NCBI Taxonomy: 887469

Streptomyces staurosporininus (ncbi_taxid: 887469)

found 2 associated metabolites at species taxonomy rank level.

Ancestor: Streptomyces

Child Taxonomies: none taxonomy data.

staurosporine

2,3,10,11,12,13-hexahydro-10R-methoxy-9S-methyl-11R-methylamino-9S,13R-epoxy-1H,9H-diindolo[1,2,3-gh;3,2,1-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one

C28H26N4O3 (466.2004806)


C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor D004791 - Enzyme Inhibitors Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer[1][2][3][4][5].