007/s10787-021-00841-8
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Journal of pharmaceutical and biomedical analysis.
2021 Jul; 201(?):114106. doi:
10.1016/j.jpba.2021.114106
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Molecules (Basel, Switzerland).
2021 Jun; 26(12):. doi:
10.3390/molecules26123651
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Biomedical chromatography : BMC.
2021 Mar; 35(3):e5000. doi:
10.1002/bmc.5000
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Pakistan journal of pharmaceutical sciences.
2021 Jan; 34(1(Supplementary)):359-365. doi:
"
. [PMID: 34275862] - Lubna Abidin, Prerna Singla, Hina Kausar, Mohd Mujeeb, Abdur Rahman, Mohd Aqil, Abul Kalam Najmi. Extraction of 11-Keto-β -Boswellic Acid from Indian Olibanum by Contemporary Extraction Modes: Optimization and Validation of HPTLC.
Combinatorial chemistry & high throughput screening.
2021; 24(8):1309-1321. doi:
10.2174/1386207323666200914091733
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PloS one.
2021; 16(5):e0252279. doi:
10.1371/journal.pone.0252279
. [PMID: 34048452] - Amy M Zimmermann-Klemd, Jakob K Reinhardt, Thanasan Nilsu, Anna Morath, Chiara M Falanga, Wolfgang W Schamel, Roman Huber, Matthias Hamburger, Carsten Gründemann. Boswellia carteri extract and 3-O-acetyl-alpha-boswellic acid suppress T cell function.
Fitoterapia.
2020 Oct; 146(?):104694. doi:
10.1016/j.fitote.2020.104694
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BMC complementary medicine and therapies.
2020 Jul; 20(1):225. doi:
10.1186/s12906-020-02985-6
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Natural product research.
2020 Jul; 34(13):1845-1852. doi:
10.1080/14786419.2018.1564295
. [PMID: 30691289] - Bruna Girardi, Maria Pricci, Floriana Giorgio, Mariano Piazzolla, Andrea Iannone, Giuseppe Losurdo, Mariabeatrice Principi, Michele Barone, Enzo Ierardi, Alfredo Di Leo. Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model.
World journal of gastroenterology.
2020 Apr; 26(14):1601-1612. doi:
10.3748/wjg.v26.i14.1601
. [PMID: 32327909] - Tarun Sharma, Snehasis Jana. Investigation of Molecular Properties that Influence the Permeability and Oral Bioavailability of Major β-Boswellic Acids.
European journal of drug metabolism and pharmacokinetics.
2020 Apr; 45(2):243-255. doi:
10.1007/s13318-019-00599-z
. [PMID: 31786725] - Anna Lewinska, Lakshman Sodagam, Dominika Bloniarz, Karsten Siems, Maciej Wnuk, Suresh I S Rattan. Plant-Derived Molecules α-Boswellic Acid Acetate, Praeruptorin-A, and Salvianolic Acid-B Have Age-Related Differential Effects in Young and Senescent Human Fibroblasts In Vitro.
Molecules (Basel, Switzerland).
2019 Dec; 25(1):. doi:
10.3390/molecules25010141
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Molecules (Basel, Switzerland).
2019 Sep; 24(19):. doi:
10.3390/molecules24193453
. [PMID: 31547594] - Nand Kishor Roy, Dey Parama, Kishore Banik, Devivasha Bordoloi, Amrita Khwairakpam Devi, Krishan Kumar Thakur, Ganesan Padmavathi, Mehdi Shakibaei, Lu Fan, Gautam Sethi, Ajaikumar B Kunnumakkara. An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases.
International journal of molecular sciences.
2019 Aug; 20(17):. doi:
10.3390/ijms20174101
. [PMID: 31443458] - Michael Schmiech, Sophia J Lang, Katharina Werner, Luay J Rashan, Tatiana Syrovets, Thomas Simmet. Comparative Analysis of Pentacyclic Triterpenic Acid Compositions in Oleogum Resins of Different Boswellia Species and Their In Vitro Cytotoxicity against Treatment-Resistant Human Breast Cancer Cells.
Molecules (Basel, Switzerland).
2019 Jun; 24(11):. doi:
10.3390/molecules24112153
. [PMID: 31181656] - Manlio Barbarisi, Alfonso Barbarisi, Gabriele De Sena, Emilia Armenia, Caterina Aurilio, Michele Libutti, Rosario Vincenzo Iaffaioli, Gerardo Botti, Nicola Maurea, Vincenzo Quagliariello. Boswellic acid has anti-inflammatory effects and enhances the anticancer activities of Temozolomide and Afatinib, an irreversible ErbB family blocker, in human glioblastoma cells.
Phytotherapy research : PTR.
2019 06; 33(6):1670-1682. doi:
10.1002/ptr.6354
. [PMID: 30924205] - Muhammed Majeed, Shaheen Majeed, Narayanan K Narayanan, Kalyanam Nagabhushanam. A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee.
Phytotherapy research : PTR.
2019 May; 33(5):1457-1468. doi:
10.1002/ptr.6338
. [PMID: 30838706] - Antonella Riva, Luca Giacomelli, Stefano Togni, Federico Franceschi, Roberto Eggenhoffner, Maria Chiara Zuccarini, Gianni Belcaro. Oral administration of a lecithin-based delivery form of boswellic acids (Casperome®) for the prevention of symptoms of irritable bowel syndrome: a randomized clinical study.
Minerva gastroenterologica e dietologica.
2019 Mar; 65(1):30-35. doi:
10.23736/s1121-421x.18.02530-8
. [PMID: 30676012] - Mohamed A Morsy, Snehal S Patel, Azza A K El-Sheikh, Jignasa K Savjani, Anroop B Nair, Jigar N Shah, Katharigatta N Venugopala. Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor.
Mediators of inflammation.
2019; 2019(?):3041438. doi:
10.1155/2019/3041438
. [PMID: 31263381] - Debayan Goswami, Ananya Das Mahapatra, Subhadip Banerjee, Amit Kar, Durbadal Ojha, Pulok K Mukherjee, Debprasad Chattopadhyay. Boswellia serrata oleo-gum-resin and β-boswellic acid inhibits HSV-1 infection in vitro through modulation of NF-кB and p38 MAP kinase signaling.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Dec; 51(?):94-103. doi:
10.1016/j.phymed.2018.10.016
. [PMID: 30466633] - Mohamed T Khayyal, Rania M El-Hazek, Walaa A El-Sabbagh, Jan Frank, Dariush Behnam, Mona Abdel-Tawab. Micellar solubilisation enhances the antiinflammatory activities of curcumin and boswellic acids in rats with adjuvant-induced arthritis.
Nutrition (Burbank, Los Angeles County, Calif.).
2018 10; 54(?):189-196. doi:
10.1016/j.nut.2018.03.055
. [PMID: 30048884] - Gianni Belcaro, Mark Dugall, Roberta Luzzi, Morio Hosoi, Andrea Ledda, Beatrice Feragalli, Shu Hu, Apurba Ganguly, Roberto Eggenhoffner, Ambra Corti, Luca Giacomelli. Phytoproflex®: supplementary management of osteoarthrosis: a supplement registry.
Minerva medica.
2018 Apr; 109(2):88-94. doi:
10.23736/s0026-4806.17.05460-x
. [PMID: 29534559] - Dan Wang, Shuke Ge, Jichang Bai, Yongwei Song. Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2018 Mar; 23(2):340-345. doi:
"
. [PMID: 29745074] - Andreas Koeberle, Arne Henkel, Moritz Verhoff, Lars Tausch, Stefanie König, Dagmar Fischer, Nicole Kather, Stefanie Seitz, Michael Paul, Johann Jauch, Oliver Werz. Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G.
Molecules (Basel, Switzerland).
2018 Feb; 23(2):. doi:
10.3390/molecules23020506
. [PMID: 29495286] - Bassant M Barakat, Hebatalla I Ahmed, Hoda I Bahr, Alaaeldeen M Elbahaie. Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway.
Oxidative medicine and cellular longevity.
2018; 2018(?):8296451. doi:
10.1155/2018/8296451
. [PMID: 29541348] - Ahmed Al-Harrasi, Najeeb Ur Rehman, Abdul Latif Khan, Muhammed Al-Broumi, Issa Al-Amri, Javid Hussain, Hidayat Hussain, René Csuk. Chemical, molecular and structural studies of Boswellia species: β-Boswellic Aldehyde and 3-epi-11β-Dihydroxy BA as precursors in biosynthesis of boswellic acids.
PloS one.
2018; 13(6):e0198666. doi:
10.1371/journal.pone.0198666
. [PMID: 29912889] - Manoj Kumar, Gurpreet Singh, Priti Bhardwaj, Sunil Kumar Dhatwalia, D K Dhawan. Understanding the role of 3-O-Acetyl-11-keto-β-boswellic acid in conditions of oxidative-stress mediated hepatic dysfunction during benzo(a)pyrene induced toxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Nov; 109(Pt 2):871-878. doi:
10.1016/j.fct.2017.03.058
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European review for medical and pharmacological sciences.
2017 Nov; 21(22):5258-5263. doi:
10.26355/eurrev_201711_13849
. [PMID: 29228442] - Ahmed Al-Harrasi, Najeeb Ur Rehman, Fazal Mabood, Muhammaed Albroumi, Liaqat Ali, Javid Hussain, Hidayat Hussain, René Csuk, Abdul Latif Khan, Tanveer Alam, Saif Alameri. Application of NIRS coupled with PLS regression as a rapid, non-destructive alternative method for quantification of KBA in Boswellia sacra.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2017 Sep; 184(?):277-285. doi:
10.1016/j.saa.2017.05.018
. [PMID: 28525862] - Ulf Siemoneit, Lars Tausch, Daniel Poeckel, Michael Paul, Hinnak Northoff, Andreas Koeberle, Johann Jauch, Oliver Werz. Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts.
Planta medica.
2017 Aug; 83(12-13):1020-1027. doi:
10.1055/s-0043-107884
. [PMID: 28403501] - Angie M Ameen, Amany Y Elkazaz, Hala M F Mohammad, Bassant M Barakat. Anti-inflammatory and neuroprotective activity of boswellic acids in rotenone parkinsonian rats.
Canadian journal of physiology and pharmacology.
2017 Jul; 95(7):819-829. doi:
10.1139/cjpp-2016-0158
. [PMID: 28249117] - Amarinder Singh, S Arvinda, Surjeet Singh, Jyotsna Suri, Surinder Koul, Dilip M Mondhe, Gurdarshan Singh, Ram Vishwakarma. IN0523 (Urs-12-ene-3α,24β-diol) a plant based derivative of boswellic acid protect Cisplatin induced urogenital toxicity.
Toxicology and applied pharmacology.
2017 03; 318(?):8-15. doi:
10.1016/j.taap.2017.01.011
. [PMID: 28122196] - Antonella Riva, Paolo Morazzoni, Christian Artaria, Pietro Allegrini, Jürgen Meins, Daniele Savio, Giovanni Appendino, Manfred Schubert-Zsilavecz, Mona Abdel-Tawab. A single-dose, randomized, cross-over, two-way, open-label study for comparing the absorption of boswellic acids and its lecithin formulation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2016 Nov; 23(12):1375-1382. doi:
10.1016/j.phymed.2016.07.009
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Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2016 Nov; 37(11):14341-14354. doi:
10.1007/s13277-016-5330-5
. [PMID: 27614685] - Giuseppe Mannino, Andrea Occhipinti, Massimo E Maffei. Quantitative Determination of 3-O-Acetyl-11-Keto-βBoswellic Acid (AKBA) and Other Boswellic Acids in Boswellia sacra Flueck (syn. B. carteri Birdw) and Boswellia serrata Roxb.
Molecules (Basel, Switzerland).
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