NCBI Taxonomy: 1437453
Streptomyces leeuwenhoekii (ncbi_taxid: 1437453)
found 52 associated metabolites at species taxonomy rank level.
Ancestor: Streptomyces
Child Taxonomies: none taxonomy data.
brevianamide F
brevianamide F
A pyrrolopyrazine that is hexahydropyrrolo[1,2-a]pyrazine-1,4-dione bearing an indol-3-ylmethyl substituent at position 3 (the 3S,8aS-diastereomer, obtained by formal cyclocondensation of L-tryptophan and L-proline). Brevianamide F (Cyclo(L-Pro-L-Trp)) is a mycotoxin isolated from Colletotrichum gloeosporioides, with antibacterial activity. Brevianamide F shows potent PI3Kα inhibitory activity with an IC50 of 4.8 μM[1][2].
1,5,12,16,23,27-hexahydroxy-1,6,12,17,23,28-hexaazacyclotritriaconta-5,16,27-triene-2,13,24-trione
1,5,12,16,23,27-hexahydroxy-1,6,12,17,23,28-hexaazacyclotritriaconta-5,16,27-triene-2,13,24-trione
C27H48N6O9 (600.3482597999999)
(7e,9s,10s,11r,12r,13r,14r,15r,16s,17s,18e,20e)-4,10,12,14,16,22-hexahydroxy-3,7,9,11,13,15,17,25-octamethyl-23-azatricyclo[22.3.1.0⁵,²⁷]octacosa-1(27),2,4,7,18,20,22,24-octaene-6,26,28-trione
(7e,9s,10s,11r,12r,13r,14r,15r,16s,17s,18e,20e)-4,10,12,14,16,22-hexahydroxy-3,7,9,11,13,15,17,25-octamethyl-23-azatricyclo[22.3.1.0⁵,²⁷]octacosa-1(27),2,4,7,18,20,22,24-octaene-6,26,28-trione
(7e,9s,10s,11r,12r,13r,14r,15r,16s,17s,18e,20z)-2,4,10,12,14,16,22-heptahydroxy-3,7,9,11,13,15,17,25-octamethyl-23-azatricyclo[22.3.1.0⁵,²⁷]octacosa-1(27),2,4,7,18,20,22,24-octaene-6,26,28-trione
(7e,9s,10s,11r,12r,13r,14r,15r,16s,17s,18e,20z)-2,4,10,12,14,16,22-heptahydroxy-3,7,9,11,13,15,17,25-octamethyl-23-azatricyclo[22.3.1.0⁵,²⁷]octacosa-1(27),2,4,7,18,20,22,24-octaene-6,26,28-trione
(6s,7r,9e,11s,12r,13r,14r,15r,16r,17s,18s,19e,21z)-2,6,11,15,17,23-hexahydroxy-3,7,12,14,16,18,26-heptamethyl-27,29-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1⁴,⁷.0⁵,²⁸]triaconta-1,3,5(28),9,19,21,23,25-octaen-13-yl acetate
(6s,7r,9e,11s,12r,13r,14r,15r,16r,17s,18s,19e,21z)-2,6,11,15,17,23-hexahydroxy-3,7,12,14,16,18,26-heptamethyl-27,29-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.1⁴,⁷.0⁵,²⁸]triaconta-1,3,5(28),9,19,21,23,25-octaen-13-yl acetate
(7e,9r,10s,11r,12r,13r,14r,15r,16s,17s,18e,20z)-2,4,10,12,14,16,22-heptahydroxy-9-(hydroxymethyl)-3,7,11,13,15,17,25-heptamethyl-23-azatricyclo[22.3.1.0⁵,²⁷]octacosa-1(27),2,4,7,18,20,22,24-octaene-6,26,28-trione
(7e,9r,10s,11r,12r,13r,14r,15r,16s,17s,18e,20z)-2,4,10,12,14,16,22-heptahydroxy-9-(hydroxymethyl)-3,7,11,13,15,17,25-heptamethyl-23-azatricyclo[22.3.1.0⁵,²⁷]octacosa-1(27),2,4,7,18,20,22,24-octaene-6,26,28-trione
(4s)-4-({[(2s,5s,11s,14s,17s,20s,23s)-14-(3-carbamimidamidopropyl)-20-(carboxymethyl)-3,6,9,12,15,18,21,26-octahydroxy-17-(c-hydroxycarbonimidoylmethyl)-5-[(4-hydroxyphenyl)methyl]-11-isopropyl-2-(2-methylpropyl)-1,4,7,10,13,16,19,22-octaazacyclohexacosa-1(26),3,6,9,12,15,18,21-octaen-23-yl](hydroxy)methylidene}amino)-4-{[(2s)-1-{[(1s)-1-{[(1s)-1-{[(1s)-1-{[(1s)-1-{[(1s)-2-carboxy-1-{[(1s)-1-{[(1s)-1-{[(2r)-1-carboxy-2-hydroxypropyl]-c-hydroxycarbonimidoyl}-2-(1h-indol-3-yl)ethyl]-c-hydroxycarbonimidoyl}-2-(4-hydroxyphenyl)ethyl]-c-hydroxycarbonimidoyl}ethyl]-c-hydroxycarbonimidoyl}-2-phenylethyl]-c-hydroxycarbonimidoyl}-2-(3h-imidazol-4-yl)ethyl]-c-hydroxycarbonimidoyl}-2-(1h-indol-3-yl)ethyl]-c-hydroxycarbonimidoyl}-2-(c-hydroxycarbonimidoyl)ethyl]-c-hydroxycarbonimidoyl}-2-methylbutyl]-c-hydroxycarbonimidoyl}butanoic acid
(4s)-4-({[(2s,5s,11s,14s,17s,20s,23s)-14-(3-carbamimidamidopropyl)-20-(carboxymethyl)-3,6,9,12,15,18,21,26-octahydroxy-17-(c-hydroxycarbonimidoylmethyl)-5-[(4-hydroxyphenyl)methyl]-11-isopropyl-2-(2-methylpropyl)-1,4,7,10,13,16,19,22-octaazacyclohexacosa-1(26),3,6,9,12,15,18,21-octaen-23-yl](hydroxy)methylidene}amino)-4-{[(2s)-1-{[(1s)-1-{[(1s)-1-{[(1s)-1-{[(1s)-1-{[(1s)-2-carboxy-1-{[(1s)-1-{[(1s)-1-{[(2r)-1-carboxy-2-hydroxypropyl]-c-hydroxycarbonimidoyl}-2-(1h-indol-3-yl)ethyl]-c-hydroxycarbonimidoyl}-2-(4-hydroxyphenyl)ethyl]-c-hydroxycarbonimidoyl}ethyl]-c-hydroxycarbonimidoyl}-2-phenylethyl]-c-hydroxycarbonimidoyl}-2-(3h-imidazol-4-yl)ethyl]-c-hydroxycarbonimidoyl}-2-(1h-indol-3-yl)ethyl]-c-hydroxycarbonimidoyl}-2-(c-hydroxycarbonimidoyl)ethyl]-c-hydroxycarbonimidoyl}-2-methylbutyl]-c-hydroxycarbonimidoyl}butanoic acid