N-Methyl-4-oxo-1,4-dihydropyridine-3-carboxamide (BioDeep_00000174136)
human metabolite blood metabolite
代谢物信息卡片
N-Methyl-4-oxo-1,4-dihydropyridine-3-carboxamide
化学式: C7H8N2O2 (152.0585748)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNC(=O)C1=CNC=CC1=O
InChI: InChI=1S/C7H8N2O2/c1-8-7(11)5-4-9-3-2-6(5)10/h2-4H,1H3,(H,8,11)(H,9,10)
数据库引用编号
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Akihiro Maeta, Mitsue Sano, Tsutomu Fukuwatari, Katsumi Shibata. Simultaneous measurement of nicotinamide and its catabolites, nicotinamide N-oxide, N(1)-methyl-2-pyridone-5-carboxamide, and N(1)-methyl-4-pyridone-3-carboxamide, in mice urine.
Bioscience, biotechnology, and biochemistry.
2014; 78(8):1306-9. doi:
10.1080/09168451.2014.918495. [PMID: 25130730] - Katsumi Shibata, Nobuya Morita, Yoshika Shibata, Tsutomu Fukuwatari. Enzymes that control the conversion of L-tryptophan-nicotinamide and the urinary excretion ratio (N(1)-methyl-2-pyridone-5-carboxamide + N(1)-methyl-4-pyridone-3-carboxamide)/N(1)-methylnicotinamide in mice.
Bioscience, biotechnology, and biochemistry.
2013; 77(10):2105-11. doi:
10.1271/bbb.130467. [PMID: 24096677] - Bolesław Rutkowski, Przemysław Rutkowski, Ewa Słomińska, Julian Swierczyński. Distribution of purine nucleotides in uremic fluids and tissues.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2010 Sep; 20(5 Suppl):S7-10. doi:
10.1053/j.jrn.2010.05.003. [PMID: 20797575] - Fengxia Zhang, Zhenhua Jia, Peng Gao, Hongwei Kong, Xiang Li, Xin Lu, Yiling Wu, Guowang Xu. Metabonomics study of urine and plasma in depression and excess fatigue rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry.
Molecular bioSystems.
2010 May; 6(5):852-61. doi:
10.1039/b914751a. [PMID: 20567771] - Susan C Connor, Michael K Hansen, Adam Corner, Randall F Smith, Terence E Ryan. Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes.
Molecular bioSystems.
2010 May; 6(5):909-21. doi:
10.1039/b914182k. [PMID: 20567778] - Roman Lang, Anika Wahl, Thomas Skurk, Erkan Firat Yagar, Ludger Schmiech, Rudolf Eggers, Hans Hauner, Thomas Hofmann. Development of a hydrophilic liquid interaction chromatography-high-performance liquid chromatography-tandem mass spectrometry based stable isotope dilution analysis and pharmacokinetic studies on bioactive pyridines in human plasma and urine after coffee consumption.
Analytical chemistry.
2010 Feb; 82(4):1486-97. doi:
10.1021/ac902616k. [PMID: 20073472] - Przemysław Rutkowski, Ewa M Slominska, Wojciech Wołyniec, Ryszard T Smoleński, Marek Szolkiewicz, Julian Swierczyński, Bolesław Rutkowski. Nicotinamide metabolites accumulate in the tissues of uremic rats.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2008 Jan; 18(1):56-9. doi:
10.1053/j.jrn.2007.10.012. [PMID: 18089445] - Laura K Schnackenberg, Jinchun Sun, Parvaneh Espandiari, Ricky D Holland, Joseph Hanig, Richard D Beger. Metabonomics evaluations of age-related changes in the urinary compositions of male Sprague Dawley rats and effects of data normalization methods on statistical and quantitative analysis.
BMC bioinformatics.
2007 Nov; 8 Suppl 7(?):S3. doi:
10.1186/1471-2105-8-s7-s3. [PMID: 18047726] - R M Menon, M H Adams, M A González, D S Tolbert, J H Leu, E A Cefali. Plasma and urine pharmacokinetics of niacin and its metabolites from an extended-release niacin formulation.
International journal of clinical pharmacology and therapeutics.
2007 Aug; 45(8):448-54. doi:
10.5414/cpp45448. [PMID: 17725178] - Przemyslaw Rutkowski, Ewa Maria Słominska, Marek Szołkiewicz, Ewa Aleksandrowicz, Ryszard Tomasz Smolenski, Wojciech Wołyniec, Marcin Renke, Krystyna Wisterowicz, Julian Swierczynski, Boleslaw Rutkowski. Relationship between uremic toxins and oxidative stress in patients with chronic renal failure.
Scandinavian journal of urology and nephrology.
2007; 41(3):243-8. doi:
10.1080/00365590601017170. [PMID: 17469035] - Ewa M Slominska, Katarzyna Kowalik, Ryszard T Smolenski, Marek Szolkiewicz, Przemyslaw Rutkowski, Boleslaw Rutkowski, Julian Swierczynski. Accumulation of poly(ADP-ribose) polymerase inhibitors in children with chronic renal failure.
Pediatric nephrology (Berlin, Germany).
2006 Jun; 21(6):800-6. doi:
10.1007/s00467-006-0072-z. [PMID: 16604373] - Kazumi Sugihara, Yoshitaka Tayama, Kazuhiro Shimomiya, Daisuke Yoshimoto, Shigeru Ohta, Shigeyuki Kitamura. Estimation of aldehyde oxidase activity in vivo from conversion ratio of N1-methylnicotinamide to pyridones, and intraspecies variation of the enzyme activity in rats.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Feb; 34(2):208-12. doi:
10.1124/dmd.105.006544. [PMID: 16299165] - Jane Delaney, Mark P Hodson, Hansa Thakkar, Susan C Connor, Brian C Sweatman, Steve P Kenny, Paul J McGill, Julie C Holder, Kathryn A Hutton, John N Haselden, Catherine J Waterfield. Tryptophan-NAD+ pathway metabolites as putative biomarkers and predictors of peroxisome proliferation.
Archives of toxicology.
2005 Apr; 79(4):208-23. doi:
10.1007/s00204-004-0625-5. [PMID: 15838709] - Stephanie Ringeissen, Susan C Connor, H Roger Brown, Brian C Sweatman, Mark P Hodson, Steve P Kenny, Richard I Haworth, Paul McGill, Mark A Price, Mike C Aylott, Derek J Nunez, John N Haselden, Catherine J Waterfield. Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N-methylnicotinamide and N-methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2003 May; 8(3-4):240-71. doi:
10.1080/1354750031000149124. [PMID: 12944176] - Hidemi Okamoto, Aya Ishikawa, Yutaka Yoshitake, Naoko Kodama, Mamoru Nishimuta, Tsutomu Fukuwatari, Katsumi Shibata. Diurnal variations in human urinary excretion of nicotinamide catabolites: effects of stress on the metabolism of nicotinamide.
The American journal of clinical nutrition.
2003 Feb; 77(2):406-10. doi:
10.1093/ajcn/77.2.406. [PMID: 12540401] - Pierre Wong, Abderrazak Bachki, Kris Banerjee, Brian Leyland-Jones. Identification of N1-methyl-2-pyridone-5-carboxamide and N1-methyl-4-pyridone-5-carboxamide as components in urine extracts of individuals consuming coffee.
Journal of pharmaceutical and biomedical analysis.
2002 Oct; 30(3):773-80. doi:
10.1016/s0731-7085(02)00384-9. [PMID: 12367703] - K Shibata, T Kondo, A Miki. Increased conversion ratio of tryptophan to niacin in severe food restriction.
Bioscience, biotechnology, and biochemistry.
1998 Mar; 62(3):580-3. doi:
10.1271/bbb.62.580. [PMID: 9571792] - K Shibata, S Toda. Effects of sex hormones on the metabolism of tryptophan to niacin and to serotonin in male rats.
Bioscience, biotechnology, and biochemistry.
1997 Jul; 61(7):1200-2. doi:
10.1271/bbb.61.1200. [PMID: 9255986] - K Shibata, H Shimada, T Kondo. Effects of feeding tryptophan-limiting diets on the conversion ratio of tryptophan to niacin in rats.
Bioscience, biotechnology, and biochemistry.
1996 Oct; 60(10):1660-6. doi:
10.1271/bbb.60.1660. [PMID: 8987665] - K Shibata, H Kakehi, H Matsuo. Niacin catabolism in rodents.
Journal of nutritional science and vitaminology.
1990 Apr; 36(2):87-98. doi:
10.3177/jnsv.36.87. [PMID: 2143779] - K Shibata, H Matsuo. Correlation between niacin equivalent intake and urinary excretion of its metabolites, N'-methylnicotinamide, N'-methyl-2-pyridone-5-carboxamide, and N'-methyl-4-pyridone-3-carboxamide, in humans consuming a self-selected food.
The American journal of clinical nutrition.
1989 Jul; 50(1):114-9. doi:
10.1093/ajcn/50.1.114. [PMID: 2526576] - K Shibata, T Kawada, K Iwai. Simultaneous micro-determination of nicotinamide and its major metabolites, N1-methyl-2-pyridone-5-carboxamide and N1-methyl-4-pyridone-3-carboxamide, by high-performance liquid chromatography.
Journal of chromatography.
1988 Jan; 424(1):23-8. doi:
10.1016/s0378-4347(00)81072-5. [PMID: 2966806] - Y A Kang-Lee, R W McKee, S M Wright, M E Swendseid, D J Jenden, R S Jope. Metabolic effects of nicotinamide administration in rats.
The Journal of nutrition.
1983 Feb; 113(2):215-21. doi:
10.1093/jn/113.2.215. [PMID: 6218261] - J I Patterson, R R Brown, H Linkswiler, A E Harper. Excretion of tryptophan-niacin metabolites by young men: effects of tryptophan, leucine, and vitamin B6 intakes.
The American journal of clinical nutrition.
1980 Oct; 33(10):2157-67. doi:
10.1093/ajcn/33.10.2157. [PMID: 6448542] - D ABELSON, A BOYLE, H SELIGSON. Identification of N'-methyl-4-pyridone-3-carboxamide in human plasma.
The Journal of biological chemistry.
1963 Feb; 238(?):717-8. doi:
10.1016/s0021-9258(18)81324-2. [PMID: 14010661]