Manzamine A (BioDeep_00000013118)

natural product

代谢物信息卡片

Keramamine A

化学式: C36H44N4O (548.3515)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(not specific) 2.78%

分子结构信息

SMILES: C1CCN2CCC3C(=CC(CCC=CC1)(C4C3(C2)CC5N4CCCCC=C5)O)C6=NC=CC7=C6NC8=CC=CC=C78
InChI: InChI=1S/C36H44N4O/c41-36-18-10-4-1-2-5-11-20-39-22-17-30(35(25-39)23-26-13-7-3-6-12-21-40(26)34(35)36)29(24-36)32-33-28(16-19-37-32)27-14-8-9-15-31(27)38-33/h1,4,7-9,13-16,19,24,26,30,34,38,41H,2-3,5-6,10-12,17-18,20-23,25H2/b4-1+,13-7-/t26-,30-,34+,35-,36-/m0/s1

描述信息

An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).

同义名列表

3 个代谢物同义名

Manzamine A; Keramamine A; Manzamine A

数据库引用编号

16 个数据库交叉引用编号

ChEBI: CHEBI:66667
KEGG: C19898
PubChem: 6509753
PubChem: 14727313
PubChem: 3705474
Metlin: METLIN73419
ChEMBL: CHEMBL403233
ChEMBL: CHEMBL326531
CAS: 104196-68-1
PMhub: MS000027516
MetaboLights: MTBLC66667
PubChem: 135626364
KNApSAcK: C00026860
RefMet: Manzamine A
LOTUS: LTS0254265
LOTUS: LTS0202401

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

39 个相关的物种来源信息

178473 - Acanthostrongylophora: 10.1248/CPB.56.866
178473 - Acanthostrongylophora: LTS0202401
178473 - Acanthostrongylophora: LTS0254265
237153 - Acanthostrongylophora ingens: 10.1021/NP500290A
237153 - Acanthostrongylophora ingens: LTS0202401
237153 - Acanthostrongylophora ingens: LTS0254265
178513 - Amphimedon:
178513 - Amphimedon: 10.1016/0040-4020(95)01057-2
178513 - Amphimedon: 10.1016/S0040-4020(01)85280-7
178513 - Amphimedon: 10.1016/S0040-4039(00)73362-4
178513 - Amphimedon: 10.1016/S0040-4039(97)10842-5
178513 - Amphimedon: 10.1021/NP50114A021
178513 - Amphimedon: LTS0254265
6056 - Chalinidae: LTS0202401
6056 - Chalinidae: LTS0254265
6042 - Demospongiae: LTS0202401
6042 - Demospongiae: LTS0254265
2759 - Eukaryota: LTS0202401
2759 - Eukaryota: LTS0254265
6061 - Halichondria: 10.1016/S0040-4039(00)95796-4
6057 - Haliclona: 10.1021/JA00280A055
6057 - Haliclona: LTS0202401
6057 - Haliclona: LTS0254265
275431 - Ircinia: 10.1021/JO00034A052
275431 - Ircinia: LTS0254265
275430 - Irciniidae: LTS0254265
33208 - Metazoa: LTS0202401
33208 - Metazoa: LTS0254265
178475 - Niphatidae: LTS0254265
1658102 - Pachypellina: 10.1021/NP50103A027
1658102 - Pachypellina: LTS0254265
68562 - Petrosiidae: 10.1021/NP020592U
68562 - Petrosiidae: LTS0202401
68562 - Petrosiidae: LTS0254265
283401 - Phloeodictyidae: LTS0254265
6040 - Porifera: LTS0202401
6040 - Porifera: LTS0254265
178550 - Xestospongia: 10.1016/0040-4020(95)95723-9
178550 - Xestospongia: LTS0254265

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表

文献列表

Li-Chun Lin, Hsin-Yi Chang, Tzu-Ting Kuo, Hsin-Yuan Chen, Wen-Shan Liu, Yii-Jwu Lo, Shih-Min Hsia, Tsui-Chin Huang. Oxidative stress mediates the inhibitory effects of Manzamine A on uterine leiomyoma cell proliferation and extracellular matrix deposition via SOAT inhibition. Redox biology. 2023 10; 66(?):102861. doi: 10.1016/j.redox.2023.102861. [PMID: 37666118]
Sneha Singh, Nandini Pathak, Eram Fatima, Arvind Singh Negi. Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine. European journal of medicinal chemistry. 2021 Dec; 226(?):113839. doi: 10.1016/j.ejmech.2021.113839. [PMID: 34536668]
Bo Luo, Xinqiang Song. A comprehensive overview of β-carbolines and its derivatives as anticancer agents. European journal of medicinal chemistry. 2021 Nov; 224(?):113688. doi: 10.1016/j.ejmech.2021.113688. [PMID: 34332400]
Navriti Chadha, Om Silakari. Indoles as therapeutics of interest in medicinal chemistry: Bird's eye view. European journal of medicinal chemistry. 2017 Jul; 134(?):159-184. doi: 10.1016/j.ejmech.2017.04.003. [PMID: 28412530]
Keisuke Eguchi, Yukio Fujiwara, Akinori Hayashida, Hasita Horlad, Hikaru Kato, Henki Rotinsulu, Fitje Losung, Remy E P Mangindaan, Nicole J de Voogd, Motohiro Takeya, Sachiko Tsukamoto. Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo. Bioorganic & medicinal chemistry. 2013 Jul; 21(13):3831-8. doi: 10.1016/j.bmc.2013.04.025. [PMID: 23665143]
Volodymyr Samoylenko, Shabana I Khan, Melissa R Jacoba, Babu L Tekwani, Larry A Walker, Charles D Hufford, Ilias Muhammad. Bioactive (+)-manzamine A and (+)-8-hydroxymanzamine A tertiary bases and salts from Acanthostrongylophora ingens and their preparations. Natural product communications. 2009 Feb; 4(2):185-92. doi: NULL. [PMID: 19370920]
Mohamed A Ibrahim, Abbas G Shilabin, Sivaprakasam Prasanna, Melissa Jacob, Shabana I Khan, Robert J Doerksen, Mark T Hamann. 2-N-Methyl modifications and SAR studies of manzamine A. Bioorganic & medicinal chemistry. 2008 Jul; 16(14):6702-6. doi: 10.1016/j.bmc.2008.05.079. [PMID: 18595720]
A Khalil, K El-Sayed, F Belal, N Y Khalil, M Hamann. Spectrofluorimetric determination of manzamine A in spiked human urine and plasma. Die Pharmazie. 2003 Jun; 58(6):385-8. doi: NULL. [PMID: 12856999]
Masako Nakagawa, Toshiaki Nagata, Koji Ono, Hideharu Uchida, Takeshi Watanabe, Keisuke Hatakeyama, Masakatsu Akiba, Mihoko Fuwa, Mitsuhiro Arisawa, Atsushi Nishida. Recent developments in marine indole alkaloid synthesis. Advances in experimental medicine and biology. 2003; 527(?):609-20. doi: 10.1007/978-1-4615-0135-0_70. [PMID: 15206780]
K K Ang, M J Holmes, T Higa, M T Hamann, U A Kara. In vivo antimalarial activity of the beta-carboline alkaloid manzamine A. Antimicrobial agents and chemotherapy. 2000 Jun; 44(6):1645-9. doi: 10.1128/aac.44.6.1645-1649.2000. [PMID: 10817722]