Chemical Formula: C27H42N7O19P3S
Chemical Formula C27H42N7O19P3S
Found 21 metabolite its formula value is C27H42N7O19P3S
3-Methylglutaconyl-CoA
C27H42N7O19P3S (893.1468972000001)
3-Methylglutaconyl-CoA is a substrate for Methylglutaconyl-CoA hydratase (mitochondrial), Methylcrotonoyl-CoA carboxylase beta chain (mitochondrial) and Methylcrotonoyl-CoA carboxylase alpha chain (mitochondrial). [HMDB]. 3-Methylglutaconyl-CoA is found in many foods, some of which are cocoa bean, evening primrose, winter squash, and rocket salad (sspecies). 3-Methylglutaconyl-CoA is a substrate for Methylglutaconyl-CoA hydratase (mitochondrial), Methylcrotonoyl-CoA carboxylase beta chain (mitochondrial) and Methylcrotonoyl-CoA carboxylase alpha chain (mitochondrial). COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
5-Carboxy-2-pentenoyl-CoA
C27H42N7O19P3S (893.1468972000001)
5-carboxy-2-pentenoyl-coa, also known as (E)-3,4-dehydroadipoyl-coa or 2,3-didehydroadipyl-coa, is a member of the class of compounds known as medium-chain 2-enoyl coas. Medium-chain 2-enoyl coas are organic compounds containing a coenzyme A substructure linked to a medium-chain 2-enoyl chain of 5 to 12 carbon atoms. Thus, 5-carboxy-2-pentenoyl-coa is considered to be a fatty ester lipid molecule. 5-carboxy-2-pentenoyl-coa is slightly soluble (in water) and an extremely strong acidic compound (based on its pKa). 5-carboxy-2-pentenoyl-coa can be found in a number of food items such as citrus, swiss chard, agave, and safflower, which makes 5-carboxy-2-pentenoyl-coa a potential biomarker for the consumption of these food products. 5-carboxy-2-pentenoyl-coa exists in all living organisms, ranging from bacteria to humans. This compound belongs to the family of Acyl CoAs. These are organic compounds contaning a coenzyme A substructure linked to another moeity through an ester bond.
3,4-Didehydroadipyl-CoA
C27H42N7O19P3S (893.1468972000001)
(2E)-3-methylpent-2-enedioyl-CoA
C27H42N7O19P3S (893.1468972000001)
(2e)-3-methylpent-2-enedioyl-coa is an acyl-CoA or acyl-coenzyme A. More specifically, it is a (2E)-3-methylpent-2-enedioic acid thioester of coenzyme A. (2e)-3-methylpent-2-enedioyl-coa is an acyl-CoA with 6 fatty acid group as the acyl moiety attached to coenzyme A. Coenzyme A was discovered in 1946 by Fritz Lipmann (Journal of Biological Chemistry (1946) 162 (3): 743–744) and its structure was determined in the early 1950s at the Lister Institute in London. Coenzyme A is a complex, thiol-containing molecule that is naturally synthesized from pantothenate (vitamin B5), which is found in various foods such as meat, vegetables, cereal grains, legumes, eggs, and milk. More specifically, coenzyme A (CoASH or CoA) consists of a beta-mercaptoethylamine group linked to the vitamin pantothenic acid (B5) through an amide linkage and 3-phosphorylated ADP. Coenzyme A is synthesized in a five-step process that requires four molecules of ATP, pantothenate and cysteine. It is believed that there are more than 1100 types of acyl-CoA’s in the human body, which also corresponds to the number of acylcarnitines in the human body. Acyl-CoAs exists in all living species, ranging from bacteria to plants to humans. The general role of acyl-CoA’s is to assist in transferring fatty acids from the cytoplasm to mitochondria. This process facilitates the production of fatty acids in cells, which are essential in cell membrane structure. Acyl-CoAs are also susceptible to beta oxidation, forming, ultimately, acetyl-CoA. Acetyl-CoA can enter the citric acid cycle, eventually forming several equivalents of ATP. In this way, fats are converted to ATP -- or biochemical energy. Acyl-CoAs can be classified into 9 different categories depending on the size of their acyl-group: 1) short-chain acyl-CoAs; 2) medium-chain acyl-CoAs; 3) long-chain acyl-CoAs; and 4) very long-chain acyl-CoAs; 5) hydroxy acyl-CoAs; 6) branched chain acyl-CoAs; 7) unsaturated acyl-CoAs; 8) dicarboxylic acyl-CoAs and 9) miscellaneous acyl-CoAs. Short-chain acyl-CoAs have acyl-groups with two to four carbons (C2-C4), medium-chain acyl-CoAs have acyl-groups with five to eleven carbons (C5-C11), long-chain acyl-CoAs have acyl-groups with twelve to twenty carbons (C12-C20) while very long-chain acyl-CoAs have acyl groups with more than 20 carbons. (2e)-3-methylpent-2-enedioyl-coa is therefore classified as a medium chain acyl-CoA. The oxidative degradation of fatty acids is a two-step process, catalyzed by acyl-CoA synthetase/synthase. Fatty acids are first converted to their acyl phosphate, the precursor to acyl-CoA. The latter conversion is mediated by acyl-CoA synthase. Three types of acyl-CoA synthases are employed, depending on the chain length of the fatty acid. (2e)-3-methylpent-2-enedioyl-coa, being a medium chain acyl-CoA is a substrate for medium chain acyl-CoA synthase. The second step of fatty acid degradation is beta oxidation. Beta oxidation occurs in mitochondria and, in the case of very long chain acyl-CoAs, the peroxisome. After its formation in the cytosol, (2E)-3-methylpent-2-enedioyl-CoA is transported into the mitochondria, the locus of beta oxidation. Transport of (2E)-3-methylpent-2-enedioyl-CoA into the mitochondria requires carnitine palmitoyltransferase 1 (CPT1), which converts (2E)-3-methylpent-2-enedioyl-CoA into (2E)-3-methylpent-2-enedioylcarnitine, which gets transported into the mitochondrial matrix. Once in the matrix, (2E)-3-methylpent-2-enedioylcarnitine is converted back to (2E)-3-methylpent-2-enedioyl-CoA by CPT2, whereupon beta-oxidation can begin. Beta oxidation of (2E)-3-methylpent-2-enedioyl-CoA occurs in four steps. First, since (2E)-3-methylpent-2-enedioyl-CoA is a medium chain acyl-CoA it is the substrate for a medium chain acyl-CoA dehydrogenase, which catalyzes dehydrogenation of (2E)-3-methylpent-2-enedioyl-CoA, creating a double bond between the alpha and beta carbons. FAD is the hydrogen acceptor, yielding FADH2. Second, Enoyl-CoA hydrase cat...
hex-3-enedioyl-CoA
C27H42N7O19P3S (893.1468972000001)
Hex-3-enedioyl-coa is an acyl-CoA or acyl-coenzyme A. More specifically, it is a hex-3-enedioic acid thioester of coenzyme A. Hex-3-enedioyl-coa is an acyl-CoA with 6 fatty acid group as the acyl moiety attached to coenzyme A. Coenzyme A was discovered in 1946 by Fritz Lipmann (Journal of Biological Chemistry (1946) 162 (3): 743–744) and its structure was determined in the early 1950s at the Lister Institute in London. Coenzyme A is a complex, thiol-containing molecule that is naturally synthesized from pantothenate (vitamin B5), which is found in various foods such as meat, vegetables, cereal grains, legumes, eggs, and milk. More specifically, coenzyme A (CoASH or CoA) consists of a beta-mercaptoethylamine group linked to the vitamin pantothenic acid (B5) through an amide linkage and 3-phosphorylated ADP. Coenzyme A is synthesized in a five-step process that requires four molecules of ATP, pantothenate and cysteine. It is believed that there are more than 1100 types of acyl-CoA’s in the human body, which also corresponds to the number of acylcarnitines in the human body. Acyl-CoAs exists in all living species, ranging from bacteria to plants to humans. The general role of acyl-CoA’s is to assist in transferring fatty acids from the cytoplasm to mitochondria. This process facilitates the production of fatty acids in cells, which are essential in cell membrane structure. Acyl-CoAs are also susceptible to beta oxidation, forming, ultimately, acetyl-CoA. Acetyl-CoA can enter the citric acid cycle, eventually forming several equivalents of ATP. In this way, fats are converted to ATP -- or biochemical energy. Acyl-CoAs can be classified into 9 different categories depending on the size of their acyl-group: 1) short-chain acyl-CoAs; 2) medium-chain acyl-CoAs; 3) long-chain acyl-CoAs; and 4) very long-chain acyl-CoAs; 5) hydroxy acyl-CoAs; 6) branched chain acyl-CoAs; 7) unsaturated acyl-CoAs; 8) dicarboxylic acyl-CoAs and 9) miscellaneous acyl-CoAs. Short-chain acyl-CoAs have acyl-groups with two to four carbons (C2-C4), medium-chain acyl-CoAs have acyl-groups with five to eleven carbons (C5-C11), long-chain acyl-CoAs have acyl-groups with twelve to twenty carbons (C12-C20) while very long-chain acyl-CoAs have acyl groups with more than 20 carbons. Hex-3-enedioyl-coa is therefore classified as a medium chain acyl-CoA. The oxidative degradation of fatty acids is a two-step process, catalyzed by acyl-CoA synthetase/synthase. Fatty acids are first converted to their acyl phosphate, the precursor to acyl-CoA. The latter conversion is mediated by acyl-CoA synthase. Three types of acyl-CoA synthases are employed, depending on the chain length of the fatty acid. Hex-3-enedioyl-coa, being a medium chain acyl-CoA is a substrate for medium chain acyl-CoA synthase. The second step of fatty acid degradation is beta oxidation. Beta oxidation occurs in mitochondria and, in the case of very long chain acyl-CoAs, the peroxisome. After its formation in the cytosol, hex-3-enedioyl-CoA is transported into the mitochondria, the locus of beta oxidation. Transport of hex-3-enedioyl-CoA into the mitochondria requires carnitine palmitoyltransferase 1 (CPT1), which converts hex-3-enedioyl-CoA into hex-3-enedioylcarnitine, which gets transported into the mitochondrial matrix. Once in the matrix, hex-3-enedioylcarnitine is converted back to hex-3-enedioyl-CoA by CPT2, whereupon beta-oxidation can begin. Beta oxidation of hex-3-enedioyl-CoA occurs in four steps. First, since hex-3-enedioyl-CoA is a medium chain acyl-CoA it is the substrate for a medium chain acyl-CoA dehydrogenase, which catalyzes dehydrogenation of hex-3-enedioyl-CoA, creating a double bond between the alpha and beta carbons. FAD is the hydrogen acceptor, yielding FADH2. Second, Enoyl-CoA hydrase catalyzes the addition of water across the newly formed double bond to make an alcohol. Third, 3-hydroxyacyl-CoA dehydrogenase oxidizes the alcohol group to a ketone and NADH is produced from NAD+. F...
Coenzyme A, S-3-methylglutaconate
C27H42N7O19P3S (893.1468972000001)
CoA 6:2;O2
C27H42N7O19P3S (893.1468972000001)
(3E)-5-{[2-(3-{3-[({[({[5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)methyl]-2-hydroxy-3-methylbutanamido}propanamido)ethyl]sulfanyl}-3-methyl-5-oxopent-3-enoic acid
C27H42N7O19P3S (893.1468972000001)
(E)-5-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-3-methyl-5-oxopent-2-enoic acid
C27H42N7O19P3S (893.1468972000001)
trans-2,3-didehydroadipoyl-CoA
C27H42N7O19P3S (893.1468972000001)
An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of trans-2,3-didehydroadipic acid.
5-oxo-furan-2-acetyl-CoA
C27H42N7O19P3S (893.1468972000001)
An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 5-oxo-furan-2-acetic acid.
trans-3-methylglutaconyl-CoA
C27H42N7O19P3S (893.1468972000001)
The S-(trans-3-methylglutaconyl) derivative of coenzyme A.
(Z)-2,3-dehydroadipoyl-CoA
C27H42N7O19P3S (893.1468972000001)
A 2-enoyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the enoic carboxy group of (Z)-hex-2-enedioic acid.
2,3-didehydroadipoyl-CoA
C27H42N7O19P3S (893.1468972000001)
A 2-enoyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the enoic carboxy group of hex-2-enedioic acid.