Chemical Formula: C8H10N6S
Chemical Formula C8H10N6S
Found 2 metabolite its formula value is C8H10N6S
Zaltidine
Zaltidine(CP-57361) is a H2-receptor antagonist, which has the antisecretory action. IC50 Value: Target: H2 receptor in vitro: in vivo: In eight healthy male volunteers single oral doses of 5 mg, 25 mg and 100 mg produced dose-related inhibition of basal and pentagastrin-stimulated acid output (M.A.O.) with an estimated ID50 of 40 mg for the latter. In eight subjects with duodenal ulceration single 100 mg and 200 mg doses produced 85\% and 97\% inhibition of M.A.O. at peak (3 h post-dose) and 20\% and 23\% inhibition at 24 h, respectively; inhibition of basal acid output was 97\% at 3 h and 50\% at 24 h with both doses [1]. One hundred and thirty-five patients were randomly allocated to 4 weeks' treatment with either 150 mg zaltidine once daily or placebo. Fifty-nine were treated for a full 4 weeks with zaltidine before the trial was stopped. Healing rates after 4 weeks of zaltidine and placebo were 86\% and 19\%, respectively (p less than 0.001) [2].
