Chemical Formula: C38H45NO7

GAMBOGIC ACID AMIDE

C38H45NO7 (627.3195860000001)

Tetrabenzyl voglibose

C38H45NO7 (627.3195860000001)

Gambogic amide

C38H45NO7 (627.3195860000001)

Gambogic amide is a potent and selective agonist of TrkA and also induces its tyrosine phosphorylation and activation of downstream signaling, including Akt and MAPK. Gambogic amide specifically interacts with the cytoplasmic juxtamembrane domain of the TrkA receptor and triggers its dimerization, leading to activation. Gambogic amide has neuroprotective activity preventing glutamate-induced neuronal cell death. Gambogic amide has improved efficacy in a transient middle cerebral artery occlusion model of stroke and could be used to study neurodegenerative diseases and stroke[1].