PC(16:0/18:2(9Z,12Z)) (BioDeep_00000017482)

描述信息

PC(16:0/18:2(9Z,12Z)) is a phosphatidylcholine (PC or GPCho). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphocholines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PC(16:0/18:2(9Z,12Z)), in particular, consists of one chain of palmitic acid at the C-1 position and one chain of linoleic acid at the C-2 position. The palmitic acid moiety is derived from fish oils, milk fats, vegetable oils and animal fats, while the linoleic acid moiety is derived from seed oils. Phospholipids, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling.While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PCs can be synthesized via three different routes. In one route, choline is activated first by phosphorylation and then by coupling to CDP prior to attachment to phosphatidic acid. PCs can also synthesized by the addition of choline to CDP-activated 1,2-diacylglycerol. A third route to PC synthesis involves the conversion of either PS or PE to PC.
Palmitoyl-linoleoyl phosphatidylcholine, also known as phosphatidylcholine(16:0/18:2) or pc(16:0/18:2), is a member of the class of compounds known as phosphatidylcholines. Phosphatidylcholines are glycerophosphocholines in which the two free -OH are attached to one fatty acid each through an ester linkage. Thus, palmitoyl-linoleoyl phosphatidylcholine is considered to be a glycerophosphocholine lipid molecule. Palmitoyl-linoleoyl phosphatidylcholine is practically insoluble (in water) and a moderately acidic compound (based on its pKa). Palmitoyl-linoleoyl phosphatidylcholine can be found in a number of food items such as wax gourd, rowanberry, arrowroot, and chicory leaves, which makes palmitoyl-linoleoyl phosphatidylcholine a potential biomarker for the consumption of these food products. Palmitoyl-linoleoyl phosphatidylcholine can be found primarily in blood, saliva, and urine, as well as throughout all human tissues. In humans, palmitoyl-linoleoyl phosphatidylcholine is involved in a couple of metabolic pathways, which include phosphatidylcholine biosynthesis PC(16:0/18:2(9Z,12Z)) and phosphatidylethanolamine biosynthesis PE(16:0/18:2(9Z,12Z)). Moreover, palmitoyl-linoleoyl phosphatidylcholine is found to be associated with schizophrenia.
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine is a phosphatidylcholine 34:2 in which the 1- and 2-acyl groups are specified as hexadecanoyl (palmitoyl) and 9Z,12Z-octadecadienoyl (linoleoyl) respectively. It is a phosphatidylcholine 34:2 and a 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine betaine.
A complex mixture of phospholipids, glycolipids, triglycerides, phosphatidylcholines, phosphatidylethanolamines, and phosphatidylinositols.
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine is a natural product found in Lycoris radiata, Vitis vinifera, and Drosophila melanogaster with data available.
Lecithin is a phospholipid with a polar choline found in phosphoester linkage to diacylglycerol.
A phosphatidylcholine 34:2 in which the 1- and 2-acyl groups are specified as hexadecanoyl (palmitoyl) and 9Z,12Z-octadecadienoyl (linoleoyl) respectively.
Lecithin is regarded as a safe, conventional phospholipid source. Phospholipids are reported to alter the fatty acid composition and microstructure of the membranes in animal cells.
Lecithin is regarded as a safe, conventional phospholipid source. Phospholipids are reported to alter the fatty acid composition and microstructure of the membranes in animal cells.

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