Biological Pathway: Reactome:R-HSA-163754

Insulin effects increased synthesis of Xylulose-5-Phosphate related metabolites

find 12 related metabolites which is associated with the biological pathway Insulin effects increased synthesis of Xylulose-5-Phosphate

this pathway object is a organism specific pathway, which is related to taxonomy Homo sapiens (human).

One of the downstream effects of insulin, mediated via protein phosphatase 2A (PP2A), is increased synthesis of Fructose-2,6-bisphosphate, an allosteric activator of phosphofructokinase 1 (PFK1). PFK1 in turn catalyzes the committed step of glycolysis so the net effect of this whole sequence of events set off by insulin is to increase cytosolic concentrations of the small molecules formed in the course of glycolysis. This in turn drives the increased synthesis of Xylulose-5-phosphate, itself a positive regulator of PP2A.

View the spectrum consensus network of the metabolites related with current biological pathway.

Sedoheptulose 7-phosphate

[(2R,3R,4R,5S)-2,3,4,5,7-pentahydroxy-6-oxoheptyl] dihydrogen phosphate

C7H15O10P (290.0403)


KEIO_ID S083

   

Magnesium

Magnesium Cation

Mg+2 (23.985)


   

Sedoheptulose 7-phosphate

sedoheptulose-7-phosphate

C7H15O10P (290.0403)


   

D-Sedoheptulose 7-phosphate

{[(2R,3S,4R,5S,6S)-3,4,5,6-tetrahydroxy-6-(hydroxymethyl)oxan-2-yl]methoxy}phosphonic acid

C7H15O10P (290.0403)


D-Sedoheptulose 7-phosphate (CAS: 2646-35-7) is an intermediate of the pentose phosphate pathway (PPP) that has two functions: (1) the generation of NADPH for reductive syntheses and oxidative stress responses within cells, and (2) the formation of ribose residues for nucleotide and nucleic acid biosynthesis (PMID: 16055050). It is formed by transketolase and acted upon (degraded) by transaldolase. Sedoheptulose 7-phosphate can be increased in the blood of patients affected with a transaldolase deficiency, a genetic disorder (PMID: 12881455). Sedoheptulose is a ketoheptose, a monosaccharide with seven carbon atoms and a ketone functional group. It is one of the few heptoses found in nature (Wikipedia). D-Sedoheptulose 7-phosphate is an intermediate of the Pentose phosphate pathway (PPP) that has two functions: the generation of NADPH for reductive syntheses and oxidative stress responses within cells, and the formation of ribose residues for nucleotide and nucleic acid biosynthesis. (PMID 16055050)

   

Thiamine(1+) diphosphate(3-)

Thiamine(1+) diphosphate(3-)

C12H16N4O7P2S-2 (422.0215)


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Xylulose 5-phosphate

Xylulose 5-phosphate

C5H9O8P-2 (228.0035)


   

D-glyceraldehyde 3-phosphate(2-)

D-glyceraldehyde 3-phosphate(2-)

C3H5O6P-2 (167.9824)


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beta-D-fructofuranose 6-phosphate(2-)

beta-D-fructofuranose 6-phosphate(2-)

C6H11O9P-2 (258.0141)


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D-erythrose 4-phosphate(2-)

D-erythrose 4-phosphate(2-)

C4H7O7P-2 (197.9929)


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D-ribofuranose 5-phosphate(2-)

D-ribofuranose 5-phosphate(2-)

C5H9O8P-2 (228.0035)


   

Magnesium Cation

Magnesium Cation

Mg+2 (23.985)


   

Sedoheptulose 7-phosphate

[(2R,3R,4R,5S)-2,3,4,5,7-pentahydroxy-6-oxoheptyl] dihydrogen phosphate

C7H15O10P (290.0403)


A ketoheptose phosphate consisting of sedoheptulose having a phosphate group at the 7-position. It is an intermediate metabolite in the pentose phosphate pathway.