4-hydroxy-2-nonenal (4-HNE) (BioDeep_00000014168)
Secondary id: BioDeep_00000608240, BioDeep_00001868099
human metabolite Endogenous blood metabolite Toxin Volatile Flavor Compounds
代谢物信息卡片
化学式: C9H16O2 (156.1150236)
中文名称: 4-羟基壬烯醛
谱图信息:
最多检出来源 Homo sapiens(blood) 0.26%
Last reviewed on 2024-09-13.
Cite this Page
4-hydroxy-2-nonenal (4-HNE). BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/4-hydroxy-2-nonenal_(4-hne) (retrieved
2024-11-21) (BioDeep RN: BioDeep_00000014168). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: CCCCCC(/C=C/C=O)O
InChI: InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
描述信息
4-Hydroxynonenal (HNE), one of the major end products of lipid peroxidation, has been shown to be involved in signal transduction and available evidence suggests that it can affect cell cycle events in a concentration-dependent manner. glutathione S-transferases (GSTs) can modulate the intracellular concentrations of HNE by affecting its generation during lipid peroxidation by reducing hydroperoxides and also by converting it into a glutathione conjugate. Overexpression of the Alpha class GSTs in cells leads to lower steady-state levels of HNE, and these cells acquire resistance to apoptosis induced by lipid peroxidation-causing agents such as H(2)O(2), UVA, superoxide anion, and pro-oxidant xenobiotics, suggesting that signaling for apoptosis by these agents is transduced through HNE. Cells with the capacity to exclude HNE from the intracellular environment at a faster rate are relatively more resistant to apoptosis caused by H(2)O(2), UVA, superoxide anion, and pro-oxidant xenobiotics as well as by HNE, suggesting that HNE may be a common denominator in mechanisms of apoptosis caused by oxidative stress. Transfection of adherent cells with HNE-metabolizing GSTs leads to transformation of these cells due to depletion of HNE. (PMID 15288119). HNE has also been identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821).
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D003432 - Cross-Linking Reagents
Constituent of beef and pork. Lipid peroxidation product
4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].
同义名列表
17 个代谢物同义名
2-Nonenal, 4-hydroxy-, (2E,4R)-; 4-Hydroxy-2-nonenal, (e)-isomer; 4-Hydroxy-2,3-trans-nonenal; trans-4-Hydroxy-2-nonenal; (2E)-4-hydroxynon-2-enal; (2E)-4-Hydroxy-2-nonenal; (e)-4-Hydroxy-2-nonenal; 4-Hydroxy-2,3-nonenal; 4-Hydroxy-2E-nonenal; 4-Hydroxynon-2-enal; 4-Hydroxy-2-nonenal; 4-Hydroxynonen-2-al; 4-hydroxynonenal; 4-HNE CPD; HNE; 4-HNE; 4-Hydroxynonenal
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:58968
- ChEBI: CHEBI:32585
- KEGG: C21642
- PubChem: 5283344
- PubChem: 1693
- HMDB: HMDB0004362
- ChEMBL: CHEMBL454280
- Wikipedia: 4-Hydroxynonenal
- KNApSAcK: C00000447
- foodb: FDB020986
- chemspider: 4446465
- CAS: 75899-68-2
- PMhub: MS000028796
- PubChem: 346930781
- RefMet: 4-Hydroxynonenal
- medchemexpress: HY-113466
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(2)
- 4-hydroxy-2-nonenal detoxification:
4-hydroxy-2-nonenal + glutathione ⟶ (glutathion-S-yl)-4-hydroxy-2-nonenal
- 4-hydroxy-2-nonenal detoxification:
4-hydroxy-2-nonenal + glutathione ⟶ (glutathion-S-yl)-4-hydroxy-2-nonenal
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 3906 - Vicia faba: 10.1016/S0021-9258(18)53134-3
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Ruifang Feng, Qinye Yu, Yulong Bao, Liang Chen, Yongkang Luo, Yuqing Tan, Hui Hong. Myofibrillar protein lipoxidation in fish induced by linoleic acid and 4-hydroxy-2-nonenal: Insights from LC-MS/MS analysis.
Food research international (Ottawa, Ont.).
2024 Jul; 187(?):114357. doi:
10.1016/j.foodres.2024.114357
. [PMID: 38763641] - Rafael Pineda-Alemán, Camila Cabarcas-Herrera, Antistio Alviz-Amador, Rodrigo Galindo-Murillo, Humberto Pérez-Gonzalez, Erika Rodríguez-Cavallo, Darío Méndez-Cuadro. Molecular dynamics of structural effects of reactive carbonyl species derivate of lipid peroxidation on bovine serum albumin.
Biochimica et biophysica acta. General subjects.
2024 Jun; 1868(6):130613. doi:
10.1016/j.bbagen.2024.130613
. [PMID: 38593934] - Zachary P Rokop, Wenjun Zhang, Nandini Ghosh, Nirupam Biswas, Amitava Das, Jingmei Lin, Chandan K Sen, Chandrashekhar Kubal. Exacerbated ischemia-reperfusion injury in fatty livers is mediated by lipid peroxidation stress and ferroptosis.
Surgery.
2024 Jun; 175(6):1539-1546. doi:
10.1016/j.surg.2024.02.001
. [PMID: 38508920] - Logan G Johnson, Chaoyu Zhai, Kitty Brown, Jessica E Prenni, Mahesh N Nair, Elisabeth Huff-Lonergan, Steven M Lonergan. Secondary Lipid Oxidation Products as Modulators of Calpain-2 Functionality In Vitro.
Journal of agricultural and food chemistry.
2024 May; 72(21):12229-12239. doi:
10.1021/acs.jafc.4c00335
. [PMID: 38743679] - Xiaoxuan Zhai, Shengchuan Cao, Jiali Wang, Bao Qiao, Xuehao Liu, Rui Hua, Menglin Zhao, Shukun Sun, Yu Han, Shuo Wu, Jiaojiao Pang, Qiuhuan Yuan, Bailu Wang, Feng Xu, Shujian Wei, Yuguo Chen. Carbonylation of Runx2 at K176 by 4-Hydroxynonenal Accelerates Vascular Calcification.
Circulation.
2024 May; 149(22):1752-1769. doi:
10.1161/circulationaha.123.065830
. [PMID: 38348663] - Jacques Dupuy, Edwin Fouché, Céline Noirot, Pierre Martin, Charline Buisson, Françoise Guéraud, Fabrice Pierre, Cécile Héliès-Toussaint. A dual model of normal vs isogenic Nrf2-depleted murine epithelial cells to explore oxidative stress involvement.
Scientific reports.
2024 05; 14(1):10905. doi:
10.1038/s41598-024-60938-2
. [PMID: 38740939] - Rafael Pineda-Alemán, Camila Cabarcas-Herrera, Antistio Alviz-Amador, Humberto Pérez-Gonzalez, Erika Rodríguez-Cavallo, Darío Méndez-Cuadro. Synthesizing Amino Acids Modified with Reactive Carbonyls in Silico to Assess Structural Effects Using Molecular Dynamics Simulations.
Journal of visualized experiments : JoVE.
2024 Apr; ?(206):. doi:
10.3791/66605
. [PMID: 38738901] - Neven Žarković, Agnieszka Gęgotek, Wojciech Łuczaj, Morana Jaganjac, Suzana Borović Šunjić, Kamelija Žarković, Elzbieta Skrzydlewska. Overview of the Lipid Peroxidation Measurements in Patients by the Enzyme-Linked Immunosorbent Assay Specific for the 4-Hydroxynonenal-Protein Adducts (4-HNE-ELISA).
Frontiers in bioscience (Landmark edition).
2024 Apr; 29(4):153. doi:
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. [PMID: 38682198] - Jun Wang, Xiaoxiao Feng, Xuejiao Liu, Guoli Wang, Yingying Xiong, Lei Zhang, Ying Zhang, Haojie Lu. In-Depth Profiling of 4-Hydroxy-2-nonenal Modification via Reversible Thiazolidine Chemistry.
Analytical chemistry.
2024 Apr; 96(13):5125-5133. doi:
10.1021/acs.analchem.3c05060
. [PMID: 38502245] - Genji Kawade, Morito Kurata, Yuko Matsuki, Sho Fukuda, Iichiroh Onishi, Yuko Kinowaki, Shiori Watabe, Sachiko Ishibashi, Masumi Ikeda, Masahide Yamamoto, Kenichi Ohashi, Masanobu Kitagawa, Kouhei Yamamoto. Mediation of Ferroptosis Suppressor Protein 1 Expression via 4-Hydroxy-2-Nonenal Accumulation Contributes to Acquisition of Resistance to Apoptosis and Ferroptosis in Diffuse Large B-Cell Lymphoma.
Laboratory investigation; a journal of technical methods and pathology.
2024 Apr; 104(4):102027. doi:
10.1016/j.labinv.2024.102027
. [PMID: 38311062] - Agnieszka Gęgotek, Elżbieta Skrzydlewska. Lipid peroxidation products' role in autophagy regulation.
Free radical biology & medicine.
2024 02; 212(?):375-383. doi:
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European journal of immunology.
2024 Jan; ?(?):e2350800. doi:
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Clinical immunology (Orlando, Fla.).
2024 01; 258(?):109861. doi:
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Biochemical pharmacology.
2023 12; 218(?):115931. doi:
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Current protocols.
2023 Sep; 3(9):e885. doi:
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. [PMID: 37672491] - Xiaoyan Yang, Dongqun Xu, Bo Wen, Jian Ji, Zeyu Zhang, Li Li, Shaoping Zhang, Hong Zhi, Jian Kong, Chong Wang, Jun Wang, Hongjie Ruan, Ming Zhang, Lan Wei, Bin Dong, Qin Wang. The mediating role of exhaled breath condensate metabolites in the effect of particulate matter on pulmonary function in schoolchildren: A crossover intervention study.
The Science of the total environment.
2023 Jul; 898(?):165517. doi:
10.1016/j.scitotenv.2023.165517
. [PMID: 37459994] - Richmond Djorgbenoo, Weixin Wang, Yingdong Zhu, Shengmin Sang. Detoxification of the Lipid Peroxidation Aldehyde, 4-Hydroxynonenal, by Apple Phloretin In Vitro and in Mice.
Journal of agricultural and food chemistry.
2023 Jul; ?(?):. doi:
10.1021/acs.jafc.3c01038
. [PMID: 37418694] - Shaowei Zhuang, Yan Ma, Yuxiao Zeng, Cheng Lu, Fenghua Yang, Nianxin Jiang, Junwei Ge, Haining Ju, Chunlin Zhong, Jiayi Wang, Jiehan Zhang, Shengyang Jiang. METTL14 promotes doxorubicin-induced cardiomyocyte ferroptosis by regulating the KCNQ1OT1-miR-7-5p-TFRC axis.
Cell biology and toxicology.
2023 06; 39(3):1015-1035. doi:
10.1007/s10565-021-09660-7
. [PMID: 34648132] - Neda Tufail, Minhal Abidi, Mohd Sharib Warsi, Tasneem Kausar, Shahid M Nayeem. Computational and physicochemical insight into 4-hydroxy-2-nonenal induced structural and functional perturbations in human low-density lipoprotein.
Journal of biomolecular structure & dynamics.
2023 May; ?(?):1-16. doi:
10.1080/07391102.2023.2208234
. [PMID: 37154523] - Jingyuan Xu, Hongyang Tian, Yajun Ji, Lei Dong, Yandong Liu, Yatao Wang, Xuefen Gao, Haitao Shi, Hong Li, Longbao Yang. Urolithin C reveals anti-NAFLD potential via AMPK-ferroptosis axis and modulating gut microbiota.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 May; ?(?):. doi:
10.1007/s00210-023-02492-8
. [PMID: 37126194] - Madhumathan Mukherjee, Chandan Kumar Jana, Nilanjana Das. Oxidation of biological molecules with age and induced oxidative stress in different growth phases of Saccharomyces cerevisiae.
Antonie van Leeuwenhoek.
2023 Apr; 116(4):353-365. doi:
10.1007/s10482-022-01807-8
. [PMID: 36749507] - Toshiyuki Matsunaga, Misato Horinouchi, Haruhi Saito, Aki Hisamatsu, Kazuhiro Iguchi, Yuta Yoshino, Satoshi Endo, Akira Ikari. Availability of aldo-keto reductase 1C3 and ATP-binding cassette B1 as therapeutic targets for alleviating paclitaxel resistance in breast cancer MCF7 cells.
Journal of biochemistry.
2023 Mar; 173(3):167-175. doi:
10.1093/jb/mvac098
. [PMID: 36413758] - Hiroyuki Kikuchi, Miki Takahashi, Hiroaki Komatsu, Paul H Axelsen. Post-Translational Chemical Modifications of Amyloid-β Peptides by 4-Hydroxy-2-Nonenal.
Journal of Alzheimer's disease : JAD.
2023 Feb; ?(?):. doi:
10.3233/jad-220940
. [PMID: 36776059] - Sandra Sánchez-Jaut, Susana Pérez-Benavente, Paloma Abad, Darío Méndez-Cuadro, Antonio Puyet, Amalia Diez, Gonzalo Galicia-Poblet, Elena Gómez-Domínguez, María J Moran-Jiménez, José M Bautista, Isabel G Azcárate. Protein Susceptibility to Peroxidation by 4-Hydroxynonenal in Hereditary Hemochromatosis.
International journal of molecular sciences.
2023 Feb; 24(3):. doi:
10.3390/ijms24032922
. [PMID: 36769239] - Muhammad I Abeer, Abbas Abdulhasan, Zahraa Haguar, Vasanthy Narayanaswami. Isoform-specific modification of apolipoprotein E by 4-hydroxynonenal: protective role of apolipoprotein E3 against oxidative species.
The FEBS journal.
2023 Jan; ?(?):. doi:
10.1111/febs.16729
. [PMID: 36661393] - Fei Liu, Nicolas Anton, Yosuke Niko, Andrey S Klymchenko. Controlled Release and Capture of Aldehydes by Dynamic Imine Chemistry in Nanoemulsions: From Delivery to Detoxification.
ACS applied bio materials.
2023 01; 6(1):246-256. doi:
10.1021/acsabm.2c00861
. [PMID: 36516427] - Matea Nikolac Perkovic, Morana Jaganjac, Lidija Milkovic, Tea Horvat, David Rojo, Kamelija Zarkovic, Marijana Ćorić, Tvrtko Hudolin, Georg Waeg, Biserka Orehovec, Neven Zarkovic. Relationship between 4-Hydroxynonenal (4-HNE) as Systemic Biomarker of Lipid Peroxidation and Metabolomic Profiling of Patients with Prostate Cancer.
Biomolecules.
2023 01; 13(1):. doi:
10.3390/biom13010145
. [PMID: 36671530] - Marina Cindrić, Ana Čipak Gašparović, Lidija Milković, Ivana Tartaro Bujak, Branka Mihaljević, Neven Žarković, Kamelija Žarković. 4-Hydroxynonenal Modulates Blood-Brain Barrier Permeability In Vitro through Changes in Lipid Composition and Oxidative Status of Endothelial Cells and Astrocytes.
International journal of molecular sciences.
2022 Nov; 23(22):. doi:
10.3390/ijms232214373
. [PMID: 36430852] - Sudha Sharma, Papori Sharma, Tara Bailey, Susmita Bhattarai, Utsab Subedi, Chloe Miller, Hosne Ara, Srivatsan Kidambi, Hong Sun, Manikandan Panchatcharam, Sumitra Miriyala. Electrophilic Aldehyde 4-Hydroxy-2-Nonenal Mediated Signaling and Mitochondrial Dysfunction.
Biomolecules.
2022 10; 12(11):. doi:
10.3390/biom12111555
. [PMID: 36358905] - Balázs Olasz, Béla Fiser, Milán Szőri, Béla Viskolcz, Michael C Owen. Computational Elucidation of the Solvent-Dependent Addition of 4-Hydroxy-2-nonenal (HNE) to Cysteine and Cysteinate Residues.
The Journal of organic chemistry.
2022 10; 87(19):12909-12920. doi:
10.1021/acs.joc.2c01487
. [PMID: 36148484] - Chia George Hsu, Camila Lage Chávez, Chongyang Zhang, Mark Sowden, Chen Yan, Bradford C Berk. The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis.
Cell death and differentiation.
2022 09; 29(9):1790-1803. doi:
10.1038/s41418-022-00966-5
. [PMID: 35264781] - J A Custodio-Mendoza, C Caamaño-Fernandez, M A Lage, P J Almeida, R A Lorenzo, A M Carro. GC-MS determination of malondialdehyde, acrolein, and 4-hydroxy-2-nonenal by ultrasound-assisted dispersive liquid-liquid microextraction in beverages.
Food chemistry.
2022 Aug; 384(?):132530. doi:
10.1016/j.foodchem.2022.132530
. [PMID: 35227997] - Zhengxuan Wang, Mingcai Liang, Hui Li, Bingxiao Liu, Lin Yang. Rice protein suppresses 4-hydroxy-2-nonenal-induced inflammation owing to methionine availability.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2022 Aug; 47(8):826-838. doi:
10.1139/apnm-2021-0575
. [PMID: 35390263] - Kaili Du, Jiahui Shi, Shixue Cheng, Shuqi Hang, Zongxian Ding, Siyu Liu, Dan Li. Upregulation of the TFEB-mediated lysosome function relieves 4-Hydroxynonenal-Induced apoptosis.
Chemico-biological interactions.
2022 Aug; 362(?):109963. doi:
10.1016/j.cbi.2022.109963
. [PMID: 35550146] - Ai Fu, Jiaomei Li, Qinchao Ding, Rui Guo, Aiwen Pi, Wenwen Yang, Yanli Chen, Xiaobing Dou, Zhenyuan Song, Songtao Li. Upregulation of 4-Hydroxynonenal Contributes to the Negative Effect of n-6 Polyunsaturated Fatty Acid on Alcohol-Induced Liver Injury and Hepatic Steatosis.
Journal of agricultural and food chemistry.
2022 Jun; 70(21):6418-6428. doi:
10.1021/acs.jafc.2c00852
. [PMID: 35588299] - Gloria A Benavides, Toni Mueller, Victor Darley-Usmar, Jianhua Zhang. Optimization of measurement of mitochondrial electron transport activity in postmortem human brain samples and measurement of susceptibility to rotenone and 4-hydroxynonenal inhibition.
Redox biology.
2022 04; 50(?):102241. doi:
10.1016/j.redox.2022.102241
. [PMID: 35066289] - Mei-Ling Li, Chun-Yin Huang, Szu-Han Chen, Chia-Ni Lee, Hsien-Tsung Yao. Citrus depressa Hayata peel ameliorates nonalcoholic fatty liver and modulates the activity of hepatic drug-metabolizing enzymes and transporters in rats fed a high-fat diet.
Food & function.
2022 Mar; 13(6):3353-3367. doi:
10.1039/d1fo03597e
. [PMID: 35212695] - Lais Alonso, Ricardo Menegatti, Miriam Leandro Dorta, Antonio Alonso. Plasma membrane rigidity effects of 4-hydroxy-2-nonenal in Leishmania, erythrocyte and macrophage.
Toxicology in vitro : an international journal published in association with BIBRA.
2022 Mar; 79(?):105294. doi:
10.1016/j.tiv.2021.105294
. [PMID: 34896601] - Monika Renuka Sanotra, Wen-Chung Huang, Simon Silver, Ching-Yu Lin, Tsuei-Chuan Chang, Doan Phuong Quy Nguyen, Ching-Kuo Lee, Shu-Huei Kao, Jonathan Chang-Cheng Shieh, Yung-Feng Lin. Serum levels of 4-hydroxynonenal adducts and responding autoantibodies correlate with the pathogenesis from hyperglycemia to Alzheimer's disease.
Clinical biochemistry.
2022 Mar; 101(?):26-34. doi:
10.1016/j.clinbiochem.2021.12.005
. [PMID: 34933007] - Jennifer S Strehse, Daniel Hoffmann, Nikolaos Protopapas, Hans-Jörg Martin, Edmund Maser. Carbonyl reduction of 4-oxonon-2-enal (4-ONE) by Sniffer from D. magna and D.pulex.
Chemico-biological interactions.
2022 Feb; 354(?):109833. doi:
10.1016/j.cbi.2022.109833
. [PMID: 35085582] - Muhammad Ali Khan, Purba Nag, Anca Grivei, Kurt T K Giuliani, Xiangju Wang, Vishal Diwan, Wendy Hoy, Helen Healy, Glenda Gobe, Andrew J Kassianos. Adenine overload induces ferroptosis in human primary proximal tubular epithelial cells.
Cell death & disease.
2022 02; 13(2):104. doi:
10.1038/s41419-022-04527-z
. [PMID: 35110539] - Mohamed E Shaker, Omnia M Hendawy, Mohamed El-Mesery, Sara H Hazem. The JAK inhibitor ruxolitinib abrogates immune hepatitis instigated by concanavalin A in mice.
International immunopharmacology.
2022 Feb; 103(?):108463. doi:
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. [PMID: 34952468] - Neven Zarkovic, Antonia Jakovcevic, Ana Mataic, Morana Jaganjac, Tea Vukovic, Georg Waeg, Kamelija Zarkovic. Post-mortem Findings of Inflammatory Cells and the Association of 4-Hydroxynonenal with Systemic Vascular and Oxidative Stress in Lethal COVID-19.
Cells.
2022 01; 11(3):. doi:
10.3390/cells11030444
. [PMID: 35159254] - Yanling Li, Tingting Zhao, Jiaxin Li, Mengyao Xia, Yuling Li, Xiaoyu Wang, Chuanguo Liu, Tingting Zheng, Renjie Chen, Dongfang Kan, Yicheng Xie, Jingjie Song, Yu Feng, Tiangui Yu, Peng Sun. Oxidative Stress and 4-hydroxy-2-nonenal (4-HNE): Implications in the Pathogenesis and Treatment of Aging-related Diseases.
Journal of immunology research.
2022; 2022(?):2233906. doi:
10.1155/2022/2233906
. [PMID: 35411309] - Zhuan Feng, Yifei Qin, Fei Huo, Zhe Jian, Xiaomin Li, Jiejie Geng, Yong Li, Jiao Wu. NMN recruits GSH to enhance GPX4-mediated ferroptosis defense in UV irradiation induced skin injury.
Biochimica et biophysica acta. Molecular basis of disease.
2022 01; 1868(1):166287. doi:
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Romanian journal of internal medicine = Revue roumaine de medecine interne.
2021 Dec; 59(4):359-368. doi:
10.2478/rjim-2021-0017
. [PMID: 33951354] - Edilburga Reyes-Jiménez, Alma Aurora Ramírez-Hernández, Jovito Cesar Santos-Álvarez, Juan Manuel Velázquez-Enríquez, Socorro Pina-Canseco, Rafael Baltiérrez-Hoyos, Verónica Rocío Vásquez-Garzón. Involvement of 4-hydroxy-2-nonenal in the pathogenesis of pulmonary fibrosis.
Molecular and cellular biochemistry.
2021 Dec; 476(12):4405-4419. doi:
10.1007/s11010-021-04244-9
. [PMID: 34463938] - Camilla Andersen, Anne Louise Grønnemose, Jannik N Pedersen, Jan S Nowak, Gunna Christiansen, Janni Nielsen, Frans A A Mulder, Daniel Erik Otzen, Thomas J D Jørgensen. Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications.
Biochemistry.
2021 11; 60(47):3644-3658. doi:
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Neurochemistry international.
2021 10; 149(?):105118. doi:
10.1016/j.neuint.2021.105118
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Biomolecules.
2021 09; 11(9):. doi:
10.3390/biom11091365
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Toxicology and applied pharmacology.
2021 09; 426(?):115636. doi:
10.1016/j.taap.2021.115636
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Food chemistry.
2021 Sep; 355(?):129403. doi:
10.1016/j.foodchem.2021.129403
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Cancers.
2021 Aug; 13(17):. doi:
10.3390/cancers13174337
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Meat science.
2021 Aug; 178(?):108523. doi:
10.1016/j.meatsci.2021.108523
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Cells.
2021 07; 10(7):. doi:
10.3390/cells10071680
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jul; 139(?):111636. doi:
10.1016/j.biopha.2021.111636
. [PMID: 33957566] - Reine-Solange Sauer, Ivo Krummenacher, Ezgi Eylül Bankoglu, Shaobing Yang, Beatrice Oehler, Friedrich Schöppler, Milad Mohammadi, Paul Güntzel, Adel Ben-Kraiem, Ulrike Holzgrabe, Helga Stopper, Jens A Broscheit, Holger Braunschweig, Norbert Roewer, Alexander Brack, Heike L Rittner. Stabilization of Delphinidin in Complex with Sulfobutylether-β-Cyclodextrin Allows for Antinociception in Inflammatory Pain.
Antioxidants & redox signaling.
2021 06; 34(16):1260-1279. doi:
10.1089/ars.2019.7957
. [PMID: 32977733] - Michael G Alvarado, Pratish Thakore, Scott Earley. Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function.
Cells.
2021 05; 10(5):. doi:
10.3390/cells10051167
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Microvascular research.
2021 05; 135(?):104133. doi:
10.1016/j.mvr.2021.104133
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Archives of biochemistry and biophysics.
2021 03; 699(?):108749. doi:
10.1016/j.abb.2020.108749
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Rapid communications in mass spectrometry : RCM.
2021 Mar; 35(5):e9023. doi:
10.1002/rcm.9023
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Molecular nutrition & food research.
2021 03; 65(6):e2000487. doi:
10.1002/mnfr.202000487
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Free radical biology & medicine.
2021 02; 164(?):303-314. doi:
10.1016/j.freeradbiomed.2021.01.002
. [PMID: 33450376] - Kai-Leun Tsai, Che-Chang Chang, Yu-Sheng Chang, Yi-Ying Lu, I-Jung Tsai, Jin-Hua Chen, Sheng-Hong Lin, Chih-Chun Tai, Yi-Fang Lin, Hui-Wen Chang, Ching-Yu Lin, Emily Chia-Yu Su. Isotypes of autoantibodies against novel differential 4-hydroxy-2-nonenal-modified peptide adducts in serum is associated with rheumatoid arthritis in Taiwanese women.
BMC medical informatics and decision making.
2021 02; 21(1):49. doi:
10.1186/s12911-020-01380-y
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Journal of proteomics.
2021 02; 232(?):104024. doi:
10.1016/j.jprot.2020.104024
. [PMID: 33122130] - Maqsood A Siddiqui, Nida N Farshori, Mai M Al-Oqail, Aditya B Pant, Abdulaziz A Al-Khedhairy. Neuroprotective Effects of Withania somnifera on 4-Hydroxynonenal Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells Through ROS Inhibition and Apoptotic Mitochondrial Pathway.
Neurochemical research.
2021 Feb; 46(2):171-182. doi:
10.1007/s11064-020-03146-4
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Cells.
2021 01; 10(2):. doi:
10.3390/cells10020269
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Journal of cellular and molecular medicine.
2021 01; 25(2):1221-1237. doi:
10.1111/jcmm.16193
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Journal of internal medicine.
2021 01; 289(1):84-96. doi:
10.1111/joim.13147
. [PMID: 32634278] - Shabbir A Ansari, Shiva Keshava, Usha R Pendurthi, L Vijaya Mohan Rao. Oxidative Stress Product, 4-Hydroxy-2-Nonenal, Induces the Release of Tissue Factor-Positive Microvesicles From Perivascular Cells Into Circulation.
Arteriosclerosis, thrombosis, and vascular biology.
2021 01; 41(1):250-265. doi:
10.1161/atvbaha.120.315187
. [PMID: 33028097] - Jia Liu, Jin Huang, Hu Liu, Chang Chen, Jianying Xu, Liangwei Zhong. Elevated serum 4HNE plus decreased serum thioredoxin: Unique feature and implications for acute exacerbation of chronic obstructive pulmonary disease.
PloS one.
2021; 16(1):e0245810. doi:
10.1371/journal.pone.0245810
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Toxicology.
2020 12; 445(?):152584. doi:
10.1016/j.tox.2020.152584
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Toxicology and applied pharmacology.
2020 12; 408(?):115258. doi:
10.1016/j.taap.2020.115258
. [PMID: 33007382] - Zubeyir Elmazoglu, Zehra Aydın Bek, Gülistan Sanem Sarıbaş, Candan Özoğul, Berna Goker, Berivan Bitik, Cem Nuri Aktekin, Çimen Karasu. TLR4, RAGE, and p-JNK/JNK mediated inflammatory aggression in osteoathritic human chondrocytes are counteracted by redox-sensitive phenolic olive compounds: Comparison with ibuprofen.
Journal of tissue engineering and regenerative medicine.
2020 12; 14(12):1841-1857. doi:
10.1002/term.3138
. [PMID: 33010113] - Fernando Pinheiro Souza-Neto, Poliana Camila Marinello, Gabriela Pasqual Melo, Leandra Zambeli Naira Ramalho, Eliana M Cela, Valeria E Campo, Daniel H González-Maglio, Rubens Cecchini, Alessandra Lourenço Cecchini. Metformin inhibits the inflammatory and oxidative stress response induced by skin UVB-irradiation and provides 4-hydroxy-2-nonenal and nitrotyrosine formation and p53 protein activation.
Journal of dermatological science.
2020 Nov; 100(2):152-155. doi:
10.1016/j.jdermsci.2020.05.012
. [PMID: 33051086] - Sowmya P Lakshmi, Aravind T Reddy, Lakshmi Devi Kodidhela, N Ch Varadacharyulu. Epigallocatechin gallate diminishes cigarette smoke-induced oxidative stress, lipid peroxidation, and inflammation in human bronchial epithelial cells.
Life sciences.
2020 Oct; 259(?):118260. doi:
10.1016/j.lfs.2020.118260
. [PMID: 32795541] - Bowen Lou, Mike Boger, Katrin Bennewitz, Carsten Sticht, Stefan Kopf, Jakob Morgenstern, Thomas Fleming, Rüdiger Hell, Zuyi Yuan, Peter Paul Nawroth, Jens Kroll. Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans.
Redox biology.
2020 10; 37(?):101723. doi:
10.1016/j.redox.2020.101723
. [PMID: 32980661] - Honglin Mei, Liping Zhao, Wen Li, Zhiwei Zheng, Dongmei Tang, Xiaoling Lu, Yingzi He. Inhibition of ferroptosis protects House Ear Institute-Organ of Corti 1 cells and cochlear hair cells from cisplatin-induced ototoxicity.
Journal of cellular and molecular medicine.
2020 10; 24(20):12065-12081. doi:
10.1111/jcmm.15839
. [PMID: 32929878] - Rushdia Zareen Yusuf, Borja Saez, Azeem Sharda, Nick van Gastel, Vionnie W C Yu, Ninib Baryawno, Elizabeth W Scadden, Sanket Acharya, Shrikanta Chattophadhyay, Cherrie Huang, Vasanthi Viswanathan, Dana S'aulis, Julien Cobert, David B Sykes, Mark A Keibler, Sudeshna Das, John N Hutchinson, Michael Churchill, Siddhartha Mukherjee, Dongjun Lee, Francois Mercier, John Doench, Lars Bullinger, David J Logan, Stuart Schreiber, Gregory Stephanopoulos, William B Rizzo, David T Scadden. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
Blood.
2020 09; 136(11):1303-1316. doi:
10.1182/blood.2019001808
. [PMID: 32458004] - Christophe O Soulage, Caroline C Pelletier, Nans Florens, Sandrine Lemoine, Laurence Dubourg, Laurent Juillard, Fitsum Guebre-Egziabher. Two Toxic Lipid Aldehydes, 4-hydroxy-2-hexenal (4-HHE) and 4-hydroxy-2-nonenal (4-HNE), Accumulate in Patients with Chronic Kidney Disease.
Toxins.
2020 09; 12(9):. doi:
10.3390/toxins12090567
. [PMID: 32899405] - Morana Jaganjac, Lidija Milkovic, Agnieszka Gegotek, Marina Cindric, Kamelija Zarkovic, Elzbieta Skrzydlewska, Neven Zarkovic. The relevance of pathophysiological alterations in redox signaling of 4-hydroxynonenal for pharmacological therapies of major stress-associated diseases.
Free radical biology & medicine.
2020 09; 157(?):128-153. doi:
10.1016/j.freeradbiomed.2019.11.023
. [PMID: 31756524] - Maren C Podszun, Joon-Yong Chung, Kris Ylaya, David E Kleiner, Stephen M Hewitt, Yaron Rotman. 4-HNE Immunohistochemistry and Image Analysis for Detection of Lipid Peroxidation in Human Liver Samples Using Vitamin E Treatment in NAFLD as a Proof of Concept.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
2020 09; 68(9):635-643. doi:
10.1369/0022155420946402
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Food chemistry.
2020 Aug; 321(?):126603. doi:
10.1016/j.foodchem.2020.126603
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Biochimica et biophysica acta. Molecular and cell biology of lipids.
2020 08; 1865(8):158705. doi:
10.1016/j.bbalip.2020.158705
. [PMID: 32244060] - Hui Liu, Frank Gambino, Crystal S Algenio, Charles Wu, Yichen Gao, Charles S Bouchard, Liang Qiao, Ping Bu, Shaozhen Zhao. Inflammation and oxidative stress induced by lipid peroxidation metabolite 4-hydroxynonenal in human corneal epithelial cells.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.
2020 Aug; 258(8):1717-1725. doi:
10.1007/s00417-020-04647-2
. [PMID: 32445015] - Eleonora Fiocchi, Michele Civettini, Pierluigi Carbonara, Walter Zupa, Giuseppe Lembo, Amedeo Manfrin. Development of molecular and histological methods to evaluate stress oxidative biomarkers in sea bass (Dicentrarchus labrax).
Fish physiology and biochemistry.
2020 Aug; 46(4):1577-1588. doi:
10.1007/s10695-020-00811-x
. [PMID: 32388830] - Danni Lin, Tao Xiang, Qiangmin Qiu, Junto Leung, Junjie Xu, Wei Zhou, Qianchao Hu, Jianan Lan, Zhongzhong Liu, Zibiao Zhong, Yanfeng Wang, Qifa Ye. Aldehyde dehydrogenase 2 regulates autophagy via the Akt-mTOR pathway to mitigate renal ischemia-reperfusion injury in hypothermic machine perfusion.
Life sciences.
2020 Jul; 253(?):117705. doi:
10.1016/j.lfs.2020.117705
. [PMID: 32334008] - Naruemon Wikan, Jiraporn Tocharus, Sivanan Sivasinprasasn, Aphisek Kongkaew, Waraluck Chaichompoo, Apichart Suksamrarn, Chainarong Tocharus. Capsaicinoid nonivamide improves nonalcoholic fatty liver disease in rats fed a high-fat diet.
Journal of pharmacological sciences.
2020 Jul; 143(3):188-198. doi:
10.1016/j.jphs.2020.03.008
. [PMID: 32414691] - Jingjing Zhao, Daniel J Conklin, Yiru Guo, Xiang Zhang, Detlef Obal, Luping Guo, Ganapathy Jagatheesan, Kartik Katragadda, Liqing He, Xinmin Yin, Md Aminul Islam Prodhan, Jasmit Shah, David Hoetker, Amit Kumar, Vijay Kumar, Michael F Wempe, Aruni Bhatnagar, Shahid P Baba. Cardiospecific Overexpression of ATPGD1 (Carnosine Synthase) Increases Histidine Dipeptide Levels and Prevents Myocardial Ischemia Reperfusion Injury.
Journal of the American Heart Association.
2020 06; 9(12):e015222. doi:
10.1161/jaha.119.015222
. [PMID: 32515247] - Garrett Ungerer, Jiankun Cui, Tina Ndam, Mikeala Bekemeier, Hailong Song, Runting Li, Heather R Siedhoff, Bo Yang, Michael K Appenteng, C Michael Greenlief, Dennis K Miller, Grace Y Sun, William R Folk, Zezong Gu. Harpagophytum procumbens Extract Ameliorates Allodynia and Modulates Oxidative and Antioxidant Stress Pathways in a Rat Model of Spinal Cord Injury.
Neuromolecular medicine.
2020 06; 22(2):278-292. doi:
10.1007/s12017-019-08585-z
. [PMID: 31900786] - Brittany Woodby, Claudia Sticozzi, Erika Pambianchi, Gino Villetti, Maurizio Civelli, Giuseppe Valacchi, Fabrizio Facchinetti. The PDE4 inhibitor CHF6001 affects keratinocyte proliferation via cellular redox pathways.
Archives of biochemistry and biophysics.
2020 05; 685(?):108355. doi:
10.1016/j.abb.2020.108355
. [PMID: 32268137] - Mario Allegra, Ignazio Restivo, Alberto Fucarino, Alessandro Pitruzzella, Sonya Vasto, Maria Antonia Livrea, Luisa Tesoriere, Alessandro Attanzio. Proeryptotic Activity of 4-Hydroxynonenal: A New Potential Physiopathological Role for Lipid Peroxidation Products.
Biomolecules.
2020 05; 10(5):. doi:
10.3390/biom10050770
. [PMID: 32429353] - D Allan Butterfield, Mark P Mattson. Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease.
Neurobiology of disease.
2020 05; 138(?):104795. doi:
10.1016/j.nbd.2020.104795
. [PMID: 32036033] - Enaam Chleilat, Abhishek Pethe, Dietmar Pfeifer, Kerstin Krieglstein, Eleni Roussa. TGF-β Signaling Regulates SLC8A3 Expression and Prevents Oxidative Stress in Developing Midbrain Dopaminergic and Dorsal Raphe Serotonergic Neurons.
International journal of molecular sciences.
2020 Apr; 21(8):. doi:
10.3390/ijms21082735
. [PMID: 32326436] - Bipradas Roy, Suresh Selvaraj Palaniyandi. Aldehyde dehydrogenase 2 inhibition potentiates 4-hydroxy-2-nonenal induced decrease in angiogenesis of coronary endothelial cells.
Cell biochemistry and function.
2020 Apr; 38(3):290-299. doi:
10.1002/cbf.3468
. [PMID: 31943249] - Namrata Mittra, Amit Kumar Chauhan, Garima Singh, Devendra Kumar Patel, Chetna Singh. Postnatal zinc or paraquat administration increases paraquat or zinc-induced loss of dopaminergic neurons: insight into augmented neurodegeneration.
Molecular and cellular biochemistry.
2020 Apr; 467(1-2):27-43. doi:
10.1007/s11010-020-03694-x
. [PMID: 32060784] - Hiroshi Maezawa, Hiroko P Indo, Noriko Usami, Hideyuki J Majima, Hiromu Ito, Ken Ohnishi, Katsumi Kobayashi. Enhancement of membrane lipid peroxidation in lung cancer cells irradiated with monoenergetic X-rays at the K-shell resonance absorption peak of phosphorus.
Journal of radiation research.
2020 Mar; 61(2):237-242. doi:
10.1093/jrr/rrz098
. [PMID: 31904079] - Ilenia Martinelli, Daniele Tomassoni, Michele Moruzzi, Proshanta Roy, Carlo Cifani, Francesco Amenta, Seyed Khosrow Tayebati. Cardiovascular Changes Related to Metabolic Syndrome: Evidence in Obese Zucker Rats.
International journal of molecular sciences.
2020 Mar; 21(6):. doi:
10.3390/ijms21062035
. [PMID: 32188150] - Shenae Louise Cafe, Brett Nixon, Matthew D Dun, Shaun Daryl Roman, Ilana Ruth Bernstein, Elizabeth Grace Bromfield. Oxidative Stress Dysregulates Protein Homeostasis Within the Male Germ Line.
Antioxidants & redox signaling.
2020 03; 32(8):487-503. doi:
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