Troxerutin (BioDeep_00000017276)

 

Secondary id: BioDeep_00000600181

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


2-(3,4-bis(2-hydroxyethoxy)phenyl)-5-hydroxy-7-(2-hydroxyethoxy)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

化学式: C33H42O19 (742.2320182000001)
中文名称: 三氧乙基芦丁, 维生素P4, 曲克芦丁, 托克芦丁, 维脑路通, 曲可芦丁
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 5.56%

分子结构信息

SMILES: CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)OCCO)C5=CC(=C(C=C5)OCCO)OCCO)O)O)O)O)O)O
InChI: InChI=1S/C33H42O19/c1-14-23(38)26(41)28(43)32(49-14)48-13-21-24(39)27(42)29(44)33(51-21)52-31-25(40)22-17(37)11-16(45-7-4-34)12-20(22)50-30(31)15-2-3-18(46-8-5-35)19(10-15)47-9-6-36/h2-3,10-12,14,21,23-24,26-29,32-39,41-44H,4-9,13H2,1H3/t14-,21+,23-,24+,26+,27-,28+,29+,32+,33-/m0/s1

描述信息

Troxerutin is a rutoside, a naturally occurring flavonoid. Flavonoids are polyphenolic compounds that are present in most fruits and vegetables. Although flavonoids are devoid of classical nutritional value, they are increasingly viewed as beneficial dietary components that act as potential protectors against human diseases such as coronary heart disease, cancers, and inflammatory bowel disease. Troxerutin is a beneficial cofactor in coumarin preparations used for the therapy of chronic venous insufficiency, since has hepatoprotective properties and thus protects the liver from a possible lipid peroxidation caused by coumarin. Oxidative stress might be involved in the upregulation of retinal vascular endothelial growth factor (VEGF) during early diabetes, and it is likely that troxerutin has comparatively effective antioxidant properties; therefore, troxerutin might be a useful treatment for attenuating diabetic retinopathy. Troxerutin offers protection against gamma-radiation-induced micronuclei formation and DNA strand breaks and enhances repair of radiation-induced DNA strand breaks, in addition to anti-erythrocytic, anti-thrombic, fibrinolytic and oedema-protective rheological activity. (PMID: 15601310, 15693708, 16294503, 16311905).
C - Cardiovascular system > C05 - Vasoprotectives > C05C - Capillary stabilizing agents > C05CA - Bioflavonoids
Troxerutin has been used in trials studying the treatment of Chronic Venous Insufficiency.
D006401 - Hematologic Agents > D000925 - Anticoagulants
C26170 - Protective Agent > C275 - Antioxidant
Bioflavonoid
Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.
Troxerutin, also known as vitamin P4, is a tri-hydroxyethylated derivative of natural bioflavonoid rutins which can inhibit the production of reactive oxygen species (ROS) and depress ER stress-mediated NOD activation.

同义名列表

88 个代谢物同义名

2-(3,4-bis(2-hydroxyethoxy)phenyl)-5-hydroxy-7-(2-hydroxyethoxy)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; 2-(3,4-bis(2-hydroxyethoxy)phenyl)-5-hydroxy-7-(2-hydroxyethoxy)-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)methyl)tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one; 2-[3,4-bis(2-hydroxyethyloxy)phenyl]-7-(2-hydroxyethyloxy)-3-[(2S,3R,4S,5S,6R)-6-[[(2R,3R,4R,5R,6S)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl]oxymethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-oxidanyl-chromen-4-one; 2-[3,4-bis(2-hydroxyethoxy)phenyl]-5-hydroxy-7-(2-hydroxyethoxy)-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-4H-chromen-4-one; 2-[3,4-bis(2-hydroxyethoxy)phenyl]-5-hydroxy-7-(2-hydroxyethoxy)-3-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-oxanyl]oxymethyl]-2-oxanyl]oxy]-1-benzopyran-4-one; 2-[3,4-bis(2-hydroxyethoxy)phenyl]-5-hydroxy-7-(2-hydroxyethoxy)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one; 4H-1-BENZOPYRAN-4-ONE, 2-(3,4-BIS(2-HYDROXYETHOXY)PHENYL)-3-((6-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-5-HYDROXY-7-(2-HYDROXYETHOXY)-; 4H-1-Benzopyran-4-one, 2-[3,4-bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-; 2-(3,4-Bis(2-hydroxyethoxy)phenyl)-3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-7-(2-hydroxy ethoxy)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one,2-[3,4-bis(2-hydroxyethoxy)phenyl]-3-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-hydroxy-7-(2-hydroxyethoxy)-; Flavone, 3,5-dihydroxy-3,4,7-tris(2-hydroxyethoxy)-, 3-(6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside); 3-[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-delta-glucopyranoside]3,5-dihydroxy-3,4,7-tris(2-hydroxyethoxy)-Flavone; 3-[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranoside]3,5-dihydroxy-3,4,7-tris(2-hydroxyethoxy)-Flavone; 3,5-Dihydroxy-3,4,7-tris(2-hydroxyethoxy)flavone 3-rutinoside; Troxerutin, European Pharmacopoeia (EP) Reference Standard; O-(.BETA.-HYDROXYETHYL)RUTOSIDE, (3,4,7)-TRI-; 3,4,7-tris(O-(2- hydroxyethyl))rutin; 3,4,7-Tri-O-(b-hydroxyethyl)rutoside; Trihydroxyethylrutin, >=80\\% (HPLC); 7,3,4-Tris(O-(2-hydroxyethyl)rutin; Trihydroxyethylrutoside [French]; SUCCINIMIDYLN-METHYLANTHRANILATE; Tris-O-(b-hydroxyethyl)rutoside; 3,4,7-Tris(hydroxyethyl)rutin; Tris-O-(2-hydroxyethyl)rutin; IYVFNTXFRYQLRP-VVSTWUKXSA-N; Tris(hydroxyethyl)rutoside; 3,4,7-trihydroxyethylrutin; Troxerutina [INN-Spanish]; TROXERUTIN [EP MONOGRAPH]; Troxerutine [INN-French]; Troxerutinum [INN-Latin]; Troxerutin [INN:BAN:DCF]; Tris(hydroxyethyl)rutin; Trihydroxyethylrutoside; Troxarutin-ratiopharm; Troxerutin-ratiopharm; Trihydroxyethylrutin; TROXERUTIN [WHO-DD]; TROXERUTIN [MART.]; TROXERUTIN [INCI]; Troxerutin (85\\%); Veinamitol Pulver; Troxérutine Mazal; Troxerutin (INN); Trioxyethylrutin; TROXERUTIN [INN]; TROXERUTIN [MI]; UNII-7Y4N11PXO8; Venotrulan Trox; Troxerutin,(S); Veniten retard; Factor P-zyma; Venoruton gel; Tox21_111450; venoruton P4; Troxerutinum; Troxerutine; Troxerutina; Troksevazin; 7Y4N11PXO8; Troxarutin; Veinamitol; Troxerutin; vitamin P4; Pherarutin; Vastribil; Flavonoid; Pur-Rutin; Venorutin; Posorutin; Venoruton; Helveton; Venaroid; Rhéoflux; oxerutin; Troxeven; Rufen-P4; Paroven; Veniten; Teboven; Relvene; Veno SL; Flebil; TriHER; Z 6000; Ruven; thr



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

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BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhi-Fang Lan, Wei Yao, Yi-Ci Xie, Wushisi Chen, Yin-Ying Zhu, Jia-Qi Chen, Xing-Yi Zhou, Jun-Qing Huang, Man-Si Wu, Jia-Xu Chen. Oral Troxerutin Alleviates Depression Symptoms in Mice by Modulating Gut Microbiota and Microbial Metabolism. Molecular nutrition & food research. 2024 Feb; 68(3):e2300603. doi: 10.1002/mnfr.202300603. [PMID: 38072646]
  • Ran Liu, Yulian Wang, Wenhao Kuai, Wenting Li, Zengfa Wang, Liang Xiao, Jianhua Wu. Troxerutin suppress inflammation response and oxidative stress in jellyfish dermatitis by activating Nrf2/HO-1 signaling pathway. Frontiers in immunology. 2024; 15(?):1369849. doi: 10.3389/fimmu.2024.1369849. [PMID: 38779681]
  • Z Nonikashvili, R Jūratė Gerbutavičienė. Ginkgo biloba, troxerutin and heptaminol chlorhydrate combined treatment for the management of venous insufficiency and hemorrhoidal crises. European review for medical and pharmacological sciences. 2022 07; 26(14):5200-5209. doi: 10.26355/eurrev_202207_29309. [PMID: 35916818]
  • Hui Li, Min Yang, Danfei Lou. Troxerutin regulates HIF-1α by activating JAK2/STAT3 signaling to inhibit oxidative stress, inflammation, and apoptosis of cardiomyocytes induced by H2 O2. Drug development research. 2022 04; 83(2):552-563. doi: 10.1002/ddr.21885. [PMID: 34622462]
  • Ahmet Güzel, Alper Özorak, Taylan Oksay, Sefa Alperen Öztürk, Kemal Kürşat Bozkurt, Sedat Yunusoğlu, Efkan Uz, Abdulhadi Cihangir Uğuz, Pınar Aslan Koşar. The efficiency of oxerutin on apoptosis and kidney function in rats with renal ischemia reperfusion injury. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES. 2022 Mar; 28(3):344-351. doi: 10.14744/tjtes.2021.15740. [PMID: 35485553]
  • Hany H Arab, Sarah A Abd El-Aal, Ahmed H Eid, El-Shaimaa A Arafa, Ayman M Mahmoud, Ahmed M Ashour. Targeting inflammation, autophagy, and apoptosis by troxerutin attenuates methotrexate-induced renal injury in rats. International immunopharmacology. 2022 Feb; 103(?):108284. doi: 10.1016/j.intimp.2021.108284. [PMID: 34953450]
  • Marco Bagnati, Chiara Puricelli, Giulia Bauce, Matteo Basile, Barbara Grigollo, Flavia Prodam, Umberto Dianzani, Giorgio Bellomo, Roberta Rolla. Short-Term Effects of Supplemental L-Arginine, Diosmin, Troxerutin, and Hesperidin in Diabetic Patients: A Pilot Study. BioMed research international. 2021; 2021(?):3508281. doi: 10.1155/2021/3508281. [PMID: 34901269]
  • Chao Gao, Yunfei Song, Taotao Dou, Shuai Jiang, Haoze Wu, Vidya Devanathadesikan Seshadri, Vishnu Priya Veeraraghavan, Pengfei Hou. Troxerutin Abrogates Ischemic/Reperfusion-Induced Brain Injury through Ameliorating Oxidative Stress and Neuronal Inflammation by Inhibiting the Expression of NLRP3 in Sprague Dawley Rats. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2021; 40(4):11-19. doi: 10.1615/jenvironpatholtoxicoloncol.2021038860. [PMID: 34936296]
  • Ramachandran Vidhya, Carani Venkatraman Anuradha. Anti-inflammatory effects of troxerutin are mediated through elastase inhibition. Immunopharmacology and immunotoxicology. 2020 Oct; 42(5):423-435. doi: 10.1080/08923973.2020.1806870. [PMID: 32762381]
  • Ayat Kaeidi, Zahra Taghipour, Mohammad Allahtavakoli, Iman Fatemi, Elham Hakimizadeh, Jalal Hassanshahi. Ameliorating effect of troxerutin in unilateral ureteral obstruction induced renal oxidative stress, inflammation, and apoptosis in male rats. Naunyn-Schmiedeberg's archives of pharmacology. 2020 05; 393(5):879-888. doi: 10.1007/s00210-019-01801-4. [PMID: 31900517]
  • Afsaneh Ghadiri, Fariba Mirzaei Bavil, Gholam Reza Hamidian, Hajar Oghbaei, Zohreh Zavvari Oskuye, Mahdi Ahmadi, Rana Keyhanmanesh. Can troxerutin pretreatment prevent testicular complications in prepubertal diabetic male rats?. Endocrine regulations. 2020 Apr; 54(2):85-95. doi: 10.2478/enr-2020-0011. [PMID: 32597159]
  • Ying Li, Pan Ma, Jin Fu, Jingjing Wu, Xue Wu. Combining an in silico approach with an animal experiment to investigate the protective effect of troxerutin for treating acute lung injury. BMC complementary and alternative medicine. 2019 Jun; 19(1):124. doi: 10.1186/s12906-019-2515-7. [PMID: 31182097]
  • Nisha Susan Thomas, Kiran George, Athavan Alias Anand Selvam. Anticancer mechanism of troxerutin via targeting Nrf2 and NF-κB signalling pathways in hepatocarcinoma cell line. Toxicology in vitro : an international journal published in association with BIBRA. 2019 Feb; 54(?):317-329. doi: 10.1016/j.tiv.2018.10.018. [PMID: 30389603]
  • Xuan Yang, Wentao Xu, Kunlun Huang, Boyang Zhang, Haomiao Wang, Xueqin Zhang, Lijing Gong, Yunbo Luo, Xiaoyun He. Precision toxicology shows that troxerutin alleviates ochratoxin A-induced renal lipotoxicity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 02; 33(2):2212-2227. doi: 10.1096/fj.201800742r. [PMID: 30247986]
  • Fereshteh Dehnamaki, Akbar Karimi, Ali Asghar Pilevarian, Iman Fatemi, Elham Hakimizadeh, Ayat Kaeidi, Mohammad Allahtavakoli, Mohammad Reza Rahmani, Morteza Khademalhosseini, Gholamreza Bazmandegan. Treatment with troxerutin protects against cisplatin-induced kidney injury in mice. Acta chirurgica Belgica. 2019 Feb; 119(1):31-37. doi: 10.1080/00015458.2018.1455418. [PMID: 29653502]
  • Boobalan Raja, Dhanasekaran Saranya, Rajendran Prabhu. Role of flavonoid troxerutin on blood pressure, oxidative stress and regulation of lipid metabolism. Frontiers in bioscience (Elite edition). 2019 01; 11(1):121-129. doi: 10.2741/e851. [PMID: 30468643]
  • Hana Malinska, Martina Hüttl, Olena Oliyarnyk, Irena Markova, Martin Poruba, Zuzana Racova, Ludmila Kazdova, Rostislav Vecera. Beneficial effects of troxerutin on metabolic disorders in non-obese model of metabolic syndrome. PloS one. 2019; 14(8):e0220377. doi: 10.1371/journal.pone.0220377. [PMID: 31404079]
  • Samir A Salama, Hany H Arab, Ibrahim A Maghrabi. Troxerutin down-regulates KIM-1, modulates p38 MAPK signaling, and enhances renal regenerative capacity in a rat model of gentamycin-induced acute kidney injury. Food & function. 2018 Dec; 9(12):6632-6642. doi: 10.1039/c8fo01086b. [PMID: 30511081]
  • Perumal Elangovan, Ramalingam Ramakrishnan, Kasinathan Amudha, Abdulkadhar Mohamed Jalaludeen, Gunasekaran Karuna Sagaran, Frankline Rajan Babu, Leelavinothan Pari. Beneficial Protective Effect of Troxerutin on Nickel-Induced Renal Dysfunction in Wistar Rats. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2018; 37(1):1-14. doi: 10.1615/jenvironpatholtoxicoloncol.2017025087. [PMID: 29772996]
  • Qun Shan, Gui-Hong Zheng, Xin-Rui Han, Xin Wen, Shan Wang, Meng-Qiu Li, Juan Zhuang, Zi-Feng Zhang, Bin Hu, Yanqiu Zhang, Yuan-Lin Zheng. Troxerutin Protects Kidney Tissue against BDE-47-Induced Inflammatory Damage through CXCR4-TXNIP/NLRP3 Signaling. Oxidative medicine and cellular longevity. 2018; 2018(?):9865495. doi: 10.1155/2018/9865495. [PMID: 29849929]
  • Rajagopalan Geetha, Chandrasekaran Sathiya Priya, Carani Venkatraman Anuradha. Troxerutin abrogates mitochondrial oxidative stress and myocardial apoptosis in mice fed calorie-rich diet. Chemico-biological interactions. 2017 Dec; 278(?):74-83. doi: 10.1016/j.cbi.2017.09.012. [PMID: 28916335]
  • Nisha Susan Thomas, Kiran George, Sivaranjani Arivalagan, Vijay Mani, Aktarul Islam Siddique, Nalini Namasivayam. The in vivo antineoplastic and therapeutic efficacy of troxerutin on rat preneoplastic liver: biochemical, histological and cellular aspects. European journal of nutrition. 2017 Oct; 56(7):2353-2366. doi: 10.1007/s00394-016-1275-0. [PMID: 27488610]
  • Yongzhi Yu, Guanzhong Zheng. Troxerutin protects against diabetic cardiomyopathy through NF‑κB/AKT/IRS1 in a rat model of type 2 diabetes. Molecular medicine reports. 2017 Jun; 15(6):3473-3478. doi: 10.3892/mmr.2017.6456. [PMID: 28440404]
  • Tourandokht Baluchnejadmojarad, Nida Jamali-Raeufy, Sedigheh Zabihnejad, Nafiseh Rabiee, Mehrdad Roghani. Troxerutin exerts neuroprotection in 6-hydroxydopamine lesion rat model of Parkinson's disease: Possible involvement of PI3K/ERβ signaling. European journal of pharmacology. 2017 Apr; 801(?):72-78. doi: 10.1016/j.ejphar.2017.03.002. [PMID: 28284752]
  • Qun Shan, Juan Zhuang, Guihong Zheng, Zifeng Zhang, Yanqiu Zhang, Jun Lu, Yuanlin Zheng. Troxerutin Reduces Kidney Damage against BDE-47-Induced Apoptosis via Inhibiting NOX2 Activity and Increasing Nrf2 Activity. Oxidative medicine and cellular longevity. 2017; 2017(?):6034692. doi: 10.1155/2017/6034692. [PMID: 29163754]
  • Liliang Shu, Wanzhe Zhang, Chen Huang, Gongcheng Huang, Gang Su. Troxerutin Protects Against Myocardial Ischemia/Reperfusion Injury Via Pi3k/Akt Pathway in Rats. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 44(5):1939-1948. doi: 10.1159/000485884. [PMID: 29241161]
  • Bin-Jiang Zhao, Zhen-Zhong Wang, Hui-Ping Luo, Jia-Kui Guo, Hai-Wang Ji, Jian Wang, Lin-Yong Yang, Wei Xiao. [A multi-center, double-blind, placebo-controlled, randomized trial for effect of Longxue Tongluo capsule in treatment of patients of atherosclerotic thrombotic cerebral infarction with blood-stasis syndrome in convalescence]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Sep; 41(18):3473-3477. doi: 10.4268/cjcmm20161825. [PMID: 28925134]
  • Niranjan A Panat, Dharmendra K Maurya, Saroj S Ghaskadbi, Santosh K Sandur. Troxerutin, a plant flavonoid, protects cells against oxidative stress-induced cell death through radical scavenging mechanism. Food chemistry. 2016 Mar; 194(?):32-45. doi: 10.1016/j.foodchem.2015.07.078. [PMID: 26471524]
  • Perumal Elangovan, Abdulkadhar Mohamed Jalaludeen, Ramalingam Ramakrishnan, Leelavinothan Pari. Protective Effect of Troxerutin on Nickel-Induced Testicular Toxicity in Wistar Rats. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 2016; 35(2):133-46. doi: 10.1615/jenvironpatholtoxicoloncol.2016015384. [PMID: 27481491]
  • Man Xu, Qing Yu, Qianru Zhao, Wei Chen, Yuanjie Lin, Yong Jin. Development and in vitro-in vivo evaluation of a water-in-oil microemulsion formulation for the oral delivery of troxerutin. Drug development and industrial pharmacy. 2016; 42(2):280-7. doi: 10.3109/03639045.2015.1047849. [PMID: 26165244]
  • Rajagopalan Geetha, Mutulur Krishnamoorthy Radika, Emayavaramban Priyadarshini, Krishnamurthy Bhavani, Carani Venkatraman Anuradha. Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice. Molecular and cellular biochemistry. 2015 Sep; 407(1-2):263-79. doi: 10.1007/s11010-015-2474-3. [PMID: 26077659]
  • Z Aziz, W L Tang, N J Chong, L Y Tho. A systematic review of the efficacy and tolerability of hydroxyethylrutosides for improvement of the signs and symptoms of chronic venous insufficiency. Journal of clinical pharmacy and therapeutics. 2015 Apr; 40(2):177-85. doi: 10.1111/jcpt.12247. [PMID: 25630350]
  • Sathish Sampath, Balasubramanian Karundevi. Effect of troxerutin on insulin signaling molecules in the gastrocnemius muscle of high fat and sucrose-induced type-2 diabetic adult male rat. Molecular and cellular biochemistry. 2014 Oct; 395(1-2):11-27. doi: 10.1007/s11010-014-2107-2. [PMID: 24880482]
  • Zi-Feng Zhang, Shao-Hua Fan, Yuan-Lin Zheng, Jun Lu, Dong-Mei Wu, Qun Shan, Bin Hu. Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice. Biochemical pharmacology. 2014 Sep; 91(1):74-86. doi: 10.1016/j.bcp.2014.07.002. [PMID: 25026599]
  • Rajagopalan Geetha, Baskaran Yogalakshmi, S Sreeja, K Bhavani, Carani Venkatraman Anuradha. Troxerutin suppresses lipid abnormalities in the heart of high-fat-high-fructose diet-fed mice. Molecular and cellular biochemistry. 2014 Feb; 387(1-2):123-34. doi: 10.1007/s11010-013-1877-2. [PMID: 24173620]
  • R Vinothkumar, R Vinoth Kumar, V Karthikkumar, P Viswanathan, J Kabalimoorthy, N Nalini. Oral supplementation with troxerutin (trihydroxyethylrutin), modulates lipid peroxidation and antioxidant status in 1,2-dimethylhydrazine-induced rat colon carcinogenesis. Environmental toxicology and pharmacology. 2014 Jan; 37(1):174-84. doi: 10.1016/j.etap.2013.11.022. [PMID: 24355798]
  • Perumal Elangovan, Leelavinothan Pari. Ameliorating effects of troxerutin on nickel-induced oxidative stress in rats. Redox report : communications in free radical research. 2013; 18(6):224-32. doi: 10.1179/1351000213y.0000000055. [PMID: 24112957]
  • Nirmal Perera, Danae Liolitsa, Satheesh Iype, Anna Croxford, Muhammed Yassin, Peter Lang, Obioha Ukaegbu, Christopher van Issum. Phlebotonics for haemorrhoids. The Cochrane database of systematic reviews. 2012 Aug; ?(8):CD004322. doi: 10.1002/14651858.cd004322.pub3. [PMID: 22895941]
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