3',4'-Dimethoxyflavone (BioDeep_00000174111)

Main id: BioDeep_00000286479

 

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


2-(3,4-dimethoxyphenyl)-4H-chromen-4-one

化学式: C17H14O4 (282.0892)
中文名称: 3,4-二甲氧基黄酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c12c(c(=O)cc(o1)c1cc(c(cc1)OC)OC)cccc2
InChI: InChI=1S/C17H14O4/c1-19-15-8-7-11(9-17(15)20-2)16-10-13(18)12-5-3-4-6-14(12)21-16/h3-10H,1-2H3

描述信息

3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects[1][2][3][4].
3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects[1][2][3][4].

同义名列表

5 个代谢物同义名

2-(3,4-dimethoxyphenyl)-4H-chromen-4-one; 2-(3,4-dimethoxyphenyl)chromen-4-one; 3,4-Dimethoxyflavone; 3,4-DMF; 3',4'-Dimethoxyflavone



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

18 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Nadja Kampschulte, Tim Berking, Ibrahim E Çelik, Stefan F Kirsch, Nils Helge Schebb. Inhibition of cytochrome P450 monooxygenase-catalyzed oxylipin formation by flavonoids: Evaluation of structure-activity relationship towards CYP4F2-selective inhibitors. European journal of medicinal chemistry. 2022 Aug; 238(?):114332. doi: 10.1016/j.ejmech.2022.114332. [PMID: 35576701]
  • Yuan Zhu, Jun Wen, Yuqing Cao, Yuanying Jiang, Jinghua Huang, Guorong Fan, Yuefen Lou. Identification of 3',4'-Dimethoxy Flavonol-3-β-d-Glucopyranoside Metabolites in Rats by Liquid Chromatography-Electrospray Ionization Ion Trap Mass Spectrometry. Molecules (Basel, Switzerland). 2016 Apr; 21(4):470. doi: 10.3390/molecules21040470. [PMID: 27070571]
  • Ke Wang, Chenchen Feng, Chenggang Li, Jun Yao, Xiaofeng Xie, Likun Gong, Yang Luan, Guozhen Xing, Xue Zhu, Xinming Qi, Jin Ren. Baicalin Protects Mice from Aristolochic Acid I-Induced Kidney Injury by Induction of CYP1A through the Aromatic Hydrocarbon Receptor. International journal of molecular sciences. 2015 Jul; 16(7):16454-68. doi: 10.3390/ijms160716454. [PMID: 26204831]
  • Cristina M Jimenez, Diego A Sampietro, Melina A Sgariglia, José R Soberón, Marta A Vattuone. Isolation, identification and usefulness of antifungal compounds from Zuccagnia punctata for control of toxigenic ear rot pathogens. Natural product communications. 2014 Oct; 9(10):1461-4. doi: ". [PMID: 25522536]
  • Shinsuke Kido, Marina Fujihara, Kengo Nomura, Shohei Sasaki, Rie Mukai, Ritsuko Ohnishi, Ichiro Kaneko, Hiroko Segawa, Sawako Tatsumi, Hiroto Izumi, Kimitoshi Kohno, Ken-ichi Miyamoto. Molecular mechanisms of cadmium-induced fibroblast growth factor 23 upregulation in osteoblast-like cells. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jun; 139(2):301-16. doi: 10.1093/toxsci/kfu043. [PMID: 24614234]
  • Yan Li, Hu Mei, Qiangen Wu, Suhui Zhang, Jia-Long Fang, Leming Shi, Lei Guo. Methysticin and 7,8-dihydromethysticin are two major kavalactones in kava extract to induce CYP1A1. Toxicological sciences : an official journal of the Society of Toxicology. 2011 Dec; 124(2):388-99. doi: 10.1093/toxsci/kfr235. [PMID: 21908763]
  • Fiona Whelan, Nan Hao, Sebastian G B Furness, Murray L Whitelaw, Anne Chapman-Smith. Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Molecular pharmacology. 2010 Jun; 77(6):1037-46. doi: 10.1124/mol.109.062927. [PMID: 20231332]
  • Ganesh Rajaraman, Guixiang Yang, Jie Chen, Thomas K H Chang. Modulation of CYP1B1 and CYP1A1 gene expression and activation of aryl hydrocarbon receptor by Ginkgo biloba extract in MCF-10A human mammary epithelial cells. Canadian journal of physiology and pharmacology. 2009 Sep; 87(9):674-83. doi: 10.1139/y09-061. [PMID: 19794518]
  • Hidenori Kuwabara, Kyoko Mouri, Hideaki Otsuka, Ryoji Kasai, Kazuo Yamasaki. Tricin from a malagasy connaraceous plant with potent antihistaminic activity. Journal of natural products. 2003 Sep; 66(9):1273-5. doi: 10.1021/np030020p. [PMID: 14510616]