Reaction Process: Reactome:R-CEL-5676934

Protein repair related metabolites

find 5 related metabolites which is associated with chemical reaction(pathway) Protein repair

R-MetO + TXN ⟶ 2xHC-TXN + L-Met

N-Methyl-D-aspartic acid

(2R)-2-(methylamino)butanedioic acid

C5H9NO4 (147.0531554)


N-Methyl-D-aspartic acid is an amino acid derivative acting as a specific agonist at the NMDA receptor, and therefore mimics the action of the neurotransmitter glutamate on that receptor. In contrast to glutamate, NMDA binds to and regulates the above receptor only, but not other glutamate receptors. NMDA is a water-soluble endogenous metabolite that plays an important role in the neuroendocrine system of species across Animalia (PMID:18096065). It was first synthesized in the 1960s (PMID:14056452). NMDA is an excitotoxin; this trait has applications in behavioural neuroscience research. The body of work utilizing this technique falls under the term "lesion studies." Researchers apply NMDA to specific regions of an (animal) subjects brain or spinal cord and subsequently test for the behaviour of interest, such as operant behaviour. If the behaviour is compromised, it suggests that the destroyed tissue was part of a brain region that made an important contribution to the normal expression of that behaviour. Examples of antagonists of the NMDA receptor are ketamine, amantadine, dextromethorphan (DXM), riluzole, and memantine. They are commonly referred to as NMDA receptor antagonists (PMID:28877137). N-Methyl-D-aspartic acid is an amino acid derivative acting as a specific agonist at the NMDA receptor, and therefore mimics the action of the neurotransmitter glutamate on that receptor. In contrast to glutamate, NMDA binds to and regulates the above receptor only, but not other glutamate receptors. D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018690 - Excitatory Amino Acid Agonists N-Methyl-DL-aspartic acid is a glutamate analogue and a?NMDA?receptor?agonist and can be used for neurological diseases research[1][2].

   

L-Methionine (R)-S-oxide

L-Methionine (R)-S-oxide

C5H11NO3S (165.0459616)


The (R)-oxido diastereomer of L-methionine S-oxide.

   

S-Adenosyl-L-methionine

S-Adenosyl-L-methionine

C15H23N6O5S+ (399.1450568)


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(2S)-2-ammonio-4-(methylsulfanyl)butanoate

(2S)-2-ammonio-4-(methylsulfanyl)butanoate

C5H11NO2S (149.0510466)


   

5-S-[(3S)-3-azaniumyl-3-carboxylatopropyl]-5-thioadenosine

5-S-[(3S)-3-azaniumyl-3-carboxylatopropyl]-5-thioadenosine

C14H20N6O5S (384.12158300000004)