D-Threitol (BioDeep_00000014516)

 

Secondary id: BioDeep_00000406038, BioDeep_00000410662

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


Threitol, ((r*,r*)-(+-))-isomer

化学式: C4H10O4 (122.057906)
中文名称: D-苏糖醇
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.43%

分子结构信息

SMILES: C(C(C(CO)O)O)O
InChI: InChI=1S/C4H10O4/c5-1-3(7)4(8)2-6/h3-8H,1-2H2

描述信息

D-Threitol can be regarded as the main end product of D-xylose metabolism in hummans. Threitol is a C4-polyol (tetritol); the total C4-polyol concentration of threitol decreases with age. Several inborn errors of metabolism with abnormal polyol concentrations in body fluids are known to date (such as pentosuria and galactosemia). Most of these defects can be diagnosed by the assessment of urinary concentrations of polyols. Several studies have revealed that urinary levels of some polyols may vary in diseases associated with carbohydrate metabolism derangements such as diabetes mellitus and uremia. The abnormal occurrence of various polyols in diseases with a specific enzyme deficiency such as pentosuria and galactosemia has also been reported (PMID:908147, 16435188, 14988808). Moreover, D-Threitol is found to be associated with ribose-5-phosphate isomerase deficiency, which is also an inborn error of metabolism. Threitol in the urine is a biomarker for the consumption of apples and other fruits.
Found in the edible fungus Armillaria mellea. Constituent of jute (Corchorus capsularis and Corchorus olitorius (Jews mallow)), and the pigeon pea plant (Cajanus cajan). Threitol in the urine is a biomarker for the consumption of apples and other fruits.
D-threitol serves as a antifreeze agent in the Alaskan beetle Upis ceramboides.
D-threitol serves as a antifreeze agent in the Alaskan beetle Upis ceramboides.

同义名列表

12 个代谢物同义名

Threitol, ((r*,r*)-(+-))-isomer; (2R,3R)-butane-1,2,3,4-tetrol; (2R,3R)-1,2,3,4-Butanetetrol; (R*,r*)-1,2,3,4-butanetetrol; Threitol, (R-(r*,r*))-isomer; 1,2,3,4-Tetrahydroxybutane; D-Threo-tetritol; (-)-Threitol; D-Threitol; Threitol; Threit; D-Threitol



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Johanna W-H Wong, Krista L Plett, Siria H A Natera, Ute Roessner, Ian C Anderson, Jonathan M Plett. Comparative metabolomics implicates threitol as a fungal signal supporting colonization of Armillaria luteobubalina on eucalypt roots. Plant, cell & environment. 2020 02; 43(2):374-386. doi: 10.1111/pce.13672. [PMID: 31797388]
  • Silvia M Titan, Gabriela Venturini, Kallyandra Padilha, Alessandra C Goulart, Paulo A Lotufo, Isabela J Bensenor, Jose E Krieger, Ravi I Thadhani, Eugene P Rhee, Alexandre C Pereira. Metabolomics biomarkers and the risk of overall mortality and ESRD in CKD: Results from the Progredir Cohort. PloS one. 2019; 14(3):e0213764. doi: 10.1371/journal.pone.0213764. [PMID: 30883578]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Gyu Song, Eleonora Napoli, Sarah Wong, Randi Hagerman, Siming Liu, Flora Tassone, Cecilia Giulivi. Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine. Molecular medicine (Cambridge, Mass.). 2016 Oct; 22(?):548-559. doi: 10.2119/molmed.2016.00122. [PMID: 27385396]
  • John-Paul Jukes, Uzi Gileadi, Hemza Ghadbane, Ting-Fong Yu, Dawn Shepherd, Liam R Cox, Gurdyal S Besra, Vincenzo Cerundolo. Non-glycosidic compounds can stimulate both human and mouse iNKT cells. European journal of immunology. 2016 05; 46(5):1224-34. doi: 10.1002/eji.201546114. [PMID: 26873393]
  • Justyna Wojno, John-Paul Jukes, Hemza Ghadbane, Dawn Shepherd, Gurdyal S Besra, Vincenzo Cerundolo, Liam R Cox. Amide analogues of CD1d agonists modulate iNKT-cell-mediated cytokine production. ACS chemical biology. 2012 May; 7(5):847-55. doi: 10.1021/cb2005017. [PMID: 22324848]
  • Randip Kaur, Jili Chen, Amina Dawoodji, Vincenzo Cerundolo, Yoel R Garcia-Diaz, Justyna Wojno, Liam R Cox, Gurdyal S Besra, Behfar Moghaddam, Yvonne Perrie. Preparation, characterisation and entrapment of a non-glycosidic threitol ceramide into liposomes for presentation to invariant natural killer T cells. Journal of pharmaceutical sciences. 2011 Jul; 100(7):2724-33. doi: 10.1002/jps.22500. [PMID: 21283989]
  • Eva K F Chan, Heather C Rowe, Bjarne G Hansen, Daniel J Kliebenstein. The complex genetic architecture of the metabolome. PLoS genetics. 2010 Nov; 6(11):e1001198. doi: 10.1371/journal.pgen.1001198. [PMID: 21079692]
  • Zeming Wu, Min Li, Chunxia Zhao, Jia Zhou, Yuwei Chang, Xiang Li, Peng Gao, Xin Lu, Yousheng Li, Guowang Xu. Urinary metabonomics study in a rat model in response to protein-energy malnutrition by using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. Molecular bioSystems. 2010 Nov; 6(11):2157-63. doi: 10.1039/c005291d. [PMID: 20717558]
  • John H Grabber, Paul F Schatz, Hoon Kim, Fachuang Lu, John Ralph. Identifying new lignin bioengineering targets: 1. Monolignol-substitute impacts on lignin formation and cell wall fermentability. BMC plant biology. 2010 Jun; 10(?):114. doi: 10.1186/1471-2229-10-114. [PMID: 20565789]
  • Stephen J Clayton, Derek B Read, Philip J Murray, Peter J Gregory. Exudation of alcohol and aldehyde sugars from roots of defoliated Lolium perenne L. grown under sterile conditions. Journal of chemical ecology. 2008 Nov; 34(11):1411-21. doi: 10.1007/s10886-008-9536-x. [PMID: 18815840]
  • A E P Heazell, M Brown, W B Dunn, S A Worton, I P Crocker, P N Baker, D B Kell. Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers. Placenta. 2008 Aug; 29(8):691-8. doi: 10.1016/j.placenta.2008.05.002. [PMID: 18573524]
  • Jonathan D Silk, Mariolina Salio, B Gopal Reddy, Dawn Shepherd, Uzi Gileadi, James Brown, S Hajar Masri, Paolo Polzella, Gerd Ritter, Gurdyal S Besra, E Yvonne Jones, Richard R Schmidt, Vincenzo Cerundolo. Cutting edge: nonglycosidic CD1d lipid ligands activate human and murine invariant NKT cells. Journal of immunology (Baltimore, Md. : 1950). 2008 May; 180(10):6452-6. doi: 10.4049/jimmunol.180.10.6452. [PMID: 18453560]
  • Kundimi Sreenath, Yeldur P Venkatesh. Reductively aminated D-xylose-albumin conjugate as the immunogen for generation of IgG and IgE antibodies specific to D-xylitol, a haptenic allergen. Bioconjugate chemistry. 2007 Nov; 18(6):1995-2003. doi: 10.1021/bc700175g. [PMID: 17979222]
  • K Sreenath, P Prabhasankar, Y P Venkatesh. Generation of an antibody specific to erythritol, a non-immunogenic food additive. Food additives and contaminants. 2006 Sep; 23(9):861-9. doi: 10.1080/02652030600722353. [PMID: 16901854]
  • Roman Brunecky, Stephanie Lee, Piotr W Rzepecki, Michael Overduin, Glenn D Prestwich, Andrei G Kutateladze, Tatiana G Kutateladze. Investigation of the binding geometry of a peripheral membrane protein. Biochemistry. 2005 Dec; 44(49):16064-71. doi: 10.1021/bi051127+. [PMID: 16331966]
  • Xuequan Lu, Hoe-Sup Byun, Robert Bittman. Synthesis of l-lyxo-phytosphingosine and its 1-phosphonate analogue using a threitol acetal synthon. The Journal of organic chemistry. 2004 Aug; 69(16):5433-8. doi: 10.1021/jo0493065. [PMID: 15287793]
  • J Roboz, D C Kappatos, J Greaves, J F Holland. Determination of polyols in serum by selected ion monitoring. Clinical chemistry. 1984 Oct; 30(10):1611-5. doi: NULL. [PMID: 6434200]
  • E Pitkänen. The conversion of D-xylose into D-threitol in patients without liver disease and in patients with portal liver cirrhosis. Clinica chimica acta; international journal of clinical chemistry. 1977 Oct; 80(1):49-54. doi: 10.1016/0009-8981(77)90262-5. [PMID: 908147]