NCBI Taxonomy: 1865
Actinoplanes (ncbi_taxid: 1865)
found 147 associated metabolites at genus taxonomy rank level.
Ancestor: Micromonosporaceae
Child Taxonomies: Actinoplanes cyaneus, Actinoplanes digitatis, Actinoplanes utahensis, Actinoplanes regularis, Actinoplanes maris, Actinoplanes luteus, Actinoplanes aureus, Actinoplanes flavus, Actinoplanes deserti, Actinoplanes humidus, Actinoplanes lobatus, Actinoplanes pyxinae, Actinoplanes couchii, Actinoplanes oblitus, Actinoplanes auranticolor, Actinoplanes brasiliensis, Actinoplanes lichenis, Actinoplanes italicus, environmental samples, Actinoplanes missouriensis, Actinoplanes toevensis, Actinoplanes abujensis, Actinoplanes sediminis, Actinoplanes aksuensis, Actinoplanes siamensis, Actinoplanes violaceus, Actinoplanes philippinensis, Actinoplanes tropicalis, Actinoplanes solisilvae, Actinoplanes bogorensis, Actinoplanes hotanensis, Actinoplanes palleronii, Actinoplanes lutulentus, Actinoplanes hulinensis, Actinoplanes pyriformis, Actinoplanes teichomyceticus, Actinoplanes ovalisporus, Actinoplanes tereljensis, Actinoplanes awajinensis, Actinoplanes yunnanensis, Actinoplanes nipponensis, Actinoplanes lichenicola, Actinoplanes friuliensis, Actinoplanes liguriensis, Actinoplanes subglobosus, Actinoplanes subtropicus, Actinoplanes deccanensis, Actinoplanes durhamensis, Actinoplanes ferrugineus, Actinoplanes globisporus, Actinoplanes tsinanensis, Actinoplanes rhizophilus, Actinoplanes capillaceus, Actinoplanes arizonaensis, Actinoplanes sandaracinus, Actinoplanes cibodasensis, Actinoplanes sichuanensis, Actinoplanes campanulatus, Actinoplanes consettensis, Actinoplanes derwentensis, unclassified Actinoplanes, Actinoplanes penicillatus, Actinoplanes rishiriensis, Actinoplanes kinshanensis, Actinoplanes octamycinicus, Actinoplanes sarveparensis, Actinoplanes xinjiangensis, Actinoplanes garbadinensis, Actinoplanes rectilineatus, Actinoplanes ianthinogenes, Actinoplanes polyasparticus, Actinoplanes atraurantiacus, Actinoplanes ramoplaninifer, Actinoplanes incertae sedis, Actinoplanes purpeobrunneus, Actinoplanes tuftoflagellus, Actinoplanes luojiashanensis, Actinoplanes roseosporangius, Actinoplanes rutilosporangius, Actinoplanes pallidoaurantiacus
Acarbose
Acarbose is a tetrasaccharide derivative consisting of a dideoxy-4-{[4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl C7 cyclitol moiety [called valienol (or valienamine)] linked via nitrogen to isomaltotriose. It has a role as an EC 3.2.1.20 (alpha-glucosidase) inhibitor, an EC 3.2.1.1 (alpha-amylase) inhibitor, a hypoglycemic agent and a geroprotector. It is a conjugate base of an acarbose(1+). Acarbose is an alpha glucosidase inhibitor which decreases intestinal absorption of carbohydrates and is used as an adjunctive therapy in the management of type 2 diabetes. Acarbose has been linked to rare instances of clinically apparent acute liver injury. Acarbose is a natural product found in Streptomyces glaucescens, Streptomyces coelicoflavus, and other organisms with data available. Acarbose is a pseudotetrasaccharide and inhibitor of alpha-glucosidase and pancreatic alpha-amylase with antihyperglycemic activity. Acarbose binds to and inhibits alpha-glucosidase, an enteric enzyme found in the brush border of the small intestines that hydrolyzes oligosaccharides and disaccharides into glucose and other monosaccharides. This prevents the breakdown of larger carbohydrates into glucose and decreases the rise in postprandial blood glucose levels. In addition, acarbose inhibits pancreatic alpha-amylase which hydrolyzes complex starches to oligosaccharides in the small intestines. An inhibitor of ALPHA-GLUCOSIDASES that retards the digestion and absorption of DIETARY CARBOHYDRATES in the SMALL INTESTINE. An inhibitor of alpha glucosidase that retards the digestion and absorption of carbohydrates in the small intestine and hence reduces the increase in blood-glucose concentrations after a carbohydrate load. It is given orally to non-insulin dependent diabetes mellitus patients where diet modification or oral hypoglycemic agents do not control their condition. (From Martindale The Extra Pharmacopoeia, 31st ed) A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BF - Alpha glucosidase inhibitors D007004 - Hypoglycemic Agents > D065089 - Glycoside Hydrolase Inhibitors D004791 - Enzyme Inhibitors Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin[1][2][3].
Fidaxomicin
Fidaxomicin
An 18-membered macrolide that is a fermentation product obtained from the Actinomycete Dactylosporangium aurantiacum. A narrow spectrum antibiotic used for treatment of Clostridium difficile-related infections.
7,8-Dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione
Acarbose
Acarbose is a tetrasaccharide derivative consisting of a dideoxy-4-{[4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl C7 cyclitol moiety [called valienol (or valienamine)] linked via nitrogen to isomaltotriose. It has a role as an EC 3.2.1.20 (alpha-glucosidase) inhibitor, an EC 3.2.1.1 (alpha-amylase) inhibitor, a hypoglycemic agent and a geroprotector. It is a conjugate base of an acarbose(1+). Acarbose is an alpha glucosidase inhibitor which decreases intestinal absorption of carbohydrates and is used as an adjunctive therapy in the management of type 2 diabetes. Acarbose has been linked to rare instances of clinically apparent acute liver injury. Acarbose is a natural product found in Streptomyces glaucescens, Streptomyces coelicoflavus, and other organisms with data available. Acarbose is a pseudotetrasaccharide and inhibitor of alpha-glucosidase and pancreatic alpha-amylase with antihyperglycemic activity. Acarbose binds to and inhibits alpha-glucosidase, an enteric enzyme found in the brush border of the small intestines that hydrolyzes oligosaccharides and disaccharides into glucose and other monosaccharides. This prevents the breakdown of larger carbohydrates into glucose and decreases the rise in postprandial blood glucose levels. In addition, acarbose inhibits pancreatic alpha-amylase which hydrolyzes complex starches to oligosaccharides in the small intestines. An inhibitor of ALPHA-GLUCOSIDASES that retards the digestion and absorption of DIETARY CARBOHYDRATES in the SMALL INTESTINE. A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BF - Alpha glucosidase inhibitors D007004 - Hypoglycemic Agents > D065089 - Glycoside Hydrolase Inhibitors D004791 - Enzyme Inhibitors C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent C471 - Enzyme Inhibitor > C2846 - Glucosidase Inhibitor Origin: Microbe, Polysaccharides Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin[1][2][3].
Lipiarmycin
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents C784 - Protein Synthesis Inhibitor > C261 - Macrolide Antibiotic C254 - Anti-Infective Agent > C258 - Antibiotic Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC90=0.12?μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research[1][2][3].