Chemical Formula: C29H33N9O12
Chemical Formula C29H33N9O12
Found 7 metabolite its formula value is C29H33N9O12
Pteroyltriglutamic acid
C29H33N9O12 (699.2248578000001)
Pteroyltriglutamic acid is a crystalline conjugate of folic acid containing three molecules of glutamic acid instead of one and having the general properties of a polypeptide. As a measure of enterocyte function, the deconjugation of Pteroylpolyglutamic acid (pteroyl-L-glutamyl-gamma-L-glutamyl-gamma-L-glutamic acid) to folic acid and subsequent active absorption was measured in 19 patients with progressive systemic sclerosis and compared with 14 controls. The absorption step of folic acid was identical in the two groups, while deconjugation of pteroyl-L-glutamyl-gamma-L-glutamyl-gamma-L-glutamic acid was significantly decreased in the patients with progressive systemic sclerosis. This observation suggests a primary epithelial defect of the small intestine in patients with progressive systemic sclerosis. (PMID 3583071). Glutamyl hydrolase cleaves the poly-g-glutamate chain folate and antifolate poly-g-glutamates. Its cellular location is lysosomal with large amts. of the enzyme constitutively secreted. The highest levels of glutamyl hydrolase mRNA in humans is found in the liver and kidney (PMID:10598552). A crystalline conjugate of folic acid containing three molecules of glutamic acid instead of one and having the general properties of a polypeptide. (http://medical-dictionary.thefreedictionary.com/pteropterin)
tetrahydropteroyl tri-L-glutamate
C29H33N9O12 (699.2248578000001)
Tetrahydropteroyl tri-l-glutamate is practically insoluble (in water) and a moderately acidic compound (based on its pKa). Tetrahydropteroyl tri-l-glutamate can be found in a number of food items such as potato, sour cherry, spearmint, and asparagus, which makes tetrahydropteroyl tri-l-glutamate a potential biomarker for the consumption of these food products.
Pteropterin
C29H33N9O12 (699.2248578000001)
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
tetrahydropteroyltri-L-glutamate(4-)
C29H33N9O12 (699.2248578000001)
Tetracarboxylate anion of tetrahydropteroyltri-L-glutamic acid; major species at pH 7.3.
2-(4-{4-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]-4-carboxybutanamido}-4-carboxybutanamido)pentanedioic acid
C29H33N9O12 (699.2248578000001)