NCBI Taxonomy: 47646
Swainsona (ncbi_taxid: 47646)
found 3 associated metabolites at genus taxonomy rank level.
Ancestor: Galegeae
Child Taxonomies: Swainsona formosa, Swainsona recta, Swainsona burkei, Swainsona kingii, Swainsona pterostylis, Swainsona villosa, Swainsona purpurea, Swainsona ecallosa, Swainsona laciniata, Swainsona canescens, Swainsona decurrens, Swainsona phacoides, Swainsona disjuncta, Swainsona murrayana, Swainsona oroboides, Swainsona cyclocarpa, Swainsona parviflora, Swainsona stenodonta, Swainsona stipularis, Swainsona galegifolia, Swainsona microphylla, Swainsona campylantha, Swainsona oligophylla, Swainsona thompsoniana, Swainsona flavicarinata, Swainsona lessertiifolia, Swainsona swainsonioides, Swainsona maccullochiana
Swainsonine
Swainsonine is an indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8. It has a role as an antineoplastic agent, an immunological adjuvant, an EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitor and a plant metabolite. An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity. Swainsonine is a natural product found in Slafractonia leguminicola, Astragalus whitneyi, and other organisms with data available. Swainsonine is a plant toxin found in locoweed (families Fabaceae, Oxytropis, Astragalus and Swainsona) and some fungi (Metarhizium anisopliae, Rizoctonia leguminicola). It has been known to cause a potentially lethal central nervous system condition in livestock known as locoism and is a significant cause of economic losses in livestock industries. Along with slaframine, the other biologially active compound of R. leguminicola, it may contribute to a condition called "slobbers syndrome" in livestock that has ingested contaminated feed. (L1248, A3092) An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity. An indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8. C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent > C2117 - Carbohydrate Processing Inhibitor C26170 - Protective Agent > C2459 - Chemoprotective Agent > C2080 - Cytoprotective Agent C471 - Enzyme Inhibitor > C2119 - Golgi Alpha-Mannosidase II Inhibitor C274 - Antineoplastic Agent > C2196 - Antimetastatic Agent D000970 - Antineoplastic Agents D007155 - Immunologic Factors D004791 - Enzyme Inhibitors
