Chemical Formula: C32H35Cl2N5O2

Chemical Formula C32H35Cl2N5O2

Found 1 metabolite its formula value is C32H35Cl2N5O2

P53R3

P53R3

C32H35Cl2N5O2 (591.216767)


P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53R175H, p53R248W?and p53R273H. P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53M237I?to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 (DR5). P53R3 is used for cancer research[1].