Gene Association: SLC9A9

UniProt Search: SLC9A9 (PROTEIN_CODING)
Function Description: solute carrier family 9 member A9

found 4 associated metabolites with current gene based on the text mining result from the pubmed database.

Guanfacine

N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide

C9H9Cl2N3O (245.0123)


A centrally acting antihypertensive agent. The drug lowers both systolic and diastolic blood pressure by activating the central nervous system alpha-2 adrenoreceptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation. [PubChem] C - Cardiovascular system > C02 - Antihypertensives > C02A - Antiadrenergic agents, centrally acting > C02AC - Imidazoline receptor agonists C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents

   

Phenamil

3,5-Diamino-6-chloro-N-(N-phenylcarbamimidoyl)pyrazine-2-carboximidate

C12H12ClN7O (305.0792)


   

GUANFACINE

GUANFACINE

C9H9Cl2N3O (245.0123)


C - Cardiovascular system > C02 - Antihypertensives > C02A - Antiadrenergic agents, centrally acting > C02AC - Imidazoline receptor agonists C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents