3-Hydroxyoctanoic acid (BioDeep_00000013655)

 

Secondary id: BioDeep_00000593861

human metabolite Endogenous blood metabolite


代谢物信息卡片


3-Hydroxyoctanoic acid, (S)-isomer

化学式: C8H16O3 (160.1099386)
中文名称: 3-羟基辛酸
谱图信息: 最多检出来源 Homo sapiens(blood) 3.13%

Reviewed

Last reviewed on 2024-07-15.

Cite this Page

3-Hydroxyoctanoic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/3-hydroxyoctanoic_acid (retrieved 2024-09-19) (BioDeep RN: BioDeep_00000013655). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CCCCCC(CC(=O)O)O
InChI: InChI=1S/C8H16O3/c1-2-3-4-5-7(9)6-8(10)11/h7,9H,2-6H2,1H3,(H,10,11)

描述信息

3-Hydroxyoctanoic acid (CAS: 14292-27-4) is an organic 3-hydroxy dicarboxylic acid, a metabolite of medium-chain fatty acid oxidation found in human urine. It is believed that urinary 3-hydroxy dicarboxylic acids are derived from the omega-oxidation of 3-hydroxy fatty acids and the subsequent beta-oxidation of longer-chain 3-hydroxy dicarboxylic acids. (PMID:1870421). 3-Hydroxyoctanoic acid has been identified in the human placenta (PMID: 32033212).
3-Hydroxycaprylic acid is an organic (3-hydroxy dicarboxylic) acid, a metabolite of medium-chain fatty acid oxidation found in human urine. It is believed that urinary 3-hydroxy dicarboxylic acids are derived from the w-oxidation of 3-hydroxy fatty acids and the subsequent b-oxidation of longer-chain 3-hydroxy dicarboxylic acids. (PMID 1870421 ) [HMDB]

同义名列表

56 个代谢物同义名

3-Hydroxyoctanoic acid, (S)-isomer; (S)-beta-Hydroxycaprylic acid; (S)-beta-Hydroxyoctanoic acid; (3S)-3-Hydroxy-octanoic acid; (3S)-3-Hydroxyoctanoic acid; (±)-3-hydroxyoctanoic acid; (S)-3-hydroxyoctanoic acid; (S)-b-Hydroxycaprylic acid; (S)-b-Hydroxyoctanoic acid; (S)-Β-hydroxyoctanoic acid; (S)-Β-hydroxycaprylic acid; (S)-3-Hydroxycaprylic acid; beta-Hydroxycaprylic acid; (S)-beta-OH-Caprylic acid; (S)-beta-Hydroxycaprylate; (S)-beta-Hydroxyoctanoate; beta-Hydroxyoctanoic acid; (S)-beta-OH-Octanoic acid; (3S)-3-Hydroxy-octanoate; S-3-Hydroxyoctanoic acid; (3S)-3-Hydroxyoctanoate; 3-hydroxy Octanoic Acid; (S)-b-Hydroxycaprylate; 3-HYDROXYOCTANOIC ACID; 3-Hydroxycaprylic acid; Β-hydroxyoctanoic acid; (S)-3-OH-Caprylic acid; (S)-b-OH-Octanoic acid; (S)-b-OH-Caprylic acid; (S)-Β-OH-caprylic acid; (S)-b-Hydroxyoctanoate; (S)-Β-hydroxycaprylate; (S)-Β-hydroxyoctanoate; (S)-3-Hydroxyoctanoate; (S)-Β-OH-octanoic acid; (S)-3-OH Octanoic acid; (S)-3-Hydroxycaprylate; Β-hydroxycaprylic acid; (±)-3-hydroxyoctanoate; (S)-beta-OH-Octanoate; beta-Hydroxycaprylate; beta-Hydroxyoctanoate; (S)-beta-OH-Caprylate; S-3-Hydroxyoctanoate; (S)-b-OH-Caprylate; 3-Hydroxycaprylate; (S)-Β-OH-octanoate; Β-hydroxyoctanoate; 3-Hydroxyoctanoate; (S)-Β-OH-caprylate; (S)-b-OH-Octanoate; Β-hydroxycaprylate; (S)-3-OH Octanoate; (S)-3-OH-Caprylate; FA(8:0(3S-OH)); FA(8:0(3-OH))



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

7 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Araceli Flores-Sánchez, Arthi Rathinasabapathy, Ma Del Rocío López-Cuellar, Berenice Vergara-Porras, Fermín Pérez-Guevara. Biosynthesis of polyhydroxyalkanoates from vegetable oil under the co-expression of fadE and phaJ genes in Cupriavidus necator. International journal of biological macromolecules. 2020 Dec; 164(?):1600-1607. doi: 10.1016/j.ijbiomac.2020.07.275. [PMID: 32768477]
  • Mohd Rafais Mohd Razaif-Mazinah, Siti Nor Syairah Anis, Hazwani Izzati Harun, Khairunnisa Abdul Rashid, Mohamad Suffian Mohamad Annuar. Unusual poly(3-hydroxyalkanoate) (PHA) biosynthesis behavior of Pseudomonas putida Bet001 and Delftia tsuruhatensis Bet002 isolated from palm oil mill effluent. Biotechnology and applied biochemistry. 2017 Mar; 64(2):259-269. doi: 10.1002/bab.1482. [PMID: 26800648]
  • Silvio Uhlig, Mariell Negård, Kari K Heldal, Anne Straumfors, Lene Madsø, Berit Bakke, Wijnand Eduard. Profiling of 3-hydroxy fatty acids as environmental markers of endotoxin using liquid chromatography coupled to tandem mass spectrometry. Journal of chromatography. A. 2016 Feb; 1434(?):119-26. doi: 10.1016/j.chroma.2016.01.038. [PMID: 26818235]
  • Yi-Jr Chen, Yan-Chia Huang, Chia-Yin Lee. Production and characterization of medium-chain-length polyhydroxyalkanoates by Pseudomonas mosselii TO7. Journal of bioscience and bioengineering. 2014 Aug; 118(2):145-52. doi: 10.1016/j.jbiosc.2014.01.012. [PMID: 24630613]
  • Q Zhou, G Li, X Y Deng, X B He, L J Chen, C Wu, Y Shi, K P Wu, L J Mei, J X Lu, N M Zhou. Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways. British journal of pharmacology. 2012 Jul; 166(6):1756-73. doi: 10.1111/j.1476-5381.2012.01875.x. [PMID: 22289163]
  • Justyna Mozejko, Andreas Wilke, Grzegorz Przybyłek, Slawomir Ciesielski. Mcl-PHAs produced by Pseudomonas sp. Gl01 using fed-batch cultivation with waste rapeseed oil as carbon source. Journal of microbiology and biotechnology. 2012 Mar; 22(3):371-7. doi: 10.4014/jmb.1106.06039. [PMID: 22450793]
  • Pierre-Henri Villard, Fabrice Barlesi, Martine Armand, Thi-Mai-Anh Dao, Jean-Marc Pascussi, Francis Fouchier, Serge Champion, Claire Dufour, Christian Giniès, Ayman Khalil, Marie-Josephe Amiot, Yves Barra, Eric Seree. CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site. PloS one. 2011 Jan; 6(1):e14629. doi: 10.1371/journal.pone.0014629. [PMID: 21304969]
  • Kashan Ahmed, Sorin Tunaru, Claus-Dieter Langhans, Julien Hanson, Christoph W Michalski, Stefan Kölker, Patricia M Jones, Jürgen G Okun, Stefan Offermanns. Deorphanization of GPR109B as a receptor for the beta-oxidation intermediate 3-OH-octanoic acid and its role in the regulation of lipolysis. The Journal of biological chemistry. 2009 Aug; 284(33):21928-21933. doi: 10.1074/jbc.m109.019455. [PMID: 19561068]
  • Norman W Schaad, Elena Postnikova, Aaron Sechler, Larry E Claflin, Anne K Vidaver, Jeffrey B Jones, Irina Agarkova, Alexander Ignatov, Ellen Dickstein, Bruce A Ramundo. Reclassification of subspecies of Acidovorax avenae as A. Avenae (Manns 1905) emend., A. cattleyae (Pavarino, 1911) comb. nov., A. citrulli Schaad et al., 1978) comb. nov., and proposal of A. oryzae sp. nov. Systematic and applied microbiology. 2008 Dec; 31(6-8):434-46. doi: 10.1016/j.syapm.2008.09.003. [PMID: 18993005]
  • Christelle Simon-Colin, Gérard Raguénès, Philippe Crassous, Xavier Moppert, Jean Guezennec. A novel mcl-PHA produced on coprah oil by Pseudomonas guezennei biovar. tikehau, isolated from a 'kopara' mat of French Polynesia. International journal of biological macromolecules. 2008 Aug; 43(2):176-81. doi: 10.1016/j.ijbiomac.2008.04.011. [PMID: 18538385]
  • Nehal Thakor, Ujjval Trivedi, K C Patel. Biosynthesis of medium chain length poly(3-hydroxyalkanoates) (mcl-PHAs) by Comamonas testosteroni during cultivation on vegetable oils. Bioresource technology. 2005 Nov; 96(17):1843-50. doi: 10.1016/j.biortech.2005.01.030. [PMID: 16084364]
  • Hyung Woo Kim, Chung Wook Chung, Sung Soo Kim, Young Baek Kim, Young Ha Rhee. Preparation and cell compatibility of acrylamide-grafted poly(3-hydroxyoctanoate). International journal of biological macromolecules. 2002 Apr; 30(2):129-35. doi: 10.1016/s0141-8130(02)00012-0. [PMID: 11911904]
  • V Gorenflo, G Schmack, R Vogel, A Steinbüchel. Development of a process for the biotechnological large-scale production of 4-hydroxyvalerate-containing polyesters and characterization of their physical and mechanical properties. Biomacromolecules. 2001; 2(1):45-57. doi: 10.1021/bm0000992. [PMID: 11749154]
  • C C Costa, L Dorland, M Kroon, I Tavares de Almeida, C Jakobs, M Duran. 3-, 6- and 7-hydroxyoctanoic acids are metabolites of medium-chain triglycerides and excreted in urine as glucuronides. Journal of mass spectrometry : JMS. 1996 Jun; 31(6):633-8. doi: 10.1002/(sici)1096-9888(199606)31:6<633::aid-jms332>3.0.co;2-l. [PMID: 8799296]