Chemical Formula: C32H43N3O6
Chemical Formula C32H43N3O6
Found 9 metabolite its formula value is C32H43N3O6
Jawsamycin
Jawsamycin
A polyketide that is 5-amino-5-deoxy-3,4,5,6-tetrahydrouridine in which one of the hydrogens of the amino group is substituted by a (1E,3E)-1-[(1R,1R,1R,1R,2S,2R,2R,2S)-2-{(E)-2-[(1R,2R)-2-methylcyclopropyl]ethenyl}[1,1:2,1:2,1-quater(cyclopropan)]-2-yl]-5-oxopenta-1,3-dien-5-yl group. It is a metabolite isolated from the bacterium, Streptoverticillium fervens and targets the catalytic subunit of the fungal UDP-glycosyltransferase, the first step in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors. It exhibits broad spectrum antifungal activity against several pathogenic fungi including Mucorales.
4-[[[(2S,3R)-9-[[cyclohexyl(oxo)methyl]amino]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-2,3,4,7-tetrahydro-1,5-benzoxazonin-2-yl]methyl-methylamino]methyl]benzoic acid
4-[[[(2S,3R)-9-[[cyclohexyl(oxo)methyl]amino]-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-2,3,4,7-tetrahydro-1,5-benzoxazonin-2-yl]methyl-methylamino]methyl]benzoic acid
N-[(5S,6R,9R)-8-[cyclohexyl(oxo)methyl]-5-methoxy-3,6,9-trimethyl-2-oxo-11-oxa-3,8-diazabicyclo[10.4.0]hexadeca-1(12),13,15-trien-14-yl]-3-methoxybenzamide
N-[(5S,6R,9R)-8-[cyclohexyl(oxo)methyl]-5-methoxy-3,6,9-trimethyl-2-oxo-11-oxa-3,8-diazabicyclo[10.4.0]hexadeca-1(12),13,15-trien-14-yl]-3-methoxybenzamide
(2e,4e)-n-{[(2r,3s,4r,5r)-3,4-dihydroxy-5-(4-hydroxy-2-oxo-5,6-dihydropyrimidin-1-yl)oxolan-2-yl]methyl}-5-[(1'r,2s)-2'-[(1'r,2r,2's)-2'-[(1e)-2-[(1r,2r)-2-methylcyclopropyl]ethenyl]-[1,1'-bi(cyclopropane)]-2-yl]-[1,1'-bi(cyclopropane)]-2-yl]penta-2,4-dienimidic acid
(2e,4e)-n-{[(2r,3s,4r,5r)-3,4-dihydroxy-5-(4-hydroxy-2-oxo-5,6-dihydropyrimidin-1-yl)oxolan-2-yl]methyl}-5-[(1'r,2s)-2'-[(1'r,2r,2's)-2'-[(1e)-2-[(1r,2r)-2-methylcyclopropyl]ethenyl]-[1,1'-bi(cyclopropane)]-2-yl]-[1,1'-bi(cyclopropane)]-2-yl]penta-2,4-dienimidic acid
7'-(3,3-dimethyloxirane-2-carbonyl)-1-formyl-2'-hydroxy-1,6-dimethyl-3a-(methylamino)-4,6,7,8,9,9a,10,10a-octahydro-3h-spiro[cyclopenta[b]quinolizine-2,3'-indol]-8-yl butanoate
7'-(3,3-dimethyloxirane-2-carbonyl)-1-formyl-2'-hydroxy-1,6-dimethyl-3a-(methylamino)-4,6,7,8,9,9a,10,10a-octahydro-3h-spiro[cyclopenta[b]quinolizine-2,3'-indol]-8-yl butanoate
(2e,4e)-n-{[(2s,3s,4r,5s)-3,4-dihydroxy-5-(4-hydroxy-2-oxo-5,6-dihydropyrimidin-1-yl)oxolan-2-yl]methyl}-5-[(1s,1's,2r,2's)-2'-[(1s,1's,2s,2'r)-2'-[(1e)-2-[(1r,2r)-2-methylcyclopropyl]ethenyl]-[1,1'-bi(cyclopropane)]-2-yl]-[1,1'-bi(cyclopropane)]-2-yl]penta-2,4-dienimidic acid
(2e,4e)-n-{[(2s,3s,4r,5s)-3,4-dihydroxy-5-(4-hydroxy-2-oxo-5,6-dihydropyrimidin-1-yl)oxolan-2-yl]methyl}-5-[(1s,1's,2r,2's)-2'-[(1s,1's,2s,2'r)-2'-[(1e)-2-[(1r,2r)-2-methylcyclopropyl]ethenyl]-[1,1'-bi(cyclopropane)]-2-yl]-[1,1'-bi(cyclopropane)]-2-yl]penta-2,4-dienimidic acid
(2e,4e)-n-{[(2s,3r,4r,5r)-3,4-dihydroxy-5-(4-hydroxy-2-oxo-5,6-dihydropyrimidin-1-yl)oxolan-2-yl]methyl}-5-[(1r,1'r,2r,2's)-2'-[(1r,1's,2r,2'r)-2'-[(1z)-2-[(1r,2r)-2-methylcyclopropyl]ethenyl]-[1,1'-bi(cyclopropane)]-2-yl]-[1,1'-bi(cyclopropane)]-2-yl]penta-2,4-dienimidic acid
(2e,4e)-n-{[(2s,3r,4r,5r)-3,4-dihydroxy-5-(4-hydroxy-2-oxo-5,6-dihydropyrimidin-1-yl)oxolan-2-yl]methyl}-5-[(1r,1'r,2r,2's)-2'-[(1r,1's,2r,2'r)-2'-[(1z)-2-[(1r,2r)-2-methylcyclopropyl]ethenyl]-[1,1'-bi(cyclopropane)]-2-yl]-[1,1'-bi(cyclopropane)]-2-yl]penta-2,4-dienimidic acid
(1r,2r,3as,6s,8r,9as,10ar)-7'-[(2s)-3,3-dimethyloxirane-2-carbonyl]-1-formyl-2'-hydroxy-1,6-dimethyl-3a-(methylamino)-4,6,7,8,9,9a,10,10a-octahydro-3h-spiro[cyclopenta[b]quinolizine-2,3'-indol]-8-yl butanoate
(1r,2r,3as,6s,8r,9as,10ar)-7'-[(2s)-3,3-dimethyloxirane-2-carbonyl]-1-formyl-2'-hydroxy-1,6-dimethyl-3a-(methylamino)-4,6,7,8,9,9a,10,10a-octahydro-3h-spiro[cyclopenta[b]quinolizine-2,3'-indol]-8-yl butanoate