NCBI Taxonomy: 1482601

Streptomyces microflavus subgroup (ncbi_taxid: 1482601)

found 89 associated metabolites at species subgroup taxonomy rank level.

Child Taxonomies: Streptomyces microflavus, Streptomyces alboviridis, Streptomyces luridiscabiei

Valinomycin

(3S,6S,9R,12R,15S,18S,21R,24R,27S,30S,33R,36R)-6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone

C54H90N6O18 (1110.631128)

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents D049990 - Membrane Transport Modulators D007476 - Ionophores A twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains. C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic Valinomycin is a potassium-specific ionophore, the valinomycin-K+ complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K+ gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research[1][2]. Valinomycin (NSC 122023), a cyclic depsipeptide antibiotic, act as a potassium selective ionophore. Valinomycin (NSC 122023) inhibits lymphocyte proliferation by its effects on the cell membrane, and induces apoptosis in CHO cells[1]. Valinomycin induces activation of PINK1 leading to Parkin Ser65 phosphorylation[2].

Adicillin

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[[(5R)-5-amino-5-carboxy-1-oxopentyl]amino]-3,3-dimethyl-7-oxo-,(2S,5R,6R)-

C14H21N3O6S (359.1151006)

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

3-Methylthymidine

1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,5-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

C11H16N2O5 (256.1059166)

9,10,11,20,21,22-hexahydroxy-3-(20-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-14-(29-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}triacontyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

9,10,11,20,21,22-hexahydroxy-3-(20-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-14-(29-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}triacontyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

C81H150O28 (1571.03131)

9,10,11,20,21,22-hexahydroxy-3-(20-hydroxy-12-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-14-(20-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

9,10,11,20,21,22-hexahydroxy-3-(20-hydroxy-12-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-14-(20-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

C72H132O28 (1444.8904671999999)

(6r,7s)-3-[(acetyloxy)methyl]-7-{[(5s)-5-amino-5-carboxy-1-hydroxypentylidene]amino}-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

C17H23N3O9S (445.1154948000001)

(1r,3s,8s,9s,10s,11s,12r,14s,19r,20s,21s,22r)-9,10,11,20,21,22-hexahydroxy-3-[(14r,20r)-20-hydroxy-14-{[(2r,3s,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl]-14-[(14r,29r)-29-hydroxy-14-{[(2r,3s,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}triacontyl]-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

(1r,3s,8s,9s,10s,11s,12r,14s,19r,20s,21s,22r)-9,10,11,20,21,22-hexahydroxy-3-[(14r,20r)-20-hydroxy-14-{[(2r,3s,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl]-14-[(14r,29r)-29-hydroxy-14-{[(2r,3s,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}triacontyl]-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

C81H150O28 (1571.03131)

2-{[2-({2-[(1,3-dihydroxy-2-{[1-hydroxy-2-({1-hydroxy-2-[(1-hydroxyhexadecylidene)amino]-3-{[5-oxo-2-(2-oxoheptadecyl)icosyl]sulfanyl}propylidene}amino)-3-(c-hydroxycarbonimidoyl)propylidene]amino}propylidene)amino]-1-hydroxyethylidene}amino)-1-hydroxyethylidene]amino}-3-hydroxypropanoic acid

2-{[2-({2-[(1,3-dihydroxy-2-{[1-hydroxy-2-({1-hydroxy-2-[(1-hydroxyhexadecylidene)amino]-3-{[5-oxo-2-(2-oxoheptadecyl)icosyl]sulfanyl}propylidene}amino)-3-(c-hydroxycarbonimidoyl)propylidene]amino}propylidene)amino]-1-hydroxyethylidene}amino)-1-hydroxyethylidene]amino}-3-hydroxypropanoic acid

C70H129N7O13S (1307.9368584)

(1r,8s,9r,10r,11s,12s,19r,20s,21s,22r)-9,10,11,20,21,22-hexahydroxy-3-(18-hydroxy-12-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}nonadecyl)-14-(20-hydroxy-14-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

(1r,8s,9r,10r,11s,12s,19r,20s,21s,22r)-9,10,11,20,21,22-hexahydroxy-3-(18-hydroxy-12-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}nonadecyl)-14-(20-hydroxy-14-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

C70H128O28 (1416.8591688000001)

1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3-methylpyrimidine-2,4-dione

C10H14N2O5 (242.09026740000002)

(6r,7s)-3-[(acetyloxy)methyl]-7-{[(5r)-5-amino-5-carboxy-1-hydroxypentylidene]amino}-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

C17H23N3O9S (445.1154948000001)

3-acetyl-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

C12H16N2O6 (284.1008316)

9,10,11,20,21,22-hexahydroxy-3-(20-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-14-(31-hydroxy-15-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}dotriacontyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

9,10,11,20,21,22-hexahydroxy-3-(20-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-14-(31-hydroxy-15-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}dotriacontyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

C83H154O28 (1599.0626084)

3-acetyl-1-[(2r,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

C12H16N2O6 (284.1008316)

9,10,11,20,21,22-hexahydroxy-3-(20-hydroxy-12-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-14-(24-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}pentacosyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

9,10,11,20,21,22-hexahydroxy-3-(20-hydroxy-12-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-14-(24-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}pentacosyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

C76H140O28 (1500.953064)

(2s,6r)-6-{[(5r)-5-amino-5-carboxy-1-hydroxypentylidene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

C14H21N3O6S (359.1151006)

4,21',24'-trihydroxy-5,11',13',22'-tetramethyl-6-(4-methylpent-2-en-2-yl)-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosane]-10',14',16',22'-tetraen-2'-one

C36H52O8 (612.3661992)

6-hydroxy-4-[2-(2-hydroxy-3,5-dimethylphenyl)-2-oxoethyl]-4,5-dihydro-3h-pyridin-2-one

C15H17NO4 (275.11575220000003)

(4s,5s,6s,8'r,10'e,13'r,14'e,16'e,20'r,21'r,24's)-6-[(2e)-but-2-en-2-yl]-4,21',24'-trihydroxy-5,11',13',22'-tetramethyl-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosane]-10',14',16',22'-tetraen-2'-one

(4s,5s,6s,8'r,10'e,13'r,14'e,16'e,20'r,21'r,24's)-6-[(2e)-but-2-en-2-yl]-4,21',24'-trihydroxy-5,11',13',22'-tetramethyl-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosane]-10',14',16',22'-tetraen-2'-one

C34H48O8 (584.3349008)

(1'r,2r,4s,4's,5s,6s,8'r,10'e,13'r,14'e,16'e,20'r,21'r,24's)-6-[(2e)-but-2-en-2-yl]-4,21',24'-trihydroxy-5,11',13',22'-tetramethyl-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosane]-10',14',16',22'-tetraen-2'-one

(1'r,2r,4s,4's,5s,6s,8'r,10'e,13'r,14'e,16'e,20'r,21'r,24's)-6-[(2e)-but-2-en-2-yl]-4,21',24'-trihydroxy-5,11',13',22'-tetramethyl-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosane]-10',14',16',22'-tetraen-2'-one

C34H48O8 (584.3349008)

3-acetyl-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

C12H16N2O6 (284.1008316)

6-(but-2-en-2-yl)-4,21',24'-trihydroxy-5,11',13',22'-tetramethyl-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosane]-10',14',16',22'-tetraen-2'-one

C34H48O8 (584.3349008)

(2s,5r,6r)-6-{[(5r)-5-amino-5-carboxy-1-hydroxypentylidene]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

C14H21N3O6S (359.1151006)

4,21',24'-trihydroxy-5,11',13',22'-tetramethyl-6-(4-methylpent-2-en-2-yl)-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosane]-10',14',16',22'-tetraene-2',18'-dione

C36H50O9 (626.345465)

(6r,7r)-3-[(acetyloxy)methyl]-7-[(5-carboxy-1-hydroxypentylidene)amino]-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

C17H22N2O9S (430.10459620000006)

(1's,2r,4s,4'r,5s,6s,7'r,8'r,9's,10'e,12'e,14'r,16'e,19'r)-4,8',9'-trihydroxy-10'-(hydroxymethyl)-7'-methoxy-5,6',14',16'-tetramethyl-6-[(2e)-4-methylpent-2-en-2-yl]-2',20'-dioxaspiro[oxane-2,21'-tricyclo[17.3.1.0⁴,⁹]tricosane]-5',10',12',16'-tetraen-3'-one

(1's,2r,4s,4'r,5s,6s,7'r,8'r,9's,10'e,12'e,14'r,16'e,19'r)-4,8',9'-trihydroxy-10'-(hydroxymethyl)-7'-methoxy-5,6',14',16'-tetramethyl-6-[(2e)-4-methylpent-2-en-2-yl]-2',20'-dioxaspiro[oxane-2,21'-tricyclo[17.3.1.0⁴,⁹]tricosane]-5',10',12',16'-tetraen-3'-one

C37H56O9 (644.3924126000001)

9,10,11,20,21,22-hexahydroxy-3-(18-hydroxy-12-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}nonadecyl)-14-(20-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

9,10,11,20,21,22-hexahydroxy-3-(18-hydroxy-12-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}nonadecyl)-14-(20-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

C70H128O28 (1416.8591688000001)

9,10,11,20,21,22-hexahydroxy-3,14-bis(18-hydroxy-12-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}nonadecyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

C68H124O28 (1388.8278704)

(4s,5s,6s,10'e,13'r,14'e,16'e,21'r,24's)-4,21',24'-trihydroxy-5,11',13',22'-tetramethyl-6-[(2e)-4-methylpent-2-en-2-yl]-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosane]-10',14',16',22'-tetraen-2'-one

(4s,5s,6s,10'e,13'r,14'e,16'e,21'r,24's)-4,21',24'-trihydroxy-5,11',13',22'-tetramethyl-6-[(2e)-4-methylpent-2-en-2-yl]-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosane]-10',14',16',22'-tetraen-2'-one

C36H52O8 (612.3661992)

(1'r,2r,4s,4's,5s,6s,8'r,10'e,13'r,14'e,16'z,20'r,21'r,24's)-4,21',24'-trihydroxy-5,11',13',22'-tetramethyl-6-[(2e)-4-methylpent-2-en-2-yl]-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosane]-10',14',16',22'-tetraene-2',18'-dione

(1'r,2r,4s,4's,5s,6s,8'r,10'e,13'r,14'e,16'z,20'r,21'r,24's)-4,21',24'-trihydroxy-5,11',13',22'-tetramethyl-6-[(2e)-4-methylpent-2-en-2-yl]-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.1⁴,⁸.0²⁰,²⁴]pentacosane]-10',14',16',22'-tetraene-2',18'-dione

C36H50O9 (626.345465)

(1r,8r,9s,10s,11r,12r,19r,20s,21s,22r)-9,10,11,20,21,22-hexahydroxy-3-(20-hydroxy-14-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-14-(29-hydroxy-14-{[(2s,3s,4r,5r,6s)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}triacontyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

(1r,8r,9s,10s,11r,12r,19r,20s,21s,22r)-9,10,11,20,21,22-hexahydroxy-3-(20-hydroxy-14-{[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-14-(29-hydroxy-14-{[(2s,3s,4r,5r,6s)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}triacontyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

C81H150O28 (1571.03131)

3-[(acetyloxy)methyl]-7-[(5-amino-5-carboxy-1-hydroxypentylidene)amino]-7-methoxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

C17H23N3O9S (445.1154948000001)

1-[(2r,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,5-dimethylpyrimidine-2,4-dione

C11H16N2O5 (256.1059166)

1-[(2r,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3-methylpyrimidine-2,4-dione

C10H14N2O5 (242.09026740000002)

4,8',9'-trihydroxy-10'-(hydroxymethyl)-7'-methoxy-5,6',14',16'-tetramethyl-6-(4-methylpent-2-en-2-yl)-2',20'-dioxaspiro[oxane-2,21'-tricyclo[17.3.1.0⁴,⁹]tricosane]-5',10',12',16'-tetraen-3'-one

C37H56O9 (644.3924126000001)

9,10,11,20,21,22-hexahydroxy-3-(20-hydroxy-12-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-14-(22-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}tricosyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

9,10,11,20,21,22-hexahydroxy-3-(20-hydroxy-12-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}henicosyl)-14-(22-hydroxy-14-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}tricosyl)-2,6,13,17,23,24-hexaoxatricyclo[17.3.1.1⁸,¹²]tetracosane-5,16-dione

C74H136O28 (1472.9217656)