Chemical Formula: C45H80N7O17P3S
Chemical Formula C45H80N7O17P3S
Found 10 metabolite its formula value is C45H80N7O17P3S
15Z-tetracosenoyl-CoA
C45H80N7O17P3S (1115.4544020000003)
15z-tetracosenoyl-coa, also known as nervonoyl-coa, is a member of the class of compounds known as very long-chain fatty acyl coas. Very long-chain fatty acyl coas are acyl CoAs where the group acylated to the coenzyme A moiety is a very long aliphatic chain of 22 carbon atoms or more. Thus, 15z-tetracosenoyl-coa is considered to be a fatty ester lipid molecule. 15z-tetracosenoyl-coa is practically insoluble (in water) and an extremely strong acidic compound (based on its pKa). 15z-tetracosenoyl-coa can be found in a number of food items such as hazelnut, sugar apple, cardamom, and ginkgo nuts, which makes 15z-tetracosenoyl-coa a potential biomarker for the consumption of these food products. In humans, 15z-tetracosenoyl-coa is involved in several metabolic disorders, some of which include de novo triacylglycerol biosynthesis TG(24:1(15Z)/22:4(7Z,10Z,13Z,16Z)/18:3(6Z,9Z,12Z)), de novo triacylglycerol biosynthesis TG(24:1(15Z)/22:1(13Z)/20:5(5Z,8Z,11Z,14Z,17Z)), de novo triacylglycerol biosynthesis TG(20:0/24:1(15Z)/20:4(5Z,8Z,11Z,14Z)), and de novo triacylglycerol biosynthesis TG(24:0/22:2(13Z,16Z)/24:1(15Z)). 15Z-tetracosenoyl-CoA is classified as a member of the Very long-chain fatty acyl CoAs. Very long-chain fatty acyl CoAs are acyl CoAs where the group acylated to the coenzyme A moiety is a very long aliphatic chain of 22 carbon atoms or more. 15Z-tetracosenoyl-CoA is considered to be practically insoluble (in water) and acidic. 15Z-tetracosenoyl-CoA is a fatty ester lipid molecule
Nervonyl CoA
C45H80N7O17P3S (1115.4544020000003)
This compound belongs to the family of Acyl CoAs. These are organic compounds contaning a coenzyme A substructure linked to another moeity through an ester bond.
(2E)-Tetracosenoyl-CoA
C45H80N7O17P3S (1115.4544020000003)
(2E)-Tetracosenoyl-CoA is also known as (e)-2-Tetracosenoyl-CoA(4-). (2E)-Tetracosenoyl-CoA is considered to be practically insoluble (in water) and acidic
(15Z)-tetracos-15-enoyl-CoA
C45H80N7O17P3S (1115.4544020000003)
(15z)-tetracos-15-enoyl-coa is an acyl-CoA or acyl-coenzyme A. More specifically, it is a (15Z)-tetracos-15-enoic acid thioester of coenzyme A. (15z)-tetracos-15-enoyl-coa is an acyl-CoA with 24 fatty acid group as the acyl moiety attached to coenzyme A. Coenzyme A was discovered in 1946 by Fritz Lipmann (Journal of Biological Chemistry (1946) 162 (3): 743–744) and its structure was determined in the early 1950s at the Lister Institute in London. Coenzyme A is a complex, thiol-containing molecule that is naturally synthesized from pantothenate (vitamin B5), which is found in various foods such as meat, vegetables, cereal grains, legumes, eggs, and milk. More specifically, coenzyme A (CoASH or CoA) consists of a beta-mercaptoethylamine group linked to the vitamin pantothenic acid (B5) through an amide linkage and 3-phosphorylated ADP. Coenzyme A is synthesized in a five-step process that requires four molecules of ATP, pantothenate and cysteine. It is believed that there are more than 1100 types of acyl-CoA’s in the human body, which also corresponds to the number of acylcarnitines in the human body. Acyl-CoAs exists in all living species, ranging from bacteria to plants to humans. The general role of acyl-CoA’s is to assist in transferring fatty acids from the cytoplasm to mitochondria. This process facilitates the production of fatty acids in cells, which are essential in cell membrane structure. Acyl-CoAs are also susceptible to beta oxidation, forming, ultimately, acetyl-CoA. Acetyl-CoA can enter the citric acid cycle, eventually forming several equivalents of ATP. In this way, fats are converted to ATP -- or biochemical energy. Acyl-CoAs can be classified into 9 different categories depending on the size of their acyl-group: 1) short-chain acyl-CoAs; 2) medium-chain acyl-CoAs; 3) long-chain acyl-CoAs; and 4) very long-chain acyl-CoAs; 5) hydroxy acyl-CoAs; 6) branched chain acyl-CoAs; 7) unsaturated acyl-CoAs; 8) dicarboxylic acyl-CoAs and 9) miscellaneous acyl-CoAs. Short-chain acyl-CoAs have acyl-groups with two to four carbons (C2-C4), medium-chain acyl-CoAs have acyl-groups with five to eleven carbons (C5-C11), long-chain acyl-CoAs have acyl-groups with twelve to twenty carbons (C12-C20) while very long-chain acyl-CoAs have acyl groups with more than 20 carbons. (15z)-tetracos-15-enoyl-coa is therefore classified as a very long chain acyl-CoA. The oxidative degradation of fatty acids is a two-step process, catalyzed by acyl-CoA synthetase/synthase. Fatty acids are first converted to their acyl phosphate, the precursor to acyl-CoA. The latter conversion is mediated by acyl-CoA synthase. Three types of acyl-CoA synthases are employed, depending on the chain length of the fatty acid. (15z)-tetracos-15-enoyl-coa, being a very long chain acyl-CoA is a substrate for very long chain acyl-CoA synthase. The second step of fatty acid degradation is beta oxidation. Beta oxidation occurs in mitochondria and, in the case of very long chain acyl-CoAs, the peroxisome. After its formation in the cytosol, (15Z)-tetracos-15-enoyl-CoA is transported into the mitochondria, the locus of beta oxidation. Transport of (15Z)-tetracos-15-enoyl-CoA into the mitochondria requires carnitine palmitoyltransferase 1 (CPT1), which converts (15Z)-tetracos-15-enoyl-CoA into (15Z)-tetracos-15-enoylcarnitine, which gets transported into the mitochondrial matrix. Once in the matrix, (15Z)-tetracos-15-enoylcarnitine is converted back to (15Z)-tetracos-15-enoyl-CoA by CPT2, whereupon beta-oxidation can begin. Beta oxidation of (15Z)-tetracos-15-enoyl-CoA occurs in four steps. First, since (15Z)-tetracos-15-enoyl-CoA is a very long chain acyl-CoA it is the substrate for a very long chain acyl-CoA dehydrogenase, which catalyzes dehydrogenation of (15Z)-tetracos-15-enoyl-CoA, creating a double bond between the alpha and beta carbons. FAD is the hydrogen acceptor, yielding FADH2. Second, Enoyl-CoA hydrase catalyzes the addition of water across the newly formed d...
trans-2-tetracosenoyl-CoA
C45H80N7O17P3S (1115.4544020000003)
A 2,3-trans-enoyl CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of trans-2-tetracosenoic acid.
Nervonoyl-CoA; (Acyl-CoA); [M+H]+
C45H80N7O17P3S (1115.4544020000003)
CoA 24:1
C45H80N7O17P3S (1115.4544020000003)
A very long-chain fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (15Z)-tetracosenoic acid.