5-Hydroxydiclofenac (BioDeep_00000018103)

   

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


2-{2-[(2,6-dichlorophenyl)amino]-5-hydroxyphenyl}acetic acid

化学式: C14H11Cl2NO3 (311.0115956000001)
中文名称: 2-[(2,6-二氯苯基)氨基]-5-羟基苯乙酸
谱图信息: 最多检出来源 Homo sapiens(urine) 16.67%

分子结构信息

SMILES: C1=CC(=C(C(=C1)Cl)NC2=C(C=C(C=C2)O)CC(=O)O)Cl
InChI: InChI=1S/C14H11Cl2NO3/c15-10-2-1-3-11(16)14(10)17-12-5-4-9(18)6-8(12)7-13(19)20/h1-6,17-18H,7H2,(H,19,20)

描述信息

5-Hydroxydiclofenac (5-OH-DCF) is a metabolite of Diclofenac. Diclofenac (cf. INN with trade names) is a nonsteroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in certain conditions. (Wikipedia)

同义名列表

7 个代谢物同义名

2-{2-[(2,6-dichlorophenyl)amino]-5-hydroxyphenyl}acetic acid; 2-[(2,6-Dichloroanilino)-5-hydroxyphenyl]acetic acid; 2-[(2,6-Dichloroanilino)-5-hydroxyphenyl]acetate; 5-Hydroxy diclofenac; 5-Hydroxydiclofenac; 5-OH-DCF; 5-OH DCF



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(1)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Weifan Jiang, Tianming Dai, Shuilin Xie, Lan Ding, Lizhen Huang, Renke Dai. Roles of diclofenac and its metabolites in immune activation associated with acute hepatotoxicity in TgCYP3A4/hPXR-humanized mice. International immunopharmacology. 2020 Sep; 86(?):106723. doi: 10.1016/j.intimp.2020.106723. [PMID: 32615451]
  • Tomonori Miura, Shotaro Uehara, Makiko Shimizu, Norie Murayama, Masahiro Utoh, Hiroshi Suemizu, Hiroshi Yamazaki. Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice. Chemical research in toxicology. 2020 02; 33(2):634-639. doi: 10.1021/acs.chemrestox.9b00446. [PMID: 31854189]
  • Tomoyuki Kishida, Tomoya Onozato, Toru Kanazawa, Satoru Tanaka, Junji Kuroda. Increase in covalent binding of 5-hydroxydiclofenac to hepatic tissues in rats co-treated with lipopolysaccharide and diclofenac: involvement in the onset of diclofenac-induced idiosyncratic hepatotoxicity. The Journal of toxicological sciences. 2012; 37(6):1143-56. doi: 10.2131/jts.37.1143. [PMID: 23208430]
  • Andrea Harrer, Roland Lang, Robert Grims, Michaela Braitsch, Thomas Hawranek, Werner Aberer, Lothar Vogel, Walther Schmid, Fatima Ferreira, Martin Himly. Diclofenac hypersensitivity: antibody responses to the parent drug and relevant metabolites. PloS one. 2010 Oct; 5(10):e13707. doi: 10.1371/journal.pone.0013707. [PMID: 21060839]
  • Ilse Forrez, Marta Carballa, Kim Verbeken, Lynn Vanhaecke, Thomas Ternes, Nico Boon, Willy Verstraete. Diclofenac oxidation by biogenic manganese oxides. Environmental science & technology. 2010 May; 44(9):3449-54. doi: 10.1021/es9027327. [PMID: 20369877]
  • Jurjen S Lagas, Rolf W Sparidans, Els Wagenaar, Jos H Beijnen, Alfred H Schinkel. Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters. Molecular pharmacology. 2010 Apr; 77(4):687-94. doi: 10.1124/mol.109.062364. [PMID: 20086033]
  • Dele Stülten, Sebastian Zühlke, Marc Lamshöft, Michael Spiteller. Occurrence of diclofenac and selected metabolites in sewage effluents. The Science of the total environment. 2008 Nov; 405(1-3):310-6. doi: 10.1016/j.scitotenv.2008.05.036. [PMID: 18640705]
  • Lata Kaphalia, Bhupendra S Kaphalia, Santosh Kumar, Mary F Kanz, Mary Treinen-Moslen. Efficient high performance liquid chromatograph/ultraviolet method for determination of diclofenac and 4'-hydroxydiclofenac in rat serum. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Jan; 830(2):231-7. doi: 10.1016/j.jchromb.2005.10.045. [PMID: 16301007]
  • Ulrich J H Sachs, Sentot Santoso, Lida Röder, Elizabeth Smart, Gregor Bein, Hartmut Kroll. Diclofenac-induced antibodies against red blood cells are heterogeneous and recognize different epitopes. Transfusion. 2004 Aug; 44(8):1226-30. doi: 10.1111/j.1537-2995.2004.04025.x. [PMID: 15265128]
  • Caroline D van der Marel, Brian J Anderson, Janne Rømsing, Evelyne Jacqz-Aigrain, Dick Tibboel. Diclofenac and metabolite pharmacokinetics in children. Paediatric anaesthesia. 2004 Jun; 14(6):443-51. doi: 10.1111/j.1460-9592.2004.01232.x. [PMID: 15153204]