3'-Hydroxy-4',5,6,7,8-pentamethoxyflavone (BioDeep_00000017363)

   

human metabolite PANOMIX_OTCML-2023 Endogenous Antitumor activity


代谢物信息卡片


4H-1-Benzopyran-4-one, 2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxy-

化学式: C20H20O8 (388.115812)
中文名称: 3'-去甲川陈皮素, 3-去甲川陈皮素, 3'-去甲川陈皮素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 20.93%

分子结构信息

SMILES: c1(c(c(c2c(c1OC)oc(cc2=O)c1ccc(c(c1)O)OC)OC)OC)OC
InChI: InChI=1S/C20H20O8/c1-23-13-7-6-10(8-11(13)21)14-9-12(22)15-16(24-2)18(25-3)20(27-5)19(26-4)17(15)28-14/h6-9,21H,1-5H3

描述信息

3-Hydroxy-4,5,6,7,8-pentamethoxyflavone is a member of flavonoids and an ether.
2-(3-Hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one is a natural product found in Citrus kinokuni, Citrus deliciosa, and other organisms with data available.
See also: Tangerine peel (part of).
3-Hydroxy-4,5,6,7,8-pentamethoxyflavone is found in citrus. 3-Hydroxy-4,5,6,7,8-pentamethoxyflavone is a constituent of mandarin orange (Citrus reticulata)
Constituent of mandarin orange (Citrus reticulata). 3-Hydroxy-4,5,6,7,8-pentamethoxyflavone is found in citrus.
3'-Demethylnobiletin, a derivative of Nobiletin, is a polymethoxyflavonoid in citrus fruits[1]. Nobiletin exhibits anticancer activity and inhibits tumor angiogenesis by regulating Src, FAK, and STAT3 signaling[2].
3'-Demethylnobiletin, a derivative of Nobiletin, is a polymethoxyflavonoid in citrus fruits[1]. Nobiletin exhibits anticancer activity and inhibits tumor angiogenesis by regulating Src, FAK, and STAT3 signaling[2].

同义名列表

11 个代谢物同义名

4H-1-Benzopyran-4-one, 2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxy-; 2-(3-HYDROXY-4-METHOXYPHENYL)-5,6,7,8-TETRAMETHOXY-4H-1-BENZOPYRAN-4-ONE; 2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxy-4H-chromen-4-one; 2-(3-hydroxy-4-methoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one; 3-hydroxy-5,6,7,8,4-pentamethoxyflavone; 3-Hydroxy-4,5,6,7,8-pentamethoxyflavone; 3'-Demethylnobiletin; 3-Demethylnobiletin; UNII-96E9T839AP; 96E9T839AP; 3'-Demethylnobiletin



数据库引用编号

13 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Shiming Li, Shengmin Sang, Min-Hsiung Pan, Ching-Shu Lai, Chih-Yu Lo, Chung S Yang, Chi-Tang Ho. Anti-inflammatory property of the urinary metabolites of nobiletin in mouse. Bioorganic & medicinal chemistry letters. 2007 Sep; 17(18):5177-81. doi: 10.1016/j.bmcl.2007.06.096. [PMID: 17644380]
  • Shiming Li, Min-Hsiung Pan, Ching-Shu Lai, Chih-Yu Lo, Slavik Dushenkov, Chi-Tang Ho. Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorganic & medicinal chemistry. 2007 May; 15(10):3381-9. doi: 10.1016/j.bmc.2007.03.021. [PMID: 17391969]
  • Zhenyu Wang, Shiming Li, Malgorzata Jonca, Ted Lambros, Stephen Ferguson, Robert Goodnow, Chi-Tang Ho. Comparison of supercritical fluid chromatography and liquid chromatography for the separation of urinary metabolites of nobiletin with chiral and non-chiral stationary phases. Biomedical chromatography : BMC. 2006 Nov; 20(11):1206-15. doi: 10.1002/bmc.686. [PMID: 16799930]