Chemical Formula: C51H57F2N9O7S2

Chemical Formula C51H57F2N9O7S2

Found 1 metabolite its formula value is C51H57F2N9O7S2

SJF-0628

SJF-0628

C51H57F2N9O7S2 (1009.3790236)


SJF-0628 (compound 512) is a PROTAC RAF degrader. SJF-0628 induces targeted degradation of BRAF mutants (DC50: 5.4 nM, 4.64 nM, 15.5 nM, 2.11 nM, 63.9 nM for BRAF V600E, V600K, G464V, G469A, K601E respectively). SJF-0628 has anti-tumor activity. SJF-0628 can be used for research of disorders that result from aggregation or accumulation of RAF, or the constitutive activation of RAF[1].