NCBI Taxonomy: 629717
Peraceae (ncbi_taxid: 629717)
found 76 associated metabolites at family taxonomy rank level.
Ancestor: Malpighiales
Child Taxonomies: Pera, Clutia, Pogonophora
Spinosin
Spinosin is a flavone C-glycoside that is flavone substituted by hydroxy groups at positions 5 and 4, a methoxy group at position 7 and a 2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl residue at position 6 via a C-glycosidic linkage. It has a role as a plant metabolite and an anxiolytic drug. It is a flavone C-glycoside, a dihydroxyflavone and a monomethoxyflavone. It is functionally related to a flavone. Spinosin is a natural product found in Clutia abyssinica, Galipea trifoliata, and other organisms with data available. A flavone C-glycoside that is flavone substituted by hydroxy groups at positions 5 and 4, a methoxy group at position 7 and a 2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl residue at position 6 via a C-glycosidic linkage. Spinosyn a C-glycoside flavonoid isolated from the seeds of Zizyphus jujube, with neuroprotective effects. Spinosin inhibits Aβ1-42 production and aggregation via activating Nrf2/HO-1 pathway[1][2][3]. Spinosyn a C-glycoside flavonoid isolated from the seeds of Zizyphus jujube, with neuroprotective effects. Spinosin inhibits Aβ1-42 production and aggregation via activating Nrf2/HO-1 pathway[1][2][3].
Lupeol
Lupeol is a pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in many edible fruits and vegetables. It has a role as an anti-inflammatory drug and a plant metabolite. It is a secondary alcohol and a pentacyclic triterpenoid. It derives from a hydride of a lupane. Lupeol has been investigated for the treatment of Acne. Lupeol is a natural product found in Ficus auriculata, Ficus septica, and other organisms with data available. See also: Calendula Officinalis Flower (part of). A pentacyclic triterpenoid that is lupane in which the hydrogen at the 3beta position is substituted by a hydroxy group. It occurs in the skin of lupin seeds, as well as in the latex of fig trees and of rubber plants. It is also found in many edible fruits and vegetables. D000893 - Anti-Inflammatory Agents Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic?triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent?androgen receptor (AR)?inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC)[1]. Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic?triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent?androgen receptor (AR)?inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC)[1].
Plumbagin
Plumbagin, also known as 5-hydroxy-2-methyl-1,4-naphthoquinone or 2-methyljuglone, is a member of the class of compounds known as naphthoquinones. Naphthoquinones are compounds containing a naphthohydroquinone moiety, which consists of a benzene ring linearly fused to a bezene-1,4-dione (quinone). Plumbagin is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Plumbagin can be found in black walnut, common walnut, japanese persimmon, and persimmon, which makes plumbagin a potential biomarker for the consumption of these food products. Plumbagin is named after the plant genus Plumbago, from which it was originally isolated. It is also commonly found in the carnivorous plant genera Drosera and Nepenthes. It is also a component of the black walnut drupe . D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor D020011 - Protective Agents > D002316 - Cardiotonic Agents D006401 - Hematologic Agents > D000925 - Anticoagulants D000970 - Antineoplastic Agents D002317 - Cardiovascular Agents D007155 - Immunologic Factors Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities[1]. Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities[1].
Spinosin
Plumbagin
Plumbagin is a hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively. It has a role as a metabolite, an immunological adjuvant, an anticoagulant and an antineoplastic agent. It is a member of phenols and a hydroxy-1,4-naphthoquinone. Plumbagin is a compound investigated for its anticancer activity. It has been found that it inactivates the Akt/NF-kB, MMP-9 and VEGF pathways. Plumbagin is a natural product found in Drosera slackii, Diospyros hebecarpa, and other organisms with data available. Synthetic Plumbagin PCUR-101 is a synthetic form of the plant-derived medicinal agent, plumbagin, with potential antineoplastic activity. Plumbagin may act by inhibiting the expression of protein kinase C epsilon (PKCe), signal transducers and activators of transcription 3 phosphorylation (Stat3), protein kinase B (AKT), and certain epithelial-to-mesenchymal transition (EMT) markers, including vimentin and slug. This results in possible inhibition of proliferation in susceptible tumor cells. PKCe, Stat3, AKT, and the EMT markers vimentin and slug have been linked to the induction and progression of prostate cancer. A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively. D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor D020011 - Protective Agents > D002316 - Cardiotonic Agents D006401 - Hematologic Agents > D000925 - Anticoagulants D000970 - Antineoplastic Agents D002317 - Cardiovascular Agents D007155 - Immunologic Factors relative retention time with respect to 9-anthracene Carboxylic Acid is 0.955 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.957 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.960 Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities[1]. Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities[1].
lupeol
D000893 - Anti-Inflammatory Agents Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic?triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent?androgen receptor (AR)?inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC)[1]. Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic?triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent?androgen receptor (AR)?inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC)[1].
Ekersenin
4-Methoxy-5-methyl-2H-chromen-2-one is a natural product found in Clutia abyssinica, Ekebergia capensis, and Bergia capensis with data available.
methyl (1s,4br,5r,8s,8as,9s,9ar)-9-(acetyloxy)-1-(furan-3-yl)-5-hydroxy-4,8-dimethyl-3-oxo-1h,4bh,5h,6h,7h,8ah,9h,9ah-indeno[2,1-c]pyran-8-carboxylate
(3r,4r,5s,10r,13s)-5-(furan-3-yl)-1,8,13-trimethyl-7,14-dioxo-6,15-dioxatetracyclo[8.5.0.0²,¹³.0⁴,⁹]pentadec-8-en-3-yl acetate
(3as,7r,7ar)-7-[(4r,6s)-6-(furan-3-yl)-3-methylidene-2-oxooxan-4-yl]-3a,7-dimethyl-6,7a-dihydro-3h-2-benzofuran-1-one
(1s,3r,6s,8r,9s,12s,13s,14r,15s)-1-(furan-3-yl)-8,13-dihydroxy-6,12,14-trimethyl-2,4,10,16-tetraoxapentacyclo[11.3.1.0³,¹⁵.0⁶,¹⁵.0⁹,¹⁴]heptadecane-5,11-dione
5-methyl-4-(methylsulfanyl)chromen-2-one
C11H10O2S (206.04014800000002)
7-[6-(furan-3-yl)-3-methylidene-2-oxooxan-4-yl]-3a,7-dimethyl-6,7a-dihydro-3h-2-benzofuran-1-one
(3ar,4r,7as)-4-[(4r,6s)-6-(furan-3-yl)-3-methylidene-2-oxooxan-4-yl]-4,7a-dimethyl-tetrahydro-3h-2-benzofuran-1-one
methyl (1s,4s,4as,4br,8s,8as,9s,9as)-9-(acetyloxy)-1-(furan-3-yl)-4a,8a-dihydroxy-4,4b,8-trimethyl-3-oxo-hexahydro-1h-indeno[2,1-c]pyran-8-carboxylate
(6s,12r)-3-(furan-3-yl)-6,12,16-trimethyl-2,8,14,17-tetraoxapentacyclo[7.6.1.1³,⁹.0¹,¹².0⁵,¹⁶]heptadecane-7,13-dione
(3s,5r,6r,11r,14s)-6-(furan-3-yl)-1,9,14-trimethyl-4,7,16-trioxapentacyclo[9.5.0.0²,¹⁴.0³,⁵.0⁵,¹⁰]hexadec-9-ene-8,15-dione
4-[6-(furan-3-yl)-3-methylidene-2-oxooxan-4-yl]-4,7a-dimethyl-tetrahydro-3h-2-benzofuran-1-one
6,7-dimethoxy-5-methyl-4-(methylsulfanyl)chromen-2-one
7-[6-(furan-3-yl)-3-methylidene-2-oxooxan-4-yl]-3a,7-dimethyl-tetrahydro-3h-2-benzofuran-1-one
(3ar,7r,7ar)-7-[(4r,6s)-6-(furan-3-yl)-3-methylidene-2-oxooxan-4-yl]-3a,7-dimethyl-6,7a-dihydro-3h-2-benzofuran-1-one
(1s,2s,3r,4r,5s,10s,12s)-5-(furan-3-yl)-1,8,10-trimethyl-7,14-dioxo-6,13-dioxatetracyclo[10.2.1.0²,¹⁰.0⁴,⁹]pentadec-8-en-3-yl acetate
methyl (1s,4s,4as,4bs,8s,8as,9r,9ar)-9-(acetyloxy)-1-(furan-3-yl)-4a-hydroxy-4,4b,8-trimethyl-3-oxo-octahydroindeno[2,1-c]pyran-8-carboxylate
1-(furan-3-yl)-8,13-dihydroxy-6,12,14-trimethyl-2,4,10,16-tetraoxapentacyclo[11.3.1.0³,¹⁵.0⁶,¹⁵.0⁹,¹⁴]heptadecane-5,11-dione
8-hydroxy-3,5-dimethyl-4-(methylsulfanyl)chromen-2-one
(1s,3r,6s,9r,12s,13s,14r,15s)-1-(furan-3-yl)-13-hydroxy-6,12,14-trimethyl-2,4,10,16-tetraoxapentacyclo[11.3.1.0³,¹⁵.0⁶,¹⁵.0⁹,¹⁴]heptadecane-5,11-dione
7-hydroxy-6-methoxy-5-methyl-4-(methylsulfanyl)chromen-2-one
C12H12O4S (252.04562719999998)