Boswellic acid (BioDeep_00000017375)

 

Secondary id: BioDeep_00000176405, BioDeep_00000404125

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid

化学式: C30H48O3 (456.36032579999994)
中文名称: β-Boswellic acid, beta-乳香酸, β-乳香酸, 乳香酸
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 5.56%

分子结构信息

SMILES: C1[C@H]([C@@]([C@H]2[C@](C1)([C@@H]1[C@@](CC2)([C@]2(C(=CC1)[C@H]1[C@@](CC2)(CC[C@H]([C@@H]1C)C)C)C)C)C)(C(=O)O)C)O
InChI: InChI=1S/C30H48O3/c1-18-10-13-26(3)16-17-28(5)20(24(26)19(18)2)8-9-21-27(4)14-12-23(31)30(7,25(32)33)22(27)11-15-29(21,28)6/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)

描述信息

Boswellic acid (BA) is an active component of Boswellia serrata (also known as Salai guggul). Extensive research in the past 30 years identified the active component of this resin as BA (a pentacyclic triterpenic acid) and its derivatives (acetyl-beta-boswellic acid, 11-keto-beta-boswellic acid and acetyl-11-keto-beta-boswellic acid). In animal models of inflammation, BA has been shown to be an effective adjuvant mitigating bovine serum albumin-induced arthritis and osteoarthritis. The anti-arthritic potential of BA is a result of its anti-inflammatory activity, mediated through inhibition of NF-kB, COX-2 and 5-LOX. ((PMID: 17475558, 3429205).
Boswellic acid is a triterpenoid.
beta-Boswellic acid is a natural product found in Cyclocarya paliurus, Boswellia papyrifera, and other organisms with data available.
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation[1]. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells[2].
β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation[1]. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells[2].
β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation[1]. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells[2].

同义名列表

24 个代谢物同义名

(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid; (3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bR)-3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picene-4-carboxylic acid; .BETA.-BOSWELLIC ACID (CONSTITUENT OF BOSWELLIA SERRATA) [DSC]; Urs-12-en-23-oic acid, 3-hydroxy-, (3.alpha.,4.beta.)-; Urs-12-en-23-oic acid, 3-hydroxy-, (3alpha,4beta)-; (3alpha,4beta)-3-hydroxy-Urs-12-en-23-oic acid; (3alpha,4beta)-3-hydroxy-Urs-12-en-23-oate; Urs-12-en-24-oic acid, 3.alpha.-hydroxy-; (4R)-3alpha-Hydroxyurs-12-en-24-oic acid; beta-Boswellic acid, analytical standard; 3.ALPHA.-HYDROXYURS-12-EN-24-OIC ACID; 3-Hydroxy-12-ursen-24-oic acid; .BETA.-BOSWELLIC ACID [MI]; .BETA.-BOSWELLIC ACID; beta-Boswellic Acid; b-Boswellic acid; β-Boswellic acid; beta-Boswellate; boswellic acid; Β-boswellate; b-Boswellate; Boswellate; 3-hydroxy-4,6a,6b,8a,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picene-4-carboxylic acid; SCHEMBL18306261



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jakob Lauß, Christoph Kappacher, Olivia Isser, Christian W Huck, Matthias Rainer. Species-Specific quantification of bioactive boswellic acids in Boswellia resin using NIR spectroscopy, HPLC and Multivariate data analysis. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2024 Aug; 316(?):124384. doi: 10.1016/j.saa.2024.124384. [PMID: 38701576]
  • Ehab A Ragab, Mohammed F Abd El-Wahab, Ahmed S Doghish, Rania M Salama, Nermin Eissa, Samar F Darwish. The journey of boswellic acids from synthesis to pharmacological activities. Naunyn-Schmiedeberg's archives of pharmacology. 2024 03; 397(3):1477-1504. doi: 10.1007/s00210-023-02725-w. [PMID: 37740772]
  • Smruti Mukadam, Chetana Ghule, Aboli Girme, Vaibhav M Shinde, Lal Hingorani, Kakasaheb R Mahadik. A Simple HPTLC Approach of Quantification of Serratol and Tirucallic Acid with Boswellic Acids in Boswellia serrata by Validated Densitometric Method with MS/MS Characterization. Journal of chromatographic science. 2023 Mar; ?(?):. doi: 10.1093/chromsci/bmad012. [PMID: 36892162]
  • Friedemann Börner, Simona Pace, Paul M Jordan, Jana Gerstmeier, Mario Gomez, Antonietta Rossi, Nathaniel C Gilbert, Marcia E Newcomer, Oliver Werz. Allosteric Activation of 15-Lipoxygenase-1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023 02; 10(6):e2205604. doi: 10.1002/advs.202205604. [PMID: 36567268]
  • Akhalesh Kumar, Saurabh Sharma, Sudhanshu Mishra, Smriti Ojha, Pawan Upadhyay. ADME Prediction, Structure-activity Relationship of Boswellic Acid Scaffold for the Aspect of Anticancer & Anti-inflammatory Potency. Anti-cancer agents in medicinal chemistry. 2023; 23(13):1499-1505. doi: 10.2174/1871520623666230417080437. [PMID: 37070442]
  • Arezoo Rajabian, Mohammadreza Farzanehfar, Hossein Hosseini, Fahimeh Lavi Arab, Ali Nikkhah. Boswellic acids as promising agents for the management of brain diseases. Life sciences. 2023 Jan; 312(?):121196. doi: 10.1016/j.lfs.2022.121196. [PMID: 36400202]
  • Faezeh Khaafi, Behjat Javadi. Molecular Targets Underlying the Neuroprotective Effects of Boswellic Acid: A Systematic Review. Mini reviews in medicinal chemistry. 2023; 23(19):1912-1925. doi: 10.2174/1389557523666230330113611. [PMID: 36998129]
  • Eman A Mohamed, Hebatalla I Ahmed, Heba S Zaky, Amira M Badr. Boswellic acids ameliorate neurodegeneration induced by AlCl3: the implication of Wnt/β-catenin pathway. Environmental science and pollution research international. 2022 Oct; 29(50):76135-76143. doi: 10.1007/s11356-022-20611-5. [PMID: 35668264]
  • Ya-Chu Tsai, Hsun-Hao Chang, Sheng-Chieh Chou, Thomas W Chu, Yu-Jou Hsu, Chien-Yu Hsiao, Yuan-Hsin Lo, Nan-Lin Wu, Der-Chen Chang, Chi-Feng Hung. Evaluation of the Anti-Atopic Dermatitis Effects of α-Boswellic Acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice. International journal of molecular sciences. 2022 Aug; 23(17):. doi: 10.3390/ijms23179863. [PMID: 36077254]
  • David Banji, Otilia J F Banji, Shaik Rashida, Saeed Alshahrani, Saad S Alqahtani. Bioavailability, anti-inflammatory and anti-arthritic effect of Acetyl Keto Boswellic acid and its combination with methotrexate in an arthritic animal model. Journal of ethnopharmacology. 2022 Jun; 292(?):115200. doi: 10.1016/j.jep.2022.115200. [PMID: 35306043]
  • Petr Jaroš, Elizaveta Timkina, Jana Michailidu, Dominik Maršík, Markéta Kulišová, Irena Kolouchová, Kateřina Demnerová. Boswellic Acids as Effective Antibacterial Antibiofilm Agents. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123795. [PMID: 35744925]
  • Huiqiang Wei, Jianghong Guo, Xiao Sun, Wenfeng Gou, Hongxin Ning, Haihua Shang, Qiang Liu, Wenbin Hou, Yiliang Li. Discovery of Natural Ursane-type SENP1 Inhibitors and the Platinum Resistance Reversal Activity Against Human Ovarian Cancer Cells: A Structure-Activity Relationship Study. Journal of natural products. 2022 05; 85(5):1248-1255. doi: 10.1021/acs.jnatprod.1c01166. [PMID: 35500202]
  • Marzieh Dehghan Shasaltaneh, Nasser Naghdi, Sadrollah Ramezani, Leila Alizadeh, Gholam Hossein Riazi. Protection of Beta Boswellic Acid against Streptozotocin-induced Alzheimer's Model by Reduction of Tau Phosphorylation Level and Enhancement of Reelin Expression. Planta medica. 2022 Apr; 88(5):367-379. doi: 10.1055/a-1502-7083. [PMID: 34116571]
  • Ajmal Khan, Imran Khan, Sobia Ahsan Halim, Najeeb Ur Rehman, Nasiara Karim, Waqar Ahmad, Majid Khan, Rene Csuk, Ahmed Al-Harrasi. Anti-diabetic potential of β-boswellic acid and 11-keto-β-boswellic acid: Mechanistic insights from computational and biochemical approaches. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Mar; 147(?):112669. doi: 10.1016/j.biopha.2022.112669. [PMID: 35121344]
  • Piao Zheng, Zhen Huang, Dong-Chang Tong, Qing Zhou, Sha Tian, Bo-Wei Chen, Di-Min Ning, Yin-Mei Guo, Wen-Hao Zhu, Yan Long, Wei Xiao, Zhe Deng, Yi-Chen Lei, Xue-Fei Tian. Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World journal of gastrointestinal oncology. 2022 Feb; 14(2):450-477. doi: 10.4251/wjgo.v14.i2.450. [PMID: 35317323]
  • Reinhard H Caliebe, Thomas Scior, Hermann P T Ammon. Binding of boswellic acids to functional proteins of the SARS-CoV-2 virus: Bioinformatic studies. Archiv der Pharmazie. 2021 Nov; 354(11):e2100160. doi: 10.1002/ardp.202100160. [PMID: 34427335]
  • Adel A Gomaa, Hanan A Farghaly, Yasmin A Abdel-Wadood, Ghada A Gomaa. Potential therapeutic effects of boswellic acids/Boswellia serrata extract in the prevention and therapy of type 2 diabetes and Alzheimer's disease. Naunyn-Schmiedeberg's archives of pharmacology. 2021 11; 394(11):2167-2185. doi: 10.1007/s00210-021-02154-7. [PMID: 34542667]
  • Aashish Kumar, Payal Srivastava, Gaurav Srivastava, Sandeep, Narendra Kumar, Chandan S Chanotiya, Sumit Ghosh. BAHD acetyltransferase contributes to wound-induced biosynthesis of oleo-gum resin triterpenes in Boswellia. The Plant journal : for cell and molecular biology. 2021 09; 107(5):1403-1419. doi: 10.1111/tpj.15388. [PMID: 34165841]
  • Münteha Özsoy, Vesen Atiroğlu, Gamze Guney Eskiler, Atheer Atiroğlu, Asuman Deveci Ozkan, Mahmut Özacar. A protein-sulfosalicylic acid/boswellic acids @metal-organic framework nanocomposite as anticancer drug delivery system. Colloids and surfaces. B, Biointerfaces. 2021 Aug; 204(?):111788. doi: 10.1016/j.colsurfb.2021.111788. [PMID: 33932885]
  • Adel A Gomaa, Hamdy S Mohamed, Rasha Bakheet Abd-Ellatief, Mohamed A Gomaa. Boswellic acids/Boswellia serrata extract as a potential COVID-19 therapeutic agent in the elderly. Inflammopharmacology. 2021 Aug; 29(4):1033-1048. doi: 10.1007/s10787-021-00841-8. [PMID: 34224069]
  • Michael Zwerger, Markus Ganzera. Analysis of boswellic acids in dietary supplements containing Indian frankincense (Boswellia serrata) by Supercritical Fluid Chromatography. Journal of pharmaceutical and biomedical analysis. 2021 Jul; 201(?):114106. doi: 10.1016/j.jpba.2021.114106. [PMID: 33962180]
  • Hippolyt L Greve, Marcel Kaiser, Pascal Mäser, Thomas J Schmidt. Boswellic Acids Show In Vitro Activity against Leishmania donovani. Molecules (Basel, Switzerland). 2021 Jun; 26(12):. doi: 10.3390/molecules26123651. [PMID: 34203815]
  • Xinyu Wang, Huibo Lei, Xiaopo Qi, Xin Guo, Xike Xu, Xianpeng Zu, Ji Ye. Simultaneous determination of five bioactive components of XiaoJin Capsule in normal and mammary gland hyperplasia rat plasma using LC-MS/MS and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2021 Mar; 35(3):e5000. doi: 10.1002/bmc.5000. [PMID: 33460195]
  • Muhammad Hassaan Shahid, Irfan Anjum, Muhammad Naveed Mushtaq, Saba Riaz. Cardioprotective effect of boswellic acids against doxorubicin induced myocardial infarction in rats. Pakistan journal of pharmaceutical sciences. 2021 Jan; 34(1(Supplementary)):359-365. doi: ". [PMID: 34275862]
  • Lubna Abidin, Prerna Singla, Hina Kausar, Mohd Mujeeb, Abdur Rahman, Mohd Aqil, Abul Kalam Najmi. Extraction of 11-Keto-β -Boswellic Acid from Indian Olibanum by Contemporary Extraction Modes: Optimization and Validation of HPTLC. Combinatorial chemistry & high throughput screening. 2021; 24(8):1309-1321. doi: 10.2174/1386207323666200914091733. [PMID: 32928084]
  • Chiara Caterino, Federica Aragosa, Giovanni Della Valle, Dario Costanza, Francesco Lamagna, Alfonso Piscitelli, Annalisa Nieddu, Gerardo Fatone. Clinical efficacy of Curcuvet and Boswellic acid combined with conventional nutraceutical product: An aid to canine osteoarthritis. PloS one. 2021; 16(5):e0252279. doi: 10.1371/journal.pone.0252279. [PMID: 34048452]
  • Bandar E Al-Dhubiab, Snehal S Patel, Mohamed A Morsy, Harika Duvva, Anroop B Nair, Pran Kishore Deb, Jigar Shah. The Beneficial Effect of Boswellic Acid on Bone Metabolism and Possible Mechanisms of Action in Experimental Osteoporosis. Nutrients. 2020 Oct; 12(10):. doi: 10.3390/nu12103186. [PMID: 33081068]
  • Amy M Zimmermann-Klemd, Jakob K Reinhardt, Thanasan Nilsu, Anna Morath, Chiara M Falanga, Wolfgang W Schamel, Roman Huber, Matthias Hamburger, Carsten Gründemann. Boswellia carteri extract and 3-O-acetyl-alpha-boswellic acid suppress T cell function. Fitoterapia. 2020 Oct; 146(?):104694. doi: 10.1016/j.fitote.2020.104694. [PMID: 32712132]
  • Ganpeng Yu, Wang Xiang, Tianqing Zhang, Liuting Zeng, Kailin Yang, Jun Li. Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC complementary medicine and therapies. 2020 Jul; 20(1):225. doi: 10.1186/s12906-020-02985-6. [PMID: 32680575]
  • Umair Shamraiz, Hidayat Hussain, Najeeb Ur Rehman, Sulaiman Al-Shidhani, Aasim Saeed, Husain Yar Khan, Ajmal Khan, Lucie Fischer, René Csuk, Amin Badshah, Ahmed Al-Rawahi, Javid Hussain, Ahmed Al-Harrasi. Synthesis of new boswellic acid derivatives as potential antiproliferative agents. Natural product research. 2020 Jul; 34(13):1845-1852. doi: 10.1080/14786419.2018.1564295. [PMID: 30691289]
  • Bruna Girardi, Maria Pricci, Floriana Giorgio, Mariano Piazzolla, Andrea Iannone, Giuseppe Losurdo, Mariabeatrice Principi, Michele Barone, Enzo Ierardi, Alfredo Di Leo. Silymarin, boswellic acid and curcumin enriched dietetic formulation reduces the growth of inherited intestinal polyps in an animal model. World journal of gastroenterology. 2020 Apr; 26(14):1601-1612. doi: 10.3748/wjg.v26.i14.1601. [PMID: 32327909]
  • Tarun Sharma, Snehasis Jana. Investigation of Molecular Properties that Influence the Permeability and Oral Bioavailability of Major β-Boswellic Acids. European journal of drug metabolism and pharmacokinetics. 2020 Apr; 45(2):243-255. doi: 10.1007/s13318-019-00599-z. [PMID: 31786725]
  • Anna Lewinska, Lakshman Sodagam, Dominika Bloniarz, Karsten Siems, Maciej Wnuk, Suresh I S Rattan. Plant-Derived Molecules α-Boswellic Acid Acetate, Praeruptorin-A, and Salvianolic Acid-B Have Age-Related Differential Effects in Young and Senescent Human Fibroblasts In Vitro. Molecules (Basel, Switzerland). 2019 Dec; 25(1):. doi: 10.3390/molecules25010141. [PMID: 31905790]
  • Somayeh Mahmoodi Baram, Saeed Karima, Somayeh Shateri, Abbas Tafakhori, Akbar Fotouhi, Behnam Safarpour Lima, Shima Rajaei, Meisam Mahdavi, Hessam Sepasi Tehrani, Vajiheh Aghamollaii, Seyed Hossein Aghamiri, Behnam Mansouri, Sina Gharahje, Samaneh Kabiri, Maryamosadat Hosseinizadeh, Shima Zare Shahamati, Amir Taher Alborzi. Functional improvement and immune-inflammatory cytokines profile of ischaemic stroke patients after treatment with boswellic acids: a randomized, double-blind, placebo-controlled, pilot trial. Inflammopharmacology. 2019 Dec; 27(6):1101-1112. doi: 10.1007/s10787-019-00627-z. [PMID: 31407195]
  • Dongrui Liang, Zhangchi Ning, Zhiqian Song, Chun Wang, Yuanyan Liu, Xiaoying Wan, Shitao Peng, Zhenli Liu, Aiping Lu. The Effects of Vinegar Processing on the Changes in the Physical Properties of Frankincense Related to the Absorption of the Main Boswellic Acids. Molecules (Basel, Switzerland). 2019 Sep; 24(19):. doi: 10.3390/molecules24193453. [PMID: 31547594]
  • Nand Kishor Roy, Dey Parama, Kishore Banik, Devivasha Bordoloi, Amrita Khwairakpam Devi, Krishan Kumar Thakur, Ganesan Padmavathi, Mehdi Shakibaei, Lu Fan, Gautam Sethi, Ajaikumar B Kunnumakkara. An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases. International journal of molecular sciences. 2019 Aug; 20(17):. doi: 10.3390/ijms20174101. [PMID: 31443458]
  • Michael Schmiech, Sophia J Lang, Katharina Werner, Luay J Rashan, Tatiana Syrovets, Thomas Simmet. Comparative Analysis of Pentacyclic Triterpenic Acid Compositions in Oleogum Resins of Different Boswellia Species and Their In Vitro Cytotoxicity against Treatment-Resistant Human Breast Cancer Cells. Molecules (Basel, Switzerland). 2019 Jun; 24(11):. doi: 10.3390/molecules24112153. [PMID: 31181656]
  • Manlio Barbarisi, Alfonso Barbarisi, Gabriele De Sena, Emilia Armenia, Caterina Aurilio, Michele Libutti, Rosario Vincenzo Iaffaioli, Gerardo Botti, Nicola Maurea, Vincenzo Quagliariello. Boswellic acid has anti-inflammatory effects and enhances the anticancer activities of Temozolomide and Afatinib, an irreversible ErbB family blocker, in human glioblastoma cells. Phytotherapy research : PTR. 2019 06; 33(6):1670-1682. doi: 10.1002/ptr.6354. [PMID: 30924205]
  • Muhammed Majeed, Shaheen Majeed, Narayanan K Narayanan, Kalyanam Nagabhushanam. A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytotherapy research : PTR. 2019 May; 33(5):1457-1468. doi: 10.1002/ptr.6338. [PMID: 30838706]
  • Antonella Riva, Luca Giacomelli, Stefano Togni, Federico Franceschi, Roberto Eggenhoffner, Maria Chiara Zuccarini, Gianni Belcaro. Oral administration of a lecithin-based delivery form of boswellic acids (Casperome®) for the prevention of symptoms of irritable bowel syndrome: a randomized clinical study. Minerva gastroenterologica e dietologica. 2019 Mar; 65(1):30-35. doi: 10.23736/s1121-421x.18.02530-8. [PMID: 30676012]
  • Mohamed A Morsy, Snehal S Patel, Azza A K El-Sheikh, Jignasa K Savjani, Anroop B Nair, Jigar N Shah, Katharigatta N Venugopala. Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor. Mediators of inflammation. 2019; 2019(?):3041438. doi: 10.1155/2019/3041438. [PMID: 31263381]
  • Debayan Goswami, Ananya Das Mahapatra, Subhadip Banerjee, Amit Kar, Durbadal Ojha, Pulok K Mukherjee, Debprasad Chattopadhyay. Boswellia serrata oleo-gum-resin and β-boswellic acid inhibits HSV-1 infection in vitro through modulation of NF-кB and p38 MAP kinase signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Dec; 51(?):94-103. doi: 10.1016/j.phymed.2018.10.016. [PMID: 30466633]
  • Mohamed T Khayyal, Rania M El-Hazek, Walaa A El-Sabbagh, Jan Frank, Dariush Behnam, Mona Abdel-Tawab. Micellar solubilisation enhances the antiinflammatory activities of curcumin and boswellic acids in rats with adjuvant-induced arthritis. Nutrition (Burbank, Los Angeles County, Calif.). 2018 10; 54(?):189-196. doi: 10.1016/j.nut.2018.03.055. [PMID: 30048884]
  • Haroon Khan, Kannan R R Rengasamy, Aini Pervaiz, Seyed Mohammad Nabavi, Atanas G Atanasov, Mohammad A Kamal. Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation. European journal of medicinal chemistry. 2018 Jun; 153(?):2-28. doi: 10.1016/j.ejmech.2017.12.059. [PMID: 29329790]
  • Gianni Belcaro, Mark Dugall, Roberta Luzzi, Morio Hosoi, Andrea Ledda, Beatrice Feragalli, Shu Hu, Apurba Ganguly, Roberto Eggenhoffner, Ambra Corti, Luca Giacomelli. Phytoproflex®: supplementary management of osteoarthrosis: a supplement registry. Minerva medica. 2018 Apr; 109(2):88-94. doi: 10.23736/s0026-4806.17.05460-x. [PMID: 29534559]
  • Dan Wang, Shuke Ge, Jichang Bai, Yongwei Song. Boswellic acid exerts potent anticancer effects in HCT-116 human colon cancer cells mediated via induction of apoptosis, cell cycle arrest, cell migration inhibition and inhibition of PI3K/AKT signalling pathway. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2018 Mar; 23(2):340-345. doi: ". [PMID: 29745074]
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