Reaction Process: PharmGKB:PA166163705

Diclofenac Pathway, Pharmacokinetics related metabolites

find 6 related metabolites which is associated with chemical reaction(pathway) Diclofenac Pathway, Pharmacokinetics

diclofenac ⟶ diclofenac acyl glucuronide

4'-Hydroxydiclofenac

2-{2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid

4-Hydroxydiclofenac is only found in individuals that have used or taken Diclofenac. 4-Hydroxydiclofenac is a metabolite of Diclofenac. 4-hydroxydiclofenac belongs to the family of Phenylacetic Acid Derivatives. These are compounds containing a phenylacetic acid moiety, which consists of a phenyl group substituted at the second position by an acetic acid.

5-Hydroxydiclofenac

2-{2-[(2,6-dichlorophenyl)amino]-5-hydroxyphenyl}acetic acid

C14H11Cl2NO3 (311.0115956000001)

5-Hydroxydiclofenac (5-OH-DCF) is a metabolite of Diclofenac. Diclofenac (cf. INN with trade names) is a nonsteroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in certain conditions. (Wikipedia)

3'-Hydroxydiclofenac

2-{2-[(2,6-dichloro-3-hydroxyphenyl)amino]phenyl}acetic acid

C14H11Cl2NO3 (311.0115956000001)

3-Hydroxydiclofenac is only found in individuals that have used or taken Diclofenac. 3-Hydroxydiclofenac is a metabolite of Diclofenac. 3-hydroxydiclofenac belongs to the family of Phenylacetic Acid Derivatives. These are compounds containing a phenylacetic acid moiety, which consists of a phenyl group substituted at the second position by an acetic acid.

Diclofenac acyl glucuronide

(2S,3S,4S,5R,6S)-6-[(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetyl)oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid

C20H19Cl2NO8 (471.04876740000003)

Diclofenac acyl glucuronide is a metabolite of diclofenac. Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in certain conditions. The name is derived from its chemical name: 2-(2,6-dichloranilino) phenylacetic acid. In the United Kingdom, India, Brazil and the United States, it may be supplied as either the sodium or potassium salt, in China most often as the sodium salt, while in some other countries only as the potassium salt. (Wikipedia)

4,5-Dihydroxydiclofenac

C14H11Cl2NO4 (327.00651060000007)

A monocarboxylic acid that is the 4,5-dihydroxylated metabolite of diclofenac.

5-Hydroxydiclofenac quinone imine

C14H9Cl2NO3 (308.9959464)

A quinone imine that is a metabolite of diclofenac arising from 5-hydroxylation followed by oxidation.